Details for: SRMS

Gene ID: 6725

Symbol: SRMS

Ensembl ID: ENSG00000125508

Description: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 9.1376
    Cell Significance Index: 190.7100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 5.8085
    Cell Significance Index: 86.9000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 3.5566
    Cell Significance Index: 72.3700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.0280
    Cell Significance Index: 16.6500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.2317
    Cell Significance Index: 3.9600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0849
    Cell Significance Index: 0.8800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0494
    Cell Significance Index: 1.2400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0422
    Cell Significance Index: 0.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0144
    Cell Significance Index: 0.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0035
    Cell Significance Index: -0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0087
    Cell Significance Index: -5.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0094
    Cell Significance Index: -5.1500
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0102
    Cell Significance Index: -0.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0176
    Cell Significance Index: -0.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0202
    Cell Significance Index: -4.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0207
    Cell Significance Index: -5.9600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0224
    Cell Significance Index: -0.5600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0245
    Cell Significance Index: -0.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0259
    Cell Significance Index: -5.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0273
    Cell Significance Index: -4.9200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0296
    Cell Significance Index: -0.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0333
    Cell Significance Index: -1.1700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0354
    Cell Significance Index: -0.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0367
    Cell Significance Index: -1.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0374
    Cell Significance Index: -5.4400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0379
    Cell Significance Index: -0.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0383
    Cell Significance Index: -1.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0409
    Cell Significance Index: -5.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0425
    Cell Significance Index: -5.2300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0444
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0444
    Cell Significance Index: -5.0900
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0458
    Cell Significance Index: -0.4900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0497
    Cell Significance Index: -0.5800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0515
    Cell Significance Index: -0.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0521
    Cell Significance Index: -6.1400
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.0534
    Cell Significance Index: -0.4600
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0551
    Cell Significance Index: -0.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0601
    Cell Significance Index: -1.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0613
    Cell Significance Index: -1.2300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0630
    Cell Significance Index: -1.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0632
    Cell Significance Index: -1.2500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0644
    Cell Significance Index: -0.4200
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0663
    Cell Significance Index: -0.6600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0697
    Cell Significance Index: -1.2100
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0735
    Cell Significance Index: -0.3500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0740
    Cell Significance Index: -0.4600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0754
    Cell Significance Index: -1.9200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0768
    Cell Significance Index: -0.5100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0819
    Cell Significance Index: -0.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0869
    Cell Significance Index: -5.3300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0885
    Cell Significance Index: -1.0400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1014
    Cell Significance Index: -0.6600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1073
    Cell Significance Index: -1.4000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1080
    Cell Significance Index: -0.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1103
    Cell Significance Index: -6.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1198
    Cell Significance Index: -5.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1202
    Cell Significance Index: -5.6500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1295
    Cell Significance Index: -2.2000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1458
    Cell Significance Index: -3.1500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1459
    Cell Significance Index: -1.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1608
    Cell Significance Index: -6.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1679
    Cell Significance Index: -4.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1685
    Cell Significance Index: -5.9200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1726
    Cell Significance Index: -2.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1734
    Cell Significance Index: -4.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1799
    Cell Significance Index: -3.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1970
    Cell Significance Index: -7.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2030
    Cell Significance Index: -5.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2309
    Cell Significance Index: -3.1500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2410
    Cell Significance Index: -3.3100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2523
    Cell Significance Index: -3.4600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2543
    Cell Significance Index: -3.4600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2655
    Cell Significance Index: -3.7800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2666
    Cell Significance Index: -3.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2826
    Cell Significance Index: -4.7300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2880
    Cell Significance Index: -3.7000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2906
    Cell Significance Index: -3.4700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2910
    Cell Significance Index: -5.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2912
    Cell Significance Index: -6.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2917
    Cell Significance Index: -6.3200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2928
    Cell Significance Index: -3.4600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2930
    Cell Significance Index: -4.4500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2958
    Cell Significance Index: -2.5000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2961
    Cell Significance Index: -3.2800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2998
    Cell Significance Index: -4.8200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3019
    Cell Significance Index: -4.4000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3024
    Cell Significance Index: -3.5700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3077
    Cell Significance Index: -3.6800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3110
    Cell Significance Index: -2.9200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3185
    Cell Significance Index: -4.0000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3217
    Cell Significance Index: -4.6700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3225
    Cell Significance Index: -5.9600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3352
    Cell Significance Index: -4.2300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3383
    Cell Significance Index: -3.7800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3465
    Cell Significance Index: -4.5600
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.3468
    Cell Significance Index: -3.6600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3479
    Cell Significance Index: -4.5700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3502
    Cell Significance Index: -4.3100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.3549
    Cell Significance Index: -4.4900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3605
    Cell Significance Index: -5.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Lack of C-terminal regulatory tyrosine and N-terminal myristylation sites:** This distinct feature of SRMS sets it apart from other tyrosine kinases, allowing it to interact with and regulate specific signaling pathways. 2. **Non-receptor tyrosine kinase activity:** SRMS is a non-receptor tyrosine kinase, meaning it does not require a ligand to activate its kinase activity. 3. **Signaling by non-receptor tyrosine kinases:** SRMS is involved in signaling by non-receptor tyrosine kinases, indicating its role in regulating cellular responses to extracellular stimuli. **Pathways and Functions:** 1. **Innate immune response:** SRMS is significantly expressed in microglial cells, a type of immune cell in the brain. Its role in the innate immune response is crucial in regulating the activation of immune cells and the production of pro-inflammatory cytokines. 2. **Positive regulation of Torc1 signaling:** SRMS is involved in the positive regulation of Torc1 signaling, a key pathway involved in cellular metabolism and autophagy. 3. **Negative regulation of signal transduction:** SRMS also plays a role in negative regulation of signal transduction, indicating its ability to modulate the strength and duration of cellular responses to extracellular stimuli. 4. **Protein binding and phosphorylation:** SRMS interacts with various proteins, including other kinases, and phosphorylates tyrosine residues on these proteins, regulating their activity and function. **Significantly Expressed Cells:** 1. **Oligodendrocyte precursor cells:** SRMS is expressed in oligodendrocyte precursor cells, a type of cell involved in the development and maintenance of the central nervous system. 2. **Microglial cells:** SRMS is significantly expressed in microglial cells, a type of immune cell in the brain involved in the innate immune response. 3. **T cells:** SRMS is expressed in T cells, a type of immune cell involved in adaptive immunity. 4. **Erythrocytes:** SRMS is expressed in erythrocytes, a type of blood cell involved in oxygen transport. **Clinical Significance:** 1. **Immune dysregulation:** Alterations in SRMS expression or function may contribute to immune dysregulation, leading to autoimmune diseases or impaired immune responses. 2. **Neurological disorders:** SRMS's role in the innate immune response and regulation of Torc1 signaling may be relevant to neurological disorders, such as Alzheimer's disease or multiple sclerosis. 3. **Cancer:** SRMS's involvement in negative regulation of signal transduction may be exploited in cancer therapy, allowing for the modulation of tumor growth and metastasis. In conclusion, the SRMS gene is a novel player in immune response and signal transduction, with significant implications for our understanding of immune regulation and neurological disorders. Further research is necessary to fully elucidate the functions of SRMS and its potential clinical applications.

