Details for: LYN

Gene ID: 4067

Symbol: LYN

Ensembl ID: ENSG00000254087

Description: LYN proto-oncogene, Src family tyrosine kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.25
    Marker Score: 3919
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.14
    Marker Score: 7578
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.99
    Marker Score: 2948
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.74
    Marker Score: 1361
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.72
    Marker Score: 151835
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.47
    Marker Score: 893
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.34
    Marker Score: 674
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.25
    Marker Score: 797
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.21
    Marker Score: 1329
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.18
    Marker Score: 4240
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.1
    Marker Score: 4409
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.94
    Marker Score: 1943
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.89
    Marker Score: 1776
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.81
    Marker Score: 892
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.79
    Marker Score: 1598
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.77
    Marker Score: 739
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.76
    Marker Score: 5235
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.75
    Marker Score: 1326
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.75
    Marker Score: 7259
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.74
    Marker Score: 1187
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.73
    Marker Score: 4298
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.67
    Marker Score: 917
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.66
    Marker Score: 1011
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.66
    Marker Score: 3025
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.64
    Marker Score: 42087
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.64
    Marker Score: 1879
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.59
    Marker Score: 784
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.54
    Marker Score: 1030
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.52
    Marker Score: 24369
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.51
    Marker Score: 487
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.48
    Marker Score: 1558
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167117
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.44
    Marker Score: 366
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.41
    Marker Score: 8582
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.41
    Marker Score: 3652
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.41
    Marker Score: 971
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.39
    Marker Score: 1622
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.38
    Marker Score: 2403
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.34
    Marker Score: 580
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.33
    Marker Score: 619
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.29
    Marker Score: 2358
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.29
    Marker Score: 450
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.26
    Marker Score: 14672
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.25
    Marker Score: 2540
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.23
    Marker Score: 855
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.21
    Marker Score: 278
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.2
    Marker Score: 749
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.2
    Marker Score: 346
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.19
    Marker Score: 1323
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.19
    Marker Score: 7733
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.18
    Marker Score: 811
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.16
    Marker Score: 275
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.14
    Marker Score: 3339
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.14
    Marker Score: 300
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.13
    Marker Score: 462
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.13
    Marker Score: 798
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.11
    Marker Score: 3828
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.09
    Marker Score: 723
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.08
    Marker Score: 738
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.08
    Marker Score: 853
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.07
    Marker Score: 1395
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.07
    Marker Score: 269
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.07
    Marker Score: 370
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.07
    Marker Score: 1087
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.07
    Marker Score: 9364
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.04
    Marker Score: 7759
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.04
    Marker Score: 525
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.03
    Marker Score: 620
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.03
    Marker Score: 790
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1
    Marker Score: 433
  • Cell Name: B cell (CL0000236)
    Fold Change: 1
    Marker Score: 952
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71678
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47902
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.98
    Marker Score: 340
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.98
    Marker Score: 599
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.98
    Marker Score: 1742
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30388
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.97
    Marker Score: 1055
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.97
    Marker Score: 794
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.97
    Marker Score: 564
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 15066
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.96
    Marker Score: 563
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.96
    Marker Score: 880
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.95
    Marker Score: 9622
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.95
    Marker Score: 1014.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2397
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.93
    Marker Score: 3816
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.92
    Marker Score: 3950
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.9
    Marker Score: 1719
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2703
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.9
    Marker Score: 1086
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.89
    Marker Score: 476
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.89
    Marker Score: 432
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.88
    Marker Score: 18817
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.88
    Marker Score: 276
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - The LYN proto-oncogene is located on chromosome 15q21.1. - It is a member of the Src family of tyrosine kinases, which are involved in various cellular processes. - LYN proto-oncogene is activated by a variety of growth factors and cytokines, including erythropoietin and receptor tyrosine kinases. - Once activated, LYN proto-oncogene translocates to the nucleus and promotes the transcription of downstream target genes. - LYN proto-oncogene is a key regulator of immune responses, and its mutations are associated with several human diseases. **Pathways and functions:** - LYN proto-oncogene is involved in the adaptive immune system through various pathways, including cell cycle regulation, cell surface interactions, and cytokine signaling. - It is essential for the development and survival of myeloid and lymphoid cells. - LYN proto-oncogene is also involved in the development of the central nervous system (CNS), where it is expressed in microglia and macrophages. - In the context of cancer, LYN proto-oncogene mutations can lead to the activation of immune cells and the development of tumors. **Clinical significance:** - Mutations in the LYN proto-oncogene have been linked to several human diseases, including cancer, autoimmune diseases, and inflammatory disorders. - Targeting the LYN proto-oncogene has emerged as a promising therapeutic strategy for cancer and other diseases where it is overexpressed. - Current LYN inhibitors are being evaluated in clinical trials to assess their potential for cancer treatment.

