Details for: MAGEA6

Gene ID: 4105

Symbol: MAGEA6

Ensembl ID: ENSG00000197172

Description: MAGE family member A6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.1077
    Cell Significance Index: 5.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.0299
    Cell Significance Index: 26.2400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.7588
    Cell Significance Index: 6.5200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.6014
    Cell Significance Index: 10.2800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.3277
    Cell Significance Index: 4.2400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3063
    Cell Significance Index: 4.2000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.3059
    Cell Significance Index: 4.9600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.1337
    Cell Significance Index: 1.4200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.0495
    Cell Significance Index: 0.2700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0249
    Cell Significance Index: 0.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0013
    Cell Significance Index: -0.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0015
    Cell Significance Index: -0.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0068
    Cell Significance Index: -0.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0080
    Cell Significance Index: -0.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0101
    Cell Significance Index: -1.3900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0190
    Cell Significance Index: -0.2000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0200
    Cell Significance Index: -0.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0262
    Cell Significance Index: -0.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0296
    Cell Significance Index: -1.0400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0426
    Cell Significance Index: -0.4400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0470
    Cell Significance Index: -0.7900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0541
    Cell Significance Index: -0.6500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0566
    Cell Significance Index: -0.6200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0573
    Cell Significance Index: -0.6100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0590
    Cell Significance Index: -0.7600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0640
    Cell Significance Index: -0.9100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0700
    Cell Significance Index: -0.9300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0700
    Cell Significance Index: -1.3700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0702
    Cell Significance Index: -0.9800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0711
    Cell Significance Index: -1.4200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0718
    Cell Significance Index: -0.8000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0728
    Cell Significance Index: -0.8300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0737
    Cell Significance Index: -0.9700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0754
    Cell Significance Index: -0.9900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0794
    Cell Significance Index: -1.0800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0796
    Cell Significance Index: -0.9400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0800
    Cell Significance Index: -0.9500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0823
    Cell Significance Index: -1.1300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0836
    Cell Significance Index: -1.4200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0853
    Cell Significance Index: -0.8800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0853
    Cell Significance Index: -0.9900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0870
    Cell Significance Index: -1.1300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0871
    Cell Significance Index: -1.0700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0876
    Cell Significance Index: -1.0500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0880
    Cell Significance Index: -1.0300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0891
    Cell Significance Index: -1.0600
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0893
    Cell Significance Index: -0.9700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0902
    Cell Significance Index: -0.9500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0904
    Cell Significance Index: -0.9600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0939
    Cell Significance Index: -1.1100
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0956
    Cell Significance Index: -1.0700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0967
    Cell Significance Index: -1.0900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0972
    Cell Significance Index: -1.0400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0973
    Cell Significance Index: -1.1500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0985
    Cell Significance Index: -1.1000
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0986
    Cell Significance Index: -0.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0986
    Cell Significance Index: -1.4100
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1002
    Cell Significance Index: -0.9300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1011
    Cell Significance Index: -1.1200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1011
    Cell Significance Index: -0.9600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1012
    Cell Significance Index: -1.0500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1040
    Cell Significance Index: -1.0600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1086
    Cell Significance Index: -1.2500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1089
    Cell Significance Index: -0.9200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1108
    Cell Significance Index: -1.0400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1117
    Cell Significance Index: -1.1400
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1203
    Cell Significance Index: -1.3900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1205
    Cell Significance Index: -1.5100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1211
    Cell Significance Index: -1.2000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1255
    Cell Significance Index: -0.7800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1268
    Cell Significance Index: -1.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1285
    Cell Significance Index: -2.1500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1329
    Cell Significance Index: -1.2600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1397
    Cell Significance Index: -1.2200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1463
    Cell Significance Index: -1.9100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1540
    Cell Significance Index: -2.1600
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1554
    Cell Significance Index: -1.2400
  • Cell Name: brush cell of tracheobronchial tree (CL0002075)
    Fold Change: -0.1595
    Cell Significance Index: -1.4400
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.1623
    Cell Significance Index: -1.6100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1645
    Cell Significance Index: -2.0000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1699
    Cell Significance Index: -1.8700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1771
    Cell Significance Index: -1.9300
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.1780
    Cell Significance Index: -1.6900
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1789
    Cell Significance Index: -1.9400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1815
    Cell Significance Index: -1.1400
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.1819
    Cell Significance Index: -1.8800
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.1836
    Cell Significance Index: -1.9200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1863
    Cell Significance Index: -1.9300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1910
    Cell Significance Index: -1.8300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2030
    Cell Significance Index: -1.9300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2052
    Cell Significance Index: -1.9200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.2101
    Cell Significance Index: -1.9300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2145
    Cell Significance Index: -1.8900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.2156
    Cell Significance Index: -1.9600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2200
    Cell Significance Index: -1.8200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2686
    Cell Significance Index: -1.6700
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2801
    Cell Significance Index: -2.1200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2864
    Cell Significance Index: -1.8600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3269
    Cell Significance Index: -1.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** MAGEA6 is predominantly expressed in germ cells and cancerous tissues, including various types of tumors such as melanoma, lung, and ovarian cancer. 2. **Cell Type Specificity:** MAGEA6 is specifically expressed in cells of the intestinal epithelium, including goblet cells, absorptive cells, and intestinal epithelial cells. 3. **Tumor Suppression:** MAGEA6 has been shown to inhibit the growth of cancer cells by inducing apoptosis and inhibiting cell proliferation. 4. **Immune Evasion:** MAGEA6 has been implicated in the evasion of immune recognition by cancer cells, making it a potential target for cancer immunotherapy. **Pathways and Functions:** MAGEA6 has been implicated in several cellular processes, including: 1. **Negative Regulation of Autophagy:** MAGEA6 has been shown to inhibit autophagy, a process by which cells recycle damaged organelles and proteins, thereby promoting cell survival. 2. **Negative Regulation of Transcription by RNA Polymerase II:** MAGEA6 has been implicated in the regulation of gene expression by inhibiting the activity of RNA polymerase II, a key enzyme involved in transcription. 3. **Histone Deacetylase Binding:** MAGEA6 has been shown to interact with histone deacetylases, enzymes involved in the regulation of gene expression through chromatin remodeling. 4. **Protein Binding:** MAGEA6 has been implicated in the binding of various proteins, including transcription factors and microRNAs, which regulate gene expression. **Clinical Significance:** The study of MAGEA6 has significant implications for the development of cancer immunotherapy. As a potential target for cancer immunotherapy, MAGEA6 has been shown to be expressed in various types of tumors, making it a promising candidate for the development of cancer vaccines and checkpoint inhibitors. 1. **Cancer Immunotherapy:** MAGEA6 has been implicated in the evasion of immune recognition by cancer cells, making it a potential target for cancer immunotherapy. 2. **Personalized Medicine:** The expression of MAGEA6 in various types of tumors has significant implications for personalized medicine, as it may be used to identify patients who are more likely to respond to cancer immunotherapy. 3. **Diagnostic Biomarkers:** MAGEA6 has been shown to be a potential diagnostic biomarker for cancer, particularly in the context of cancer immunotherapy. In conclusion, MAGEA6 is a gene with significant implications for the regulation of immune responses and cancer evasion. Its expression in cancerous tissues and germ cells makes it a potential target for cancer immunotherapy, and its role in regulating autophagy and gene expression highlights its importance in cellular processes. Further research is needed to fully elucidate the mechanisms by which MAGEA6 regulates immune responses and cancer evasion, and to explore its potential as a therapeutic target in cancer immunotherapy.

