Details for: GLI1

Gene ID: 2735

Symbol: GLI1

Ensembl ID: ENSG00000111087

Description: GLI family zinc finger 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7688
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71837
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2537
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48061
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.97
    Marker Score: 2000
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.89
    Marker Score: 713
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.78
    Marker Score: 1585
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.78
    Marker Score: 12159
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.72
    Marker Score: 378
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.7
    Marker Score: 222
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.67
    Marker Score: 1266
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.6
    Marker Score: 359
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.6
    Marker Score: 192
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.55
    Marker Score: 1294
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.51
    Marker Score: 393
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.5
    Marker Score: 608
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.47
    Marker Score: 1101
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 204
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.41
    Marker Score: 129
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.41
    Marker Score: 339
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.4
    Marker Score: 429
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 305
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.26
    Marker Score: 327
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 114
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.26
    Marker Score: 2883
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.25
    Marker Score: 3318
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.24
    Marker Score: 1566
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.22
    Marker Score: 309
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.19
    Marker Score: 501
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.19
    Marker Score: 4004
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.18
    Marker Score: 68
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.17
    Marker Score: 168
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.17
    Marker Score: 293
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.16
    Marker Score: 164
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.16
    Marker Score: 141
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.16
    Marker Score: 311
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.15
    Marker Score: 909
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.13
    Marker Score: 360
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.13
    Marker Score: 177
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.13
    Marker Score: 44
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.13
    Marker Score: 29
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.12
    Marker Score: 139
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.11
    Marker Score: 196
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.11
    Marker Score: 187
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 103
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.11
    Marker Score: 145
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 123
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1
    Marker Score: 51
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.1
    Marker Score: 316
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.1
    Marker Score: 129
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.1
    Marker Score: 138
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.09
    Marker Score: 174
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.09
    Marker Score: 66
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.09
    Marker Score: 371
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.08
    Marker Score: 825
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.07
    Marker Score: 75
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.07
    Marker Score: 143
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.07
    Marker Score: 82
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.07
    Marker Score: 103
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.06
    Marker Score: 75
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.06
    Marker Score: 40
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.06
    Marker Score: 76
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.06
    Marker Score: 31

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Other Information

**Key characteristics:** * GLI1 is a zinc finger protein that is characterized by its ability to bind to DNA and regulate gene expression. * It is a key regulator of Hedgehog signaling, which is a critical pathway for development and tissue maintenance. * GLI1 is also involved in the regulation of other cellular processes, such as cell differentiation, proliferation, and apoptosis. **Pathways and functions:** * GLI1 is a key regulator of Hedgehog signaling, which is a critical pathway for development and tissue maintenance. * It is involved in the regulation of cell differentiation, proliferation, and apoptosis. * GLI1 also plays a role in the regulation of other cellular processes, such as cell migration, adhesion, and differentiation. **Clinical significance:** * Mutations in the GLI1 gene have been linked to a number of human diseases, including cancer and developmental disorders. * Studies of GLI1 have led to the development of new diagnostic and therapeutic approaches for these diseases. **Additional information:** * GLI1 is a member of the zinc finger family of transcription factors. * It is expressed in high levels in many cell types, including embryonic stem cells, neural stem cells, and cancer cells. * GLI1 is a highly conserved protein, with a similar sequence in mammals, birds, and fish.

Genular Protein ID: 2279080230

Symbol: GLI1_HUMAN

Name: Zinc finger protein GLI1

UniProtKB Accession Codes:

P08151 D0EUY3 E9PQQ9 F5H6H8 Q8TDN9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEMBL 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 46 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 4 RefSeq 4 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2832761

Title: The GLI gene is a member of the Kruppel family of zinc finger proteins.

PubMed ID: 2832761

DOI: 10.1038/332371a0

PubMed ID: 19706761

Title: A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion.

PubMed ID: 19706761

DOI: 10.1158/0008-5472.can-09-0886

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2105456

Title: The GLI gene encodes a nuclear protein which binds specific sequences in the human genome.

PubMed ID: 2105456

DOI: 10.1128/mcb.10.2.634-642.1990

PubMed ID: 10806483

Title: Gli regulation by the opposing activities of fused and suppressor of fused.

PubMed ID: 10806483

DOI: 10.1038/35010610

PubMed ID: 11238441

Title: Physical and functional interactions between Zic and Gli proteins.

PubMed ID: 11238441

DOI: 10.1074/jbc.c000773200

PubMed ID: 19878745

Title: Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway.

PubMed ID: 19878745

DOI: 10.1016/j.yexcr.2009.10.018

PubMed ID: 20081843

Title: Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation.

PubMed ID: 20081843

DOI: 10.1038/ncb2013

PubMed ID: 24076122

Title: Fem1b promotes ubiquitylation and suppresses transcriptional activity of Gli1.

PubMed ID: 24076122

DOI: 10.1016/j.bbrc.2013.09.090

PubMed ID: 28965847

Title: Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.

PubMed ID: 28965847

DOI: 10.1016/j.ajhg.2017.08.017

PubMed ID: 28973407

Title: GLI1 inactivation is associated with developmental phenotypes overlapping with Ellis-van Creveld syndrome.

PubMed ID: 28973407

DOI: 10.1093/hmg/ddx335

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 8378770

Title: Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.