Genular Protein ID: 2896308138

Symbol: LYN_HUMAN

Name: Tyrosine-protein kinase Lyn

UniProtKB Accession Codes:

P07948 A0AVQ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 6 DrugCentral 1 EC 2 ELM 1 EMBL 6 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PIR 1 PRINTS 3 PRO 1 PROSITE 5 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 36 RefSeq 3 Rhea 3 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3561390

Title: The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.

PubMed ID: 3561390

DOI: 10.1128/mcb.7.1.237-243.1987

PubMed ID: 8125304

Title: The cDNAs encoding two forms of the LYN protein tyrosine kinase are expressed in rat mast cells and human myeloid cells.

PubMed ID: 8125304

DOI: 10.1016/0378-1119(94)90811-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2247464

Title: Putative tyrosine kinases expressed in K-562 human leukemia cells.

PubMed ID: 2247464

DOI: 10.1073/pnas.87.22.8913

PubMed ID: 1510669

Title: Expression of the B cell-associated tyrosine kinase gene Lyn in primary neuroblastoma tumours and its modulation during the differentiation of neuroblastoma cell lines.

PubMed ID: 1510669

DOI: 10.1016/s0006-291x(05)81562-1

PubMed ID: 7687428

Title: CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells.

PubMed ID: 7687428

DOI: 10.1006/bbrc.1993.1807

PubMed ID: 7682714

Title: Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling.

PubMed ID: 7682714

DOI: 10.1073/pnas.90.8.3631

PubMed ID: 8064233

Title: Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn.

PubMed ID: 8064233

DOI: 10.1084/jem.180.3.1165

PubMed ID: 7935444

Title: Functional analysis of Csk in signal transduction through the B-cell antigen receptor.

PubMed ID: 7935444

DOI: 10.1128/mcb.14.11.7306-7313.1994

PubMed ID: 7895172

Title: Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases.

PubMed ID: 7895172

DOI: 10.1016/s1074-7613(95)80040-9

PubMed ID: 9171348

Title: Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets.

PubMed ID: 9171348

DOI: 10.1093/emboj/16.9.2342

PubMed ID: 9020138

Title: Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.

PubMed ID: 9020138

DOI: 10.1074/jbc.272.7.4230

PubMed ID: 9232445

Title: Fc gamma receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell.

PubMed ID: 9232445

DOI: 10.1016/s0165-2478(97)00055-2

PubMed ID: 9341198

Title: Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells.

PubMed ID: 9341198

DOI: 10.1074/jbc.272.43.27450

PubMed ID: 10574931

Title: Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage.

PubMed ID: 10574931

DOI: 10.1074/jbc.274.49.34663

PubMed ID: 10362357

Title: cbl-3: a new mammalian cbl family protein.

PubMed ID: 10362357

DOI: 10.1038/sj.onc.1202753

PubMed ID: 10748115

Title: Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor.

PubMed ID: 10748115

DOI: 10.1074/jbc.m909044199

PubMed ID: 11435302

Title: Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.

PubMed ID: 11435302

DOI: 10.1182/blood.v98.2.343

PubMed ID: 11306681

Title: Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic AMP-specific phosphodiesterase PDE4A10.

PubMed ID: 11306681

DOI: 10.1124/mol.59.5.996

PubMed ID: 10891478

Title: Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage.

PubMed ID: 10891478

DOI: 10.1128/mcb.20.15.5370-5380.2000

PubMed ID: 11517336

Title: Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis.

PubMed ID: 11517336

DOI: 10.1073/pnas.191130798

PubMed ID: 11825908

Title: Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling.

PubMed ID: 11825908

DOI: 10.1074/jbc.m200277200

PubMed ID: 12750561

Title: DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7.

PubMed ID: 12750561

DOI: 10.4161/cbt.2.2.282

PubMed ID: 12496276

Title: Identification of UNC119 as a novel activator of SRC-type tyrosine kinases.

PubMed ID: 12496276

DOI: 10.1074/jbc.m208261200

PubMed ID: 14726379

Title: Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors.

