FGF3 | ENSG00000186895 | NCBI 2248

Details for: FGF3

Gene ID: 2248

Symbol: FGF3

Ensembl ID: ENSG00000186895

Description: fibroblast growth factor 3

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Fgfr1 ligand binding and activation
(R-HSA-190242)
Fgfr1b ligand binding and activation
(R-HSA-190370)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2b ligand binding and activation
(R-HSA-190377)
Fgfrl1 modulation of fgfr1 signaling
(R-HSA-5658623)
Frs-mediated fgfr1 signaling
(R-HSA-5654693)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade: fgfr1
(R-HSA-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr1
(R-HSA-5654688)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Anatomical structure morphogenesis
(GO:0009653)
Cell-cell signaling
(GO:0007267)
Cytoplasm
(GO:0005737)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Negative regulation of cardiac muscle tissue development
(GO:0055026)
Neurogenesis
(GO:0022008)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of mapk cascade
(GO:0043410)
Protein binding
(GO:0005515)
Regulation of cell migration
(GO:0030334)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.0625
Cell Significance Index: 17.5300
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.8095
Cell Significance Index: 17.7300
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.2060
Cell Significance Index: 2.9500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1393
Cell Significance Index: 27.6500
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.0322
Cell Significance Index: 0.5500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0290
Cell Significance Index: 1.5200
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: 0.0146
Cell Significance Index: 0.1600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0004
Cell Significance Index: -0.7700
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0005
Cell Significance Index: -0.9200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0005
Cell Significance Index: -0.7700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0012
Cell Significance Index: -0.0200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0019
Cell Significance Index: -0.8500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0033
Cell Significance Index: -0.5600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0036
Cell Significance Index: -0.7300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0042
Cell Significance Index: -0.2100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0043
Cell Significance Index: -0.4900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0071
Cell Significance Index: -0.9700
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.0107
Cell Significance Index: -0.1300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0112
Cell Significance Index: -0.6300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0128
Cell Significance Index: -0.8600
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: -0.0144
Cell Significance Index: -0.1400
Cell Name: ciliated cell (CL0000064)
Fold Change: -0.0166
Cell Significance Index: -0.1800
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.0170
Cell Significance Index: -0.1900
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0173
Cell Significance Index: -0.3500
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: -0.0177
Cell Significance Index: -0.1900
Cell Name: osteoblast (CL0000062)
Fold Change: -0.0180
Cell Significance Index: -0.1700
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0182
Cell Significance Index: -0.4400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0194
Cell Significance Index: -0.8600
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.0198
Cell Significance Index: -0.2400
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0214
Cell Significance Index: -0.2800
Cell Name: adipocyte (CL0000136)
Fold Change: -0.0215
Cell Significance Index: -0.2900
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0218
Cell Significance Index: -0.4300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0221
Cell Significance Index: -0.7300
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0227
Cell Significance Index: -0.8000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0229
Cell Significance Index: -0.7300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0232
Cell Significance Index: -0.8800
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0261
Cell Significance Index: -0.6500
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0279
Cell Significance Index: -0.7100
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0289
Cell Significance Index: -0.3700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0298
Cell Significance Index: -0.8500
Cell Name: stromal cell (CL0000499)
Fold Change: -0.0314
Cell Significance Index: -0.3200
Cell Name: stem cell (CL0000034)
Fold Change: -0.0316
Cell Significance Index: -0.2300
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0317
Cell Significance Index: -0.7600
Cell Name: neural cell (CL0002319)
Fold Change: -0.0321
Cell Significance Index: -0.3800
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0333
Cell Significance Index: -0.7200
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0333
Cell Significance Index: -0.5400
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0335
Cell Significance Index: -0.6600
Cell Name: retinal astrocyte (CL4033015)
Fold Change: -0.0346
Cell Significance Index: -0.3400
Cell Name: myelocyte (CL0002193)
Fold Change: -0.0348
Cell Significance Index: -0.3700
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.0354
Cell Significance Index: -0.3700
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0355
Cell Significance Index: -0.7400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0356
Cell Significance Index: -0.6000
Cell Name: tendon cell (CL0000388)
Fold Change: -0.0356
Cell Significance Index: -0.4800
Cell Name: naive B cell (CL0000788)
Fold Change: -0.0364
Cell Significance Index: -0.3800
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.0367
Cell Significance Index: -0.3700
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0369
Cell Significance Index: -0.7400
Cell Name: neuron (CL0000540)
Fold Change: -0.0375
Cell Significance Index: -0.3600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0375
Cell Significance Index: -1.0000
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0377
Cell Significance Index: -0.8000
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.0377
Cell Significance Index: -0.4000
Cell Name: macroglial cell (CL0000126)
Fold Change: -0.0380
Cell Significance Index: -0.4400
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.0383
Cell Significance Index: -0.3700
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.0388
Cell Significance Index: -0.4500
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0394
Cell Significance Index: -0.3900
Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
Fold Change: -0.0403
Cell Significance Index: -0.4800
Cell Name: microglial cell (CL0000129)
Fold Change: -0.0408
Cell Significance Index: -0.4800
Cell Name: immature B cell (CL0000816)
Fold Change: -0.0408
Cell Significance Index: -0.3900
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.0409
Cell Significance Index: -0.3200
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0410
Cell Significance Index: -0.8100
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0410
Cell Significance Index: -0.5300
Cell Name: amacrine cell (CL0000561)
Fold Change: -0.0415
Cell Significance Index: -0.5200
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0416
Cell Significance Index: -0.7200
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.0417
Cell Significance Index: -0.4800
Cell Name: chondrocyte (CL0000138)
Fold Change: -0.0422
Cell Significance Index: -0.4900
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0439
Cell Significance Index: -0.5000
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0448
Cell Significance Index: -0.6500
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.0448
Cell Significance Index: -0.4500
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: -0.0451
Cell Significance Index: -0.5100
Cell Name: mast cell (CL0000097)
Fold Change: -0.0464
Cell Significance Index: -0.6100
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.0506
Cell Significance Index: -0.6600
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.0519
Cell Significance Index: -0.4500
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0525
Cell Significance Index: -0.7200
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.0532
Cell Significance Index: -0.6600
Cell Name: pericyte (CL0000669)
Fold Change: -0.0534
Cell Significance Index: -0.6400
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.0543
Cell Significance Index: -0.4400
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0548
Cell Significance Index: -0.7300
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.0556
Cell Significance Index: -0.7300
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: -0.0558
Cell Significance Index: -0.6700
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.0560
Cell Significance Index: -0.6700
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: -0.0562
Cell Significance Index: -0.6800
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0572
Cell Significance Index: -0.8500
Cell Name: basal cell (CL0000646)
Fold Change: -0.0580
Cell Significance Index: -0.6900
Cell Name: astrocyte (CL0000127)
Fold Change: -0.0581
Cell Significance Index: -0.6700
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0586
Cell Significance Index: -0.7400
Cell Name: Schwann cell (CL0002573)
Fold Change: -0.0589
Cell Significance Index: -0.6600
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.0592
Cell Significance Index: -0.8500
Cell Name: ependymal cell (CL0000065)
Fold Change: -0.0594
Cell Significance Index: -0.7000
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0606
Cell Significance Index: -0.6600
Cell Name: leukocyte (CL0000738)
Fold Change: -0.0606
Cell Significance Index: -1.0300
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.0609
Cell Significance Index: -0.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** FGF3 is a secreted glycoprotein that belongs to the fibroblast growth factor family. It is highly expressed in various tissues, including the heart, liver, lung, and kidney, and is also found in the extracellular matrix. FGF3 is a potent mitogen that stimulates cell proliferation, differentiation, and migration. It is also involved in the regulation of angiogenesis, wound healing, and tissue remodeling. **Pathways and Functions:** FGF3 interacts with its receptor, FGF receptor 2 (FGFR2), to activate a signaling cascade that regulates various cellular processes. The FGF3- FGFR2 pathway is involved in: 1. **Cell proliferation and differentiation**: FGF3 stimulates the proliferation and differentiation of cells, including cardiac muscle cells, intestinal epithelial cells, and pericytes. 2. **Angiogenesis**: FGF3 promotes angiogenesis by stimulating the formation of new blood vessels. 3. **Wound healing**: FGF3 is involved in the regulation of wound healing by promoting the proliferation and migration of fibroblasts and other cells. 4. **Tissue remodeling**: FGF3 plays a role in tissue remodeling by regulating the degradation and synthesis of extracellular matrix components. **Clinical Significance:** FGF3 has been implicated in various diseases, including: 1. **Cancer**: FGF3 is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is associated with tumor progression and metastasis. 2. **Cardiovascular disease**: FGF3 is involved in the regulation of cardiac muscle cell proliferation and differentiation, and its dysregulation has been implicated in cardiac hypertrophy and heart failure. 3. **Neurological disorders**: FGF3 has been implicated in the regulation of neuronal migration and differentiation, and its dysregulation has been associated with neurological disorders, including autism and schizophrenia. 4. **Gastrointestinal disorders**: FGF3 is involved in the regulation of intestinal epithelial cell proliferation and differentiation, and its dysregulation has been implicated in gastrointestinal disorders, including inflammatory bowel disease and cancer. In conclusion, FGF3 is a multifaceted gene that plays a crucial role in various cellular processes, including cell signaling, development, and disease. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disease, neurological disorders, and gastrointestinal disorders. Further research is needed to fully understand the role of FGF3 in human disease and to develop targeted therapies for its dysregulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Fibroblast growth factor 3

