Details for: IGHV3 29

Gene ID: 28440

Symbol: IGHV3 29

Ensembl ID: ENSG00000254289

Description: immunoglobulin heavy variable 3-29 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.4969
    Cell Significance Index: 5.0500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.2359
    Cell Significance Index: 2.9000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.2012
    Cell Significance Index: 2.5500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.0864
    Cell Significance Index: 1.0300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0523
    Cell Significance Index: 0.6600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.0419
    Cell Significance Index: 0.5000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.0227
    Cell Significance Index: 0.2300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0174
    Cell Significance Index: 0.2100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0128
    Cell Significance Index: 0.1800
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.0127
    Cell Significance Index: 0.1300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0060
    Cell Significance Index: 0.0900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.0032
    Cell Significance Index: 0.0300
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.0014
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0004
    Cell Significance Index: 0.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0005
    Cell Significance Index: -0.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0018
    Cell Significance Index: -0.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0022
    Cell Significance Index: -0.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0023
    Cell Significance Index: -0.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0024
    Cell Significance Index: -0.0500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0031
    Cell Significance Index: -0.0800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0032
    Cell Significance Index: -0.0600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0036
    Cell Significance Index: -0.0800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0043
    Cell Significance Index: -0.0700
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.0044
    Cell Significance Index: -0.0400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0057
    Cell Significance Index: -0.0700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0067
    Cell Significance Index: -0.0800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0070
    Cell Significance Index: -0.0800
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0077
    Cell Significance Index: -0.0700
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0107
    Cell Significance Index: -0.0600
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.0114
    Cell Significance Index: -0.0800
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.0131
    Cell Significance Index: -0.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0157
    Cell Significance Index: -0.7100
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.0161
    Cell Significance Index: -0.0800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0197
    Cell Significance Index: -0.2700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0238
    Cell Significance Index: -0.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0244
    Cell Significance Index: -0.6200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0272
    Cell Significance Index: -0.3500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0318
    Cell Significance Index: -0.5400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0348
    Cell Significance Index: -0.5100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0349
    Cell Significance Index: -0.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0355
    Cell Significance Index: -0.9500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0362
    Cell Significance Index: -0.4900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0397
    Cell Significance Index: -0.4600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0443
    Cell Significance Index: -0.5100
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0463
    Cell Significance Index: -0.4700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0482
    Cell Significance Index: -0.5000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0487
    Cell Significance Index: -0.6300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0530
    Cell Significance Index: -0.5700
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0530
    Cell Significance Index: -0.4600
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0538
    Cell Significance Index: -0.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0541
    Cell Significance Index: -0.5200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0546
    Cell Significance Index: -0.6100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0550
    Cell Significance Index: -0.6500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0559
    Cell Significance Index: -0.7300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0591
    Cell Significance Index: -0.4100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0611
    Cell Significance Index: -0.6500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0611
    Cell Significance Index: -0.6700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0645
    Cell Significance Index: -1.0500
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0654
    Cell Significance Index: -0.5800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0659
    Cell Significance Index: -0.6200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0670
    Cell Significance Index: -0.6200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0704
    Cell Significance Index: -0.8800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0728
    Cell Significance Index: -0.9000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0729
    Cell Significance Index: -0.9600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0762
    Cell Significance Index: -0.6500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0765
    Cell Significance Index: -0.9000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0793
    Cell Significance Index: -1.0400
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0809
    Cell Significance Index: -0.6500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0813
    Cell Significance Index: -0.9600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0831
    Cell Significance Index: -0.8400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0850
    Cell Significance Index: -0.9500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0850
    Cell Significance Index: -0.9000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0863
    Cell Significance Index: -0.9200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0955
    Cell Significance Index: -0.9100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0965
    Cell Significance Index: -1.1100
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0973
    Cell Significance Index: -0.9600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0994
    Cell Significance Index: -1.1200
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1003
    Cell Significance Index: -0.9100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1101
    Cell Significance Index: -1.0300
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1120
    Cell Significance Index: -1.0600
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.1176
    Cell Significance Index: -0.5900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1255
    Cell Significance Index: -1.1700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1269
    Cell Significance Index: -1.1100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1289
    Cell Significance Index: -1.1100
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1345
    Cell Significance Index: -1.1200
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1523
    Cell Significance Index: -1.1500
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: -0.1575
    Cell Significance Index: -1.1100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1671
    Cell Significance Index: -1.4100
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1705
    Cell Significance Index: -1.1100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2146
    Cell Significance Index: -1.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** IGHV3-29 is a pseudogene, meaning it lacks the ability to encode a functional protein due to mutations or deletions. 2. **Ubiquitous expression:** IGHV3-29 is significantly expressed in a wide range of immune cells, including macrophages, dendritic cells, monocytes, neutrophils, and progenitor cells. 3. **Cell-type specificity:** While IGHV3-29 is broadly expressed, its expression levels vary across different cell types, suggesting potential functional differences. **Pathways and Functions:** Despite being a pseudogene, IGHV3-29 may still participate in immune regulation through several mechanisms: 1. **Transcriptional regulation:** IGHV3-29 may influence the expression of nearby genes, modulating immune responses. 2. **Epigenetic regulation:** IGHV3-29 could interact with epigenetic marks, affecting chromatin structure and gene expression. 3. **Non-coding RNA (ncRNA) function:** IGHV3-29 may generate ncRNAs, which can regulate gene expression, cell differentiation, and immune responses. 4. **Gene conversion:** IGHV3-29 may participate in gene conversion events, where genetic material is exchanged between different IGHV genes, potentially influencing immune receptor function. **Clinical Significance:** The clinical significance of IGHV3-29 is an area of ongoing research. Potential applications include: 1. **Immunotherapy:** Understanding IGHV3-29's role in immune regulation may lead to the development of novel immunotherapies targeting specific immune cell populations. 2. **Autoimmune diseases:** IGHV3-29's expression in autoimmune-relevant cells, such as macrophages and dendritic cells, suggests its potential involvement in autoimmune disease pathogenesis. 3. **Cancer immunology:** IGHV3-29's expression in cancer-associated immune cells, such as neutrophils and monocytes, raises questions about its role in cancer immunosurveillance. 4. **Regulatory T cell development:** IGHV3-29's expression in early T lineage precursor cells may influence the development of regulatory T cells, which play a crucial role in immune tolerance. In conclusion, IGHV3-29 is a pseudogene with a complex and multifaceted role in the immune system. Further research is necessary to elucidate its functions and clinical significance, ultimately shedding light on its potential applications in immunotherapy and disease management.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.