Details for: MAGEA6

Gene ID: 4105

Symbol: MAGEA6

Ensembl ID: ENSG00000197172

Description: MAGE family member A6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10783
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7548
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3642
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.11
    Marker Score: 613.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.05
    Marker Score: 32668
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5326.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 739
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.44
    Marker Score: 232
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.4
    Marker Score: 551.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.35
    Marker Score: 207
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.27
    Marker Score: 302
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.26
    Marker Score: 109.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.24
    Marker Score: 68
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.23
    Marker Score: 439.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.23
    Marker Score: 131
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2
    Marker Score: 3202
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.19
    Marker Score: 381.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.15
    Marker Score: 101
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.15
    Marker Score: 88
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.13
    Marker Score: 72
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.13
    Marker Score: 75
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 51
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.11
    Marker Score: 73
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.11
    Marker Score: 660
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.11
    Marker Score: 73
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.09
    Marker Score: 55
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.08
    Marker Score: 72
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.08
    Marker Score: 38
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.08
    Marker Score: 126
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 70
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.08
    Marker Score: 59
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.07
    Marker Score: 88
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.07
    Marker Score: 116
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 63
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.07
    Marker Score: 72
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.06
    Marker Score: 199
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.06
    Marker Score: 69
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.06
    Marker Score: 99
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.06
    Marker Score: 64
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.06
    Marker Score: 74
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.06
    Marker Score: 75
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.06
    Marker Score: 75
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 66.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.05
    Marker Score: 57
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.05
    Marker Score: 39
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.04
    Marker Score: 75
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.04
    Marker Score: 82
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.03
    Marker Score: 66.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.03
    Marker Score: 75
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 70
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.02
    Marker Score: 87
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.02
    Marker Score: 76
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.02
    Marker Score: 75
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.01
    Marker Score: 51

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Other Information

**Key characteristics:** * MAGEA6 is a protein of the MAGA family, which are a large family of proteins that are involved in a variety of cellular processes, including cell cycle regulation, proliferation, differentiation, and apoptosis. * MAGEA6 is a negative regulator of autophagy. * It binds to the ATG5 and ATG13 proteins, which are key regulators of autophagy. * When MAGEA6 binds to these proteins, it inhibits their activity, which leads to the inhibition of autophagy. **Pathways and functions:** * MAGEA6 negatively regulates autophagy by binding to the ATG5 and ATG13 proteins. * This binding inhibits the activity of these proteins, which leads to the inhibition of autophagy. * MAGEA6 is also involved in the regulation of cell cycle progression, proliferation, and differentiation. **Clinical significance:** * MAGEA6 is a potential therapeutic target for a variety of cancers, including breast cancer, lung cancer, and colon cancer. * Inhibition of MAGEA6 has been shown to promote autophagy, leading to cell death. * Therefore, MAGEA6 is a promising target for cancer therapy.

Genular Protein ID: 1223572214

Symbol: MAGA6_HUMAN

Name: Cancer/testis antigen 1.6

UniProtKB Accession Codes:

P43360 A8IF93 Q6NW44

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7927540

Title: Structure, chromosomal localization, and expression of 12 genes of the MAGE family.

PubMed ID: 7927540

DOI: 10.1007/bf01246677

PubMed ID: 8037761

Title: Cloning and analysis of MAGE-1-related genes.

PubMed ID: 8037761

DOI: 10.1006/bbrc.1994.1963

PubMed ID: 7642112

Title: Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens.

PubMed ID: 7642112

DOI: 10.1016/0378-1119(94)00680-q

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17942928

Title: MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines.

PubMed ID: 17942928

DOI: 10.1158/0008-5472.can-07-1478

PubMed ID: 20864041

Title: MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.

PubMed ID: 20864041

DOI: 10.1016/j.molcel.2010.08.029

PubMed ID: 31267705

Title: Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability.

PubMed ID: 31267705

DOI: 10.15252/embr.201847352

PubMed ID: 20598277

Title: Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene.

PubMed ID: 20598277

DOI: 10.1016/j.ajhg.2010.06.008

Sequence Information:

  • Length: 314
  • Mass: 34891
  • Checksum: 29B83C7FA6E50263
  • Sequence:
    • MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQEAAS SSSTLVEVTL GEVPAAESPD 
PPQSPQGASS LPTTMNYPLW SQSYEDSSNQ EEEGPSTFPD LESEFQAALS RKVAKLVHFL 
LLKYRAREPV TKAEMLGSVV GNWQYFFPVI FSKASDSLQL VFGIELMEVD PIGHVYIFAT 
CLGLSYDGLL GDNQIMPKTG FLIIILAIIA KEGDCAPEEK IWEELSVLEV FEGREDSIFG 
DPKKLLTQYF VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHM VKISGGPRIS 
YPLLHEWALR EGEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.