Details for: ASTN2

Gene ID: 23245

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ASTN2

Ensembl ID: ENSG00000148219

Description: astrotactin 2

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • pvalb GABAergic cortical interneuron CL4023018
    CSI 52.76
    rCSI 65.64%
    PRS 76.67
  • sst GABAergic cortical interneuron CL4023017
    CSI 51.1
    rCSI 65.87%
    PRS 79.93
  • VIP GABAergic cortical interneuron CL4023016
    CSI 48.69
    rCSI 58.16%
    PRS 78.9
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 38.26
    rCSI 69.52%
    PRS 85.1
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 36.24
    rCSI 60.84%
    PRS 78.86
  • cerebellar granule cell CL0001031
    CSI 32.53
    rCSI 47.82%
    PRS 86.35
  • ependymal cell CL0000065
    CSI 32.31
    rCSI 65.57%
    PRS 74.31
  • oligodendrocyte precursor cell CL0002453
    CSI 32.29
    rCSI 71.05%
    PRS 74.76
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 28.76
    rCSI 40.77%
    PRS 88.99
  • astrocyte of the cerebral cortex CL0002605
    CSI 22.62
    rCSI 50.71%
    PRS 79.22
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 20.13
    rCSI 48.93%
    PRS 76.71
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 19.7
    rCSI 61.61%
    PRS 81.83
  • inhibitory interneuron CL0000498
    CSI 19.4
    rCSI 44.78%
    PRS 82.44
  • cardiac neuron CL0010022
    CSI 19.12
    rCSI 61.19%
    PRS 89.81
  • L6b glutamatergic cortical neuron CL4023038
    CSI 19.1
    rCSI 59.69%
    PRS 80.16
  • interneuron CL0000099
    CSI 18.31
    rCSI 36.77%
    PRS 85.33
  • neuron CL0000540
    CSI 18.13
    rCSI 48.28%
    PRS 79.71
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 18.12
    rCSI 43.34%
    PRS 81.31
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 17.87
    rCSI 46.2%
    PRS 88.54
  • epithelial cell of proximal tubule CL0002306
    CSI 16.8
    rCSI 41.04%
    PRS 84.83
  • cerebral cortex endothelial cell CL1001602
    CSI 16.76
    rCSI 28.98%
    PRS 86.05
  • retinal ganglion cell CL0000740
    CSI 15.98
    rCSI 35.31%
    PRS 81.17
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 15.78
    rCSI 59.65%
    PRS 79.04
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 15.48
    rCSI 40.35%
    PRS 92.44
  • amacrine cell CL0000561
    CSI 15.44
    rCSI 44.73%
    PRS 83.23
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 15.41
    rCSI 55.47%
    PRS 76.88
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 13.96
    rCSI 16.12%
    PRS 84
  • retinal bipolar neuron CL0000748
    CSI 13.85
    rCSI 25.93%
    PRS 83.24
  • regular atrial cardiac myocyte CL0002129
    CSI 13.65
    rCSI 43.93%
    PRS 87.77
  • retinal rod cell CL0000604
    CSI 13.34
    rCSI 23.52%
    PRS 87.24
  • GABAergic amacrine cell CL4030027
    CSI 13.09
    rCSI 44.82%
    PRS 79.15
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 12.63
    rCSI 16.21%
    PRS 87.58
  • glioblast CL0000030
    CSI 12.48
    rCSI 19.92%
    PRS 83.92
  • neural cell CL0002319
    CSI 12.35
    rCSI 46.59%
    PRS 76.82
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 11.73
    rCSI 38.54%
    PRS 80.23
  • adipocyte CL0000136
    CSI 11.44
    rCSI 14.69%
    PRS 83.45
  • retina horizontal cell CL0000745
    CSI 11.41
    rCSI 17.39%
    PRS 88.11
  • Bergmann glial cell CL0000644
    CSI 11.31
    rCSI 15.47%
    PRS 84
  • neural crest cell CL0011012
    CSI 11.2
    rCSI 8.85%
    PRS 84.56
  • GABAergic neuron CL0000617
    CSI 10.38
    rCSI 34.78%
    PRS 78.39
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 10.2
    rCSI 18.01%
    PRS 78.25
  • glycinergic amacrine cell CL4030028
    CSI 10
    rCSI 26.05%
    PRS 85.55
  • vascular leptomeningeal cell CL4023051
    CSI 9.6
    rCSI 16.82%
    PRS 87.76
  • retinal cone cell CL0000573
