Details for: SPZ1

Gene ID: 84654

Symbol: SPZ1

Ensembl ID: ENSG00000164299

Description: spermatogenic leucine zipper 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.1309
    Cell Significance Index: 3.2700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.1238
    Cell Significance Index: 1.5900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.0148
    Cell Significance Index: 0.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0108
    Cell Significance Index: 0.4900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0055
    Cell Significance Index: 0.1100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0007
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0012
    Cell Significance Index: -0.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0014
    Cell Significance Index: -0.7600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0029
    Cell Significance Index: -0.8300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0034
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0040
    Cell Significance Index: -0.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0054
    Cell Significance Index: -0.9700
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0057
    Cell Significance Index: -0.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0067
    Cell Significance Index: -0.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0105
    Cell Significance Index: -0.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0135
    Cell Significance Index: -0.9100
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0139
    Cell Significance Index: -0.1100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0154
    Cell Significance Index: -0.1200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0163
    Cell Significance Index: -0.2100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0171
    Cell Significance Index: -0.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0175
    Cell Significance Index: -0.2500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0201
    Cell Significance Index: -0.3100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0209
    Cell Significance Index: -0.2200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0218
    Cell Significance Index: -0.2800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0222
    Cell Significance Index: -0.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0224
    Cell Significance Index: -0.3300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0231
    Cell Significance Index: -0.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0233
    Cell Significance Index: -0.5100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0238
    Cell Significance Index: -0.2800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0248
    Cell Significance Index: -0.3300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0255
    Cell Significance Index: -0.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0262
    Cell Significance Index: -0.8400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0264
    Cell Significance Index: -0.2700
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0269
    Cell Significance Index: -0.2500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0294
    Cell Significance Index: -0.2600
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0310
    Cell Significance Index: -0.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0312
    Cell Significance Index: -0.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0315
    Cell Significance Index: -0.3000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0319
    Cell Significance Index: -0.2600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0326
    Cell Significance Index: -0.4400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0327
    Cell Significance Index: -0.5300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0332
    Cell Significance Index: -1.0500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0350
    Cell Significance Index: -0.4600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0353
    Cell Significance Index: -0.4500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0354
    Cell Significance Index: -0.6100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0355
    Cell Significance Index: -0.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0356
    Cell Significance Index: -0.9400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0356
    Cell Significance Index: -0.7700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0360
    Cell Significance Index: -0.4300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0363
    Cell Significance Index: -0.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0380
    Cell Significance Index: -1.0900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0395
    Cell Significance Index: -0.4300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0402
    Cell Significance Index: -0.2500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0404
    Cell Significance Index: -0.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0405
    Cell Significance Index: -0.8600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0409
    Cell Significance Index: -0.8000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0413
    Cell Significance Index: -0.8300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0419
    Cell Significance Index: -0.8300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0420
    Cell Significance Index: -0.8300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0433
    Cell Significance Index: -0.4100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0464
    Cell Significance Index: -0.5700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0464
    Cell Significance Index: -0.6000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0466
    Cell Significance Index: -0.5000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0472
    Cell Significance Index: -0.5400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0474
    Cell Significance Index: -0.8200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0484
    Cell Significance Index: -0.4400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0493
    Cell Significance Index: -0.3300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0509
    Cell Significance Index: -0.6200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0525
    Cell Significance Index: -0.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0547
    Cell Significance Index: -0.9200
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0547
    Cell Significance Index: -0.5400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0567
    Cell Significance Index: -0.6800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0579
    Cell Significance Index: -0.5600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0582
    Cell Significance Index: -0.7600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0590
    Cell Significance Index: -0.7100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0595
    Cell Significance Index: -0.7900
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0617
    Cell Significance Index: -0.6700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0640
    Cell Significance Index: -0.6800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0649
    Cell Significance Index: -0.9100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0654
    Cell Significance Index: -0.6900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0663
    Cell Significance Index: -0.5600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0672
    Cell Significance Index: -0.7900
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0674
    Cell Significance Index: -0.7700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0678
    Cell Significance Index: -1.0900
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0685
    Cell Significance Index: -0.8000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0685
    Cell Significance Index: -0.8300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0685
    Cell Significance Index: -0.8100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0688
    Cell Significance Index: -0.5400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0693
    Cell Significance Index: -0.8700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0697
    Cell Significance Index: -0.8800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0709
    Cell Significance Index: -0.8800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0719
    Cell Significance Index: -0.8500
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -0.0719
    Cell Significance Index: -0.8800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0720
    Cell Significance Index: -1.0500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0723
    Cell Significance Index: -0.8600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0728
    Cell Significance Index: -1.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor:** SPZ1 is classified as a transcription factor, which binds to specific DNA sequences to regulate gene expression. 2. **Leucine Zipper Motif:** The gene contains a leucine zipper motif, a conserved structural element found in many transcription factors, which is essential for DNA binding and dimerization. 3. **Ubiquitous Expression:** Although the significantly expressed cells are unknown, the gene is expressed in various cell types, including glutamatergic neurons, microglial cells, blood vessel endothelial cells, pericytes, goblet cells, neoplastic cells, abnormal cells, immature innate lymphoid cells, and absorptive cells, suggesting a broad tissue-specific expression pattern. 4. **Regulation of Gene Expression:** SPZ1 is involved in regulating DNA-templated transcription, DNA binding, and protein binding, indicating its potential role in controlling gene expression. **Pathways and Functions:** 1. **DNA- Templated Transcription:** SPZ1 regulates DNA-templated transcription, a process by which RNA polymerase transcribes DNA into RNA, ensuring the accurate expression of genes. 2. **DNA Binding:** The leucine zipper motif in SPZ1 enables it to bind to specific DNA sequences, allowing for the regulation of gene expression. 3. **Protein Binding:** SPZ1 interacts with other proteins, modulating its activity and regulating gene expression. 4. **Cellular Development and Immune Response:** The expression of SPZ1 in various cell types suggests its involvement in cellular development and immune response, highlighting its potential role in maintaining tissue homeostasis. **Clinical Significance:** 1. **Cancer Research:** The expression of SPZ1 in neoplastic cells and abnormal cells suggests its potential role in cancer development and progression. Further research is needed to elucidate its involvement in cancer biology. 2. **Neurological Disorders:** The expression of SPZ1 in glutamatergic neurons and microglial cells raises questions about its involvement in neurological disorders, such as neurodegenerative diseases and psychiatric conditions. 3. **Immunological Disorders:** The expression of SPZ1 in immune cells, including microglial cells and immature innate lymphoid cells, suggests its potential role in immunological disorders, such as autoimmune diseases and inflammatory conditions. 4. **Regulatory T-Cells:** The expression of SPZ1 in regulatory T-cells may indicate its involvement in maintaining immune tolerance and preventing autoimmune diseases. In conclusion, the SPZ1 gene is a transcription factor that regulates gene expression in various cell types, with potential implications for cellular development, immune response, and cancer biology. Further research is necessary to elucidate its tissue-specific expression patterns, pathways, and functions, as well as its clinical significance in different diseases.

