Details for: IL9R

Gene ID: 3581

Symbol: IL9R

Ensembl ID: ENSG00000124334

Description: interleukin 9 receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.2
    Marker Score: 2218
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1998
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4821
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.11
    Marker Score: 705
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 504
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 637
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 474
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.56
    Marker Score: 3594
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.44
    Marker Score: 241.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.37
    Marker Score: 215.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.3
    Marker Score: 408.5
  • Cell Name: group 2 innate lymphoid cell (CL0001069)
    Fold Change: 0.25
    Marker Score: 85
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.21
    Marker Score: 122
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.2
    Marker Score: 155
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.19
    Marker Score: 182
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.19
    Marker Score: 1850
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.19
    Marker Score: 384.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.18
    Marker Score: 198
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.18
    Marker Score: 213
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.15
    Marker Score: 171
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.14
    Marker Score: 64
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.13
    Marker Score: 70
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.13
    Marker Score: 50
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.12
    Marker Score: 129
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.12
    Marker Score: 70
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.12
    Marker Score: 98
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.11
    Marker Score: 68
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.11
    Marker Score: 54
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.1
    Marker Score: 67
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 95
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.09
    Marker Score: 134
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.09
    Marker Score: 69
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.09
    Marker Score: 58
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 94
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.08
    Marker Score: 179
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.08
    Marker Score: 16
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 75
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.08
    Marker Score: 123
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 65
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.07
    Marker Score: 56
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.06
    Marker Score: 75
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.06
    Marker Score: 114
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.05
    Marker Score: 103
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.05
    Marker Score: 39
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.05
    Marker Score: 50
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.05
    Marker Score: 54
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.05
    Marker Score: 83
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.05
    Marker Score: 62
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.05
    Marker Score: 39
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.05
    Marker Score: 49
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.05
    Marker Score: 16

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Other Information

**Key characteristics:** - IL9R is a type I transmembrane receptor. - It is expressed in a variety of cell types, including blood vessel endothelial cells, enterocytes, and immune cells. - It is a key regulator of immune responses. **Pathways and functions:** - IL-9 signaling is involved in a variety of immune responses, including inflammation, tissue repair, and immune tolerance. - It is a key regulator of the inflammatory response. - It is involved in the regulation of cell population proliferation and differentiation. - It is involved in the regulation of epithelial cell function. **Clinical significance:** - Mutations in the IL9R gene have been linked to a number of autoimmune diseases, including rheumatoid arthritis, Crohn's disease, and psoriasis. - IL-9 is a promising target for the treatment of inflammatory diseases. **Other relevant information:** - The IL9R gene is located on chromosome 1. - It is a highly conserved gene, with a similar sequence in humans and mice. - It is a member of the interleukin-9 receptor family of receptors. - It is a key regulator of the immune system.

Genular Protein ID: 3530700411

Symbol: IL9R_HUMAN

Name: Interleukin-9 receptor

UniProtKB Accession Codes:

Q01113 B9ZVT0 Q14634 Q8WWU1 Q96TF0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 Ensembl 4 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 10 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1376929

Title: Expression cloning of the murine and human interleukin 9 receptor cDNAs.

PubMed ID: 1376929

DOI: 10.1073/pnas.89.12.5690

PubMed ID: 8666384

Title: The IL-9 receptor gene (IL9R): genomic structure, chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes, and identification of IL9R pseudogenes at 9qter, 10pter, 16pter, and 18pter.

PubMed ID: 8666384

DOI: 10.1006/geno.1995.9992

PubMed ID: 10655549

Title: Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region.

PubMed ID: 10655549

DOI: 10.1093/hmg/9.3.395

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 8193355

Title: Isolation and characterization of the human interleukin-9 receptor gene.

PubMed ID: 8193355

Sequence Information:

  • Length: 521
  • Mass: 57147
  • Checksum: 07C40436466173F3
  • Sequence:
    • MGLGRCIWEG WTLESEALRR DMGTWLLACI CICTCVCLGV SVTGEGQGPR SRTFTCLTNN 
ILRIDCHWSA PELGQGSSPW LLFTSNQAPG GTHKCILRGS ECTVVLPPEA VLVPSDNFTI 
TFHHCMSGRE QVSLVDPEYL PRRHVKLDPP SDLQSNISSG HCILTWSISP ALEPMTTLLS 
YELAFKKQEE AWEQAQHRDH IVGVTWLILE AFELDPGFIH EARLRVQMAT LEDDVVEEER 
YTGQWSEWSQ PVCFQAPQRQ GPLIPPWGWP GNTLVAVSIF LLLTGPTYLL FKLSPRVKRI 
FYQNVPSPAM FFQPLYSVHN GNFQTWMGAH GAGVLLSQDC AGTPQGALEP CVQEATALLT 
CGPARPWKSV ALEEEQEGPG TRLPGNLSSE DVLPAGCTEW RVQTLAYLPQ EDWAPTSLTR 
PAPPDSEGSR SSSSSSSSNN NNYCALGCYG GWHLSALPGN TQSSGPIPAL ACGLSCDHQG 
LETQQGVAWV LAGHCQRPGL HEDLQGMLLP SVLSKARSWT F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.