Details for: KIR2DL3

Gene ID: 3804

Symbol: KIR2DL3

Ensembl ID: ENSG00000243772

Description: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8273
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3173
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.48
    Marker Score: 6856
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.27
    Marker Score: 412
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.97
    Marker Score: 923
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.88
    Marker Score: 673.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1374
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.79
    Marker Score: 2306
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 509
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.77
    Marker Score: 1130
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.74
    Marker Score: 388
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.67
    Marker Score: 386
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 508
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.58
    Marker Score: 934
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.57
    Marker Score: 1803
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.56
    Marker Score: 298.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.53
    Marker Score: 222
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.52
    Marker Score: 693
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.5
    Marker Score: 483
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.5
    Marker Score: 685
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 477
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.47
    Marker Score: 364
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.43
    Marker Score: 382
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.41
    Marker Score: 233
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.39
    Marker Score: 222
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.38
    Marker Score: 345
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.37
    Marker Score: 478.5
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.36
    Marker Score: 180
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.35
    Marker Score: 208
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.3
    Marker Score: 218
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.29
    Marker Score: 133
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.29
    Marker Score: 499
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.25
    Marker Score: 211
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.22
    Marker Score: 150
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.2
    Marker Score: 137
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.2
    Marker Score: 165
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.19
    Marker Score: 44
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.18
    Marker Score: 58
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.17
    Marker Score: 168
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.17
    Marker Score: 167
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.17
    Marker Score: 189
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.16
    Marker Score: 133
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.14
    Marker Score: 154
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.14
    Marker Score: 343
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.14
    Marker Score: 228
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.14
    Marker Score: 84
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.14
    Marker Score: 1610
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.13
    Marker Score: 70
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.12
    Marker Score: 785
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.1
    Marker Score: 92
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.1
    Marker Score: 64
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.08
    Marker Score: 75
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.08
    Marker Score: 185
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.08
    Marker Score: 87
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 136
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.06
    Marker Score: 117.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.06
    Marker Score: 133
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.06
    Marker Score: 46
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.06
    Marker Score: 174
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.05
    Marker Score: 27

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Other Information

**Key characteristics:** - KIR2DL3 is a type I transmembrane receptor with two Ig domains and a long cytoplasmic tail. - It is expressed in high levels in certain cell types, including oligodendrocyte precursor cells, blood vessel endothelial cells, and certain immune cells. - The protein is a key immune checkpoint molecule that regulates the immune response. **Pathways and functions:** - KIR2DL3 is expressed on the surface of immune cells, including natural killer (NK) cells and activated CD8+ T cells. - Upon binding to its ligand, HLA-E, KIR2DL3 triggers inhibitory signals that inhibit the immune response. - KIR2DL3 is also expressed on tumor cells, where it can interact with HLA-E on antigen-presenting cells, leading to immune evasion. - By regulating the immune response through interaction with HLA-E, KIR2DL3 plays an important role in maintaining immune homeostasis and preventing autoimmune diseases. **Clinical significance:** - KIR2DL3 mutations have been linked to several human cancers, including colon cancer, breast cancer, and leukemia. - Blockade of KIR2DL3 signaling with antibodies or small molecules has been shown to enhance antitumor immune responses and improve patient outcomes in preclinical models of cancer. - Therefore, KIR2DL3 is a promising target for cancer immunotherapy.

Genular Protein ID: 87219218

Symbol: KI2L3_HUMAN

Name: CD158 antigen-like family member B2

UniProtKB Accession Codes:

P43628 O43472 P78402 Q14944 Q14945 Q9UM51 Q9UQ70

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 24 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7716543

Title: Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells.

PubMed ID: 7716543

DOI: 10.1126/science.7716543

PubMed ID: 7749980

Title: Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.

PubMed ID: 7749980

DOI: 10.1016/1074-7613(95)90025-x

PubMed ID: 8662091

Title: Alternatively spliced forms of human killer inhibitory receptors.

PubMed ID: 8662091

DOI: 10.1007/bf02602590

PubMed ID: 9430221

Title: Human diversity in killer cell inhibitory receptor genes.

PubMed ID: 9430221

DOI: 10.1016/s1074-7613(00)80394-5

PubMed ID: 9059894

Title: Polymorphism and domain variability of human killer cell inhibitory receptors.

PubMed ID: 9059894

DOI: 10.1111/j.1600-065x.1997.tb00951.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9234478

Title: Genomic organization of a human killer cell inhibitory receptor gene.

PubMed ID: 9234478

DOI: 10.1111/j.1399-0039.1997.tb02804.x

PubMed ID: 18604210

Title: An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.

PubMed ID: 18604210

DOI: 10.1038/ni.1635

PubMed ID: 10196125

Title: Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I.

PubMed ID: 10196125

DOI: 10.1016/s0969-2126(99)80052-5

Sequence Information:

  • Length: 341
  • Mass: 37886
  • Checksum: C21EAFF80EA9AAB2
  • Sequence:
    • MSLMVVSMVC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW SDVRFQHFLL 
HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI 
VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHERR FSAGPKVNGT 
FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSETGN 
PRHLHVLIGT SVVIILFILL LFFLLHRWCC NKKNAVVMDQ EPAGNRTVNR EDSDEQDPQE 
VTYAQLNHCV FTQRKITRPS QRPKTPPTDI IVYTELPNAE P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.