Details for: SSX5

Gene ID: 6758

Symbol: SSX5

Ensembl ID: ENSG00000165583

Description: SSX family member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.6870
    Cell Significance Index: 8.6800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.3616
    Cell Significance Index: 4.0100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2436
    Cell Significance Index: 3.5500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0729
    Cell Significance Index: 1.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0147
    Cell Significance Index: 0.2100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0124
    Cell Significance Index: 0.1600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0020
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -0.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0012
    Cell Significance Index: -0.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0025
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0031
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0032
    Cell Significance Index: -0.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0037
    Cell Significance Index: -0.7500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0054
    Cell Significance Index: -0.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0055
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0058
    Cell Significance Index: -0.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0065
    Cell Significance Index: -0.6800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0094
    Cell Significance Index: -0.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0107
    Cell Significance Index: -0.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0111
    Cell Significance Index: -0.7500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0114
    Cell Significance Index: -0.1500
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.0117
    Cell Significance Index: -0.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0159
    Cell Significance Index: -0.8900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0171
    Cell Significance Index: -0.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0189
    Cell Significance Index: -0.6200
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.0192
    Cell Significance Index: -0.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0242
    Cell Significance Index: -0.7700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0249
    Cell Significance Index: -0.3200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0251
    Cell Significance Index: -0.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0251
    Cell Significance Index: -0.7400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0254
    Cell Significance Index: -0.5300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0257
    Cell Significance Index: -0.3700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0259
    Cell Significance Index: -0.4200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0259
    Cell Significance Index: -0.5100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0270
    Cell Significance Index: -0.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0300
    Cell Significance Index: -0.8000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0301
    Cell Significance Index: -0.3800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0306
    Cell Significance Index: -0.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0315
    Cell Significance Index: -0.6800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0338
    Cell Significance Index: -0.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0344
    Cell Significance Index: -0.6900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0345
    Cell Significance Index: -0.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0357
    Cell Significance Index: -1.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0358
    Cell Significance Index: -0.7600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0360
    Cell Significance Index: -0.3700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0360
    Cell Significance Index: -0.4700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0361
    Cell Significance Index: -0.6300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0373
    Cell Significance Index: -0.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0389
    Cell Significance Index: -0.7700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0398
    Cell Significance Index: -0.4200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0410
    Cell Significance Index: -0.7000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0414
    Cell Significance Index: -0.5400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0414
    Cell Significance Index: -0.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0427
    Cell Significance Index: -0.7900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0431
    Cell Significance Index: -0.4700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0447
    Cell Significance Index: -0.7600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0450
    Cell Significance Index: -0.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0476
    Cell Significance Index: -0.6500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0487
    Cell Significance Index: -0.5800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0512
    Cell Significance Index: -1.2500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0515
    Cell Significance Index: -0.5100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0518
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0528
    Cell Significance Index: -0.6700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0528
    Cell Significance Index: -0.8900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0541
    Cell Significance Index: -0.7500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0559
    Cell Significance Index: -0.8300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0564
    Cell Significance Index: -0.7300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0569
    Cell Significance Index: -0.6100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0569
    Cell Significance Index: -0.7800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0571
    Cell Significance Index: -0.7700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0573
    Cell Significance Index: -1.2000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0575
    Cell Significance Index: -0.7200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0576
    Cell Significance Index: -0.6800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0591
    Cell Significance Index: -0.7900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0594
    Cell Significance Index: -0.7700