Genular Protein ID: 787574721

Symbol: FGF3_HUMAN

Name: Fibroblast growth factor 3

UniProtKB Accession Codes:

P11487 Q0VG69

Database IDs:

Citations:

PubMed ID: 2470007

Title: Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells.

PubMed ID: 2470007

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 17236138

Title: Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia.

PubMed ID: 17236138

DOI: 10.1086/510920

PubMed ID: 18435799

Title: Homozygous FGF3 mutations result in congenital deafness with inner ear agenesis, microtia, and microdontia.

PubMed ID: 18435799

DOI: 10.1111/j.1399-0004.2008.01004.x

Sequence Information:

Length: 239
Mass: 26887
Checksum: 8DBEF17D2B2E3C63
Sequence:

MGLIWLLLLS LLEPGWPAAG PGARLRRDAG GRGGVYEHLG GAPRRRKLYC ATKYHLQLHP 
SGRVNGSLEN SAYSILEITA VEVGIVAIRG LFSGRYLAMN KRGRLYASEH YSAECEFVER 
IHELGYNTYA SRLYRTVSST PGARRQPSAE RLWYVSVNGK GRPRRGFKTR RTQKSSLFLP 
RVLDHRDHEM VRQLQSGLPR PPGKGVQPRR RRQKQSPDNL EPSHVQASRL GSQLEASAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FGF3

Associated with

Cells (max top 100)

Other Information

Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells. PubMed ID: 2470007

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Receptor specificity of the fibroblast growth factor family. PubMed ID: 8663044

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia. PubMed ID: 17236138