    CSI 9.58
    rCSI 15.41%
    PRS 83.76
  • Schwann cell CL0002573
    CSI 9.36
    rCSI 26.6%
    PRS 87.71
  • neuroendocrine cell CL0000165
    CSI 9.24
    rCSI 35.72%
    PRS 93.87
  • ciliated epithelial cell CL0000067
    CSI 9.21
    rCSI 8.1%
    PRS 82.82
  • oligodendrocyte CL0000128
    CSI 8.6
    rCSI 25.42%
    PRS 81.93
  • kidney connecting tubule epithelial cell CL1000768
    CSI 8.49
    rCSI 21.54%
    PRS 85.27
  • choroid plexus epithelial cell CL0000706
    CSI 8.29
    rCSI 13.58%
    PRS 84.54
  • hepatic stellate cell CL0000632
    CSI 8.28
    rCSI 31.02%
    PRS 86.82
  • glutamatergic neuron CL0000679
    CSI 8.19
    rCSI 16.82%
    PRS 80.04
  • cerebral cortex neuron CL0010012
    CSI 7.98
    rCSI 32.53%
    PRS 84.26
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 7.6
    rCSI 44.73%
    PRS 79.3
  • alveolar type 1 fibroblast cell CL4028004
    CSI 7.4
    rCSI 8.11%
    PRS 92.51
  • melanocyte CL0000148
    CSI 7.36
    rCSI 5.45%
    PRS 87.67
  • sncg GABAergic cortical interneuron CL4023015
    CSI 7.29
    rCSI 11.72%
    PRS 79.72
  • H1 horizontal cell CL0004217
    CSI 7.17
    rCSI 28.4%
    PRS 85.11
  • peripheral nervous system neuron CL2000032
    CSI 7.14
    rCSI 9.73%
    PRS 85.16
  • kidney collecting duct intercalated cell CL1001432
    CSI 7.08
    rCSI 50.58%
    PRS 87.5
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 7.01
    rCSI 15.21%
    PRS 80.56
  • innate lymphoid cell CL0001065
    CSI 6.99
    rCSI 14.43%
    PRS 85.51
  • renal beta-intercalated cell CL0002201
    CSI 6.95
    rCSI 16.56%
    PRS 91.2
  • parietal epithelial cell CL1000452
    CSI 6.92
    rCSI 18.5%
    PRS 86.07
  • Mueller cell CL0000636
    CSI 6.69
    rCSI 15.26%
    PRS 84.96
  • fibroblast of cardiac tissue CL0002548
    CSI 6.65
    rCSI 31.83%
    PRS 91.9
  • lung secretory cell CL1000272
    CSI 6.53
    rCSI 16.18%
    PRS 91.7
  • chondrocyte CL0000138
    CSI 6.38
    rCSI 10.15%
    PRS 86.67
  • mature astrocyte CL0002627
    CSI 6.26
    rCSI 26.6%
    PRS 84.68
  • dopaminergic neuron CL0000700
    CSI 6.18
    rCSI 34.95%
    PRS 81
  • endocardial cell CL0002350
    CSI 6.11
    rCSI 29.26%
    PRS 87.72
  • central nervous system neuron CL2000029
    CSI 6
    rCSI 44.12%
    PRS 83.36
  • macroglial cell CL0000126
    CSI 5.81
    rCSI 14.93%
    PRS 87.59
  • renal interstitial pericyte CL1001318
    CSI 5.68
    rCSI 15.66%
    PRS 88.57
  • rod bipolar cell CL0000751
    CSI 5.56
    rCSI 9.99%
    PRS 86.47
  • serotonergic neuron CL0000850
    CSI 5.34
    rCSI 23.87%
    PRS 77.44
  • diffuse bipolar 3b cell CL4033030
    CSI 5.21
    rCSI 34.61%
    PRS 85.65
  • respiratory suprabasal cell CL4033048
    CSI 4.95
    rCSI 6.34%
    PRS 92.57
  • brush cell of tracheobronchial tree CL0002075
    CSI 4.79
    rCSI 14.23%
    PRS 95.84
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 4.46
    rCSI 5.41%
    PRS 72.5
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 4.33
    rCSI 9.88%
    PRS 84.52
  • glial cell CL0000125
    CSI 4.23
    rCSI 16.09%
    PRS 84.97
  • renal principal cell CL0005009
    CSI 3.85
    rCSI 10.01%
    PRS 90.38
  • lung ciliated cell CL1000271
    CSI 3.82
    rCSI 4.42%
    PRS 85.88
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 3.8
    rCSI 32.85%
    PRS 85.95
  • cerebellar neuron CL1001611
    CSI 3.8
    rCSI 33.44%
    PRS 79.2
  • ON parasol ganglion cell CL4033052
    CSI 3.74
    rCSI 53.07%
    PRS 83.99
  • medium spiny neuron CL1001474
    CSI 3.45
    rCSI 29.71%
    PRS 83.7
  • basket cell CL0000118
    CSI 2.99
    rCSI 18.73%
    PRS 72
  • ON midget ganglion cell CL4033046
    CSI 2.7
    rCSI 55.08%
    PRS 82.93
  • OFF midget ganglion cell CL4033047
    CSI 2.69
    rCSI 54.77%
    PRS 83.56
  • podocyte CL0000653
