Details for: ASIC5

Gene ID: 51802

Symbol: ASIC5

Ensembl ID: ENSG00000256394

Description: acid sensing ion channel subunit family member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.2874
    Cell Significance Index: 105.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.5447
    Cell Significance Index: 55.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.4008
    Cell Significance Index: 147.1900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.7900
    Cell Significance Index: 19.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8496
    Cell Significance Index: 38.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7859
    Cell Significance Index: 149.5600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6756
    Cell Significance Index: 16.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5895
    Cell Significance Index: 12.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4424
    Cell Significance Index: 26.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3852
    Cell Significance Index: 38.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3621
    Cell Significance Index: 39.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3398
    Cell Significance Index: 306.7800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3266
    Cell Significance Index: 4.7600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2800
    Cell Significance Index: 3.6800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2557
    Cell Significance Index: 4.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2333
    Cell Significance Index: 37.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1902
    Cell Significance Index: 13.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1600
    Cell Significance Index: 4.0000
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.1482
    Cell Significance Index: 1.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1257
    Cell Significance Index: 1.8000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0447
    Cell Significance Index: 0.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0337
    Cell Significance Index: 0.7000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0285
    Cell Significance Index: 0.4000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0245
    Cell Significance Index: 0.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0219
    Cell Significance Index: 4.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0111
    Cell Significance Index: 0.3200
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.0077
    Cell Significance Index: 0.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0074
    Cell Significance Index: 0.2600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0053
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0005
    Cell Significance Index: 0.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0005
    Cell Significance Index: 0.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -1.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0008
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0019
    Cell Significance Index: -1.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0022
    Cell Significance Index: -1.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0024
    Cell Significance Index: -1.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0027
    Cell Significance Index: -0.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0042
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0050
    Cell Significance Index: -1.0600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0053
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0061
    Cell Significance Index: -1.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0062
    Cell Significance Index: -1.1100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0080
    Cell Significance Index: -0.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0085
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0086
    Cell Significance Index: -0.9800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0109
    Cell Significance Index: -0.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0111
    Cell Significance Index: -0.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0116
    Cell Significance Index: -1.4300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0129
    Cell Significance Index: -0.1500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0130
    Cell Significance Index: -0.1900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0138
    Cell Significance Index: -0.3400
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0152
    Cell Significance Index: -0.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0152
    Cell Significance Index: -0.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0168
    Cell Significance Index: -0.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0186
    Cell Significance Index: -0.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0198
    Cell Significance Index: -0.5300
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0261
    Cell Significance Index: -0.2700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0279
    Cell Significance Index: -0.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0281
    Cell Significance Index: -0.7500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0297
    Cell Significance Index: -0.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0302
    Cell Significance Index: -1.4200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0309
    Cell Significance Index: -0.6200
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0315
    Cell Significance Index: -0.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0330
    Cell Significance Index: -1.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0336
    Cell Significance Index: -1.1000
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0340
    Cell Significance Index: -0.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0343
    Cell Significance Index: -0.5700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0347
    Cell Significance Index: -0.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0361
    Cell Significance Index: -1.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0378
    Cell Significance Index: -1.4300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0383
    Cell Significance Index: -0.5100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0390
    Cell Significance Index: -0.3800
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.0397
    Cell Significance Index: -0.4200
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0408
    Cell Significance Index: -0.4400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0437
    Cell Significance Index: -1.0900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0446
    Cell Significance Index: -0.4700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0450
    Cell Significance Index: -0.3000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0454
    Cell Significance Index: -0.5300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0458
    Cell Significance Index: -0.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0461
    Cell Significance Index: -0.9000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0466
    Cell Significance Index: -0.9300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0467
    Cell Significance Index: -0.5900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0470
    Cell Significance Index: -0.5600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0470
    Cell Significance Index: -0.7200
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0479
    Cell Significance Index: -0.4400
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0491
    Cell Significance Index: -0.5700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0494
    Cell Significance Index: -1.0300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0495
    Cell Significance Index: -1.0700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0499
    Cell Significance Index: -0.7100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0503
    Cell Significance Index: -0.6900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0511
    Cell Significance Index: -0.5500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0518
    Cell Significance Index: -0.5400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0520
    Cell Significance Index: -0.6800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0528
    Cell Significance Index: -0.8900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0536
    Cell Significance Index: -0.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0542
    Cell Significance Index: -1.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0544
    Cell Significance Index: -1.0700
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0553
    Cell Significance Index: -0.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of Acid-Sensing Ion Channels**: ASIC5 is a subunit of the acid-sensing ion channel family, which is composed of multiple subunits that work together to detect changes in extracellular pH. 2. **Significant Expression in Intestinal Cells**: The ASIC5 gene is significantly expressed in various cell types of the intestinal epithelium, including transit-amplifying cells, Paneth cells, and intestinal crypt stem cells. 3. **Ion Transport Regulation**: ASIC5 plays a crucial role in regulating ion transport across the plasma membrane, including sodium ion transmembrane transport and proton transmembrane transport. 4. **Ligand-Gated Sodium Channel Activity**: ASIC5 is involved in ligand-gated sodium channel activity, which is essential for the regulation of neuronal and epithelial function. **Pathways and Functions:** 1. **Proton-Sensing and Sodium Ion Transport**: ASIC5 detects changes in extracellular pH and regulates ion transport across the plasma membrane, playing a crucial role in maintaining the integrity of the intestinal epithelium. 2. **Ligand-Gated Sodium Channel Activity**: ASIC5 is involved in ligand-gated sodium channel activity, which is essential for the regulation of neuronal and epithelial function. 3. **Proton Channel Activity**: ASIC5 is a proton channel, which allows the transport of protons across the plasma membrane. 4. **Stimuli-Sensing Channels**: ASIC5 is a stimuli-sensing channel, which detects changes in extracellular pH and regulates ion transport in response to these changes. **Clinical Significance:** 1. **Gastrointestinal Disorders**: ASIC5 has been implicated in various gastrointestinal disorders, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and gastroesophageal reflux disease (GERD). 2. **Intestinal Epithelial Integrity**: ASIC5 plays a crucial role in maintaining the integrity of the intestinal epithelium, and its dysregulation may contribute to the development of gastrointestinal disorders. 3. **Neurological Disorders**: ASIC5 has also been implicated in various neurological disorders, including neuropathic pain and migraines, highlighting its potential role in the regulation of neuronal function. 4. **Cancer Research**: ASIC5 has been identified as a potential biomarker for cancer diagnosis and treatment, as its expression is altered in various types of cancer. In conclusion, the ASIC5 gene is a critical component of the acid-sensing ion channel family, playing a vital role in the regulation of proton-sensing and sodium ion transport. Its significant expression in various cell types and its involvement in multiple signaling pathways highlight its clinical significance in the regulation of intestinal epithelial integrity and its potential involvement in various gastrointestinal and neurological disorders. Further research is needed to fully elucidate the role of ASIC5 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1118808867