PubMed ID: 14726379

DOI: 10.1182/blood-2003-10-3566

PubMed ID: 15173188

Title: Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain.

PubMed ID: 15173188

DOI: 10.1083/jcb.200403011

PubMed ID: 16129412

Title: Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.

PubMed ID: 16129412

DOI: 10.1016/j.bbrc.2005.08.055

PubMed ID: 15795233

Title: Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein.

PubMed ID: 15795233

DOI: 10.1074/jbc.m412634200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16467205

Title: Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34+ marrow cells.

PubMed ID: 16467205

DOI: 10.1182/blood-2005-08-3343

PubMed ID: 16912036

Title: Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity.

PubMed ID: 16912036

DOI: 10.1074/jbc.m605902200

PubMed ID: 16920712

Title: Csk-binding protein mediates sequential enzymatic down-regulation and degradation of Lyn in erythropoietin-stimulated cells.

PubMed ID: 16920712

DOI: 10.1074/jbc.m602637200

PubMed ID: 17233630

Title: Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets.

PubMed ID: 17233630

DOI: 10.1042/bj20061618

PubMed ID: 17640867

Title: Leupaxin negatively regulates B cell receptor signaling.

PubMed ID: 17640867

DOI: 10.1074/jbc.m704625200

PubMed ID: 17977829

Title: TOM1L1 is a Lyn substrate involved in FcepsilonRI signaling in mast cells.

PubMed ID: 17977829

DOI: 10.1074/jbc.m705168200

PubMed ID: 18056483

Title: A critical role for Lyn in acute myeloid leukemia.

PubMed ID: 18056483

DOI: 10.1182/blood-2007-04-082099

PubMed ID: 18070987

Title: Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts.

PubMed ID: 18070987

DOI: 10.1182/blood-2007-05-090985

PubMed ID: 18235045

Title: Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.

PubMed ID: 18235045

DOI: 10.1182/blood-2007-08-109330

PubMed ID: 18817770

Title: Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity.

PubMed ID: 18817770

DOI: 10.1016/j.yexcr.2008.08.019

PubMed ID: 18802065

Title: Monocyte migration and LFA-1-mediated attachment to brain microvascular endothelia is regulated by SDF-1 alpha through Lyn kinase.

PubMed ID: 18802065

DOI: 10.4049/jimmunol.181.7.4632

PubMed ID: 18577747

Title: Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase.

PubMed ID: 18577747

DOI: 10.1093/jnci/djn188

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19718658

Title: Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins.

PubMed ID: 19718658

DOI: 10.1002/jcb.22317

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20037584

Title: CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

PubMed ID: 20037584

DOI: 10.1038/ni.1836

PubMed ID: 20534535

Title: Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.

PubMed ID: 20534535

DOI: 10.1073/pnas.0911714107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21930792

Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.

PubMed ID: 21930792

DOI: 10.1128/mcb.05817-11

PubMed ID: 15220000

Title: Src-family kinases: rheostats of immune cell signaling.

PubMed ID: 15220000

DOI: 10.1016/j.molimm.2004.04.010

PubMed ID: 15489917

Title: Src-family kinases in B-cell development and signaling.

PubMed ID: 15489917

DOI: 10.1038/sj.onc.1208075

PubMed ID: 15664155

Title: Lyn tyrosine kinase: accentuating the positive and the negative.

PubMed ID: 15664155

DOI: 10.1016/j.immuni.2004.12.004

PubMed ID: 16801133

Title: The duplicitous nature of the Lyn tyrosine kinase in growth factor signaling.

PubMed ID: 16801133

DOI: 10.1080/08977190600581327

PubMed ID: 18772004

Title: New insights on mast cell activation via the high affinity receptor for IgE.

PubMed ID: 18772004

DOI: 10.1016/s0065-2776(08)00403-3

PubMed ID: 19290919

Title: Multiple roles of Lyn kinase in myeloid cell signaling and function.

PubMed ID: 19290919

DOI: 10.1111/j.1600-065x.2008.00758.x

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11955060

Title: Structural investigation of the binding of a herpesviral protein to the SH3 domain of tyrosine kinase Lck.

PubMed ID: 11955060

DOI: 10.1021/bi015986j

PubMed ID: 16155203

Title: Structural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition motif that enhances binding affinity.

PubMed ID: 16155203

DOI: 10.1110/ps.051563605

PubMed ID: 19857964

Title: Structural basis for the inhibitor recognition of human Lyn kinase domain.