Genular Protein ID: 1223572214

Symbol: MAGA6_HUMAN

Name: Cancer/testis antigen 1.6

UniProtKB Accession Codes:

P43360 A8IF93 Q6NW44

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7927540

Title: Structure, chromosomal localization, and expression of 12 genes of the MAGE family.

PubMed ID: 7927540

DOI: 10.1007/bf01246677

PubMed ID: 8037761

Title: Cloning and analysis of MAGE-1-related genes.

PubMed ID: 8037761

DOI: 10.1006/bbrc.1994.1963

PubMed ID: 7642112

Title: Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens.

PubMed ID: 7642112

DOI: 10.1016/0378-1119(94)00680-q

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17942928

Title: MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines.

PubMed ID: 17942928

DOI: 10.1158/0008-5472.can-07-1478

PubMed ID: 20864041

Title: MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.

PubMed ID: 20864041

DOI: 10.1016/j.molcel.2010.08.029

PubMed ID: 31267705

Title: Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability.

PubMed ID: 31267705

DOI: 10.15252/embr.201847352

PubMed ID: 20598277

Title: Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene.

PubMed ID: 20598277

DOI: 10.1016/j.ajhg.2010.06.008

Sequence Information:

  • Length: 314
  • Mass: 34891
  • Checksum: 29B83C7FA6E50263
  • Sequence:
    • MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQEAAS SSSTLVEVTL GEVPAAESPD 
PPQSPQGASS LPTTMNYPLW SQSYEDSSNQ EEEGPSTFPD LESEFQAALS RKVAKLVHFL 
LLKYRAREPV TKAEMLGSVV GNWQYFFPVI FSKASDSLQL VFGIELMEVD PIGHVYIFAT 
CLGLSYDGLL GDNQIMPKTG FLIIILAIIA KEGDCAPEEK IWEELSVLEV FEGREDSIFG 
DPKKLLTQYF VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHM VKISGGPRIS 
YPLLHEWALR EGEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.