Details for: EBLN1

Gene ID: 340900

Symbol: EBLN1

Ensembl ID: ENSG00000223601

Description: endogenous Bornavirus like nucleoprotein 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1092
    Cell Significance Index: 1.3800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0035
    Cell Significance Index: 0.0400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.0027
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0012
    Cell Significance Index: -0.8900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0025
    Cell Significance Index: -0.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0037
    Cell Significance Index: -0.7400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0073
    Cell Significance Index: -0.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0086
    Cell Significance Index: -0.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0127
    Cell Significance Index: -0.3400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0142
    Cell Significance Index: -0.1500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0143
    Cell Significance Index: -0.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0158
    Cell Significance Index: -0.3300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0165
    Cell Significance Index: -0.1800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0171
    Cell Significance Index: -0.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0184
    Cell Significance Index: -0.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0200
    Cell Significance Index: -0.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0201
    Cell Significance Index: -0.7000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0203
    Cell Significance Index: -0.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0221
    Cell Significance Index: -0.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0227
    Cell Significance Index: -0.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0230
    Cell Significance Index: -0.3300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0232
    Cell Significance Index: -0.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0235
    Cell Significance Index: -0.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0238
    Cell Significance Index: -0.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0239
    Cell Significance Index: -0.7600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0244
    Cell Significance Index: -0.5100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0271
    Cell Significance Index: -0.3600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0281
    Cell Significance Index: -0.7000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0286
    Cell Significance Index: -0.3200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0291
    Cell Significance Index: -0.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0316
    Cell Significance Index: -0.8300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0319
    Cell Significance Index: -0.6900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0319
    Cell Significance Index: -0.3700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0320
    Cell Significance Index: -0.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0342
    Cell Significance Index: -0.7300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0350
    Cell Significance Index: -0.4600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0352
    Cell Significance Index: -0.4400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0356
    Cell Significance Index: -0.4800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0363
    Cell Significance Index: -0.4600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0366
    Cell Significance Index: -0.7300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0373
    Cell Significance Index: -0.4500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0379
    Cell Significance Index: -0.7600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0389
    Cell Significance Index: -0.5100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0402
    Cell Significance Index: -0.3900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0404
    Cell Significance Index: -0.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0406
    Cell Significance Index: -0.6800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0410
    Cell Significance Index: -0.8100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0410
    Cell Significance Index: -0.4900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0411
    Cell Significance Index: -0.3900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0413
    Cell Significance Index: -0.4000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0425
    Cell Significance Index: -0.8300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0427
    Cell Significance Index: -0.5200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0431
    Cell Significance Index: -0.5300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0451
    Cell Significance Index: -0.7800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0462
    Cell Significance Index: -0.5000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0463
    Cell Significance Index: -0.5300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0475
    Cell Significance Index: -0.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0479
    Cell Significance Index: -0.4600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0498
    Cell Significance Index: -0.6500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0499
    Cell Significance Index: -0.5100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0511
    Cell Significance Index: -0.4800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0528
    Cell Significance Index: -0.4700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0535
    Cell Significance Index: -0.6300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0544
    Cell Significance Index: -0.4600
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0551
    Cell Significance Index: -0.6400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0566
    Cell Significance Index: -0.6200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0568
    Cell Significance Index: -0.5800
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0569
    Cell Significance Index: -0.6500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0575
    Cell Significance Index: -0.6800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0578
    Cell Significance Index: -0.6800
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0610
    Cell Significance Index: -0.7000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0622
    Cell Significance Index: -0.6600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0624
    Cell Significance Index: -0.4800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0624
    Cell Significance Index: -0.3700
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0626
    Cell Significance Index: -0.4500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0640
    Cell Significance Index: -0.6800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0640
    Cell Significance Index: -0.8200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0647
    Cell Significance Index: -0.4000
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0649
    Cell Significance Index: -0.4500
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0652
    Cell Significance Index: -0.5500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0654
    Cell Significance Index: -0.3500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0659
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0671
    Cell Significance Index: -0.8500
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0675
    Cell Significance Index: -0.7500
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0699
    Cell Significance Index: -0.8400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0711
    Cell Significance Index: -0.5900
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.0718
    Cell Significance Index: -0.7600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0767
    Cell Significance Index: -0.4800
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0768
    Cell Significance Index: -0.9300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0791
    Cell Significance Index: -0.7500
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0806
    Cell Significance Index: -0.8200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0809
    Cell Significance Index: -0.9400
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0812
    Cell Significance Index: -0.7100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0821
    Cell Significance Index: -0.5200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0827
    Cell Significance Index: -0.7600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0846
    Cell Significance Index: -0.5400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0851
    Cell Significance Index: -0.7500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0919
    Cell Significance Index: -0.6100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0927
    Cell Significance Index: -0.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The EBLN1 gene is a non-coding RNA that shares structural similarities with the Bornavirus nucleoprotein, a virus known for its ability to manipulate host cell biology. Notably, EBLN1 is significantly expressed in cells from various tissues, including the brain, heart, and tumor tissues. Its expression profile is characterized by a high degree of variability across different cell types, suggesting a complex role in regulating cellular processes. Bioinformatics analysis has revealed that EBLN1 exhibits a high degree of sequence similarity to the Bornavirus nucleoprotein, hinting at a possible evolutionary relationship. **Pathways and Functions:** The EBLN1 gene is thought to play a critical role in modulating immune responses and cellular homeostasis. Its expression in immune cells, such as microglial cells and pericytes, suggests a potential involvement in the regulation of immune cell function and tissue homeostasis. Furthermore, EBLN1's expression in neoplastic cells implies a possible role in tumorigenesis and cancer progression. Recent studies have implicated EBLN1 in the regulation of cellular signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, which are critical for cell growth, survival, and differentiation. **Clinical Significance:** The discovery of the EBLN1 gene has significant clinical implications, particularly in the context of immune-related disorders and cancer. Its expression in immune cells and neoplastic cells suggests a potential role in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. Additionally, EBLN1's involvement in tumorigenesis and cancer progression implies a potential therapeutic target for cancer treatment. Further research is needed to fully elucidate the clinical significance of EBLN1 and to explore its potential as a biomarker or therapeutic target. **Future Directions:** To fully harness the potential of the EBLN1 gene, future research should focus on elucidating its molecular mechanisms of action, including its interactions with other proteins and signaling pathways. Additionally, studies investigating the clinical significance of EBLN1 in various disease contexts will be essential for unlocking its therapeutic potential. The integration of EBLN1 into existing immunological and oncological frameworks will be crucial for advancing our understanding of this enigmatic gene and its role in human disease. In conclusion, the EBLN1 gene represents a novel player in the complex landscape of immune regulation and disease pathogenesis. Further research is needed to fully unravel the mysteries of this enigmatic gene and to explore its potential as a therapeutic target. As an expert immunologist, I am excited to contribute to the ongoing investigation of EBLN1 and to shed light on its significance in human health and disease.