    CSI 2.56
    rCSI 11.38%
    PRS 91.41
  • cardiac muscle cell CL0000746
    CSI 2.41
    rCSI 3.46%
    PRS 83.57
  • enteroglial cell CL4040002
    CSI 2.31
    rCSI 12.14%
    PRS 90.95
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.15
    rCSI 51.88%
    PRS 76.78
  • mesangial cell CL0000650
    CSI 2.14
    rCSI 8.72%
    PRS 95.28
  • direct pathway medium spiny neuron CL4023026
    CSI 2.11
    rCSI 50.64%
    PRS 76.64
  • retinal pigment epithelial cell CL0002586
    CSI 2.05
    rCSI 4.07%
    PRS 87.8
  • diffuse bipolar 4 cell CL4033031
    CSI 1.63
    rCSI 18.64%
    PRS 79.41
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 1.45
    rCSI 15.38%
    PRS 87.38
  • luminal cell of prostate epithelium CL0002340
    CSI 0.6
    rCSI 3.1%
    PRS 94.5%
  • midbrain dopaminergic neuron CL2000097
    CSI 1.1
    rCSI 7.2%
    PRS 85.6%
  • regular ventricular cardiac myocyte CL0002131
    CSI 1.2
    rCSI 7.3%
    PRS 85.2%
  • H2 horizontal cell CL0004218
    CSI 1.3
    rCSI 6.7%
    PRS 86.0%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 1.5
    rCSI 15.4%
    PRS 87.4%
  • diffuse bipolar 4 cell CL4033031
    CSI 1.6
    rCSI 18.6%
    PRS 79.4%
  • retinal pigment epithelial cell CL0002586
    CSI 2.1
    rCSI 4.1%
    PRS 87.8%
  • direct pathway medium spiny neuron CL4023026
    CSI 2.1
    rCSI 50.6%
    PRS 76.6%
  • mesangial cell CL0000650
    CSI 2.1
    rCSI 8.7%
    PRS 95.3%
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.2
    rCSI 51.9%
    PRS 76.8%
  • enteroglial cell CL4040002
    CSI 2.3
    rCSI 12.1%
    PRS 91.0%
  • cardiac muscle cell CL0000746
    CSI 2.4
    rCSI 3.5%
    PRS 83.6%
  • podocyte CL0000653
    CSI 2.6
    rCSI 11.4%
    PRS 91.4%
  • OFF midget ganglion cell CL4033047
    CSI 2.7
    rCSI 54.8%
    PRS 83.6%
  • ON midget ganglion cell CL4033046
    CSI 2.7
    rCSI 55.1%
    PRS 82.9%
  • basket cell CL0000118
    CSI 3.0
    rCSI 18.7%
    PRS 72.0%
  • medium spiny neuron CL1001474
    CSI 3.5
    rCSI 29.7%
    PRS 83.7%
  • ON parasol ganglion cell CL4033052
    CSI 3.7
    rCSI 53.1%
    PRS 84.0%
  • cerebellar neuron CL1001611
    CSI 3.8
    rCSI 33.4%
    PRS 79.2%
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 3.8
    rCSI 32.9%
    PRS 86.0%
  • lung ciliated cell CL1000271
    CSI 3.8
    rCSI 4.4%
    PRS 85.9%
  • renal principal cell CL0005009
    CSI 3.9
    rCSI 10.0%
    PRS 90.4%
  • glial cell CL0000125
    CSI 4.2
    rCSI 16.1%
    PRS 85.0%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 4.3
    rCSI 9.9%
    PRS 84.5%
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 4.5
    rCSI 5.4%
    PRS 72.5%
  • brush cell of tracheobronchial tree CL0002075
    CSI 4.8
    rCSI 14.2%
    PRS 95.8%
  • respiratory suprabasal cell CL4033048
    CSI 5.0
    rCSI 6.3%
    PRS 92.6%
  • diffuse bipolar 3b cell CL4033030
    CSI 5.2
    rCSI 34.6%
    PRS 85.7%
  • serotonergic neuron CL0000850
    CSI 5.3
    rCSI 23.9%
    PRS 77.4%
  • rod bipolar cell CL0000751
    CSI 5.6
    rCSI 10.0%
    PRS 86.5%
  • renal interstitial pericyte CL1001318
    CSI 5.7
    rCSI 15.7%
    PRS 88.6%
  • macroglial cell CL0000126
    CSI 5.8
    rCSI 14.9%
    PRS 87.6%
  • central nervous system neuron CL2000029
    CSI 6.0
    rCSI 44.1%
    PRS 83.4%
  • endocardial cell CL0002350
    CSI 6.1
    rCSI 29.3%
    PRS 87.7%
  • dopaminergic neuron CL0000700
    CSI 6.2
    rCSI 35.0%
    PRS 81.0%
  • mature astrocyte CL0002627
    CSI 6.3
    rCSI 26.6%
    PRS 84.7%
  • chondrocyte CL0000138
    CSI 6.4
    rCSI 10.2%
    PRS 86.7%
  • lung secretory cell CL1000272
    CSI 6.5
    rCSI 16.2%
    PRS 91.7%
  • fibroblast of cardiac tissue CL0002548
    CSI 6.7
    rCSI 31.8%
    PRS 91.9%
  • Mueller cell CL0000636
    CSI 6.7
    rCSI 15.3%
    PRS 85.0%