PubMed ID: 8378770

DOI: 10.1126/science.8378770

PubMed ID: 24311597

Title: Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.

PubMed ID: 24311597

DOI: 10.1107/s0907444913028473

PubMed ID: 24217340

Title: Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.

PubMed ID: 24217340

DOI: 10.1038/ncomms3608

PubMed ID: 10951255

Title: Identification of polymorphic variants of the GLI1 oncogene.

PubMed ID: 10951255

DOI: 10.1046/j.1523-1747.2000.00065.x

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 30620395

Title: A novel homozygous sequence variant in GLI1 underlies first case of autosomal recessive pre-axial polydactyly.

PubMed ID: 30620395

DOI: 10.1111/cge.13495

Sequence Information:

  • Length: 1106
  • Mass: 117904
  • Checksum: E29B11D1A6CD3D91
  • Sequence:
    • MFNSMTPPPI SSYGEPCCLR PLPSQGAPSV GTEGLSGPPF CHQANLMSGP HSYGPARETN 
SCTEGPLFSS PRSAVKLTKK RALSISPLSD ASLDLQTVIR TSPSSLVAFI NSRCTSPGGS 
YGHLSIGTMS PSLGFPAQMN HQKGPSPSFG VQPCGPHDSA RGGMIPHPQS RGPFPTCQLK 
SELDMLVGKC REEPLEGDMS SPNSTGIQDP LLGMLDGRED LEREEKREPE SVYETDCRWD 
GCSQEFDSQE QLVHHINSEH IHGERKEFVC HWGGCSRELR PFKAQYMLVV HMRRHTGEKP 
HKCTFEGCRK SYSRLENLKT HLRSHTGEKP YMCEHEGCSK AFSNASDRAK HQNRTHSNEK 
PYVCKLPGCT KRYTDPSSLR KHVKTVHGPD AHVTKRHRGD GPLPRAPSIS TVEPKREREG 
GPIREESRLT VPEGAMKPQP SPGAQSSCSS DHSPAGSAAN TDSGVEMTGN AGGSTEDLSS 
LDEGPCIAGT GLSTLRRLEN LRLDQLHQLR PIGTRGLKLP SLSHTGTTVS RRVGPPVSLE 
RRSSSSSSIS SAYTVSRRSS LASPFPPGSP PENGASSLPG LMPAQHYLLR ARYASARGGG 
TSPTAASSLD RIGGLPMPPW RSRAEYPGYN PNAGVTRRAS DPAQAADRPA PARVQRFKSL 
GCVHTPPTVA GGGQNFDPYL PTSVYSPQPP SITENAAMDA RGLQEEPEVG TSMVGSGLNP 
YMDFPPTDTL GYGGPEGAAA EPYGARGPGS LPLGPGPPTN YGPNPCPQQA SYPDPTQETW 
GEFPSHSGLY PGPKALGGTY SQCPRLEHYG QVQVKPEQGC PVGSDSTGLA PCLNAHPSEG 
PPHPQPLFSH YPQPSPPQYL QSGPYTQPPP DYLPSEPRPC LDFDSPTHST GQLKAQLVCN 
YVQSQQELLW EGGGREDAPA QEPSYQSPKF LGGSQVSPSR AKAPVNTYGP GFGPNLPNHK 
SGSYPTPSPC HENFVVGANR ASHRAAAPPR LLPPLPTCYG PLKVGGTNPS CGHPEVGRLG 
GGPALYPPPE GQVCNPLDSL DLDNTQLDFV AILDEPQGLS PPPSHDQRGS SGHTPPPSGP 
PNMAVGNMSV LLRSLPGETE FLNSSA

Genular Protein ID: 2211545332

Symbol: B4DNF7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DNF7

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 574
  • Mass: 62989
  • Checksum: B98EC21168AA64A6
  • Sequence:
    • MSPSLGFPAQ MNHQKGPSPS FGVQPCGPHD SARGGMIPHP QSRGPFPTCQ LKSELDMLVG 
KCREEPLEGD MSSPNSTGIQ DPLLGMLDGR EDLEREEKRE PESVYETDCR WDGCSQEFDS 
QEQLVHHINS EHIHGERKEF VCHWGGCSRE LRPFKAQYML VVHMRRHTGE KPHKCTFEGC 
RKSYSRLENL KTHLRSHTGE KPYMCEHEGC SKAFSNASDR AKHQNRTHSN EKPYVCKLPG 
CTKRYTDPSS LRKHVKTVHG PDAHVTKRHR GDGPLPRAPS ISTVEPKRER EGGPIREESR 
LTVPEGAMKP HPQPLFSHYP QPSPPQYLQS GPYTQPPPDY LPSEPRPCLD FDSPTHSTGQ 
LKAQLVCNYV QSQQELLWEG GGREDAPAQE PSYQSPKFLG GSQVSPSRAK APVNTYGPGF 
GPNLPNHKSG SYPTPSPCHE NFVVGANRAS HRAAAPPRLL PPLPTCYGPL KVGGTNPSCG 
HPEVGRLGGG PALYPPPEGQ VCNPLDSLDL DNTQLDFVAI LDEPQGLSPP PSHDQRGSSG 
HTPPPSGPPN MAVGNMSVLL RSLPGETEFL NSSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.