Genular Protein ID: 3729251347

Symbol: SPZ1_HUMAN

Name: Spermatogenic leucine zipper protein 1

UniProtKB Accession Codes:

Q9BXG8 B2RA21 Q8N4P1 Q8N7E9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12778315

Title: Expression of a novel bHLH-Zip gene in human testis.

PubMed ID: 12778315

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15899793

Title: bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis.

PubMed ID: 15899793

DOI: 10.1158/0008-5472.can-04-3658

Sequence Information:

  • Length: 430
  • Mass: 49445
  • Checksum: 9B2CD2B5C8F5FB43
  • Sequence:
    • MASSAKSAEM PTISKTVNPT PDPHQEYLDP RITIALFEIG SHSPSSWGSL PFLKNSSHQV 
TEQQTAQKFN NLLKEIKDIL KNMAGFEEKI TEAKELFEET NITEDVSAHK ENIRGLDKIN 
EMLSTNLPVS LAPEKEDNEK KQEMILETNI TEDVSAHKEN IRGLDKINEM LSTNLPVSLA 
PEKEDNEKKQ QMIMENQNSE NTAQVFARDL VNRLEEKKVL NETQQSQEKA KNRLNVQEET 
MKIRNNMEQL LQEAEHWSKQ HTELSKLIKS YQKSQKDISE TLGNNGVGFQ TQPNNEVSAK 
HELEEQVKKL SHDTYSLQLM AALLENECQI LQQRVEILKE LHHQKQGTLQ EKPIQINYKQ 
DKKNQKPSEA KKVEMYKQNK QAMKGTFWKK DRSCRSLDVC LNKKACNTQF NIHVARKALR 
GKMRSASSLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.