Details for: GUCY2F

Gene ID: 2986

Symbol: GUCY2F

Ensembl ID: ENSG00000101890

Description: guanylate cyclase 2F, retinal

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.22
    Marker Score: 2231
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.72
    Marker Score: 3560
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7529
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.99
    Marker Score: 951
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.96
    Marker Score: 2451.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.95
    Marker Score: 1802
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.87
    Marker Score: 1760
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.74
    Marker Score: 821
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.66
    Marker Score: 196
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 465
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 320
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.51
    Marker Score: 7926
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.48
    Marker Score: 214
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.4
    Marker Score: 208
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.38
    Marker Score: 121.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.35
    Marker Score: 817
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.34
    Marker Score: 160
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3
    Marker Score: 869.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.29
    Marker Score: 169
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.26
    Marker Score: 972
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.25
    Marker Score: 111
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.22
    Marker Score: 766
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.22
    Marker Score: 130
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 65
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.21
    Marker Score: 165.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.21
    Marker Score: 69
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.2
    Marker Score: 199
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.19
    Marker Score: 555
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.18
    Marker Score: 57
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.15
    Marker Score: 69
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.12
    Marker Score: 80
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.12
    Marker Score: 100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.11
    Marker Score: 171.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 90
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 88
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 74
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.08
    Marker Score: 88
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.07
    Marker Score: 985
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.07
    Marker Score: 93
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.07
    Marker Score: 88
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.07
    Marker Score: 131
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.07
    Marker Score: 571.5
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.06
    Marker Score: 109
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.06
    Marker Score: 202
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.06
    Marker Score: 173
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.05
    Marker Score: 310
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.05
    Marker Score: 59
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.05
    Marker Score: 184
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.04
    Marker Score: 182
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.04
    Marker Score: 23

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - GUCY2F is a transmembrane protein with a molecular weight of approximately 130 kDa. - It is a member of the GUCY family of guanylyl cyclase enzymes. - It is expressed in high levels in the retina, where it is responsible for the phototransduction cascade. **Pathways and functions:** - GUCY2F is involved in the regulation of visual perception by controlling the activity of the phototransduction cascade. - The phototransduction cascade is a complex signaling pathway that is responsible for converting light into electrical signals that are sent to the brain. - GUCY2F is a key component of the phototransduction cascade, and its activity is essential for the initiation of the cascade. **Clinical significance:** Mutations in the GUCY2F gene have been linked to several eye diseases, including retinitis pigmentosa and age-related macular degeneration. These diseases are characterized by the loss of vision, and GUCY2F is a key protein in the phototransduction cascade, which is responsible for converting light into electrical signals that are sent to the brain. **Conclusion:** GUCY2F is a critical protein in the visual perception pathway. Its activity is essential for the initiation of the phototransduction cascade, which is responsible for converting light into electrical signals that are sent to the brain. Mutations in the GUCY2F gene have been linked to several eye diseases, which underscores the importance of this protein in human health.

Genular Protein ID: 81123956

Symbol: GUC2F_HUMAN

Name: Retinal guanylyl cyclase 2

UniProtKB Accession Codes:

P51841 Q9UJF1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7777544

Title: Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2.

PubMed ID: 7777544

DOI: 10.1073/pnas.92.12.5535

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 29515371

Title: Control of the Nucleotide Cycle in Photoreceptor Cell Extracts by Retinal Degeneration Protein 3.

PubMed ID: 29515371

DOI: 10.3389/fnmol.2018.00052

Sequence Information:

  • Length: 1108
  • Mass: 124850
  • Checksum: B047BBF1A3C009F9
  • Sequence:
    • MFLGLGRFSR LVLWFAAFRK LLGHHGLASA KFLWCLCLLS VMSLPQQVWT LPYKIGVVGP 
WACDSLFSKA LPEVAARLAI ERINRDPSFD LSYSFEYVIL NEDCQTSRAL SSFISHHQMA 
SGFIGPTNPG YCEAASLLGN SWDKGIFSWA CVNYELDNKI SYPTFSRTLP SPIRVLVTVM 
KYFQWAHAGV ISSDEDIWVH TANRVASALR SHGLPVGVVL TTGQDSQSMR KALQRIHQAD 
RIRIIIMCMH SALIGGETQM HLLECAHDLK MTDGTYVFVP YDALLYSLPY KHTPYRVLRN 
NPKLREAYDA VLTITVESQE KTFYQAFTEA AARGEIPEKL EFDQVSPLFG TIYNSIYFIA 
QAMNNAMKEN GQAGAASLVQ HSRNMQFHGF NQLMRTDSNG NGISEYVILD TNLKEWELHS 
TYTVDMEMEL LRFGGTPIHF PGGRPPRADA KCWFAEGKIC HGGIDPAFAM MVCLTLLIAL 
LSINGFAYFI RRRINKIQLI KGPNRILLTL EDVTFINPHF GSKRGSRASV SFQITSEVQS 
GRSPRLSFSS GSLTPATYEN SNIAIYEGDW VWLKKFSLGD FGDLKSIKSR ASDVFEMMKD 
LRHENINPLL GFFYDSGMFA IVTEFCSRGS LEDILTNQDV KLDWMFKSSL LLDLIKGMKY 
LHHREFVHGR LKSRNCVVDG RFVLKVTDYG FNDILEMLRL SEEESSMEEL LWTAPELLRA 
PRGSRLGSFA GDVYSFAIIM QEVMVRGTPF CMMDLPAQEI INRLKKPPPV YRPVVPPEHA 
PPECLQLMKQ CWAEAAEQRP TFDEIFNQFK TFNKGKKTNI IDSMLRMLEQ YSSNLEDLIR 
ERTEELEIEK QKTEKLLTQM LPPSVAESLK KGCTVEPEGF DLVTLYFSDI VGFTTISAMS 
EPIEVVDLLN DLYTLFDAII GSHDVYKVET IGDAYMVASG LPKRNGSRHA AEIANMSLDI 
LSSVGTFKMR HMPEVPVRIR IGLHSGPVVA GVVGLTMPRY CLFGDTVNTA SRMESTGLPY 
RIHVSLSTVT ILQNLSEGYE VELRGRTELK GKGTEETFWL IGKKGFMKPL PVPPPVDKDG 
QVGHGLQPVE IAAFQRRKAE RQLVRNKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.