No CSI details found for gene ID: 4105
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1223572214
Symbol: MAGA6_HUMAN
Name: Cancer/testis antigen 1.6
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7927540
Title: Structure, chromosomal localization, and expression of 12 genes of the MAGE family.
PubMed ID: 7927540
DOI: 10.1007/bf01246677
PubMed ID: 8037761
PubMed ID: 7642112
Title: Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens.
PubMed ID: 7642112
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17942928
Title: MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines.
PubMed ID: 17942928
PubMed ID: 20864041
Title: MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.
PubMed ID: 20864041
PubMed ID: 31267705
Title: Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability.
PubMed ID: 31267705
PubMed ID: 20598277
Title: Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene.
PubMed ID: 20598277
Sequence Information:
- Length: 314
- Mass: 34891
- Checksum: 29B83C7FA6E50263
- Sequence:
MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQEAAS SSSTLVEVTL GEVPAAESPD PPQSPQGASS LPTTMNYPLW SQSYEDSSNQ EEEGPSTFPD LESEFQAALS RKVAKLVHFL LLKYRAREPV TKAEMLGSVV GNWQYFFPVI FSKASDSLQL VFGIELMEVD PIGHVYIFAT CLGLSYDGLL GDNQIMPKTG FLIIILAIIA KEGDCAPEEK IWEELSVLEV FEGREDSIFG DPKKLLTQYF VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHM VKISGGPRIS YPLLHEWALR EGEE
Details Unavailable
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{
"geneID": 4105,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC244102.3"
]
},
"genePos": {
"start": 151032689,
"end": 151036258
},
"orientation": false,
"symbol": "MAGEA6",
"created": {
"$date": {
"$numberLong": "1738333348982"
}
},
"crossReference": {
"enseGeneID": "ENSG00000197172",
"enseRnaID": [
"ENST00000329342.10"
],
"enseProtID": [
"ENSP00000329199.5"
]
},
"chrom": {
"loc": "Xq28"
},
"desc": "MAGE family member A6",
"geneType": 5,
"mim": [
{
"id": 300176,
"relation": 0
}
],
"ontology": [
{
"id": "GO:0003674",
"term": "molecular_function",
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
20864041,
21516116,
25416956,
25910212,
26871637,
31515488,
32296183,
32814053
],
"cat": 0
},
{
"id": "GO:0042826",
"term": "histone deacetylase binding",
"cat": 0
},
{
"id": "GO:0000122",
"term": "negative regulation of transcription by RNA polymerase II",
"cat": 1
},
{
"id": "GO:0010507",
"term": "negative regulation of autophagy",
"pubMed": [
31267705
],
"cat": 1
},
{
"id": "GO:0005575",
"term": "cellular_component",
"cat": 2
},
{
"id": "GO:0005634",
"term": "nucleus",
"cat": 2
}
],
"protein": [
{
"symbol": "MAGA6_HUMAN",
"name": "Cancer\/testis antigen 1.6",
"accession": [
"P43360",
"A8IF93",
"Q6NW44"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"U10691",
"U10339",
"D32076",
"EU161101",
"BX640600",
"BC041599",
"BC067731"
],
"CCDS": [
"CCDS76050.1"
],
"PIR": [
"JC2360"
],
"RefSeq": [
"NP_005354.1",
"NP_787064.1"
],
"AlphaFoldDB": [
"P43360"
],
"SMR": [
"P43360"
],
"BioGRID": [
"110279"
],
"IntAct": [
"P43360"
],
"MINT": [
"P43360"
],
"STRING": [
"9606.ENSP00000480637"
],
"iPTMnet": [
"P43360"
],
"PhosphoSitePlus": [
"P43360"
],
"BioMuta": [
"MAGEA6"
],
"DMDM": [
"1170860"
],
"jPOST": [
"P43360"
],
"MassIVE": [
"P43360"
],
"PaxDb": [
