Details for: GABPA

Gene ID: 2551

Symbol: GABPA

Ensembl ID: ENSG00000154727

Description: GA binding protein transcription factor subunit alpha

Associated with

  • Mitochondrial biogenesis
    (R-HSA-1592230)
  • Organelle biogenesis and maintenance
    (R-HSA-1852241)
  • Transcriptional activation of mitochondrial biogenesis
    (R-HSA-2151201)
  • Blastocyst formation
    (GO:0001825)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Negative regulation of megakaryocyte differentiation
    (GO:0045653)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.99
    Marker Score: 3483
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16928
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.01
    Marker Score: 8660
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71714
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47938
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.98
    Marker Score: 1414
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30395
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.96
    Marker Score: 1485
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2397
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.93
    Marker Score: 8829
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.92
    Marker Score: 56857
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2705
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.9
    Marker Score: 19148
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4838
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.83
    Marker Score: 31602
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.83
    Marker Score: 3212
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.82
    Marker Score: 492
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.82
    Marker Score: 7676
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.8
    Marker Score: 11952
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.79
    Marker Score: 6058
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.79
    Marker Score: 227
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.78
    Marker Score: 3192
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.78
    Marker Score: 1836
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 579
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.74
    Marker Score: 7658
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.72
    Marker Score: 430
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.72
    Marker Score: 251
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.71
    Marker Score: 175
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.7
    Marker Score: 25962
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2949
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.7
    Marker Score: 694
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.7
    Marker Score: 1901.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7
    Marker Score: 4185
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.7
    Marker Score: 873
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.7
    Marker Score: 800
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.69
    Marker Score: 216
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.67
    Marker Score: 488
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 215
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 609
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.67
    Marker Score: 160
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.66
    Marker Score: 152
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.66
    Marker Score: 874
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.66
    Marker Score: 2725
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.64
    Marker Score: 688
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.64
    Marker Score: 363
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.63
    Marker Score: 693
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.63
    Marker Score: 12444
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.62
    Marker Score: 1316.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.62
    Marker Score: 295
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 406.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.61
    Marker Score: 551
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.61
    Marker Score: 562
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.6
    Marker Score: 1207
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.6
    Marker Score: 521
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.6
    Marker Score: 406
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.6
    Marker Score: 601
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.59
    Marker Score: 710
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.59
    Marker Score: 2178
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.59
    Marker Score: 831
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.57
    Marker Score: 1376
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.57
    Marker Score: 1695
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.57
    Marker Score: 544
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.57
    Marker Score: 2385.5
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.57
    Marker Score: 514
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.57
    Marker Score: 1248
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.57
    Marker Score: 663
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.56
    Marker Score: 422
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.56
    Marker Score: 226
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.55
    Marker Score: 137
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.55
    Marker Score: 378.5
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.55
    Marker Score: 667
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.55
    Marker Score: 587
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.55
    Marker Score: 376
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.55
    Marker Score: 532
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.55
    Marker Score: 527
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.54
    Marker Score: 189
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.54
    Marker Score: 575
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.54
    Marker Score: 571
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 428
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.53
    Marker Score: 688
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.53
    Marker Score: 535
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.53
    Marker Score: 195
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.53
    Marker Score: 112
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.52
    Marker Score: 139
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.52
    Marker Score: 563
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.52
    Marker Score: 6066
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.52
    Marker Score: 330
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.52
    Marker Score: 124
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.52
    Marker Score: 194
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.52
    Marker Score: 211
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.51
    Marker Score: 350
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.51
    Marker Score: 1398

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * The GABPA gene is located on chromosome 17q21.1. * It is a member of the GABPA family of transcription factors. * It is expressed in high levels in germ cells, cardiac muscle myoblasts, L6b glutamatergic cortical neurons, cerebral cortex GABAergic interneurons, forebrain radial glial cells, oogonial cells, and intestinal crypt stem cells. * It is a key regulator of mitochondrial biogenesis, as it is required for the expression of genes involved in mitochondrial biogenesis. * It is also a key regulator of transcription by RNA polymerase II, as it binds to the Rna polymerase II cis-regulatory region sequence and facilitates its binding to DNA. **Pathways and functions:** * GABPA protein is involved in the regulation of cell differentiation by binding to the Rna polymerase II cis-regulatory region sequence of the genes that are responsible for the development of the germ layer and the early stages of the nervous system. * It also plays a role in the regulation of cell proliferation by binding to the Rna polymerase II cis-regulatory region of the genes that are responsible for the proliferation of muscle cells. * It is also involved in the regulation of apoptosis by binding to the Rna polymerase II cis-regulatory region of the genes that are responsible for the regulation of cell death. **Clinical significance:** * Mutations in the GABPA gene have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. * The GABPA gene is a potential target for the treatment of these disorders, as it is a key regulator of cell differentiation, proliferation, and apoptosis.

Genular Protein ID: 521555527

Symbol: GABPA_HUMAN

Name: GA-binding protein alpha chain

UniProtKB Accession Codes:

Q06546 Q12939

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8441384

Title: cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs.

PubMed ID: 8441384

DOI: 10.1128/mcb.13.3.1385-1391.1993

PubMed ID: 7799916

Title: Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain.

PubMed ID: 7799916

DOI: 10.1128/mcb.15.1.102

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 22306510

Title: Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP.

PubMed ID: 22306510

DOI: 10.1016/j.freeradbiomed.2012.01.003

Sequence Information:

  • Length: 454
  • Mass: 51295
  • Checksum: 1AF2ABBBC79191DD
  • Sequence:
    • MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYAPAECVSQ AIDINEPIGN LKKLLEPRLQ 
CSLDAHEICL QDIQLDPERS LFDQGVKTDG TVQLSVQVIS YQGIEPKLNI LEIVKPADTV 
EVVIDPDAHH AESEAHLVEE AQVITLDGTK HITTISDETS EQVTRWAAAL EGYRKEQERL 
GIPYDPIQWS TDQVLHWVVW VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL 
WSHLELLRKY VLASQEQQMN EIVTIDQPVQ IIPASVQSAT PTTIKVINSS AKAAKVQRAP 
RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL NQPELVAQKW 
GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV CDLKTLIGYS AAELNRLVTE 
CEQKKLAKMQ LHGIAQPVTA VALATASLQT EKDN

Genular Protein ID: 3918519117

Symbol: Q8IYS3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IYS3

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 6 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 454
  • Mass: 51311
  • Checksum: 1AF2BD61C79191DD
  • Sequence:
    • MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYAPAECVSQ AIDINEPIGN LKKLLEPRLQ 
CSLDAHEICL QDIQLDPERS LFDQGVKTDG TVQLSVQVIS YQGIEPKLNI LEIVKPADTV 
EVVIDPDAHH AESEAHLVEE AQVITLDGTK HITTISDETS EQVTRWAAAL EGYRKEQERL 
GIPYDPIQWS TDQVLHWVVW VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL 
WSHLELLRKY VLASQEQQMN EIVTIDQPVQ IIPASVQSAT PTTIKVINSS AKAAKVQRAP 
RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL NQPELVAQKW 
GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV CDLKTLIGYS AAELNRLVTE 
CEQKKLAKMQ LHGIAQPVTA VALSTASLQT EKDN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.