  • parietal epithelial cell CL1000452
    CSI 6.9
    rCSI 18.5%
    PRS 86.1%
  • renal beta-intercalated cell CL0002201
    CSI 7.0
    rCSI 16.6%
    PRS 91.2%
  • innate lymphoid cell CL0001065
    CSI 7.0
    rCSI 14.4%
    PRS 85.5%
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 7.0
    rCSI 15.2%
    PRS 80.6%
  • kidney collecting duct intercalated cell CL1001432
    CSI 7.1
    rCSI 50.6%
    PRS 87.5%
  • peripheral nervous system neuron CL2000032
    CSI 7.1
    rCSI 9.7%
    PRS 85.2%
  • H1 horizontal cell CL0004217
    CSI 7.2
    rCSI 28.4%
    PRS 85.1%
  • sncg GABAergic cortical interneuron CL4023015
    CSI 7.3
    rCSI 11.7%
    PRS 79.7%
  • melanocyte CL0000148
    CSI 7.4
    rCSI 5.5%
    PRS 87.7%
  • alveolar type 1 fibroblast cell CL4028004
    CSI 7.4
    rCSI 8.1%
    PRS 92.5%
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 7.6
    rCSI 44.7%
    PRS 79.3%
  • cerebral cortex neuron CL0010012
    CSI 8.0
    rCSI 32.5%
    PRS 84.3%
  • glutamatergic neuron CL0000679
    CSI 8.2
    rCSI 16.8%
    PRS 80.0%
  • hepatic stellate cell CL0000632
    CSI 8.3
    rCSI 31.0%
    PRS 86.8%
  • choroid plexus epithelial cell CL0000706
    CSI 8.3
    rCSI 13.6%
    PRS 84.5%
  • kidney connecting tubule epithelial cell CL1000768
    CSI 8.5
    rCSI 21.5%
    PRS 85.3%
  • oligodendrocyte CL0000128
    CSI 8.6
    rCSI 25.4%
    PRS 81.9%
  • ciliated epithelial cell CL0000067
    CSI 9.2
    rCSI 8.1%
    PRS 82.8%
  • neuroendocrine cell CL0000165
    CSI 9.2
    rCSI 35.7%
    PRS 93.9%
  • Schwann cell CL0002573
    CSI 9.4
    rCSI 26.6%
    PRS 87.7%
  • retinal cone cell CL0000573
    CSI 9.6
    rCSI 15.4%
    PRS 83.8%
  • vascular leptomeningeal cell CL4023051
    CSI 9.6
    rCSI 16.8%
    PRS 87.8%
  • glycinergic amacrine cell CL4030028
    CSI 10.0
    rCSI 26.1%
    PRS 85.6%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 10.2
    rCSI 18.0%
    PRS 78.3%
  • GABAergic neuron CL0000617
    CSI 10.4
    rCSI 34.8%
    PRS 78.4%
  • neural crest cell CL0011012
    CSI 11.2
    rCSI 8.9%
    PRS 84.6%
  • Bergmann glial cell CL0000644
    CSI 11.3
    rCSI 15.5%
    PRS 84.0%
  • retina horizontal cell CL0000745
    CSI 11.4
    rCSI 17.4%
    PRS 88.1%
  • adipocyte CL0000136
    CSI 11.4
    rCSI 14.7%
    PRS 83.5%
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 11.7
    rCSI 38.5%
    PRS 80.2%
  • neural cell CL0002319
    CSI 12.4
    rCSI 46.6%
    PRS 76.8%
  • glioblast CL0000030
    CSI 12.5
    rCSI 19.9%
    PRS 83.9%
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 12.6
    rCSI 16.2%
    PRS 87.6%
  • GABAergic amacrine cell CL4030027
    CSI 13.1
    rCSI 44.8%
    PRS 79.2%
  • retinal rod cell CL0000604
    CSI 13.3
    rCSI 23.5%
    PRS 87.2%
  • regular atrial cardiac myocyte CL0002129
    CSI 13.7
    rCSI 43.9%
    PRS 87.8%
  • retinal bipolar neuron CL0000748
    CSI 13.9
    rCSI 25.9%
    PRS 83.2%
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 14.0
    rCSI 16.1%
    PRS 84.0%
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 15.4
    rCSI 55.5%
    PRS 76.9%
  • amacrine cell CL0000561
    CSI 15.4
    rCSI 44.7%
    PRS 83.2%
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 15.5
    rCSI 40.4%
    PRS 92.4%
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 15.8
    rCSI 59.7%
    PRS 79.0%
  • retinal ganglion cell CL0000740
    CSI 16.0
    rCSI 35.3%
    PRS 81.2%
  • cerebral cortex endothelial cell CL1001602
    CSI 16.8
    rCSI 29.0%
    PRS 86.1%
  • epithelial cell of proximal tubule CL0002306
    CSI 16.8
    rCSI 41.0%
    PRS 84.8%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 17.9
    rCSI 46.2%
    PRS 88.5%
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 18.1
    rCSI 43.3%
    PRS 81.3%
  • neuron CL0000540
    CSI 18.1