Genular Protein ID: 2224228575

Symbol: SRMS_HUMAN

Name: Tyrosine-protein kinase Srms

UniProtKB Accession Codes:

Q9H3Y6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 1 Ensembl 1 GO 14 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 23822091

Title: The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate Dok1.

PubMed ID: 23822091

DOI: 10.1111/febs.12420

PubMed ID: 29496907

Title: Phosphoproteomics analysis identifies novel candidate substrates of the non-receptor tyrosine kinase, SRMS.

PubMed ID: 29496907

DOI: 10.1074/mcp.ra118.000643

PubMed ID: 35927303

Title: Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor.

PubMed ID: 35927303

DOI: 10.1038/s41418-022-01047-3

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 488
  • Mass: 54507
  • Checksum: 83193AD26C5F6F68
  • Sequence:
    • MEPFLRRRLA FLSFFWDKIW PAGGEPDHGT PGSLDPNTDP VPTLPAEPCS PFPQLFLALY 
DFTARCGGEL SVRRGDRLCA LEEGGGYIFA RRLSGQPSAG LVPITHVAKA SPETLSDQPW 
YFSGVSRTQA QQLLLSPPNE PGAFLIRPSE SSLGGYSLSV RAQAKVCHYR VSMAADGSLY 
LQKGRLFPGL EELLTYYKAN WKLIQNPLLQ PCMPQKAPRQ DVWERPHSEF ALGRKLGEGY 
FGEVWEGLWL GSLPVAIKVI KSANMKLTDL AKEIQTLKGL RHERLIRLHA VCSGGEPVYI 
VTELMRKGNL QAFLGTPEGR ALRLPPLLGF ACQVAEGMSY LEEQRVVHRD LAARNVLVDD 
GLACKVADFG LARLLKDDIY SPSSSSKIPV KWTAPEAANY RVFSQKSDVW SFGVLLHEVF 
TYGQCPYEGM TNHETLQQIM RGYRLPRPAA CPAEVYVLML ECWRSSPEER PSFATLREKL 
HAIHRCHP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.