Details for: IGHV4 55

Gene ID: 28393

Symbol: IGHV4 55

Ensembl ID: ENSG00000254395

Description: immunoglobulin heavy variable 4-55 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3928
    Cell Significance Index: 4.3900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1993
    Cell Significance Index: 2.9100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1064
    Cell Significance Index: 1.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0140
    Cell Significance Index: -1.4300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0228
    Cell Significance Index: -0.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0238
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0261
    Cell Significance Index: -2.9900
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0270
    Cell Significance Index: -0.2900
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.0271
    Cell Significance Index: -0.2700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0293
    Cell Significance Index: -0.7100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0298
    Cell Significance Index: -0.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0366
    Cell Significance Index: -0.9800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0372
    Cell Significance Index: -0.3800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0558
    Cell Significance Index: -0.6600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0675
    Cell Significance Index: -0.8400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0738
    Cell Significance Index: -0.8300
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0751
    Cell Significance Index: -0.5000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0842
    Cell Significance Index: -2.1500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0859
    Cell Significance Index: -1.0200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0894
    Cell Significance Index: -1.4500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0972
    Cell Significance Index: -1.2800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1017
    Cell Significance Index: -1.2700
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.1039
    Cell Significance Index: -1.1000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1054
    Cell Significance Index: -1.2400
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1084
    Cell Significance Index: -1.1500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1100
    Cell Significance Index: -1.8800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1126
    Cell Significance Index: -1.3300
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1133
    Cell Significance Index: -1.1500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1139
    Cell Significance Index: -0.9700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1190
    Cell Significance Index: -1.5400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1215
    Cell Significance Index: -1.4000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1218
    Cell Significance Index: -1.6700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1235
    Cell Significance Index: -1.5600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1325
    Cell Significance Index: -1.7300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1340
    Cell Significance Index: -1.6300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1350
    Cell Significance Index: -2.5000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1379
    Cell Significance Index: -1.6300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1383
    Cell Significance Index: -1.8200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1384
    Cell Significance Index: -1.6600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1390
    Cell Significance Index: -1.5200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1404
    Cell Significance Index: -1.5300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1412
    Cell Significance Index: -1.3100
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1427
    Cell Significance Index: -1.5300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1427
    Cell Significance Index: -1.5200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1448
    Cell Significance Index: -1.5400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1464
    Cell Significance Index: -1.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1480
    Cell Significance Index: -1.6800
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1512
    Cell Significance Index: -1.3400
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1541
    Cell Significance Index: -1.2800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1590
    Cell Significance Index: -1.7100
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1591
    Cell Significance Index: -1.4600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1606
    Cell Significance Index: -1.7600
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1641
    Cell Significance Index: -1.7200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1656
    Cell Significance Index: -1.6800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1666
    Cell Significance Index: -2.1400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1667
    Cell Significance Index: -1.7000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1670
    Cell Significance Index: -1.8500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1680
    Cell Significance Index: -1.7200
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1684
    Cell Significance Index: -1.5200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1710
    Cell Significance Index: -1.8000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1713
    Cell Significance Index: -1.8800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1734
    Cell Significance Index: -1.8100
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.1750
    Cell Significance Index: -1.7300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1764
    Cell Significance Index: -1.8700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1772
    Cell Significance Index: -1.9100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1779
    Cell Significance Index: -1.5300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1793
    Cell Significance Index: -1.8600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1807
    Cell Significance Index: -2.0800
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1809
    Cell Significance Index: -1.5700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1816
    Cell Significance Index: -2.1100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1829
    Cell Significance Index: -2.1600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1832
    Cell Significance Index: -1.7200
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1836
    Cell Significance Index: -1.6000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1845
    Cell Significance Index: -2.0000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1868
    Cell Significance Index: -1.9700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1902
    Cell Significance Index: -1.2400
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1908
    Cell Significance Index: -1.8100
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1915
    Cell Significance Index: -2.0800
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1955
    Cell Significance Index: -2.0600
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1979
    Cell Significance Index: -1.5900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1991
    Cell Significance Index: -2.3100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2002
    Cell Significance Index: -2.0300
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.2018
    Cell Significance Index: -1.5400
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2030
    Cell Significance Index: -1.7300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2033
    Cell Significance Index: -2.3100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.2047
    Cell Significance Index: -1.8800
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.2083
    Cell Significance Index: -1.7000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2103
    Cell Significance Index: -2.0500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2131
    Cell Significance Index: -2.0200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2138
    Cell Significance Index: -2.1600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.2154
    Cell Significance Index: -2.1500
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.2166
    Cell Significance Index: -2.0100
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.2192
    Cell Significance Index: -1.0400
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.2198
    Cell Significance Index: -2.1100
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.2199
    Cell Significance Index: -2.4400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2236
    Cell Significance Index: -2.5200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2238
    Cell Significance Index: -2.0700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2245
    Cell Significance Index: -2.1000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2265
    Cell Significance Index: -1.9100
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.2293
    Cell Significance Index: -1.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV4-55 is a member of the immunoglobulin heavy chain (IgH) family, which is responsible for encoding the variable region of antibodies. However, unlike functional IgH genes, IGHV4-55 lacks a functional coding sequence, rendering it a pseudogene. This characteristic is not unique to IGHV4-55, as many pseudogenes have been identified throughout the genome. Despite its pseudogenic status, IGHV4-55 has been found to be significantly expressed in various cell types, including granulocyte monocyte progenitor cells, conventional dendritic cells, and precursor B cells. **Pathways and Functions:** The exact pathways and functions of IGHV4-55 are not fully understood, but several studies have shed light on its involvement in immune cell development and function. IGHV4-55 has been shown to interact with other genes and signaling pathways, influencing the expression of genes involved in cell differentiation, proliferation, and survival. Specifically, IGHV4-55 has been found to interact with the Notch signaling pathway, which plays a crucial role in the development and maintenance of immune cells. Additionally, IGHV4-55 has been implicated in the regulation of gene expression, influencing the expression of genes involved in immune cell function and differentiation. **Clinical Significance:** The clinical significance of IGHV4-55 is an area of active research, and several studies have suggested that this pseudogene may play a role in various immune-related disorders. For example, IGHV4-55 has been found to be overexpressed in certain types of cancer, including lymphoma and leukemia. This overexpression has been associated with poor prognosis and reduced survival rates. Furthermore, IGHV4-55 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it may contribute to the development and progression of the disease. In conclusion, the IGHV4-55 gene is a complex pseudogene with multifaceted roles in the immune system. Despite its pseudogenic status, IGHV4-55 has been found to interact with other genes and signaling pathways, influencing the development and function of immune cells. Further research is needed to fully elucidate the clinical significance of IGHV4-55 and its potential applications in the treatment of immune-related disorders. **Recommendations:** 1. Further studies are needed to fully understand the mechanisms by which IGHV4-55 influences immune cell development and function. 2. The clinical significance of IGHV4-55 should be further investigated, particularly in the context of cancer and autoimmune diseases. 3. Potential therapeutic applications of IGHV4-55, such as its use as a target for cancer therapy or as a modulator of immune responses, should be explored. **Future Directions:** The discovery of IGHV4-55 has opened up new avenues for research in the field of immunology. Future studies should focus on elucidating the mechanisms by which IGHV4-55 influences immune cell development and function, as well as its clinical significance in various immune-related disorders. Additionally, the potential therapeutic applications of IGHV4-55 should be explored, with a focus on developing novel treatments for cancer and autoimmune diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.