Details for: CMKLR2

Gene ID: 2825

Symbol: CMKLR2

Ensembl ID: ENSG00000183671

Description: chemerin chemokine-like receptor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169269
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.06
    Marker Score: 475
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.96
    Marker Score: 2447
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5332
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.65
    Marker Score: 3936
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.51
    Marker Score: 471
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.48
    Marker Score: 733
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.47
    Marker Score: 3131
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.42
    Marker Score: 418
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.38
    Marker Score: 456
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.38
    Marker Score: 218
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.3
    Marker Score: 106
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.28
    Marker Score: 161
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.25
    Marker Score: 162
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.24
    Marker Score: 2092
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.24
    Marker Score: 215
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.24
    Marker Score: 75
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.23
    Marker Score: 2346
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.22
    Marker Score: 858
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 129
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.21
    Marker Score: 177
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.2
    Marker Score: 194
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.2
    Marker Score: 125
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.2
    Marker Score: 1683
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.19
    Marker Score: 503
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.18
    Marker Score: 246
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.17
    Marker Score: 167
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.16
    Marker Score: 64
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.16
    Marker Score: 46
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.16
    Marker Score: 149
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.15
    Marker Score: 130
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.15
    Marker Score: 105
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.14
    Marker Score: 201
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.14
    Marker Score: 156
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.14
    Marker Score: 168
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.14
    Marker Score: 129
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.13
    Marker Score: 27
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.13
    Marker Score: 43
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.13
    Marker Score: 519
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.13
    Marker Score: 448
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.12
    Marker Score: 84
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.12
    Marker Score: 108
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.12
    Marker Score: 149
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.12
    Marker Score: 28
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.12
    Marker Score: 898
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.11
    Marker Score: 123
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.11
    Marker Score: 147
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.11
    Marker Score: 74
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.11
    Marker Score: 67
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.11
    Marker Score: 74
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.11
    Marker Score: 127
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.1
    Marker Score: 41
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.1
    Marker Score: 131
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.1
    Marker Score: 49
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.1
    Marker Score: 168
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.1
    Marker Score: 156
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.1
    Marker Score: 200
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1
    Marker Score: 21
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.09
    Marker Score: 105
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.09
    Marker Score: 54
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.09
    Marker Score: 71
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.09
    Marker Score: 48
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.09
    Marker Score: 206
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.09
    Marker Score: 254.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.09
    Marker Score: 162
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.08
    Marker Score: 28.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.08
    Marker Score: 153
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 0.08
    Marker Score: 27

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Other Information

**Key characteristics:** - CMKLR2 is a type I transmembrane receptor that belongs to the chemokine receptor superfamily. - It is composed of a single extracellular domain and a single transmembrane domain. - It is expressed in high levels in the brain, particularly in areas involved in inflammation and immunity. **Pathways and functions:** - CMKLR2 is a key receptor for adiponectin, a protein produced by adipose tissue and immune cells. - It is involved in the regulation of inflammation, cell migration, and differentiation. - It is also involved in the regulation of glucose metabolism, cell growth, and apoptosis. **Clinical significance:** - Mutations in CMKLR2 have been linked to a number of human diseases, including asthma, inflammatory bowel disease, and cancer. - Targeting CMKLR2 has been explored as a therapeutic strategy for these diseases. **Additional information:** - CMKLR2 is a highly conserved protein with significant expression in the central nervous system. - It is a promising target for the development of novel therapeutic strategies for inflammatory and neurodegenerative diseases.

Genular Protein ID: 1716395266

Symbol: CML2_HUMAN

Name: Chemokine-like receptor 2

UniProtKB Accession Codes:

P46091 A5JUU6 A8K4L1 Q53TR9 Q6NVX4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 7 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 8 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7851889

Title: Cloning of human genes encoding novel G protein-coupled receptors.

PubMed ID: 7851889

DOI: 10.1006/geno.1994.1549

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10233994

Title: An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cells.

PubMed ID: 10233994

DOI: 10.1128/jvi.73.6.5231-5239.1999

PubMed ID: 18165312

Title: The genetic design of signaling cascades to record receptor activation.

PubMed ID: 18165312

DOI: 10.1073/pnas.0710487105

PubMed ID: 27716822

Title: Signaling properties of chemerin receptors CMKLR1, GPR1 and CCRL2.

PubMed ID: 27716822

DOI: 10.1371/journal.pone.0164179

PubMed ID: 29279348

Title: International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) Nomenclature, Pharmacology, and Function.

PubMed ID: 29279348

DOI: 10.1124/pr.116.013177

Sequence Information:

  • Length: 355
  • Mass: 41431
  • Checksum: E25D54CBA59F9C8F
  • Sequence:
    • MEDLEETLFE EFENYSYDLD YYSLESDLEE KVQLGVVHWV SLVLYCLAFV LGIPGNAIVI 
WFTGFKWKKT VTTLWFLNLA IADFIFLLFL PLYISYVAMN FHWPFGIWLC KANSFTAQLN 
MFASVFFLTV ISLDHYIHLI HPVLSHRHRT LKNSLIVIIF IWLLASLIGG PALYFRDTVE 
FNNHTLCYNN FQKHDPDLTL IRHHVLTWVK FIIGYLFPLL TMSICYLCLI FKVKKRSILI 
SSRHFWTILV VVVAFVVCWT PYHLFSIWEL TIHHNSYSHH VMQAGIPLST GLAFLNSCLN 
PILYVLISKK FQARFRSSVA EILKYTLWEV SCSGTVSEQL RNSETKNLCL LETAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.