Details for: PAGE1

Gene ID: 8712

Symbol: PAGE1

Ensembl ID: ENSG00000068985

Description: PAGE family member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.8066
    Cell Significance Index: 43.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 1.5754
    Cell Significance Index: -0.6400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3129
    Cell Significance Index: 4.5600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.2429
    Cell Significance Index: 2.7500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1967
    Cell Significance Index: 1.4900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0607
    Cell Significance Index: 0.8700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0496
    Cell Significance Index: 0.7100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0313
    Cell Significance Index: 0.1900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0271
    Cell Significance Index: 0.5400
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.0226
    Cell Significance Index: 0.1800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: 0.0055
    Cell Significance Index: 0.0600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0038
    Cell Significance Index: 0.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0004
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.6300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0004
    Cell Significance Index: 0.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0007
    Cell Significance Index: -0.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0010
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0011
    Cell Significance Index: -0.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0023
    Cell Significance Index: -0.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0025
    Cell Significance Index: -0.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0029
    Cell Significance Index: -0.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0031
    Cell Significance Index: -0.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0033
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0036
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0058
    Cell Significance Index: -0.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0063
    Cell Significance Index: -0.6600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0065
    Cell Significance Index: -0.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0173
    Cell Significance Index: -0.5700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0173
    Cell Significance Index: -0.4400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0188
    Cell Significance Index: -0.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0201
    Cell Significance Index: -0.6400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0216
    Cell Significance Index: -0.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0217
    Cell Significance Index: -0.5800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0218
    Cell Significance Index: -0.2300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0222
    Cell Significance Index: -0.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0224
    Cell Significance Index: -0.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0231
    Cell Significance Index: -0.4500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0234
    Cell Significance Index: -0.5800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0242
    Cell Significance Index: -0.2000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0245
    Cell Significance Index: -0.2600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0270
    Cell Significance Index: -0.3600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0271
    Cell Significance Index: -0.4600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0273
    Cell Significance Index: -0.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0287
    Cell Significance Index: -0.6100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0295
    Cell Significance Index: -0.5800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0299
    Cell Significance Index: -0.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0304
    Cell Significance Index: -0.6100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0307
    Cell Significance Index: -0.6000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0308
    Cell Significance Index: -0.6100
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0312
    Cell Significance Index: -0.4300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0314
    Cell Significance Index: -0.4100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0321
    Cell Significance Index: -0.6700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0330
    Cell Significance Index: -0.3800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0333
    Cell Significance Index: -0.5400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0348
    Cell Significance Index: -0.2100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0350
    Cell Significance Index: -0.4200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0352
    Cell Significance Index: -0.4600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0358
    Cell Significance Index: -0.4100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0364
    Cell Significance Index: -0.6300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0369
    Cell Significance Index: -0.6300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0372
    Cell Significance Index: -0.4700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0375
    Cell Significance Index: -0.6300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0386
    Cell Significance Index: -0.4800
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0392
    Cell Significance Index: -0.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0394
    Cell Significance Index: -0.6600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0413
    Cell Significance Index: -0.5500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0415
    Cell Significance Index: -0.4900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0416
    Cell Significance Index: -0.4700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0423
    Cell Significance Index: -0.5000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0428
    Cell Significance Index: -0.5500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0429
    Cell Significance Index: -0.5100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0437
    Cell Significance Index: -0.5100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0444
    Cell Significance Index: -0.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0445
    Cell Significance Index: -0.5300
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0446
    Cell Significance Index: -0.4700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0447
    Cell Significance Index: -0.6600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0452
    Cell Significance Index: -0.6100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0453
    Cell Significance Index: -0.5400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0461
    Cell Significance Index: -0.6400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0470
    Cell Significance Index: -0.5200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0471
    Cell Significance Index: -0.6600
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0472
    Cell Significance Index: -0.5200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0473
    Cell Significance Index: -0.5500
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0476
    Cell Significance Index: -0.4700
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0488
    Cell Significance Index: -0.5900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0493
    Cell Significance Index: -0.5900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0495
    Cell Significance Index: -0.4500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0496
    Cell Significance Index: -0.5400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0496
    Cell Significance Index: -0.5400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0501
    Cell Significance Index: -0.6100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0502
    Cell Significance Index: -0.5900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0503
    Cell Significance Index: -0.6100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0504
    Cell Significance Index: -0.5200
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: -0.0505
    Cell Significance Index: -0.3700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0506
    Cell Significance Index: -0.6100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0507
    Cell Significance Index: -0.6400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0508
    Cell Significance Index: -0.6500
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0508
    Cell Significance Index: -0.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The PAGE1 gene exhibits several key characteristics that highlight its importance in biological processes. Firstly, its expression is significantly elevated in progenitor cells, oligodendrocyte precursor cells, and microglial cells, suggesting a role in cell differentiation and development. Additionally, PAGE1 is also expressed in T cells, plasma cells, and endothelial cells, indicating its involvement in immune regulation and vascular homeostasis. Furthermore, PAGE1 has been associated with the regulation of cell adhesion, migration, and proliferation, further emphasizing its role in tissue development and maintenance. **Pathways and Functions:** The PAGE1 gene is involved in several biological pathways, including protein binding, which is critical for its function. The P antigen family, to which PAGE1 belongs, is known to interact with various proteins, influencing cell signaling, adhesion, and migration. Specifically, PAGE1 has been shown to interact with CD147, a receptor that plays a crucial role in the regulation of cell adhesion and migration. This interaction is thought to be involved in the regulation of immune responses, particularly in the context of inflammation and tissue damage. Additionally, PAGE1 has been implicated in the regulation of angiogenesis, the process by which new blood vessels are formed from pre-existing vessels, which is essential for tissue development and repair. **Clinical Significance:** The clinical significance of the PAGE1 gene is multifaceted. Firstly, its expression in T cells and plasma cells suggests that it may play a role in the regulation of immune responses, particularly in the context of autoimmune diseases and cancers. For example, alterations in PAGE1 expression have been observed in patients with multiple sclerosis, a disease characterized by inflammation and demyelination in the central nervous system. Additionally, PAGE1 has been implicated in the regulation of angiogenesis, which is critical in the development of various cancers. Therefore, the PAGE1 gene may serve as a potential therapeutic target for the treatment of diseases characterized by aberrant angiogenesis and immune dysregulation. In conclusion, the PAGE1 gene is a vital component of the P antigen family, playing a crucial role in immune regulation, cell differentiation, and tissue homeostasis. Its expression in multiple cell types and its interactions with various proteins highlight its importance in biological processes. Further research is needed to fully elucidate the functions and clinical significance of the PAGE1 gene, but its potential as a therapeutic target for diseases characterized by immune dysregulation and angiogenesis is promising.

Genular Protein ID: 3972250501

Symbol: PAGE1_HUMAN

Name: P antigen family member 1

UniProtKB Accession Codes:

O75459 Q6FGM3 Q9BSS7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMART 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9651357

Title: Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens.

PubMed ID: 9651357

DOI: 10.1074/jbc.273.28.17618

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18179644

Title: An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members.

PubMed ID: 18179644

DOI: 10.1111/j.1399-0039.2007.00997.x

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 146
  • Mass: 16150
  • Checksum: E6C7BA94D898DCB2
  • Sequence:
    • MGFLRRLIYR RRPMIYVESS EESSDEQPDE VESPTQSQDS TPAEEREDEG ASAAQGQEPE 
ADSQELVQPK TGCELGDGPD TKRVCLRNEE QMKLPAEGPE PEADSQEQVH PKTGCERGDG 
PDVQELGLPN PEEVKTPEED EGQSQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.