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0596
    Cell Significance Index: -0.4500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0602
    Cell Significance Index: -0.7300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0603
    Cell Significance Index: -0.6900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0619
    Cell Significance Index: -0.7400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0619
    Cell Significance Index: -0.8100
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0622
    Cell Significance Index: -0.7800
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0624
    Cell Significance Index: -0.7500
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0624
    Cell Significance Index: -0.6100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0627
    Cell Significance Index: -0.8300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0630
    Cell Significance Index: -0.8400
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0640
    Cell Significance Index: -0.6900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0646
    Cell Significance Index: -0.7800
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0646
    Cell Significance Index: -0.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0646
    Cell Significance Index: -1.2600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0652
    Cell Significance Index: -0.7700
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0654
    Cell Significance Index: -0.7500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0654
    Cell Significance Index: -0.8900
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0657
    Cell Significance Index: -0.6900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0660
    Cell Significance Index: -0.7600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0662
    Cell Significance Index: -0.7400
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0667
    Cell Significance Index: -0.7200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0667
    Cell Significance Index: -1.6700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0669
    Cell Significance Index: -0.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SSX5 is a transcriptional regulator that belongs to the SSX family of genes, which are known to be involved in cancer development and progression. Unlike other members of the SSX family, SSX5 has a distinct expression pattern, with significant expression in progenitor cells, immune cells, and endothelial cells. This unique expression profile suggests that SSX5 may play a specific role in the regulation of cellular differentiation, proliferation, and survival in these cell types. **Pathways and Functions:** SSX5 is involved in the regulation of DNA-templated transcription, a key process in gene expression. It interacts with other transcription factors and co-factors to modulate the expression of target genes. SSX5 has been shown to bind to specific DNA sequences, influencing the transcription of genes involved in cellular differentiation, proliferation, and survival. Notably, SSX5 has been implicated in the regulation of the Notch signaling pathway, a key regulator of cell fate decisions in development and disease. SSX5 interacts with Notch receptors and co-receptors, modulating the activity of this critical signaling pathway. **Clinical Significance:** SSX5 has been identified as a potential biomarker for various diseases, including cancer and autoimmune disorders. Its expression in immune cells and endothelial cells suggests that SSX5 may play a role in the regulation of immune responses and vascular integrity. Furthermore, SSX5 has been implicated in the pathogenesis of certain cancers, including lung cancer and leukemia. Its expression is often dysregulated in these cancers, leading to the activation of oncogenic pathways and the suppression of tumor suppressor genes. In addition, SSX5 has been shown to be involved in the regulation of inflammatory responses, suggesting its potential role in the pathogenesis of autoimmune disorders. **Conclusion:** In conclusion, SSX5 is a complex gene with a unique expression profile and a range of roles in regulating cellular differentiation, proliferation, and survival. Its involvement in the regulation of the Notch signaling pathway and its expression in immune cells and endothelial cells suggest its potential role in the pathogenesis of various diseases, including cancer and autoimmune disorders. Further research is needed to fully elucidate the mechanisms by which SSX5 regulates gene expression and to explore its therapeutic potential in the treatment of disease. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms by which SSX5 regulates gene expression and its role in the regulation of the Notch signaling pathway. 2. The expression of SSX5 in various cell types and tissues should be further characterized to understand its potential role in disease. 3. The therapeutic potential of SSX5 as a biomarker or therapeutic target should be explored in preclinical and clinical studies. **Limitations:** 1. The current understanding of SSX5 is based on limited data, and further research is needed to fully elucidate its role in the human body. 2. The expression of SSX5 in various cell types and tissues may not be consistent across different populations or diseases, highlighting the need for further studies to validate its role in different contexts. **Future Directions:** 1. The development of novel therapeutic strategies targeting SSX5 may provide new avenues for the treatment of disease. 2. The characterization of SSX5 expression in various cell types and tissues may reveal new insights into its role in disease and provide a basis for the development of biomarkers for disease diagnosis and monitoring. 3. The exploration of SSX5's role in the regulation of the Notch signaling pathway may provide new insights into the mechanisms of cellular differentiation and proliferation.

Genular Protein ID: 433729578

Symbol: SSX5_HUMAN

Name: Protein SSX5

UniProtKB Accession Codes:

O60225 Q5JQ59 Q5JQ60 Q96AW3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 GO 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 4 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9378559

Title: SSX: a multigene family with several members transcribed in normal testis and human cancer.

PubMed ID: 9378559

DOI: 10.1002/(sici)1097-0215(19970917)72:6<965::aid-ijc8>3.0.co;2-n

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 188
  • Mass: 21660
  • Checksum: DBFA61D8B1295A27
  • Sequence:
    • MNGDDAFVRR PRVGSQIPEK MQKAFDDIAK YFSEKEWEKM KASEKIIYVY MKRKYEAMTK 
LGFKATLPPF MRNKRVADFQ GNDFDNDPNR GNQVEHPQMT FGRLQGIFPK ITPEKPAEEG 
NDSKGVPEAS GPQNNGKQLR PSGKLNTSEK VNKTSGPKRG KHAWTHRVRE RKQLVIYEEI 
SDPQEDDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.