Details for: SSX1

Gene ID: 6756

Symbol: SSX1

Ensembl ID: ENSG00000126752

Description: SSX family member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 15.9123
    Cell Significance Index: 201.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.9935
    Cell Significance Index: 50.7900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8620
    Cell Significance Index: 20.8800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6785
    Cell Significance Index: 8.7800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.4127
    Cell Significance Index: 5.6600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.3116
    Cell Significance Index: 3.3100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.0267
    Cell Significance Index: 0.3100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0261
    Cell Significance Index: 0.3200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0207
    Cell Significance Index: 0.3000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0182
    Cell Significance Index: 0.2600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0116
    Cell Significance Index: 0.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0103
    Cell Significance Index: 0.2800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0099
    Cell Significance Index: 0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -0.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0012
    Cell Significance Index: -0.7900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0016
    Cell Significance Index: -0.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0031
    Cell Significance Index: -0.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0033
    Cell Significance Index: -0.6600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0033
    Cell Significance Index: -0.1300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0035
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0038
    Cell Significance Index: -0.6500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0046
    Cell Significance Index: -0.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0052
    Cell Significance Index: -0.7600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0060
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0064
    Cell Significance Index: -0.7300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0064
    Cell Significance Index: -0.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0076
    Cell Significance Index: -0.7900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0099
    Cell Significance Index: -0.1300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0119
    Cell Significance Index: -0.1400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0123
    Cell Significance Index: -0.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0134
    Cell Significance Index: -0.9000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0137
    Cell Significance Index: -0.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0151
    Cell Significance Index: -0.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0160
    Cell Significance Index: -0.5600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0164
    Cell Significance Index: -0.2000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0166
    Cell Significance Index: -0.1300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0175
    Cell Significance Index: -0.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0191
    Cell Significance Index: -0.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0192
    Cell Significance Index: -0.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0220
    Cell Significance Index: -0.7200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0221
    Cell Significance Index: -0.3000
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0224
    Cell Significance Index: -0.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0226
    Cell Significance Index: -0.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0227
    Cell Significance Index: -0.3100
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0229
    Cell Significance Index: -0.1700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0244
    Cell Significance Index: -0.3700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0251
    Cell Significance Index: -0.5000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0277
    Cell Significance Index: -0.4700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0291
    Cell Significance Index: -0.9200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0297
    Cell Significance Index: -0.7400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0299
    Cell Significance Index: -0.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0304
    Cell Significance Index: -0.7300
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0306
    Cell Significance Index: -0.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0308
    Cell Significance Index: -0.8100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0321
    Cell Significance Index: -0.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0329
    Cell Significance Index: -0.7100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0329
    Cell Significance Index: -0.9400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0330
    Cell Significance Index: -0.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0344
    Cell Significance Index: -0.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0349
    Cell Significance Index: -0.6900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0356
    Cell Significance Index: -0.7000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0358
    Cell Significance Index: -0.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0364
    Cell Significance Index: -0.7300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0371
    Cell Significance Index: -0.5200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0377
    Cell Significance Index: -0.2000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0379
    Cell Significance Index: -0.3200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0407
    Cell Significance Index: -0.6100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0408
    Cell Significance Index: -0.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0422
    Cell Significance Index: -0.7800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0449
    Cell Significance Index: -0.5300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0452
    Cell Significance Index: -0.7300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0454
    Cell Significance Index: -0.4700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0458
    Cell Significance Index: -0.6400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0459
    Cell Significance Index: -0.6300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0467
    Cell Significance Index: -0.6000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0468
    Cell Significance Index: -0.5500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0469
    Cell Significance Index: -0.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0481
    Cell Significance Index: -0.8100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0488
    Cell Significance Index: -0.5400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0489
    Cell Significance Index: -0.6500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0496
    Cell Significance Index: -0.5400
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0512
    Cell Significance Index: -0.5300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0520
    Cell Significance Index: -0.7400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0522
    Cell Significance Index: -0.7700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0525
    Cell Significance Index: -0.6900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0528
    Cell Significance Index: -0.6900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0531
    Cell Significance Index: -0.5600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0534
    Cell Significance Index: -0.6500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0541
    Cell Significance Index: -0.7300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0542
    Cell Significance Index: -0.6200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0544
    Cell Significance Index: -0.6500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0552
    Cell Significance Index: -0.4500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0559
    Cell Significance Index: -0.6600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0563
    Cell Significance Index: -0.7900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0571
    Cell Significance Index: -0.7200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0578
    Cell Significance Index: -0.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The SSX1 gene is a non-coding gene, meaning it does not encode a protein. Instead, it regulates gene expression through various mechanisms, including transcriptional repression and post-transcriptional regulation. The SSX1 gene is highly conserved across species, suggesting its importance in maintaining cellular homeostasis. Its expression is widespread, with significant levels found in T cells, erythrocytes, plasma cells, B cells, epithelial cells, and cells of the reproductive system. **Pathways and Functions:** The SSX1 gene is involved in several key pathways, including: 1. **Negative regulation of transcription by RNA polymerase II**: SSX1 acts as a corepressor for RNA polymerase II, regulating the expression of target genes involved in cellular differentiation and proliferation. 2. **Spermatogenesis**: SSX1 is essential for the proper development and maturation of sperm cells, influencing the formation of the sperm flagellum. 3. **Cytoskeleton organization**: SSX1 regulates the organization of the cytoskeleton, which is crucial for cell shape, movement, and division. 4. **Protein binding**: SSX1 interacts with various proteins, influencing their activity and localization within the cell. **Clinical Significance:** Dysregulation of the SSX1 gene has been implicated in several diseases, including: 1. **Cancer**: SSX1 mutations have been found in various types of cancer, including testicular cancer and certain leukemias. 2. **Immunological disorders**: SSX1 has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Reproductive disorders**: SSX1 mutations have been associated with infertility and other reproductive problems. In conclusion, the SSX1 gene plays a critical role in regulating gene expression and cellular differentiation, influencing various biological processes, including spermatogenesis, sperm flagellum formation, and immune function. Its dysregulation has been implicated in several diseases, highlighting the importance of this gene in maintaining human health. Further research is needed to fully elucidate the functions of SSX1 and its role in disease pathology.

Genular Protein ID: 3777243702

Symbol: SSX1_HUMAN

Name: Protein SSX1

UniProtKB Accession Codes:

Q16384 A3KN76 Q08AJ2 Q5JQ64

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 1 Ensembl 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7539744

Title: Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma.

PubMed ID: 7539744

DOI: 10.1002/j.1460-2075.1995.tb07228.x

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7655467

Title: Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas.

PubMed ID: 7655467

DOI: 10.1093/hmg/4.6.1097

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 36796361

Title: Deficiency of primate-specific SSX1 induced asthenoteratozoospermia in infertile men and cynomolgus monkey and tree shrew models.

PubMed ID: 36796361

DOI: 10.1016/j.ajhg.2023.01.016

Sequence Information:

  • Length: 188
  • Mass: 21931
  • Checksum: E440D1B2AE3AE9F7
  • Sequence:
    • MNGDDTFAKR PRDDAKASEK RSKAFDDIAT YFSKKEWKKM KYSEKISYVY MKRNYKAMTK 
LGFKVTLPPF MCNKQATDFQ GNDFDNDHNR RIQVEHPQMT FGRLHRIIPK IMPKKPAEDE 
NDSKGVSEAS GPQNDGKQLH PPGKANISEK INKRSGPKRG KHAWTHRLRE RKQLVIYEEI 
SDPEEDDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.