Symbol: ASIC5_HUMAN

Name: Acid-sensing ion channel 5

UniProtKB Accession Codes:

Q9NY37

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10767424

Title: Molecular cloning, functional expression and chromosomal localization of an amiloride-sensitive Na(+) channel from human small intestine.

PubMed ID: 10767424

DOI: 10.1016/s0014-5793(00)01403-4

Sequence Information:

  • Length: 505
  • Mass: 57464
  • Checksum: 3479F297202789D6
  • Sequence:
    • MEQTEKSKVY AENGLLEKIK LCLSKKPLPS PTERKKFDHD FAISTSFHGI HNIVQNRSKI 
RRVLWLVVVL GSVSLVTWQI YIRLLNYFTW PTTTSIEVQY VEKMEFPAVT FCNLNRFQTD 
AVAKFGVIFF LWHIVSKVLH LQEITANSTG SREATDFAAS HQNFSIVEFI RNKGFYLNNS 
TLLDCEFFGK PCSPKDFAHV FTEYGNCFTF NHGETLQAKR KVSVSGRGLS LLFNVNQEAF 
TDNPALGFVD AGIIFVIHSP KKVPQFDGLG LLSPVGMHAR VTIRQVKTVH QEYPWGECNP 
NIKLQNFSSY STSGCLKECK AQHIKKQCGC VPFLLPGYGI ECDLQKYFSC VSPVLDHIEF 
KDLCTVGTHN SSCPVSCEEI EYPATISYSS FPSQKALKYL SKKLNQSRKY IRENLVKIEI 
NYSDLNYKIT QQQKAVSVSE LLADLGGQLG LFCGASLITI IEIIEYLFTN FYWICIFFLL 
KISEMTQWTP PPQNHLGNKN RIEEC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.