IGHV3 53 | ENSG00000211967 | NCBI 28420

Details for: IGHV3 53

Gene ID: 28420

Symbol: IGHV3 53

Ensembl ID: ENSG00000211967

Description: immunoglobulin heavy variable 3-53

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.2647
Cell Significance Index: 14.1400
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.2741
Cell Significance Index: 4.2400
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.1400
Cell Significance Index: 2.0400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0518
Cell Significance Index: -5.2900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0798
Cell Significance Index: -2.1700
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0824
Cell Significance Index: -2.0000
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0878
Cell Significance Index: -1.2800
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1048
Cell Significance Index: -6.7600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1488
Cell Significance Index: -3.9800
Cell Name: stromal cell (CL0000499)
Fold Change: -0.2065
Cell Significance Index: -2.1100
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.2147
Cell Significance Index: -2.7200
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.2218
Cell Significance Index: -2.5200
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.2314
Cell Significance Index: -5.7800
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2461
Cell Significance Index: -6.2700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2486
Cell Significance Index: -11.5900
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2509
Cell Significance Index: -6.4100
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.2591
Cell Significance Index: -3.2100
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.2644
Cell Significance Index: -2.8900
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: -0.3041
Cell Significance Index: -2.3400
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.3417
Cell Significance Index: -6.6800
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.3500
Cell Significance Index: -4.8000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3550
Cell Significance Index: -18.4400
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3560
Cell Significance Index: -6.5800
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.3714
Cell Significance Index: -4.3700
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.3743
Cell Significance Index: -6.4000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.3767
Cell Significance Index: -10.8500
Cell Name: monocyte (CL0000576)
Fold Change: -0.3841
Cell Significance Index: -4.4200
Cell Name: melanocyte (CL0000148)
Fold Change: -0.3844
Cell Significance Index: -3.6000
Cell Name: helper T cell (CL0000912)
Fold Change: -0.3915
Cell Significance Index: -5.5600
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.3970
Cell Significance Index: -6.4300
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.4095
Cell Significance Index: -3.3800
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.4163
Cell Significance Index: -4.9200
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.4192
Cell Significance Index: -5.0600
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.4478
Cell Significance Index: -5.8000
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.4489
Cell Significance Index: -5.8700
Cell Name: glial cell (CL0000125)
Fold Change: -0.4719
Cell Significance Index: -5.1700
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.4820
Cell Significance Index: -3.2100
Cell Name: promyelocyte (CL0000836)
Fold Change: -0.4907
Cell Significance Index: -4.8500
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.4919
Cell Significance Index: -5.8400
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.4946
Cell Significance Index: -6.4900
Cell Name: thymocyte (CL0000893)
Fold Change: -0.5034
Cell Significance Index: -6.3600
Cell Name: paneth cell (CL0000510)
Fold Change: -0.5075
Cell Significance Index: -5.2500
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.5156
Cell Significance Index: -5.6600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.5195
Cell Significance Index: -11.2600
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.5248
Cell Significance Index: -5.5800
Cell Name: blood cell (CL0000081)
Fold Change: -0.5374
Cell Significance Index: -4.5800
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.5379
Cell Significance Index: -6.9100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.5394
Cell Significance Index: -6.1300
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.5429
Cell Significance Index: -5.7700
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.5457
Cell Significance Index: -5.5400
Cell Name: lung macrophage (CL1001603)
Fold Change: -0.5502
Cell Significance Index: -6.0100
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.5511
Cell Significance Index: -5.2900
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.5546
Cell Significance Index: -6.3000
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.5560
Cell Significance Index: -6.5700
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.5584
Cell Significance Index: -6.0200
Cell Name: podocyte (CL0000653)
Fold Change: -0.5623
Cell Significance Index: -6.4500
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: -0.5653
Cell Significance Index: -5.6100
Cell Name: plasma cell (CL0000786)
Fold Change: -0.5675
Cell Significance Index: -6.3400
Cell Name: promonocyte (CL0000559)
Fold Change: -0.5739
Cell Significance Index: -6.1300
Cell Name: platelet (CL0000233)
Fold Change: -0.5798
Cell Significance Index: -5.9700
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.5805
Cell Significance Index: -6.3500
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: -0.5827
Cell Significance Index: -6.2000
Cell Name: leukocyte (CL0000738)
Fold Change: -0.5864
Cell Significance Index: -9.9600
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.5866
Cell Significance Index: -6.6100
Cell Name: naive B cell (CL0000788)
Fold Change: -0.5907
