Details for: GRM2

Gene ID: 2912

Symbol: GRM2

Ensembl ID: ENSG00000164082

Description: glutamate metabotropic receptor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1178
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.4
    Marker Score: 2905
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 877
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 862
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 803
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.05
    Marker Score: 6949
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.04
    Marker Score: 430
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71838
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48063
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 514
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 467
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.97
    Marker Score: 445
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.77
    Marker Score: 1460
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3222.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.72
    Marker Score: 44129
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.64
    Marker Score: 5477
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.63
    Marker Score: 364
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.62
    Marker Score: 9708
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 493
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.59
    Marker Score: 188
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.58
    Marker Score: 895
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 235
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.53
    Marker Score: 1086
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.52
    Marker Score: 4943
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.51
    Marker Score: 271
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.48
    Marker Score: 979
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.42
    Marker Score: 1716
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.38
    Marker Score: 884
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.32
    Marker Score: 195
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 326
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.28
    Marker Score: 135
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.27
    Marker Score: 763
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.25
    Marker Score: 252
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.24
    Marker Score: 419
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.23
    Marker Score: 89
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.22
    Marker Score: 251
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 66
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 118
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.2
    Marker Score: 154
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.18
    Marker Score: 180
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.18
    Marker Score: 65
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.14
    Marker Score: 82
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.14
    Marker Score: 710
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.13
    Marker Score: 52
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.13
    Marker Score: 48
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.13
    Marker Score: 102
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.13
    Marker Score: 47
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.13
    Marker Score: 426
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.12
    Marker Score: 148
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.11
    Marker Score: 64
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.1
    Marker Score: 966
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.1
    Marker Score: 41
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.1
    Marker Score: 994
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.09
    Marker Score: 135
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.09
    Marker Score: 62
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.09
    Marker Score: 115
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.09
    Marker Score: 55
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.09
    Marker Score: 85
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.08
    Marker Score: 139
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.08
    Marker Score: 99
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.08
    Marker Score: 333.5
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.07
    Marker Score: 89
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.07
    Marker Score: 101
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.07
    Marker Score: 63
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.06
    Marker Score: 173
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.06
    Marker Score: 54
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.06
    Marker Score: 67
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.06
    Marker Score: 2110
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.06
    Marker Score: 32

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Other Information

**Key characteristics:** * GRM2 is a protein of the glutamate receptor family. * It is expressed in a variety of cell types, including neurons, astrocytes, and immune cells. * It is a key regulator of synaptic transmission in the central nervous system. * It is also involved in the regulation of calcium signaling and immune responses. **Pathways and functions:** * GRM2 is a ligand-gated channel that is expressed in the plasma membrane of neurons and astrocytes. * When GRM2 binds to glutamate, it opens a channel that allows calcium ions to flow into the cell. * This calcium influx activates a variety of intracellular signaling pathways, including the adenylate cyclase-inhibiting g protein-coupled glutamate receptor signaling pathway and the calcium channel regulator activity pathway. * These pathways regulate a variety of cellular processes, including synaptic transmission, calcium signaling, and immune responses. **Clinical significance:** * GRM2 mutations are associated with a number of neurological and psychiatric disorders, including autism, schizophrenia, and epilepsy. * Drugs that block GRM2 have been shown to be effective in treating these disorders. **Additional information:** * GRM2 is a highly conserved gene, with a similar gene found in mammals, birds, and reptiles. * It is a member of the glutamate receptor family of G protein-coupled receptors. * GRM2 is a key regulator of synaptic transmission in the central nervous system. * It is also involved in the regulation of calcium signaling and immune responses.

Genular Protein ID: 839156664

Symbol: GRM2_HUMAN

Name: Metabotropic glutamate receptor 2

UniProtKB Accession Codes:

Q14416 B0M0K7 Q14CU5 Q52MC6 Q9H3N6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 7 EMDB 9 Ensembl 1 ExpressionAtlas 1 GO 26 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 34 PDBsum 25 PRINTS 3 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7620613

Title: Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2.

PubMed ID: 7620613

DOI: 10.1111/j.1460-9568.1995.tb00666.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18297054

Title: Identification of a serotonin/glutamate receptor complex implicated in psychosis.

PubMed ID: 18297054

DOI: 10.1038/nature06612

PubMed ID: 23129762

Title: Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A.mGlu2) receptor heteromerization and its psychoactive behavioral function.

PubMed ID: 23129762

DOI: 10.1074/jbc.m112.413161

PubMed ID: 22300836

Title: Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades.

PubMed ID: 22300836

DOI: 10.1016/j.neuropharm.2012.01.010

Sequence Information:

  • Length: 872
  • Mass: 95568
  • Checksum: 801976D034AA8100
  • Sequence:
    • MGSLLALLAL LLLWGAVAEG PAKKVLTLEG DLVLGGLFPV HQKGGPAEDC GPVNEHRGIQ 
RLEAMLFALD RINRDPHLLP GVRLGAHILD SCSKDTHALE QALDFVRASL SRGADGSRHI 
CPDGSYATHG DAPTAITGVI GGSYSDVSIQ VANLLRLFQI PQISYASTSA KLSDKSRYDY 
FARTVPPDFF QAKAMAEILR FFNWTYVSTV ASEGDYGETG IEAFELEARA RNICVATSEK 
VGRAMSRAAF EGVVRALLQK PSARVAVLFT RSEDARELLA ASQRLNASFT WVASDGWGAL 
ESVVAGSEGA AEGAITIELA SYPISDFASY FQSLDPWNNS RNPWFREFWE QRFRCSFRQR 
DCAAHSLRAV PFEQESKIMF VVNAVYAMAH ALHNMHRALC PNTTRLCDAM RPVNGRRLYK 
DFVLNVKFDA PFRPADTHNE VRFDRFGDGI GRYNIFTYLR AGSGRYRYQK VGYWAEGLTL 
DTSLIPWASP SAGPLPASRC SEPCLQNEVK SVQPGEVCCW LCIPCQPYEY RLDEFTCADC 
GLGYWPNASL TGCFELPQEY IRWGDAWAVG PVTIACLGAL ATLFVLGVFV RHNATPVVKA 
SGRELCYILL GGVFLCYCMT FIFIAKPSTA VCTLRRLGLG TAFSVCYSAL LTKTNRIARI 
FGGAREGAQR PRFISPASQV AICLALISGQ LLIVVAWLVV EAPGTGKETA PERREVVTLR 
CNHRDASMLG SLAYNVLLIA LCTLYAFKTR KCPENFNEAK FIGFTMYTTC IIWLAFLPIF 
YVTSSDYRVQ TTTMCVSVSL SGSVVLGCLF APKLHIILFQ PQKNVVSHRA PTSRFGSAAA 
RASSSLGQGS GSQFVPTVCN GREVVDSTTS SL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.