Gene FGF3 - ENSG00000186895 | NCBI Gene ID: 2248

Details for: FGF3

Gene ID: 2248

Symbol: FGF3

Ensembl ID: ENSG00000186895

Description: fibroblast growth factor 3

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Fgfr1 ligand binding and activation
(R-HSA-190242)
Fgfr1b ligand binding and activation
(R-HSA-190370)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2b ligand binding and activation
(R-HSA-190377)
Fgfrl1 modulation of fgfr1 signaling
(R-HSA-5658623)
Frs-mediated fgfr1 signaling
(R-HSA-5654693)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade: fgfr1
(R-HSA-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr1
(R-HSA-5654688)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Anatomical structure morphogenesis
(GO:0009653)
Animal organ morphogenesis
(GO:0009887)
Cell-cell signaling
(GO:0007267)
Cell differentiation
(GO:0030154)
Cytoplasm
(GO:0005737)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Negative regulation of cardiac muscle tissue development
(GO:0055026)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein binding
(GO:0005515)
Regulation of cell migration
(GO:0030334)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pericyte (CL0000669)
Fold Change: 1.35
Marker Score: 791
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.32
Marker Score: 2500
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7691
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30397
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5344
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.92
Marker Score: 1496
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.88
Marker Score: 13803
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5279
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.8
Marker Score: 380
Cell Name: brush cell (CL0002204)
Fold Change: 0.79
Marker Score: 718
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.75
Marker Score: 1529
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.68
Marker Score: 542
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.66
Marker Score: 3994.5
Cell Name: stromal cell (CL0000499)
Fold Change: 0.64
Marker Score: 745
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.58
Marker Score: 346
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.5
Marker Score: 129
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.47
Marker Score: 133.5
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.45
Marker Score: 146
Cell Name: male germ cell (CL0000015)
Fold Change: 0.44
Marker Score: 127.5
Cell Name: interneuron (CL0000099)
Fold Change: 0.4
Marker Score: 184
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.4
Marker Score: 125.5
Cell Name: leukocyte (CL0000738)
Fold Change: 0.4
Marker Score: 227
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.39
Marker Score: 150.5
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.35
Marker Score: 157
Cell Name: podocyte (CL0000653)
Fold Change: 0.34
Marker Score: 127
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.34
Marker Score: 108.5
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.33
Marker Score: 354
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.31
Marker Score: 125.5
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.31
Marker Score: 111
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.29
Marker Score: 101.5
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.28
Marker Score: 587
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.24
Marker Score: 111
Cell Name: secretory cell (CL0000151)
Fold Change: 0.24
Marker Score: 443
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.24
Marker Score: 130.5
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.23
Marker Score: 129.5
Cell Name: mast cell (CL0000097)
Fold Change: 0.23
Marker Score: 132
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.22
Marker Score: 123.5
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.21
Marker Score: 143
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.21
Marker Score: 109.5
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.2
Marker Score: 114.5
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.2
Marker Score: 126.5
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.2
Marker Score: 131.5
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.17
Marker Score: 130.5
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.17
Marker Score: 161
Cell Name: amacrine cell (CL0000561)
Fold Change: 0.17
Marker Score: 533.5
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.16
Marker Score: 144
Cell Name: astrocyte (CL0000127)
Fold Change: 0.16
Marker Score: 137.5
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.16
Marker Score: 83
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.15
Marker Score: 97
Cell Name: glial cell (CL0000125)
Fold Change: 0.15
Marker Score: 159.5
Cell Name: B cell (CL0000236)
Fold Change: 0.14
Marker Score: 137
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.13
Marker Score: 356.5
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.12
Marker Score: 120.5
Cell Name: neuron (CL0000540)
Fold Change: 0.11
Marker Score: 440
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.11
Marker Score: 133.5
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.11
Marker Score: 131.5
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.1
Marker Score: 80.5
Cell Name: basal cell (CL0000646)
Fold Change: 0.1
Marker Score: 132.5
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.1
Marker Score: 127.5
Cell Name: fibroblast (CL0000057)
Fold Change: 0.1
Marker Score: 95
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.1
Marker Score: 133.5
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.09
Marker Score: 131.5
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.09
Marker Score: 214
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.09
Marker Score: 91.5
Cell Name: T cell (CL0000084)
Fold Change: 0.08
Marker Score: 139
Cell Name: macrophage (CL0000235)
Fold Change: 0.08
Marker Score: 89
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.08
Marker Score: 98.5
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.07
Marker Score: 126.5
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.07
Marker Score: 120.5
Cell Name: germ cell (CL0000586)
Fold Change: 0.07
Marker Score: 125.5
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.07
Marker Score: 144
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.07
Marker Score: 97.5
Cell Name: microglial cell (CL0000129)
Fold Change: 0.06
Marker Score: 117.5
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.06
Marker Score: 82
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.06
Marker Score: 71.5
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.05
Marker Score: 1768
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.05
Marker Score: 123
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.05
Marker Score: 132.5
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.04
Marker Score: 122.5
Cell Name: Unknown (CL0000003)
Fold Change: 0.04
Marker Score: 111.5
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.03
Marker Score: 133.5
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.03
Marker Score: 105
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.03
Marker Score: 133
Cell Name: progenitor cell (CL0011026)
Fold Change: 0.02
Marker Score: 135
Cell Name: granule cell (CL0000120)
Fold Change: 0.02
Marker Score: 128.5
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.02
Marker Score: 141
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.02
Marker Score: 80
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.01
Marker Score: 144
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.01
Marker Score: 20
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.01
Marker Score: 126
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.01
Marker Score: 131.5
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.01
Marker Score: 129.5
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0
Marker Score: 864
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0
Marker Score: 125.5
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0
Marker Score: 126.5
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0
Marker Score: 109.5
Cell Name: mural cell (CL0008034)
Fold Change: 0
Marker Score: 142

