IGHV3 53 | ENSG00000211967 | NCBI 28420

Details for: IGHV3 53

Gene ID: 28420

Symbol: IGHV3 53

Ensembl ID: ENSG00000211967

Description: immunoglobulin heavy variable 3-53

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 872
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.17
Marker Score: 2,966
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7,678
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 798
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,817
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,394
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.96
Marker Score: 1,559
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,726
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5,170
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,281
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 703
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.68
Marker Score: 544
Cell Name: Unknown (CL0000003)
Fold Change: 0.64
Marker Score: 1,972
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 146
Cell Name: neutrophil (CL0000775)
Fold Change: 0.54
Marker Score: 327
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.34
Marker Score: 94
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.31
Marker Score: 239
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.24
Marker Score: 206
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.22
Marker Score: 557
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.17
Marker Score: 179
Cell Name: plasmablast (CL0000980)
Fold Change: 0.16
Marker Score: 211
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.15
Marker Score: 69
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.14
Marker Score: 287
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.13
Marker Score: 78
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.13
Marker Score: 34
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.1
Marker Score: 36
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.1
Marker Score: 135
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.1
Marker Score: 40
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.09
Marker Score: 62
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.09
Marker Score: 117
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.09
Marker Score: 108
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.09
Marker Score: 39
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.08
Marker Score: 72
Cell Name: memory B cell (CL0000787)
Fold Change: 0.08
Marker Score: 63
Cell Name: immature B cell (CL0000816)
Fold Change: 0.08
Marker Score: 53
Cell Name: platelet (CL0000233)
Fold Change: 0.08
Marker Score: 35
Cell Name: B cell (CL0000236)
Fold Change: 0.07
Marker Score: 70
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.07
Marker Score: 50
Cell Name: blood cell (CL0000081)
Fold Change: 0.07
Marker Score: 842
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.07
Marker Score: 47
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.07
Marker Score: 35
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.07
Marker Score: 39
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.07
Marker Score: 133
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.06
Marker Score: 16
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.06
Marker Score: 58
Cell Name: stromal cell (CL0000499)
Fold Change: 0.06
Marker Score: 70
Cell Name: naive B cell (CL0000788)
Fold Change: 0.06
Marker Score: 52
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.05
Marker Score: 14
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.05
Marker Score: 148
Cell Name: colon macrophage (CL0009038)
Fold Change: 0.05
Marker Score: 15
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.05
Marker Score: 12
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.05
Marker Score: 64
Cell Name: macrophage (CL0000235)
Fold Change: 0.05
Marker Score: 57
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.05
Marker Score: 45
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.05
Marker Score: 51
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.05
Marker Score: 31
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.05
Marker Score: 41
Cell Name: plasma cell (CL0000786)
Fold Change: 0.05
Marker Score: 52
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.05
Marker Score: 16
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.05
Marker Score: 80
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.04
Marker Score: 24
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.04
Marker Score: 16
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.04
Marker Score: 69
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.04
Marker Score: 15
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.04
Marker Score: 10
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.04
Marker Score: 16
Cell Name: mature B cell (CL0000785)
Fold Change: 0.04
Marker Score: 30
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.04
Marker Score: 15
Cell Name: monocyte (CL0000576)
Fold Change: 0.04
Marker Score: 50
Cell Name: mast cell (CL0000097)
Fold Change: 0.04
Marker Score: 21
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.04
Marker Score: 21
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.04
Marker Score: 34
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.04
Marker Score: 79
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.03
Marker Score: 16
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.03
Marker Score: 16
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.03
Marker Score: 24
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.03
Marker Score: 18
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.03
Marker Score: 16
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.03
Marker Score: 11
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.03
Marker Score: 31
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.03
Marker Score: 13
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.03
Marker Score: 33
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.03
Marker Score: 21
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.03
Marker Score: 33
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.03
Marker Score: 17
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.03
Marker Score: 25
Cell Name: pericyte (CL0000669)
Fold Change: 0.03
Marker Score: 16
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.03
Marker Score: 24
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.03
Marker Score: 15
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.03
Marker Score: 22
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.03
Marker Score: 17
Cell Name: naive T cell (CL0000898)
Fold Change: 0.02
Marker Score: 16
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.02
Marker Score: 15
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.02
Marker Score: 58
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.02
Marker Score: 39
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.02
Marker Score: 17
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.02
Marker Score: 13
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.02
Marker Score: 13
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.02
Marker Score: 14

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics:** IGHV3-53 shares several key characteristics with other immunoglobulin genes, including its involvement in the adaptive immune response and its expression in various cell types. Its structure consists of a variable region, which is responsible for antigen binding, and a constant region, which is involved in the activation of complement and the regulation of immune responses. The gene's expression is tightly regulated, and its dysregulation has been implicated in various immune-related disorders. **Pathways and Functions:** IGHV3-53 is involved in multiple pathways, including: 1. **Antigen Binding:** The variable region of IGHV3-53 is responsible for binding to antigens, which triggers the activation of B cell receptors and the generation of second messengers. 2. **Complement Activation:** The constant region of IGHV3-53 is involved in the activation of the complement cascade, which plays a crucial role in eliminating pathogens from the body. 3. **Immune Response Regulation:** IGHV3-53 is also involved in the regulation of immune responses, including the activation of T cells and the production of cytokines. 4. **Phagocytosis:** The gene's expression is involved in the phagocytosis of pathogens, including Leishmania parasites. 5. **Hemostasis:** IGHV3-53 plays a role in maintaining hemostasis, which is essential for preventing excessive bleeding. **Clinical Significance:** IGHV3-53 has significant clinical implications in the context of infectious diseases, such as Leishmania parasite infection. Its dysregulation may contribute to the development of immune-related disorders, including autoimmune diseases and cancer. Furthermore, IGHV3-53 may play a role in the pathogenesis of SARS-CoV infections. Understanding the function of IGHV3-53 is essential for the development of novel therapeutic strategies for these diseases. **Significantly Expressed Cells:** IGHV3-53 is expressed in various cell types, including: 1. Granulocyte-monocyte progenitor cells 2. Intestinal crypt stem cells of the colon 3. Goblet cells 4. Early T lineage precursor cells 5. Fallopian tube secretory epithelial cells 6. Absorptive cells 7. Intestinal epithelial cells 8. Abnormal cells 9. Transit amplifying cells 10. Neoplastic cells In conclusion, IGHV3-53 is a gene that plays a crucial role in the adaptive immune system. Its expression is observed in various cell types, and its involvement in multiple pathways, including antigen binding, complement activation, and regulation of immune responses, makes it a key player in the immune system. Further research is necessary to fully understand the function of IGHV3-53 and its clinical significance in infectious diseases and immune-related disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.