Genular Protein ID: 2242191852

Symbol: EBLN1_HUMAN

Name: Endogenous Bornavirus-like nucleoprotein 1

UniProtKB Accession Codes:

P0CF75 S4R316

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 20054395

Title: Endogenous non-retroviral RNA virus elements in mammalian genomes.

PubMed ID: 20054395

DOI: 10.1038/nature08695

Sequence Information:

  • Length: 366
  • Mass: 40313
  • Checksum: DA7E68FDB877E53A
  • Sequence:
    • MSRPRNNPQT SSPQDSTKDG SSFHYFQGRF ELSGKSRQYP ADALEPQPGI GDVKVIEKAT 
KSMLDPAQRS HFYLVTPSLV FLCFIFDGLH KALLSVGVSK RSNIVIGNEN KETGTLYASK 
FEDVLPTFTA LEMSSILRHC CDLIGIAAGS SDPICTNSLQ VQRQFKAMMI SIGRPLHSES 
ADLLISYNAG PAIDWINSRP WVGGLMFTFL FGEFESPACE LLDQVKVVAS KAQMMTYYTV 
RMFLDQCVDG STALPAVVLE IPVFEQKKPL AKKVLGDFFE FGGVLRHPVI GVLSPQMFPN 
LATAANYWAK RRNSTFSGFE ALDIIPGSTI TFPVLQMASA QKISRGSDMD PYTLNILRGY 
GISGFE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.