Details for: PAGE1

Gene ID: 8712

Symbol: PAGE1

Ensembl ID: ENSG00000068985

Description: PAGE family member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.18
    Marker Score: 52,695
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.6
    Marker Score: 8,164
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.7
    Marker Score: 6,730
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.14
    Marker Score: 3,158
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.34
    Marker Score: 4,026
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.9
    Marker Score: 2,121
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.78
    Marker Score: 390
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.56
    Marker Score: 379
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.56
    Marker Score: 385
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.28
    Marker Score: 1,217
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.22
    Marker Score: 385
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,692
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.07
    Marker Score: 388
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.01
    Marker Score: 590
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.99
    Marker Score: 71,460
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,695
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.94
    Marker Score: 390
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,338
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,288
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.87
    Marker Score: 389
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.87
    Marker Score: 502
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.84
    Marker Score: 386
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1,339
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.81
    Marker Score: 406
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.8
    Marker Score: 231
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.79
    Marker Score: 389
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 406
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1,200
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.73
    Marker Score: 323
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 702
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.72
    Marker Score: 378
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7
    Marker Score: 1,320
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 549
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.67
    Marker Score: 372
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.64
    Marker Score: 305
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.62
    Marker Score: 389
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.57
    Marker Score: 376
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.56
    Marker Score: 385
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.54
    Marker Score: 1,093
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.49
    Marker Score: 381
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.49
    Marker Score: 7,696
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.49
    Marker Score: 366
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 285
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.45
    Marker Score: 390
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 389
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.43
    Marker Score: 388
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.39
    Marker Score: 234
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.37
    Marker Score: 380
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.35
    Marker Score: 381
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.34
    Marker Score: 365
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.34
    Marker Score: 380
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.33
    Marker Score: 380
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.32
    Marker Score: 389
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.31
    Marker Score: 1,866
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.31
    Marker Score: 361
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.3
    Marker Score: 389
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.3
    Marker Score: 389
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.3
    Marker Score: 375
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.3
    Marker Score: 383
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.27
    Marker Score: 386
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.24
    Marker Score: 379
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.23
    Marker Score: 706
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.23
    Marker Score: 388
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.2
    Marker Score: 245
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.19
    Marker Score: 345
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.18
    Marker Score: 389
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.17
    Marker Score: 244
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.16
    Marker Score: 389
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.16
    Marker Score: 321
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 363
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.15
    Marker Score: 383
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.15
    Marker Score: 963
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.15
    Marker Score: 382
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.13
    Marker Score: 390
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.13
    Marker Score: 377
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.13
    Marker Score: 346
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.12
    Marker Score: 485
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.11
    Marker Score: 196
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.11
    Marker Score: 390
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1
    Marker Score: 379
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.07
    Marker Score: 737
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.07
    Marker Score: 175
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.07
    Marker Score: 388
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.06
    Marker Score: 385
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.05
    Marker Score: 390
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.05
    Marker Score: 387
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.05
    Marker Score: 390
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.04
    Marker Score: 378
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.04
    Marker Score: 315
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.03
    Marker Score: 389
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.03
    Marker Score: 389
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.03
    Marker Score: 384
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.03
    Marker Score: 389
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.02
    Marker Score: 390
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.02
    Marker Score: 389
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.02
    Marker Score: 390

Other Information

**Key Characteristics:** The PAGE1 gene exhibits several key characteristics that highlight its importance in biological processes. Firstly, its expression is significantly elevated in progenitor cells, oligodendrocyte precursor cells, and microglial cells, suggesting a role in cell differentiation and development. Additionally, PAGE1 is also expressed in T cells, plasma cells, and endothelial cells, indicating its involvement in immune regulation and vascular homeostasis. Furthermore, PAGE1 has been associated with the regulation of cell adhesion, migration, and proliferation, further emphasizing its role in tissue development and maintenance. **Pathways and Functions:** The PAGE1 gene is involved in several biological pathways, including protein binding, which is critical for its function. The P antigen family, to which PAGE1 belongs, is known to interact with various proteins, influencing cell signaling, adhesion, and migration. Specifically, PAGE1 has been shown to interact with CD147, a receptor that plays a crucial role in the regulation of cell adhesion and migration. This interaction is thought to be involved in the regulation of immune responses, particularly in the context of inflammation and tissue damage. Additionally, PAGE1 has been implicated in the regulation of angiogenesis, the process by which new blood vessels are formed from pre-existing vessels, which is essential for tissue development and repair. **Clinical Significance:** The clinical significance of the PAGE1 gene is multifaceted. Firstly, its expression in T cells and plasma cells suggests that it may play a role in the regulation of immune responses, particularly in the context of autoimmune diseases and cancers. For example, alterations in PAGE1 expression have been observed in patients with multiple sclerosis, a disease characterized by inflammation and demyelination in the central nervous system. Additionally, PAGE1 has been implicated in the regulation of angiogenesis, which is critical in the development of various cancers. Therefore, the PAGE1 gene may serve as a potential therapeutic target for the treatment of diseases characterized by aberrant angiogenesis and immune dysregulation. In conclusion, the PAGE1 gene is a vital component of the P antigen family, playing a crucial role in immune regulation, cell differentiation, and tissue homeostasis. Its expression in multiple cell types and its interactions with various proteins highlight its importance in biological processes. Further research is needed to fully elucidate the functions and clinical significance of the PAGE1 gene, but its potential as a therapeutic target for diseases characterized by immune dysregulation and angiogenesis is promising.

Genular Protein ID: 3972250501

Symbol: PAGE1_HUMAN

Name: P antigen family member 1

UniProtKB Accession Codes:

O75459 Q6FGM3 Q9BSS7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9651357

Title: Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens.

PubMed ID: 9651357

DOI: 10.1074/jbc.273.28.17618

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18179644

Title: An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members.

PubMed ID: 18179644

DOI: 10.1111/j.1399-0039.2007.00997.x

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 146
  • Mass: 16150
  • Checksum: E6C7BA94D898DCB2
  • Sequence:
    • MGFLRRLIYR RRPMIYVESS EESSDEQPDE VESPTQSQDS TPAEEREDEG ASAAQGQEPE 
ADSQELVQPK TGCELGDGPD TKRVCLRNEE QMKLPAEGPE PEADSQEQVH PKTGCERGDG 
PDVQELGLPN PEEVKTPEED EGQSQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.