Details for: IGHV7 81

Gene ID: 28378

Symbol: IGHV7 81

Ensembl ID: ENSG00000211979

Description: immunoglobulin heavy variable 7-81 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 2.5214
    Cell Significance Index: 28.1800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.6061
    Cell Significance Index: 8.8000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.3374
    Cell Significance Index: 4.2200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1973
    Cell Significance Index: 2.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0652
    Cell Significance Index: 1.7500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0630
    Cell Significance Index: 1.0200
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.0396
    Cell Significance Index: 0.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0024
    Cell Significance Index: -0.4800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0033
    Cell Significance Index: -0.0500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0064
    Cell Significance Index: -0.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0065
    Cell Significance Index: -0.1700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0067
    Cell Significance Index: -0.0900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0127
    Cell Significance Index: -0.1300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0144
    Cell Significance Index: -0.1700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0228
    Cell Significance Index: -0.3000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0229
    Cell Significance Index: -0.2800
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0236
    Cell Significance Index: -0.2400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0284
    Cell Significance Index: -0.3600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0290
    Cell Significance Index: -0.3800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0298
    Cell Significance Index: -0.3900
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0300
    Cell Significance Index: -0.3200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0322
    Cell Significance Index: -0.3600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0329
    Cell Significance Index: -0.3500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0345
    Cell Significance Index: -0.3900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0350
    Cell Significance Index: -0.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0354
    Cell Significance Index: -0.3400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0365
    Cell Significance Index: -0.4200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0379
    Cell Significance Index: -0.4900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0437
    Cell Significance Index: -0.4100
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0448
    Cell Significance Index: -0.3600
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.0465
    Cell Significance Index: -0.5100
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0475
    Cell Significance Index: -0.5100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0509
    Cell Significance Index: -1.0000
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0527
    Cell Significance Index: -0.5000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0533
    Cell Significance Index: -0.6300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0544
    Cell Significance Index: -0.5800
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0553
    Cell Significance Index: -0.4900
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0577
    Cell Significance Index: -0.6100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0584
    Cell Significance Index: -0.5300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0601
    Cell Significance Index: -0.6500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0605
    Cell Significance Index: -0.8300
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0611
    Cell Significance Index: -0.5300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0636
    Cell Significance Index: -0.6200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0678
    Cell Significance Index: -0.6000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0680
    Cell Significance Index: -0.7400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0693
    Cell Significance Index: -0.7300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0698
    Cell Significance Index: -0.7500
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0722
    Cell Significance Index: -0.6300
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.0736
    Cell Significance Index: -0.5400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0742
    Cell Significance Index: -0.9600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0781
    Cell Significance Index: -1.9900
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0826
    Cell Significance Index: -0.5500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0827
    Cell Significance Index: -0.8800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0836
    Cell Significance Index: -0.8800
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0856
    Cell Significance Index: -0.8100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0871
    Cell Significance Index: -0.7200
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0878
    Cell Significance Index: -0.4200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0880
    Cell Significance Index: -1.0400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0942
    Cell Significance Index: -0.8000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0959
    Cell Significance Index: -0.9800
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.0985
    Cell Significance Index: -0.4500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1005
    Cell Significance Index: -1.0200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1015
    Cell Significance Index: -1.3300
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.1028
    Cell Significance Index: -0.4800
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1076
    Cell Significance Index: -1.0000
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.1110
    Cell Significance Index: -0.5400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1336
    Cell Significance Index: -2.4700
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.1405
    Cell Significance Index: -0.7000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1448
    Cell Significance Index: -1.6800
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.1448
    Cell Significance Index: -0.7700
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1465
    Cell Significance Index: -0.7800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1482
    Cell Significance Index: -1.7500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1512
    Cell Significance Index: -1.7400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1580
    Cell Significance Index: -1.7500
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1598
    Cell Significance Index: -1.0400
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1689
    Cell Significance Index: -1.7500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1727
    Cell Significance Index: -1.7400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1751
    Cell Significance Index: -1.6600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1763
    Cell Significance Index: -2.4700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1848
    Cell Significance Index: -1.9600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1861
    Cell Significance Index: -2.0600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1881
    Cell Significance Index: -1.7600
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.1900
    Cell Significance Index: -1.7700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1904
    Cell Significance Index: -2.2500
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1908
    Cell Significance Index: -1.7500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.2004
    Cell Significance Index: -1.8600
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.2010
    Cell Significance Index: -2.0700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2041
    Cell Significance Index: -1.7400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.2079
    Cell Significance Index: -2.0800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2103
    Cell Significance Index: -2.3700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2175
    Cell Significance Index: -2.2100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2183
    Cell Significance Index: -2.2100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2223
    Cell Significance Index: -2.0700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.2289
    Cell Significance Index: -2.0500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2355
    Cell Significance Index: -2.0600
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.2380
    Cell Significance Index: -2.1200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2411
    Cell Significance Index: -2.0800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.2516
    Cell Significance Index: -2.2400
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.2595
    Cell Significance Index: -2.1400
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.2667
    Cell Significance Index: -2.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-functional immunoglobulin variable region**: IGHV7-81 is a heavy chain variable region that does not appear to participate in the selection or affinity maturation of antibodies. 2. **Widespread expression**: IGHV7-81 is expressed in a variety of cell types, including macrophages, hematopoietic cells, conventional dendritic cells, monocytes, granulocyte-monocyte progenitor cells, goblet cells, early T lineage precursors, absorptive cells, intestinal crypt stem cells, and transit amplifying cells. 3. **Antigen-binding potential**: Although IGHV7-81 is non-functional, its expression in cells with antigen-presenting capabilities, such as dendritic cells and macrophages, raises questions about its potential role in modulating immune responses. **Pathways and Functions:** 1. **Antigen-binding pathways**: IGHV7-81's expression in cells with antigen-presenting capabilities suggests that it may play a role in modulating immune responses, potentially through the regulation of antigen presentation or the activation of immune cells. 2. **Extracellular region**: As a heavy chain variable region, IGHV7-81 is likely to be present on the surface of cells, where it may interact with antigens or other molecules. 3. **Immunoglobulin complex**: Although IGHV7-81 is non-functional, its expression in cells with immunoglobulin complexes may indicate a role in the formation or regulation of these complexes. **Clinical Significance:** 1. **Immune system dysregulation**: The widespread expression of IGHV7-81 in various cell types raises concerns about its potential role in immune system dysregulation, particularly in diseases characterized by aberrant immune responses. 2. **Cancer association**: The expression of IGHV7-81 in hematopoietic cells and immune cells has been associated with certain types of cancer, including multiple myeloma and lymphoma. 3. **Innate immune system modulation**: IGHV7-81's expression in cells with innate immune functions, such as macrophages and dendritic cells, suggests that it may play a role in modulating innate immune responses, potentially influencing disease outcomes. In conclusion, the IGHV7-81 gene is a non-functional immunoglobulin variable region with a complex expression profile that warrants further investigation into its role in the human immune system. Its widespread expression in various cell types and potential involvement in immune responses make it an intriguing candidate for study in the context of immune system dysregulation and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.