    rCSI 48.3%
    PRS 79.7%
  • interneuron CL0000099
    CSI 18.3
    rCSI 36.8%
    PRS 85.3%
  • L6b glutamatergic cortical neuron CL4023038
    CSI 19.1
    rCSI 59.7%
    PRS 80.2%
  • cardiac neuron CL0010022
    CSI 19.1
    rCSI 61.2%
    PRS 89.8%
  • inhibitory interneuron CL0000498
    CSI 19.4
    rCSI 44.8%
    PRS 82.4%
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 19.7
    rCSI 61.6%
    PRS 81.8%
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 20.1
    rCSI 48.9%
    PRS 76.7%
  • astrocyte of the cerebral cortex CL0002605
    CSI 22.6
    rCSI 50.7%
    PRS 79.2%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 28.8
    rCSI 40.8%
    PRS 89.0%
  • oligodendrocyte precursor cell CL0002453
    CSI 32.3
    rCSI 71.1%
    PRS 74.8%
  • ependymal cell CL0000065
    CSI 32.3
    rCSI 65.6%
    PRS 74.3%
  • cerebellar granule cell CL0001031
    CSI 32.5
    rCSI 47.8%
    PRS 86.4%
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 36.2
    rCSI 60.8%
    PRS 78.9%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ASTN2](/details-gene/23245) (Astrotactin 2) is a protein-coding gene located on chromosome 9q33.1. It plays a significant role in neuronal development and function, particularly in processes such as neuron migration, cell-cell adhesion, and protein transport. Functional annotations indicate its involvement in regulating the localization of proteins to the cell surface and its presence in endosomal pathways. Expression data reveals that **`Overall`**, [ASTN2](/details-gene/23245) is a highly significant gene within the central nervous system, showing prominent expression in various subtypes of GABAergic cortical interneurons, including [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) and [sst GABAergic cortical interneuron](/details-cell/CL4023017), as well as in glial cells like [oligodendrocyte precursor cell](/details-cell/CL0002453)s and [astrocyte of the cerebral cortex](/details-cell/CL0002605). Its association with neurodevelopment is further supported by literature linking it to intellectual disability [Link](https://doi.org/10.1007/s00439-017-1843-2). ## Cellular Roles and Expression Landscape The expression profile of [ASTN2](/details-gene/23245) underscores its specialized function within the nervous system. The gene exhibits its highest significance in a diverse array of neural cell types. **`Overall`**, it is a defining marker for several classes of inhibitory neurons, with the highest significance scores observed in [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 52.76), [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: 51.10), [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 48.69), and [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 36.24). This strong and specific expression pattern suggests a crucial role for [ASTN2](/details-gene/23245) in the development, migration, or function of these distinct cortical interneuron populations. In addition to its prominence in interneurons, [ASTN2](/details-gene/23245) is also highly significant in glial lineages. It shows high CSI values in both [differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059) (CSI: 38.26) and [oligodendrocyte precursor cell](/details-cell/CL0002453) (CSI: 32.29), as well as in [astrocyte of the cerebral cortex](/details-cell/CL0002605) (CSI: 22.62). This suggests a potential role in glial development, migration, or neuron-glia interactions. The gene's expression extends to other neuronal types, including [cerebellar granule cell](/details-cell/CL0001031) and various glutamatergic neurons, albeit at a lower significance level. The notable expression in [ependymal cell](/details-cell/CL0000065) and [kidney loop of Henle thin descending limb epithelial cell](/details-cell/CL1001111) indicates