Details for: LAMP1

Gene ID: 3916

Symbol: LAMP1

Ensembl ID: ENSG00000185896

Description: lysosomal associated membrane protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.26
    Marker Score: 4714
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3
    Marker Score: 3618
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.55
    Marker Score: 5806
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.54
    Marker Score: 64925
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.49
    Marker Score: 6325
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.47
    Marker Score: 9530
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.46
    Marker Score: 6207
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.43
    Marker Score: 2776.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.34
    Marker Score: 17387
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.31
    Marker Score: 78748
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.29
    Marker Score: 19703
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.25
    Marker Score: 6036
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.2
    Marker Score: 17213
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.16
    Marker Score: 5664
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.15
    Marker Score: 5931
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.12
    Marker Score: 18629
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.1
    Marker Score: 9036
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.07
    Marker Score: 6054
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.05
    Marker Score: 7289
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.05
    Marker Score: 2077
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.04
    Marker Score: 646
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.01
    Marker Score: 2847
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.01
    Marker Score: 2957
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.01
    Marker Score: 2127
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.99
    Marker Score: 928
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.98
    Marker Score: 9495.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.98
    Marker Score: 2382
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.96
    Marker Score: 452
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.96
    Marker Score: 1108
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.96
    Marker Score: 2058.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.94
    Marker Score: 3211
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.92
    Marker Score: 9441
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.92
    Marker Score: 7553
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.92
    Marker Score: 1058
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.92
    Marker Score: 3610
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.91
    Marker Score: 4675
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.9
    Marker Score: 1667.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.9
    Marker Score: 3050
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.89
    Marker Score: 11486
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.89
    Marker Score: 1890
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.86
    Marker Score: 3719
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.86
    Marker Score: 537
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.86
    Marker Score: 6886
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.84
    Marker Score: 3266
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.84
    Marker Score: 765
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.83
    Marker Score: 1964.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.82
    Marker Score: 1889
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.82
    Marker Score: 3835
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.81
    Marker Score: 5677
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.8
    Marker Score: 2489
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.79
    Marker Score: 1495
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.79
    Marker Score: 749
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.79
    Marker Score: 4277
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.78
    Marker Score: 61804
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.77
    Marker Score: 424
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.76
    Marker Score: 2792
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.75
    Marker Score: 1509
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.75
    Marker Score: 638
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.74
    Marker Score: 1016
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.74
    Marker Score: 2563
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.74
    Marker Score: 1265
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.73
    Marker Score: 1553
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.72
    Marker Score: 19422
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.72
    Marker Score: 3912
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.71
    Marker Score: 1136
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.7
    Marker Score: 419
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.68
    Marker Score: 627
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.68
    Marker Score: 4719
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.68
    Marker Score: 1121
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.67
    Marker Score: 2093
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.66
    Marker Score: 401
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.66
    Marker Score: 16821
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.66
    Marker Score: 10815
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.66
    Marker Score: 2140
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.65
    Marker Score: 1557
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.65
    Marker Score: 476
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.65
    Marker Score: 10535
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.65
    Marker Score: 2543.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.65
    Marker Score: 1594
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.64
    Marker Score: 91860
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.64
    Marker Score: 2769
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.64
    Marker Score: 2978.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.63
    Marker Score: 604
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.63
    Marker Score: 16165
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.63
    Marker Score: 1910
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.62
    Marker Score: 364
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.62
    Marker Score: 645
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.61
    Marker Score: 1017
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.6
    Marker Score: 1310
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.6
    Marker Score: 5044.5
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.59
    Marker Score: 370
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.58
    Marker Score: 1079.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.58
    Marker Score: 1452
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.57
    Marker Score: 417
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.57
    Marker Score: 1943
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.57
    Marker Score: 2255
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.56
    Marker Score: 1668
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.56
    Marker Score: 974
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.56
    Marker Score: 305
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.56
    Marker Score: 1692

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Other Information

**Key characteristics:** - The gene is located on chromosome 19p13.3. - It is a single-exon gene with a predicted protein of 132 amino acids. - It is highly expressed in many cell types, including endothelial cells, macrophages, and leukocytes. **Pathways and functions:** - The protein encoded by the LAMP1 gene is a key regulator of the lysosomal lumen acidification pathway, which is a pathway that is involved in the clearance of damaged or dysfunctional organelles and proteins from the lysosome. - The pathway is activated by the binding of the protein HMGB1 to the LAMP1 protein. - Once activated, the pathway leads to the degradation of damaged or dysfunctional proteins and organelles. **Clinical significance:** - Mutations in the LAMP1 gene have been linked to a number of human diseases, including amyloidosis and lysosomal disorders. - In amyloidosis, the LAMP1 protein is mutated in a large percentage of patients with the disease. - In lysosomal disorders, the LAMP1 protein is mutated in a significant percentage of patients with the disease. - Targeting the LAMP1 gene has been investigated as a therapeutic strategy for amyloidosis and lysosomal disorders. **Additional notes:** - The LAMP1 gene has also been shown to be involved in the regulation of the immune system, the innate immune system, and the regulation of organelle transport along microtubules. - The protein encoded by the LAMP1 gene is a member of the LAMP family of lysosomal associated membrane proteins. - The LAMP1 protein is a highly conserved protein, with a similar protein found in other mammals.