PubMed ID: 19857964

DOI: 10.1016/j.bmcl.2009.10.038

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 512
  • Mass: 58574
  • Checksum: 408D3D461204E378
  • Sequence:
    • MGCIKSKGKD SLSDDGVDLK TQPVRNTERT IYVRDPTSNK QQRPVPESQL LPGQRFQTKD 
PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW KAKSLLTKKE GFIPSNYVAK 
LNTLETEEWF FKDITRKDAE RQLLAPGNSA GAFLIRESET LKGSFSLSVR DFDPVHGDVI 
KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQADGLCR RLEKACISPK PQKPWDKDAW 
EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD 
KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER 
KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF 
TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRVENCPD ELYDIMKMCW 
KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP

Genular Protein ID: 382349888

Symbol: A8K379_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K379

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 6 DNASU 1 EC 1 EMBL 2 GO 4 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 10 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 7 PROSITE-ProRule 3 Pfam 3 RefSeq 1 Rhea 3 RuleBase 1 SAM 1 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 512
  • Mass: 58619
  • Checksum: 5C911DFC2EA1FD47
  • Sequence:
    • MGCIKSKGKD SLSDDGVDLK TQPVRNTERT IYVRDPTSNK QQRPVPESQL LPGQRFQTKD 
PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW KAKSLLTKKE GFIPSNYVAK 
LNTLETEEWF FKDITRKDAE RQLLAPGNSA GAFLIRESET LKGSFSLSVR DFDPVHGDVI 
KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQADGLCR RLEKACISPK PQKPWDKDAW 
EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD 
KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEEMAYIER 
KNYIHRDLRA ASVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF 
TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRVENCPD ELYDIMKMCW 
KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP

Genular Protein ID: 1028377744

Symbol: Q6NUK7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NUK7

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 EC 1 EMBL 3 GO 4 Gene3D 3 GenomeRNAi 1 InterPro 12 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 8 PROSITE-ProRule 3 PeptideAtlas 1 Pfam 3 RefSeq 2 Rhea 3 RuleBase 1 SAM 1 SMART 3 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 582
  • Mass: 65809
  • Checksum: 1CFF99768C28E9BB
  • Sequence:
    • VPLPPRRAAL PLAPRPWRLR ARRAAASSPR QAGRPRHPRP RASSPSPRVQ RSRPAASPYA 
GPAGPPRRAP HSELKSPWSS AAPKLSPRAG NMGCIKSKGK DSLSDDGVDL KTQPVPESQL 
LPGQRFQTKD PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW KAKSLLTKKE 
GFIPSNYVAK LNTLETEEWF FKDITRKDAE RQLLAPGNSA GAFLIRESET LKGSFSLSVR 
DFDPVHGDVI KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQADGLCR RLEKACISPK 
PQKPWDKDAW EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE 
ANLMKTLQHD KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ 
IAEGMAYIER KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT 
APEAINFGCF TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRVENCPD 
ELYDIMKMCW KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP

Genular Protein ID: 1170068907

Symbol: B4DQ79_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DQ79

Database IDs:

ARBA 9 AlphaFoldDB 1 CDD 2 CTD 1 ChEBI 6 EC 1 EMBL 2 GO 4 Gene3D 3 InterPro 11 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 8 PROSITE-ProRule 3 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 3 RuleBase 1 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 423
  • Mass: 48561
  • Checksum: 760A154D4DF0F453
  • Sequence:
    • MKVLEEHGEW WKAKSLLTKK EGFIPSNYVA KLNTLETEEW FFKDITRKDA ERQLLAPGNS 
AGAFLIRESE TLKGSFSLSV RDFDPVHGDV IKHYKIRSLD NGGYYISPRI TFPCISDMIK 
HYQKQADGLC RRLEKACISP KPQKPWDKDA WEIPRESIKL VKRLGAGQFG EVWMGYYNNS 
TKVAVKTLKP GTMSVQAFLE EANLMKTLQH DKLVRLYAVV TREEPIYIIT EYMAKGSLLD 
FLKSDEGGKV LLPKLIDFSA QIAEGMAYIE RKNYIHRDLR AANVLVSESL MCKIADFGLA 
RVIEDNEYTA REGAKFPIKW TAPEAINFGC FTIKSDVWSF GILLYEIVTY GKIPYPGRTN 
ADVMTALSQG YRMPRVENCP DELYDIMKMC WKEKAEERPT FDYLQSVLDD FYTATEGQYQ 
QQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.