Details for: PTGDR2

Gene ID: 11251

Symbol: PTGDR2

Ensembl ID: ENSG00000183134

Description: prostaglandin D2 receptor 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 5.28
    Marker Score: 2,051
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.16
    Marker Score: 2,173
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,648
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,819
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.04
    Marker Score: 2,146
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,057
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,343
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.94
    Marker Score: 388
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,291
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.86
    Marker Score: 394
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 587
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 299
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.7
    Marker Score: 966
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.56
    Marker Score: 650
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: group 2 innate lymphoid cell (CL0001069)
    Fold Change: 0.34
    Marker Score: 116
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.29
    Marker Score: 292
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.28
    Marker Score: 333
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.28
    Marker Score: 665
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.25
    Marker Score: 62
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.23
    Marker Score: 177
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.21
    Marker Score: 228
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.2
    Marker Score: 195
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2
    Marker Score: 85
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.2
    Marker Score: 115
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.19
    Marker Score: 67
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.17
    Marker Score: 209
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.17
    Marker Score: 345
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.17
    Marker Score: 135
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.17
    Marker Score: 165
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.16
    Marker Score: 303
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.16
    Marker Score: 77
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.15
    Marker Score: 62
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.15
    Marker Score: 229
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.14
    Marker Score: 61
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.14
    Marker Score: 145
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.14
    Marker Score: 2,150
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.13
    Marker Score: 43
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.13
    Marker Score: 73
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.13
    Marker Score: 69
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.12
    Marker Score: 83
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.12
    Marker Score: 200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.11
    Marker Score: 53
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.11
    Marker Score: 73
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.11
    Marker Score: 52
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.1
    Marker Score: 101
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.1
    Marker Score: 94
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.09
    Marker Score: 26
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.09
    Marker Score: 90
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.09
    Marker Score: 47
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.09
    Marker Score: 377
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.09
    Marker Score: 92
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.08
    Marker Score: 56
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 77
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.08
    Marker Score: 213
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.07
    Marker Score: 93
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 58
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.06
    Marker Score: 71
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.06
    Marker Score: 28

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor specificity:** PTGDR2 is a specific receptor for Prostaglandin D2 (PGD2), a bioactive lipid mediator involved in various physiological and pathological processes. 2. **G protein-coupled receptor (GPCR) activity:** PTGDR2 belongs to the class A/1 rhodopsin-like receptors, characterized by their ability to activate G proteins, leading to downstream signaling events. 3. **Widespread expression:** PTGDR2 is expressed in numerous cell types, including neuroendocrine cells, endothelial cells, stem cells, and neurons, highlighting its diverse roles in the body. 4. **Signaling pathways:** PTGDR2 modulates multiple signaling pathways, including adenylate cyclase-inhibiting G protein-coupled receptor signaling, calcium-mediated signaling, and chemotaxis. **Pathways and Functions:** 1. **Immune response:** PTGDR2 plays a crucial role in regulating immune responses, including chemotaxis and the activation of immune cells. 2. **Neuroprotection:** PTGDR2 has been implicated in neuroprotection, with studies suggesting its involvement in the regulation of neuronal survival and function. 3. **Male germ cell proliferation:** PTGDR2 negatively regulates male germ cell proliferation, highlighting its role in reproductive biology. 4. **Inflammation:** PTGDR2 modulates inflammatory responses by influencing the activity of immune cells and the production of pro-inflammatory mediators. 5. **Cardiovascular function:** PTGDR2 has been linked to cardiovascular function, with studies suggesting its involvement in the regulation of blood vessel endothelial cell function. **Clinical Significance:** 1. **Immunomodulatory therapies:** PTGDR2 may serve as a therapeutic target for the development of immunomodulatory therapies, particularly in the treatment of autoimmune diseases and cancer. 2. **Neurological disorders:** The involvement of PTGDR2 in neuroprotection and neurodegenerative diseases, such as Alzheimer's and Parkinson's, highlights its potential as a therapeutic target. 3. **Reproductive biology:** PTGDR2's role in regulating male germ cell proliferation makes it a potential target for the treatment of male infertility and reproductive disorders. 4. **Cardiovascular disease:** The modulation of blood vessel endothelial cell function by PTGDR2 may have implications for the treatment of cardiovascular disease. In conclusion, PTGDR2 is a multifunctional receptor with a wide range of biological activities, from immune regulation to neuroprotection and reproductive biology. Further research is necessary to fully elucidate the role of PTGDR2 in human health and disease, and to explore its potential as a therapeutic target.

Genular Protein ID: 1437236942

Symbol: PD2R2_HUMAN

Name: Prostaglandin D2 receptor 2

UniProtKB Accession Codes:

Q9Y5Y4 O94765 Q4QRI6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EMBL 6 Ensembl 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10036181

Title: Discovery of three novel orphan G-protein-coupled receptors.

PubMed ID: 10036181

DOI: 10.1006/geno.1998.5655

PubMed ID: 9973380

Title: Selective expression of a novel surface molecule by human Th2 cells in vivo.

PubMed ID: 9973380

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11535533

Title: Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor.

PubMed ID: 11535533

DOI: 10.1182/blood.v98.6.1942

PubMed ID: 11168006

Title: A novel surface molecule of Th2- and Tc2-type cells, CRTH2 expression on human peripheral and decidual CD4+ and CD8+ T cells during the early stage of pregnancy.

PubMed ID: 11168006

DOI: 10.1046/j.1365-2249.2001.01422.x

PubMed ID: 11208866

Title: Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2.

PubMed ID: 11208866

DOI: 10.1084/jem.193.2.255

PubMed ID: 12466225

Title: Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.

PubMed ID: 12466225

DOI: 10.1038/sj.bjp.0704973

PubMed ID: 17196174

Title: Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2).

PubMed ID: 17196174

DOI: 10.1016/j.bcp.2006.11.021

PubMed ID: 17207480

Title: Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2.

PubMed ID: 17207480

DOI: 10.1016/j.ejphar.2006.11.058

PubMed ID: 20035740

Title: Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif.

PubMed ID: 20035740

DOI: 10.1016/j.ejphar.2009.12.022

Sequence Information:

  • Length: 395
  • Mass: 43268
  • Checksum: 99A63CBDA418DEC9
  • Sequence:
    • MSANATLKPL CPILEQMSRL QSHSNTSIRY IDHAAVLLHG LASLLGLVEN GVILFVVGCR 
MRQTVVTTWV LHLALSDLLA SASLPFFTYF LAVGHSWELG TTFCKLHSSI FFLNMFASGF 
LLSAISLDRC LQVVRPVWAQ NHRTVAAAHK VCLVLWALAV LNTVPYFVFR DTISRLDGRI 
MCYYNVLLLN PGPDRDATCN SRQVALAVSK FLLAFLVPLA IIASSHAAVS LRLQHRGRRR 
PGRFVRLVAA VVAAFALCWG PYHVFSLLEA RAHANPGLRP LVWRGLPFVT SLAFFNSVAN 
PVLYVLTCPD MLRKLRRSLR TVLESVLVDD SELGGAGSSR RRRTSSTARS ASPLALCSRP 
EEPRGPARLL GWLLGSCAAS PQTGPLNRAL SSTSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.