Cell Significance Index: -6.2200
Cell Name: peg cell (CL4033014)
Fold Change: -0.5928
Cell Significance Index: -13.7000
Cell Name: pericyte (CL0000669)
Fold Change: -0.6004
Cell Significance Index: -7.2000
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.6088
Cell Significance Index: -6.7400
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.6143
Cell Significance Index: -6.0100
Cell Name: neutrophil (CL0000775)
Fold Change: -0.6180
Cell Significance Index: -7.7200
Cell Name: plasmablast (CL0000980)
Fold Change: -0.6206
Cell Significance Index: -5.7600
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.6291
Cell Significance Index: -7.2400
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.6329
Cell Significance Index: -8.4100
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.6334
Cell Significance Index: -5.0900
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.6423
Cell Significance Index: -7.4500
Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
Fold Change: -0.6474
Cell Significance Index: -7.0000
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.6478
Cell Significance Index: -6.3900
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.6481
Cell Significance Index: -5.7900
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: -0.6565
Cell Significance Index: -6.4100
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.6580
Cell Significance Index: -6.6300
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.6585
Cell Significance Index: -7.0800
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.6597
Cell Significance Index: -5.9500
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.6607
Cell Significance Index: -6.3500
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: -0.6620
Cell Significance Index: -6.7200
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: -0.6648
Cell Significance Index: -5.9600
Cell Name: elicited macrophage (CL0000861)
Fold Change: -0.6652
Cell Significance Index: -5.8200
Cell Name: immature B cell (CL0000816)
Fold Change: -0.6658
Cell Significance Index: -6.3000
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.6658
Cell Significance Index: -6.4900
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.6704
Cell Significance Index: -5.9800
Cell Name: memory B cell (CL0000787)
Fold Change: -0.6749
Cell Significance Index: -7.1800
Cell Name: intermediate monocyte (CL0002393)
Fold Change: -0.6762
Cell Significance Index: -6.3000
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.6781
Cell Significance Index: -7.5100
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.6785
Cell Significance Index: -8.8600
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.6802
Cell Significance Index: -6.7100
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.6894
Cell Significance Index: -7.3100
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: -0.6897
Cell Significance Index: -6.3400
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.6917
Cell Significance Index: -8.4200
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.6928
Cell Significance Index: -6.0600
Cell Name: myofibroblast cell (CL0000186)
Fold Change: -0.6945
Cell Significance Index: -7.2800
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.6968
Cell Significance Index: -6.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** IGHV3-53 shares several key characteristics with other immunoglobulin genes, including its involvement in the adaptive immune response and its expression in various cell types. Its structure consists of a variable region, which is responsible for antigen binding, and a constant region, which is involved in the activation of complement and the regulation of immune responses. The gene's expression is tightly regulated, and its dysregulation has been implicated in various immune-related disorders. **Pathways and Functions:** IGHV3-53 is involved in multiple pathways, including: 1. **Antigen Binding:** The variable region of IGHV3-53 is responsible for binding to antigens, which triggers the activation of B cell receptors and the generation of second messengers. 2. **Complement Activation:** The constant region of IGHV3-53 is involved in the activation of the complement cascade, which plays a crucial role in eliminating pathogens from the body. 3. **Immune Response Regulation:** IGHV3-53 is also involved in the regulation of immune responses, including the activation of T cells and the production of cytokines. 4. **Phagocytosis:** The gene's expression is involved in the phagocytosis of pathogens, including Leishmania parasites. 5. **Hemostasis:** IGHV3-53 plays a role in maintaining hemostasis, which is essential for preventing excessive bleeding. **Clinical Significance:** IGHV3-53 has significant clinical implications in the context of infectious diseases, such as Leishmania parasite infection. Its dysregulation may contribute to the development of immune-related disorders, including autoimmune diseases and cancer. Furthermore, IGHV3-53 may play a role in the pathogenesis of SARS-CoV infections. Understanding the function of IGHV3-53 is essential for the development of novel therapeutic strategies for these diseases. **Significantly Expressed Cells:** IGHV3-53 is expressed in various cell types, including: 1. Granulocyte-monocyte progenitor cells 2. Intestinal crypt stem cells of the colon 3. Goblet cells 4. Early T lineage precursor cells 5. Fallopian tube secretory epithelial cells 6. Absorptive cells 7. Intestinal epithelial cells 8. Abnormal cells 9. Transit amplifying cells 10. Neoplastic cells In conclusion, IGHV3-53 is a gene that plays a crucial role in the adaptive immune system. Its expression is observed in various cell types, and its involvement in multiple pathways, including antigen binding, complement activation, and regulation of immune responses, makes it a key player in the immune system. Further research is necessary to fully understand the function of IGHV3-53 and its clinical significance in infectious diseases and immune-related disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.