that its function may not be exclusively restricted to neurons and glia. ## Pathways and Molecular Function The functions of [ASTN2](/details-gene/23245) are tightly linked to the dynamic processes of neural development and cellular trafficking. Its involvement in biological processes such as [neuron migration](/details-cell/GO:0001764) and [neuron cell-cell adhesion](/details-cell/GO:0007158) is highly consistent with its expression pattern in migratory interneurons and oligodendrocyte precursors. These processes are fundamental for establishing the intricate circuitry of the brain. At the molecular level, [ASTN2](/details-gene/23245) is implicated in the regulation of membrane composition through its roles in [protein localization to cell surface](/details-cell/GO:0034394) and [negative regulation of protein localization to cell surface](/details-cell/GO:2000009). This suggests that it may control the surface expression of receptors or adhesion molecules that guide migrating cells or mediate synaptic contacts. This function is supported by its localization to the [cell cortex](/details-cell/GO:0005938) and various components of the endocytic pathway, including [clathrin-coated vesicle](/details-cell/GO:0030136)s, [early endosome](/details-cell/GO:0005769)s, and [late endosome](/details-cell/GO:0005770)s. The protein's annotated ability for [calcium ion binding](/details-cell/GO:0005509) further points towards a role in calcium-dependent signaling events, which are ubiquitous in neuronal function and development. ## Research Directions The specific expression profile and functional annotations of [ASTN2](/details-gene/23245) offer several avenues for future investigation into its role in neural health and disease. Based on the available data, two testable hypotheses can be proposed: 1. Given its exceptionally high significance in multiple, distinct subtypes of cortical interneurons, [ASTN2](/details-gene/23245) is essential for the proper tangential migration and laminar integration of these cells during corticogenesis. Its dysfunction could lead to aberrant circuit formation, consistent with its association with neurodevelopmental disorders such as intellectual disability [Link](https://doi.org/10.1007/s00439-017-1843-2). 2. The high expression of [ASTN2](/details-gene/23245) in oligodendrocyte precursor cells suggests it plays a critical role in the regulation of myelination. It may function by controlling the surface expression of receptors necessary for OPCs to recognize and ensheath axons, and its loss could impair developmental myelination or remyelination after injury. To test the first hypothesis regarding the role of [ASTN2](/details-gene/23245) in interneuron development, a key experiment would be to use a mouse model with conditional knockout of *Astn2* specifically in interneuron progenitors originating from the medial ganglionic eminence (MGE). Using fate-mapping techniques to label the knockout cells, one could then perform immunohistochemical analysis of postnatal brain sections to assess their migratory paths, final laminar positions, and dendritic morphology compared to wild-type controls. This would provide direct evidence of its necessity for proper interneuron integration into cortical circuits. Given that loss-of-function variants of [ASTN2](/details-gene/23245) are associated with neurodevelopmental disorders, therapeutic strategies would likely focus on restoring its function rather than inhibition. However, its broad expression across many essential CNS cell types makes it a challenging pharmacological target. Future therapeutic avenues might involve highly targeted approaches like gene therapy aimed at specific affected cell populations during critical developmental windows, although such strategies remain speculative.