"9606-ENSP00000480637"
],
"PeptideAtlas": [
"P43360"
],
"ProteomicsDB": [
"55622"
],
"Antibodypedia": [
"30735"
],
"DNASU": [
"4105"
],
"Ensembl": [
"ENST00000329342.10",
"ENST00000616035.4",
"ENST00000710006.1",
"ENST00000710007.1"
],
"KEGG": [
"hsa:4105"
],
"MANE-Select": [
"ENST00000329342.10"
],
"UCSC": [
"uc033fan.1"
],
"AGR": [
"HGNC:6804"
],
"CTD": [
"4105"
],
"DisGeNET": [
"4105"
],
"GeneCards": [
"MAGEA6"
],
"HGNC": [
"HGNC:6804"
],
"HPA": [
"ENSG00000197172"
],
"MIM": [
"300176"
],
"neXtProt": [
"NX_P43360"
],
"OpenTargets": [
"ENSG00000197172"
],
"PharmGKB": [
"PA30550"
],
"VEuPathDB": [
"HostDB:ENSG00000197172"
],
"eggNOG": [
"KOG4562"
],
"GeneTree": [
"ENSGT00940000164672"
],
"HOGENOM": [
"CLU_039582_1_2_1"
],
"InParanoid": [
"P43360"
],
"OMA": [
"SPLHEWA"
],
"OrthoDB": [
"3128316at2759"
],
"PhylomeDB": [
"P43360"
],
"TreeFam": [
"TF328505"
],
"PathwayCommons": [
"P43360"
],
"SignaLink": [
"P43360"
],
"SIGNOR": [
"P43360"
],
"BioGRID-ORCS": [
"4105"
],
"GenomeRNAi": [
"4105"
],
"Pharos": [
"P43360"
],
"PRO": [
"PR:P43360"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P43360"
],
"Bgee": [
"ENSG00000197172"
],
"ExpressionAtlas": [
"P43360"
],
"GO": [
"GO:0005634",
"GO:0042826",
"GO:0010507",
"GO:0000122"
],
"Gene3D": [
"1.10.10.1200",
"1.10.10.1210"
],
"InterPro": [
"IPR037445",
"IPR021072",
"IPR041898",
"IPR041899",
"IPR002190"
],
"PANTHER": [
"PTHR11736:SF60",
"PTHR11736"
],
"Pfam": [
"PF01454",
"PF12440"
],
"SMART": [
"SM01373",
"SM01392"
],
"PROSITE": [
"PS50838"
]
},
"citations": [
{
"title": "Structure, chromosomal localization, and expression of 12 genes of the MAGE family.",
"pubmedID": "7927540",
"doi": "10.1007\/bf01246677"
},
{
"title": "Cloning and analysis of MAGE-1-related genes.",
"pubmedID": "8037761",
"doi": "10.1006\/bbrc.1994.1963"
},
{
"title": "Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens.",
"pubmedID": "7642112",
"doi": "10.1016\/0378-1119(94)00680-q"
},
{
"title": "The full-ORF clone resource of the German cDNA consortium.",
"pubmedID": "17974005",
"doi": "10.1186\/1471-2164-8-399"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101\/gr.2596504"
},
{
"title": "MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines.",
"pubmedID": "17942928",
"doi": "10.1158\/0008-5472.can-07-1478"
},
{
"title": "MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.",
"pubmedID": "20864041",
"doi": "10.1016\/j.molcel.2010.08.029"
},
{
"title": "Regulation of MAGE-A3\/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability.",
"pubmedID": "31267705",
"doi": "10.15252\/embr.201847352"
},
{
"title": "Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene.",
"pubmedID": "20598277",
"doi": "10.1016\/j.ajhg.2010.06.008"
}
],
"sequence": {
"length": 314,
"mass": 34891,
"checksum": "29B83C7FA6E50263",
"modified": {
"$date": {
"$numberLong": "815184000000"
}
},
"version": 1,
"sequence": "MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAKLVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASDSLQLVFGIELMEVDPIGHVYIFATCLGLSYDGLLGDNQIMPKTGFLIIILAIIAKEGDCAPEEKIWEELSVLEVFEGREDSIFGDPKKLLTQYFVQENYLEYRQVPGSDPACYEFLWGPRALIETSYVKVLHHMVKISGGPRISYPLLHEWALREGEE"
},
"existence": 0,
"relevance": 1,
"proteinID": 1223572214
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}