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## Summary FGF3 (fibroblast growth factor 3) is a protein that plays a crucial role in various biological processes, including cell proliferation, migration, and survival. It is highly expressed in different cell types, including pericytes, cardiac endothelial cells, goblet cells, and intestinal epithelial cells. ## Key characteristics * FGF3 is a secreted protein that belongs to the fibroblast growth factor family. * It is a key regulator of cell growth, proliferation, and differentiation. * It plays a crucial role in embryonic development and tissue homeostasis. * It is involved in wound healing, tissue repair, and fibrosis. * It is frequently overexpressed in cancer cells. ## Pathways and functions * FGF3 binds to receptors on the surface of target cells, including FGFR1, FGFR2, and IGF1R. * Binding of FGF3 to FGFR1 or FGFR2 triggers the activation of downstream signaling pathways, including the PI3K/AKT pathway, MAPK pathway, and ERK pathway. * These pathways promote cell proliferation, survival, and migration. * FGF3 also activates the MAPK pathway, leading to the activation of MAPK target proteins, including p38 MAPK and JNK. * These pathways contribute to cell growth, survival, and differentiation. ## Clinical significance * Mutations in the FGF3 gene have been linked to various human diseases, including cancer, cardiovascular disease, and metabolic disorders. * FGF3 is a potential therapeutic target for cancer treatment. * Inhibition of FGF3 signaling has been shown to inhibit cancer growth and metastasis. * FGF3 is a promising target for the development of novel therapeutic strategies for various diseases. **Additional notes:** * FGF3 is a pleiotropic protein with both pro-tumorigenic and anti-tumorigenic activities. * The balance between FGF3 signaling and other growth factor signaling pathways is critical for maintaining tissue homeostasis and preventing cancer development. * Dysregulation of FGF3 signaling has been implicated in various human diseases, including cancer, cardiovascular disease, and diabetes.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Fibroblast growth factor 3

Genular Protein ID: 787574721

Symbol: FGF3_HUMAN

Name: Fibroblast growth factor 3

UniProtKB Accession Codes:

P11487 Q0VG69

Database IDs:

Citations:

PubMed ID: 2470007

Title: Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells.

PubMed ID: 2470007

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 17236138

Title: Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia.

PubMed ID: 17236138

DOI: 10.1086/510920

PubMed ID: 18435799

Title: Homozygous FGF3 mutations result in congenital deafness with inner ear agenesis, microtia, and microdontia.

PubMed ID: 18435799

DOI: 10.1111/j.1399-0004.2008.01004.x

Sequence Information:

Length: 239
Mass: 26887
Checksum: 8DBEF17D2B2E3C63
Sequence:

MGLIWLLLLS LLEPGWPAAG PGARLRRDAG GRGGVYEHLG GAPRRRKLYC ATKYHLQLHP 
SGRVNGSLEN SAYSILEITA VEVGIVAIRG LFSGRYLAMN KRGRLYASEH YSAECEFVER 
IHELGYNTYA SRLYRTVSST PGARRQPSAE RLWYVSVNGK GRPRRGFKTR RTQKSSLFLP 
RVLDHRDHEM VRQLQSGLPR PPGKGVQPRR RRQKQSPDNL EPSHVQASRL GSQLEASAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: FGF3

Associated with

Cells (max top 100)

Other Information

Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells. PubMed ID: 2470007

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Receptor specificity of the fibroblast growth factor family. PubMed ID: 8663044

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia. PubMed ID: 17236138