Genular Protein ID: 3513968272

Symbol: ASTN2_HUMAN

Name: Astrotactin-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Title: Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development.

DOI: 10.1098/RSOB.160053

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

PubMed ID: 28940097

Title: Expanding the genetic heterogeneity of intellectual disability.

PubMed ID: 28940097

DOI: 10.1007/s00439-017-1843-2

PubMed ID: 29288388

Title: Correction to: Expanding the genetic heterogeneity of intellectual disability.

PubMed ID: 29288388

DOI: 10.1007/s00439-017-1859-7

Sequence Information:

  • Length: 1339
  • Mass: 148243
  • Checksum: 7B914F1A736F798F
  • Sequence:
  • MAAAGARLSP GPGSGLRGRP RLCFHPGPPP LLPLLLLFLL LLPPPPLLAG ATAAASREPD 
    SPCRLKTVTV STLPALRESD IGWSGARAGA GAGTGAGAAA AAASPGSPGS AGTAAESRLL 
    LFVRNELPGR IAVQDDLDNT ELPFFTLEMS GTAADISLVH WRQQWLENGT LYFHVSMSSS 
    GQLAQATAPT LQEPSEIVEE QMHILHISVM GGLIALLLLL LVFTVALYAQ RRWQKRRRIP 
    QKSASTEATH EIHYIPSVLL GPQARESFRS SRLQTHNSVI GVPIRETPIL DDYDCEEDEE 
    PPRRANHVSR EDEFGSQVTH TLDSLGHPGE EKVDFEKKAA AEATQETVES LMQKFKESFR 
    ANTPIEIGQL QPPLRSTSAG KRKRRSKSRG GISFGRAKGT SGSEADDETQ LTFYTEQYRS 
    RRRSKGLLKS PVNKTALTLI AVSSCILAMV CGSQMSCPLT VKVTLHVPEH FIADGSSFVV 
    SEGSYLDISD WLNPAKLSLY YQINATSPWV RDLCGQRTTD ACEQLCDPET GECSCHEGYA 
    PDPVHRHLCV RSDWGQSEGP WPYTTLERGY DLVTGEQAPE KILRSTFSLG QGLWLPVSKS 
    FVVPPVELSI NPLASCKTDV LVTEDPADVR EEAMLSTYFE TINDLLSSFG PVRDCSRNNG 
    GCTRNFKCVS DRQVDSSGCV CPEELKPMKD GSGCYDHSKG IDCSDGFNGG CEQLCLQQTL 
    PLPYDATSST IFMFCGCVEE YKLAPDGKSC LMLSDVCEGP KCLKPDSKFN DTLFGEMLHG 
    YNNRTQHVNQ GQVFQMTFRE NNFIKDFPQL ADGLLVIPLP VEEQCRGVLS EPLPDLQLLT 
    GDIRYDEAMG YPMVQQWRVR SNLYRVKLST ITLAAGFTNV LKILTKESSR EELLSFIQHY 
    GSHYIAEALY GSELTCIIHF PSKKVQQQLW LQYQKETTEL GSKKELKSMP FITYLSGLLT 
    AQMLSDDQLI SGVEIRCEEK GRCPSTCHLC RRPGKEQLSP TPVLLEINRV VPLYTLIQDN 
    GTKEAFKSAL MSSYWCSGKG DVIDDWCRCD LSAFDANGLP NCSPLLQPVL RLSPTVEPSS 
    TVVSLEWVDV QPAIGTKVSD YILQHKKVDE YTDTDLYTGE FLSFADDLLS GLGTSCVAAG 
    RSHGEVPEVS IYSVIFKCLE PDGLYKFTLY AVDTRGRHSE LSTVTLRTAC PLVDDNKAEE 
    IADKIYNLYN GYTSGKEQQM AYNTLMEVSA SMLFRVQHHY NSHYEKFGDF VWRSEDELGP 
    RKAHLILRRL ERVSSHCSSL LRSAYIQSRV ETVPYLFCRS EEVRPAGMVW YSILKDTKIT 
    CEEKMVSMAR NTYGESKGR

