Details for: TBXT

Gene ID: 6862

Symbol: TBXT

Ensembl ID: ENSG00000164458

Description: T-box transcription factor T

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.7902
    Cell Significance Index: 16.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2933
    Cell Significance Index: 4.2000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1238
    Cell Significance Index: 0.9400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0569
    Cell Significance Index: 0.5500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0358
    Cell Significance Index: 0.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0192
    Cell Significance Index: 2.2600
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.0171
    Cell Significance Index: 0.0400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0116
    Cell Significance Index: 0.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0115
    Cell Significance Index: 0.2500
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.0114
    Cell Significance Index: 0.1000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0102
    Cell Significance Index: 0.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0085
    Cell Significance Index: 0.1700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0069
    Cell Significance Index: 0.0900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0040
    Cell Significance Index: 0.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0035
    Cell Significance Index: 0.1800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0010
    Cell Significance Index: 0.5800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0003
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0004
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0005
    Cell Significance Index: -0.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0006
    Cell Significance Index: -0.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0010
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0013
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0015
    Cell Significance Index: -0.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0016
    Cell Significance Index: -0.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0017
    Cell Significance Index: -0.2300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0032
    Cell Significance Index: -0.0300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0041
    Cell Significance Index: -0.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0043
    Cell Significance Index: -0.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0043
    Cell Significance Index: -0.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0055
    Cell Significance Index: -0.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0055
    Cell Significance Index: -0.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0060
    Cell Significance Index: -0.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0061
    Cell Significance Index: -0.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0062
    Cell Significance Index: -0.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0072
    Cell Significance Index: -0.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0072
    Cell Significance Index: -0.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0074
    Cell Significance Index: -0.2600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0075
    Cell Significance Index: -0.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0085
    Cell Significance Index: -0.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0085
    Cell Significance Index: -0.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0086
    Cell Significance Index: -0.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0088
    Cell Significance Index: -0.2200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0090
    Cell Significance Index: -0.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0091
    Cell Significance Index: -0.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0091
    Cell Significance Index: -0.2600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0094
    Cell Significance Index: -0.1000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0094
    Cell Significance Index: -0.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0095
    Cell Significance Index: -0.2500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0102
    Cell Significance Index: -0.2000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0104
    Cell Significance Index: -0.1100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0109
    Cell Significance Index: -0.1300
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: -0.0110
    Cell Significance Index: -0.0700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0113
    Cell Significance Index: -0.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0113
    Cell Significance Index: -0.2400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0116
    Cell Significance Index: -0.2500
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0116
    Cell Significance Index: -0.1200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0118
    Cell Significance Index: -0.2000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0119
    Cell Significance Index: -0.2900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0121
    Cell Significance Index: -0.1500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0122
    Cell Significance Index: -0.1500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0124
    Cell Significance Index: -0.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0125
    Cell Significance Index: -0.2500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0125
    Cell Significance Index: -0.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0125
    Cell Significance Index: -0.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0126
    Cell Significance Index: -0.2500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0127
    Cell Significance Index: -0.1300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0130
    Cell Significance Index: -0.1500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0130
    Cell Significance Index: -0.1100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0132
    Cell Significance Index: -0.3300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0133
    Cell Significance Index: -0.1800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0134
    Cell Significance Index: -0.1600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0134
    Cell Significance Index: -0.1700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0135
    Cell Significance Index: -0.1800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0137
    Cell Significance Index: -0.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0138
    Cell Significance Index: -0.2100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0142
    Cell Significance Index: -0.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0143
    Cell Significance Index: -0.2400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0144
    Cell Significance Index: -0.1700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0144
    Cell Significance Index: -0.1700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0144
    Cell Significance Index: -0.2100
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0146
    Cell Significance Index: -0.1300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0150
    Cell Significance Index: -0.1500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0150
    Cell Significance Index: -0.2600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0150
    Cell Significance Index: -0.1900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0152
    Cell Significance Index: -0.2600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0156
    Cell Significance Index: -0.1700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0156
    Cell Significance Index: -0.2000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0168
    Cell Significance Index: -0.2200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0169
    Cell Significance Index: -0.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor Function:** TBXT is a T-box transcription factor, a class of transcription factors that play crucial roles in regulating gene expression during development and cell differentiation. 2. **Developmental Expression:** TBXT is significantly expressed in embryonic development, including the formation of axial mesoderm, definitive endoderm, and paraxial mesoderm. 3. **Cell Fate Specification:** TBXT regulates the expression of genes involved in cell fate specification, influencing the development of various cell types during embryogenesis. 4. **Immune Cell Differentiation:** TBXT is also expressed in immune cells, including T cells, monocytes, and microglial cells, suggesting its role in immune cell differentiation and function. 5. **Cellular Localization:** TBXT is found in the nucleus and cytoplasm, indicating its involvement in both transcriptional regulation and post-transcriptional processes. **Pathways and Functions:** 1. **Anterior-Posterior Axis Specification:** TBXT is involved in the specification of the anterior-posterior axis during embryogenesis, regulating the expression of genes involved in this process. 2. **Cardiac Muscle Cell Myoblast Differentiation:** TBXT regulates the differentiation of cardiac muscle cells, influencing the development of the heart. 3. **Cardiogenesis:** TBXT is involved in the formation of the heart, regulating the expression of genes involved in cardiac development. 4. **Cell Fate Specification:** TBXT regulates the expression of genes involved in cell fate specification, influencing the development of various cell types during embryogenesis. 5. **Chromatin Remodeling:** TBXT interacts with chromatin remodeling complexes, influencing the regulation of gene expression. 6. **RNA Polymerase II-Specific Transcription:** TBXT regulates the expression of genes involved in RNA polymerase II-specific transcription, influencing the regulation of gene expression. **Clinical Significance:** 1. **Disease Association:** TBXT has been associated with various diseases, including cardiovascular disease and immune disorders, highlighting its potential as a therapeutic target. 2. **Cancer Association:** TBXT has been identified as a potential oncogene, suggesting its involvement in cancer development and progression. 3. **Immune Modulation:** TBXT's expression in immune cells suggests its potential role in modulating immune responses, influencing the development of autoimmune diseases. 4. **Regenerative Medicine:** TBXT's involvement in developmental processes and cell fate specification makes it a potential target for regenerative medicine applications. In conclusion, the TBXT gene plays a critical role in developmental processes and immune function, influencing the regulation of gene expression and cell fate specification. Its involvement in various diseases and potential therapeutic targets highlight the importance of further research into the TBXT gene.

