Details for: TRNW

Gene ID: 4578

Symbol: TRNW

Ensembl ID: ENSG00000210117

Description: tRNA-Trp

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.8569
    Cell Significance Index: 32.0100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.7244
    Cell Significance Index: 43.0700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.6300
    Cell Significance Index: 7.5100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.5276
    Cell Significance Index: 8.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5209
    Cell Significance Index: 23.6100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.4949
    Cell Significance Index: 4.5800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.4930
    Cell Significance Index: 6.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1538
    Cell Significance Index: 4.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0252
    Cell Significance Index: 1.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0166
    Cell Significance Index: 1.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0049
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0503
    Cell Significance Index: -8.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0631
    Cell Significance Index: -12.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0659
    Cell Significance Index: -9.5800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0966
    Cell Significance Index: -1.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1359
    Cell Significance Index: -8.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1452
    Cell Significance Index: -9.1500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2021
    Cell Significance Index: -5.1500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2107
    Cell Significance Index: -3.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2111
    Cell Significance Index: -2.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2631
    Cell Significance Index: -9.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2711
    Cell Significance Index: -7.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3097
    Cell Significance Index: -4.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3239
    Cell Significance Index: -9.5400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.3316
    Cell Significance Index: -4.4200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3848
    Cell Significance Index: -5.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4334
    Cell Significance Index: -8.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4508
    Cell Significance Index: -9.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4542
    Cell Significance Index: -9.8400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.5243
    Cell Significance Index: -8.9100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.5255
    Cell Significance Index: -4.6300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.5268
    Cell Significance Index: -6.3600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.5302
    Cell Significance Index: -4.9600
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.5484
    Cell Significance Index: -6.8100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.5556
    Cell Significance Index: -6.5600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.5647
    Cell Significance Index: -6.1200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.5842
    Cell Significance Index: -7.3300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.5952
    Cell Significance Index: -6.1400
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.6021
    Cell Significance Index: -4.9800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.6036
    Cell Significance Index: -7.5400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.6184
    Cell Significance Index: -6.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6300
    Cell Significance Index: -22.0700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.6301
    Cell Significance Index: -8.2400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.6471
    Cell Significance Index: -7.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6475
    Cell Significance Index: -9.5600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.6584
    Cell Significance Index: -6.3700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.6811
    Cell Significance Index: -9.4500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6842
    Cell Significance Index: -9.8400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.6907
    Cell Significance Index: -9.5800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.6950
    Cell Significance Index: -7.5500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.7036
    Cell Significance Index: -9.2600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.7111
    Cell Significance Index: -9.6700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7145
    Cell Significance Index: -10.2600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.7216
    Cell Significance Index: -8.4900
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.7371
    Cell Significance Index: -8.9600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.7418
    Cell Significance Index: -9.2900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.7519
    Cell Significance Index: -7.8500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.7620
    Cell Significance Index: -9.2700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.7633
    Cell Significance Index: -9.8300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.7851
    Cell Significance Index: -7.3100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.7918
    Cell Significance Index: -8.0900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.7944
    Cell Significance Index: -9.2300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.7961
    Cell Significance Index: -9.6500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7997
    Cell Significance Index: -19.9500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.8123
    Cell Significance Index: -8.8500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.8181
    Cell Significance Index: -8.6300
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.8196
    Cell Significance Index: -8.7200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.8257
    Cell Significance Index: -9.3800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.8281
    Cell Significance Index: -9.0900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.8306
    Cell Significance Index: -8.4800
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.8315
    Cell Significance Index: -9.3100
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.8321
    Cell Significance Index: -8.7000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.8409
    Cell Significance Index: -9.3100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.8443
    Cell Significance Index: -9.3900
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.8445
    Cell Significance Index: -9.3800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.8458
    Cell Significance Index: -11.1000
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: -0.8512
    Cell Significance Index: -10.2900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.8518
    Cell Significance Index: -14.5600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.8541
    Cell Significance Index: -11.1500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.8562
    Cell Significance Index: -8.8600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.8616
    Cell Significance Index: -10.5900
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.8634
    Cell Significance Index: -9.4300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.8636
    Cell Significance Index: -9.3500
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.8688
    Cell Significance Index: -9.4200
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.8760
    Cell Significance Index: -9.3600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.8786
    Cell Significance Index: -9.2600
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.8844
    Cell Significance Index: -9.3600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.8915
    Cell Significance Index: -8.3700
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.8922
    Cell Significance Index: -9.6200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.8940
    Cell Significance Index: -9.2600
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.8957
    Cell Significance Index: -10.1600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.8978
    Cell Significance Index: -11.9300
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.9023
    Cell Significance Index: -9.6300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.9080
    Cell Significance Index: -10.7300
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.9115
    Cell Significance Index: -8.7200
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.9150
    Cell Significance Index: -8.0000
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.9165
    Cell Significance Index: -9.6300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.9198
    Cell Significance Index: -11.0300
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.9221
    Cell Significance Index: -9.4200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.9223
    Cell Significance Index: -12.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TRNW is significantly expressed in a wide range of cells, including CD4-positive and CD8-positive T cells, goblet cells, intestinal epithelial cells, and stem cells from the intestinal crypt. This widespread expression suggests that tRNA-Trp plays a crucial role in maintaining the balance of immune responses and tissue homeostasis. 2. **Amino Acid Encoding:** TRNW encodes the amino acid tryptophan, an essential amino acid that is involved in various cellular processes, including protein synthesis, neurotransmission, and immune function. 3. **tRNA Structure and Function:** tRNA-Trp is a small RNA molecule that is involved in the translation of mRNA into protein. It recognizes specific codons on the mRNA and provides the corresponding amino acid to the ribosome during protein synthesis. **Pathways and Functions:** 1. **Immune Response:** TRNW plays a critical role in the regulation of immune responses, particularly in the activation and proliferation of T cells. The expression of TRNW is essential for the proper functioning of the immune system, and its dysregulation can lead to impaired immune responses. 2. **Tissue Homeostasis:** TRNW is also involved in maintaining tissue homeostasis, particularly in the intestinal epithelium. The expression of TRNW is necessary for the proper functioning of goblet cells, which produce mucus that protects the intestinal epithelium. 3. **Signaling Pathways:** TRNW is involved in various signaling pathways, including the NF-κB pathway, which is critical for the regulation of immune responses. The expression of TRNW can modulate the activity of this pathway, leading to the activation or suppression of immune responses. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Dysregulation of TRNW expression has been implicated in various immunodeficiency disorders, including chronic inflammatory diseases and autoimmune disorders. The identification of TRNW as a critical regulator of immune responses has significant implications for the development of novel therapeutic strategies. 2. **Cancer:** TRNW expression has been found to be altered in various types of cancer, including colon cancer and lymphoma. The dysregulation of TRNW expression can contribute to the development and progression of cancer. 3. **Gastrointestinal Disorders:** TRNW expression is also involved in the pathogenesis of gastrointestinal disorders, including inflammatory bowel disease and irritable bowel syndrome. The identification of TRNW as a critical regulator of tissue homeostasis has significant implications for the development of novel therapeutic strategies. In conclusion, TRNW is a crucial gene that plays a vital role in maintaining tissue homeostasis and immune function. Its widespread expression in immune cells and non-immune cells underscores its importance in regulating various cellular processes. Further studies are necessary to fully elucidate the role of TRNW in human disease, but its significance in immunodeficiency disorders, cancer, and gastrointestinal disorders is already clear.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.