Genular Protein ID: 373512371

Symbol: X6R5P2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 194
  • Mass: 21707
  • Checksum: 5FFAD0B625B1D3AA
  • Sequence:
  • MPFITYLSGL LTAQMLSDDQ LISGVEIRCE EKGRCPSTCH LCRRPGKEQL SPTPVLLEIN 
    RVVPLYTLIQ DNGTKEAFKS ALMSSYWCSG KGDVIDDWCR CDLSAFDANG LPNCSPLLQP 
    VLRLSPTVEP SSTVVSLEWV DVQPAIGTKV SDYILQHKKV DEYTDTDLYT VYCWITFIDL 
    RILNQPCIPG MKPT

Genular Protein ID: 1490009516

Symbol: B7ZKP4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 375
  • Mass: 42270
  • Checksum: 19B15C7AAFD58F5F
  • Sequence:
  • MPFITYLSGL LTAQMLSDDQ LISGVEIRCE EKGRCPSTCH LCRRPGKEQL SPTPVLLEIN 
    RVVPLYTLIQ DNGTKEAFKS ALMSSYWCSG KGDVIDDWCR CDLSAFDANG LPNCSPLLQP 
    VLRLSPTVEP SSTVVSLEWV DVQPAIGTKV SDYILQHKKV DEYTDTDLYT GEFLSFADDL 
    LSGLGTSCVA AGRSHGEVPE VSIYSVIFKC LEPDGLYKFT LYAVDTRGRH SELSTVTLRT 
    ACPLVDDNKA EEIADKIYNL YNGYTSGKEQ QMAYNTLMEV SASMLFRVQH HYNSHYEKFG 
    DFVWRSEDEL GPRKAHLILR RLERVSSHCS SLLRSAYIQS RVETVPYLFC RSEEVRPAGM 
    VWYSILKDTK ITYII

Genular Protein ID: 3660253714

Symbol: B7ZKP5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 402
  • Mass: 45339
  • Checksum: 19279BAF9FD3525C
  • Sequence:
  • MPFITYLSGL LTAQMLSDDQ LISGVEIRCE EKGRCPSTCH LCRRPGKEQL SPTPVLLEIN 
    RVVPLYTLIQ DNGTKEAFKS ALMSSYWCSG KGDVIDDWCR CDLSAFDANG LPNCSPLLQP 
    VLRLSPTVEP SSTVVSLEWV DVQPAIGTKV SDYILQHKKV DEYTDTDLYT GEFLSFADDL 
    LSGLGTSCVA AGRSHGEVPE VSIYSVIFKC LEPDGLYKFT LYAVDTRGRH SELSTVTLRT 
    ACPLVDDNKA EEIADKIYNL YNGYTSGKEQ QMAYNTLMEV SASMLFRVQH HYNSHYEKFG 
    DFVWRSEDEL GPRKAHLILR RLERVSSHCS SLLRSAYIQS RVETVPYLFC RSEEVRPAGM 
    VWYSILKDTK ITCEEKMVSM ARNTYGESKG RYYLTLSKVS PF

Genular Protein ID: 3249066810

Symbol: B3KN99_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 395
  • Mass: 44545
  • Checksum: 5F710CABB02EC4F8
  • Sequence:
  • MPFITYLSGL LTAQMLSDDQ LISGVEIRCE EKGRCPSTCH LCRRPGKEQL SPTPVLLEIN 
    RVVPLYTLIQ DNGTKEAFKS APMSSYWCSG KGDVIDDWCR CDLSAFDANG LPNCSPLLQP 
    VLRLSPTVEP SSTVVSLEWV DVQPAIGTKV SDYILQHKKV DEYTDTDLYT GEFLSFADDL 
    LSGLGTSCVA AGRSHGEVPE VSIYSVIFKC LEPDGLYKFT LYAVDTRGRH SELSTVTLRT 
    ACPLVDDNKA EEIADKIYNL YNGYTSGKEQ QMAYNTLMEV SASMLFRVQH HYNSHYEKFG 
    DFVWRSEDEL GPRKAHLILR RLERVSSHCS SLLRSAYIQS RVETVPYLFC RSEEVRPAGM 
    VWYSILKDTK ITCEEKMVSM ARNTYYLTLS KVSPF