Genular Protein ID: 3243905410

Symbol: LAMP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P11279 B4DWL3 Q8WU33 Q96I40 Q9BRD2 Q9NP13

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 10 EMDB 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 34 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3198605

Title: Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences.

PubMed ID: 3198605

DOI: 10.1016/s0021-9258(18)37370-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2912382

Title: Purification and characterization of human lysosomal membrane glycoproteins.

PubMed ID: 2912382

DOI: 10.1016/0003-9861(89)90597-3

PubMed ID: 3131762

Title: Molecular cloning of cDNAs encoding lamp A, a human lysosomal membrane glycoprotein with apparent Mr approximately equal to 120,000.

PubMed ID: 3131762

DOI: 10.1073/pnas.85.11.3743

PubMed ID: 8517882

Title: The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes.

PubMed ID: 8517882

DOI: 10.1016/s0021-9258(18)52972-0

PubMed ID: 2584229

Title: Structure of human lysosomal membrane glycoprotein 1. Assignment of disulfide bonds and visualization of its domain arrangement.

PubMed ID: 2584229

DOI: 10.1016/s0021-9258(19)47094-4

PubMed ID: 2243102

Title: The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones.

PubMed ID: 2243102

DOI: 10.1016/s0021-9258(17)30530-6

PubMed ID: 2022921

Title: Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.

PubMed ID: 2022921

DOI: 10.1084/jem.173.5.1099

PubMed ID: 8323299

Title: Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2.

PubMed ID: 8323299

DOI: 10.1006/abbi.1993.1322

PubMed ID: 7685349

Title: E-selectin-dependent adhesion efficiency of colonic carcinoma cells is increased by genetic manipulation of their cell surface lysosomal membrane glycoprotein-1 expression levels.

PubMed ID: 7685349

DOI: 10.1016/s0021-9258(18)31441-8

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16176980

Title: The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments.

PubMed ID: 16176980

DOI: 10.1091/mbc.e05-03-0189

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22641697

Title: The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2.

PubMed ID: 22641697

DOI: 10.1242/jcs.087346

PubMed ID: 24088571

Title: Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.

PubMed ID: 24088571

DOI: 10.1091/mbc.e13-05-0259

PubMed ID: 23847195

Title: Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage.

PubMed ID: 23847195

DOI: 10.1182/blood-2012-07-441832

PubMed ID: 23632890

Title: LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity.

PubMed ID: 23632890

DOI: 10.1182/blood-2012-08-453738

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24970085

Title: Virus entry. Lassa virus entry requires a trigger-induced receptor switch.

PubMed ID: 24970085

DOI: 10.1126/science.1252480

PubMed ID: 25972533

Title: Molecular Mechanism for LAMP1 Recognition by Lassa Virus.

PubMed ID: 25972533

DOI: 10.1128/jvi.00651-15

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27605678

Title: Role of LAMP1 Binding and pH Sensing by the Spike Complex of Lassa Virus.

PubMed ID: 27605678

DOI: 10.1128/jvi.01624-16

PubMed ID: 28448640

Title: Mapping of the Lassa virus LAMP1 binding site reveals unique determinants not shared by other old world arenaviruses.

PubMed ID: 28448640

DOI: 10.1371/journal.ppat.1006337

PubMed ID: 29295909

Title: Lamp1 Increases the Efficiency of Lassa Virus Infection by Promoting Fusion in Less Acidic Endosomal Compartments.

PubMed ID: 29295909

DOI: 10.1128/mbio.01818-17

PubMed ID: 32295904

Title: Lysosome-Associated Membrane Proteins Support the Furin-Mediated Processing of the Mumps Virus Fusion Protein.

PubMed ID: 32295904

DOI: 10.1128/jvi.00050-20

PubMed ID: 37390818

Title: Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.

PubMed ID: 37390818

DOI: 10.1016/j.molcel.2023.06.004

Sequence Information:

  • Length: 417
  • Mass: 44882
  • Checksum: 3E0A285744DD6588
  • Sequence:
    • MAAPGSARRP LLLLLLLLLL GLMHCASAAM FMVKNGNGTA CIMANFSAAF SVNYDTKSGP 
KNMTFDLPSD ATVVLNRSSC GKENTSDPSL VIAFGRGHTL TLNFTRNATR YSVQLMSFVY 
NLSDTHLFPN ASSKEIKTVE SITDIRADID KKYRCVSGTQ VHMNNVTVTL HDATIQAYLS 
NSSFSRGETR CEQDRPSPTT APPAPPSPSP SPVPKSPSVD KYNVSGTNGT CLLASMGLQL 
NLTYERKDNT TVTRLLNINP NKTSASGSCG AHLVTLELHS EGTTVLLFQF GMNASSSRFF 
LQGIQLNTIL PDARDPAFKA ANGSLRALQA TVGNSYKCNA EEHVRVTKAF SVNIFKVWVQ 
AFKVEGGQFG SVEECLLDEN SMLIPIAVGG ALAGLVLIVL IAYLVGRKRS HAGYQTI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.