Genular Protein ID: 3091987023

Symbol: TBXT_HUMAN

Name: Protein T

UniProtKB Accession Codes:

O15178 E7ERD6 Q4KMP4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MIM 7 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 54 PDBsum 54 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 6 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8963900

Title: The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27.

PubMed ID: 8963900

DOI: 10.1101/gr.6.3.226

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15449172

Title: The human T locus and spina bifida risk.

PubMed ID: 15449172

DOI: 10.1007/s00439-004-1185-8

PubMed ID: 19801981

Title: T (brachyury) gene duplication confers major susceptibility to familial chordoma.

PubMed ID: 19801981

DOI: 10.1038/ng.454

PubMed ID: 22611028

Title: Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancer.

PubMed ID: 22611028

DOI: 10.1158/1078-0432.ccr-11-3211

PubMed ID: 24253444

Title: Mutations in the T (brachyury) gene cause a novel syndrome consisting of sacral agenesis, abnormal ossification of the vertebral bodies and a persistent notochordal canal.

PubMed ID: 24253444

DOI: 10.1136/jmedgenet-2013-102001

PubMed ID: 30237576

Title: Autozygome and high throughput confirmation of disease genes candidacy.

PubMed ID: 30237576

DOI: 10.1038/s41436-018-0138-x

Sequence Information:

  • Length: 435
  • Mass: 47443
  • Checksum: 9D470088C8602631
  • Sequence:
    • MSSPGTESAG KSLQYRVDHL LSAVENELQA GSEKGDPTER ELRVGLEESE LWLRFKELTN 
EMIVTKNGRR MFPVLKVNVS GLDPNAMYSF LLDFVAADNH RWKYVNGEWV PGGKPEPQAP 
SCVYIHPDSP NFGAHWMKAP VSFSKVKLTN KLNGGGQIML NSLHKYEPRI HIVRVGGPQR 
MITSHCFPET QFIAVTAYQN EEITALKIKY NPFAKAFLDA KERSDHKEMM EEPGDSQQPG 
YSQWGWLLPG TSTLCPPANP HPQFGGALSL PSTHSCDRYP TLRSHRSSPY PSPYAHRNNS 
PTYSDNSPAC LSMLQSHDNW SSLGMPAHPS MLPVSHNASP PTSSSQYPSL WSVSNGAVTP 
GSQAAAVSNG LGAQFFRGSP AHYTPLTHPV SAPSSSGSPL YEGAAAATDI VDSQYDAAAQ 
GRLIASWTPV SPPSM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.