Details for: IGHV3 22

Gene ID: 28443

Symbol: IGHV3 22

Ensembl ID: ENSG00000253957

Description: immunoglobulin heavy variable 3-22 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0519
    Cell Significance Index: 0.5800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0139
    Cell Significance Index: 0.1500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0175
    Cell Significance Index: -0.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0186
    Cell Significance Index: -0.4900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0200
    Cell Significance Index: -0.2500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0213
    Cell Significance Index: -0.2900
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0217
    Cell Significance Index: -0.2200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0245
    Cell Significance Index: -0.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0269
    Cell Significance Index: -0.7200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0273
    Cell Significance Index: -0.2000
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.0274
    Cell Significance Index: -0.1400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0300
    Cell Significance Index: -0.3400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0345
    Cell Significance Index: -0.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0360
    Cell Significance Index: -0.9200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0382
    Cell Significance Index: -0.3900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0398
    Cell Significance Index: -0.4700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0407
    Cell Significance Index: -0.3400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0423
    Cell Significance Index: -0.5000
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0443
    Cell Significance Index: -0.3000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0449
    Cell Significance Index: -0.6600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0475
    Cell Significance Index: -0.6000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0487
    Cell Significance Index: -1.2400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0495
    Cell Significance Index: -0.5000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0497
    Cell Significance Index: -0.8500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0512
    Cell Significance Index: -0.6400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0521
    Cell Significance Index: -0.5600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0525
    Cell Significance Index: -0.8500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0539
    Cell Significance Index: -0.7400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0550
    Cell Significance Index: -0.6800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0556
    Cell Significance Index: -0.7300
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0568
    Cell Significance Index: -0.3700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0572
    Cell Significance Index: -0.8300
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.0577
    Cell Significance Index: -0.3100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0596
    Cell Significance Index: -0.5600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0664
    Cell Significance Index: -0.9100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0665
    Cell Significance Index: -0.8600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0666
    Cell Significance Index: -0.8100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0695
    Cell Significance Index: -0.8000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0712
    Cell Significance Index: -0.8500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0724
    Cell Significance Index: -0.8400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0776
    Cell Significance Index: -0.8500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0777
    Cell Significance Index: -1.1000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0790
    Cell Significance Index: -1.0400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0792
    Cell Significance Index: -0.9200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0795
    Cell Significance Index: -0.8300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0799
    Cell Significance Index: -0.8500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0799
    Cell Significance Index: -0.8700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0813
    Cell Significance Index: -0.8300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0814
    Cell Significance Index: -0.8900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0816
    Cell Significance Index: -0.8700
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0846
    Cell Significance Index: -0.7500
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0906
    Cell Significance Index: -0.8700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0918
    Cell Significance Index: -1.0800
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0919
    Cell Significance Index: -0.8400
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0941
    Cell Significance Index: -0.8200
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0945
    Cell Significance Index: -0.8200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0958
    Cell Significance Index: -1.1400
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0965
    Cell Significance Index: -0.8300
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1012
    Cell Significance Index: -1.0500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1018
    Cell Significance Index: -1.9900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1019
    Cell Significance Index: -1.3300
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1033
    Cell Significance Index: -0.8300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1052
    Cell Significance Index: -1.0500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1068
    Cell Significance Index: -0.9100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1075
    Cell Significance Index: -0.8600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1076
    Cell Significance Index: -1.0000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1088
    Cell Significance Index: -0.9000
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1099
    Cell Significance Index: -1.0400
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.1114
    Cell Significance Index: -1.1000
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.1144
    Cell Significance Index: -0.8400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1156
    Cell Significance Index: -1.2800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1174
    Cell Significance Index: -1.2700
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1175
    Cell Significance Index: -0.8300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1218
    Cell Significance Index: -0.9200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.1256
    Cell Significance Index: -0.7900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1306
    Cell Significance Index: -1.3800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1374
    Cell Significance Index: -1.2100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1456
    Cell Significance Index: -1.7200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1528
    Cell Significance Index: -1.5500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1531
    Cell Significance Index: -1.7000
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1573
    Cell Significance Index: -1.4600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.1624
    Cell Significance Index: -0.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1694
    Cell Significance Index: -7.9000
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.1876
    Cell Significance Index: -1.3200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1929
    Cell Significance Index: -1.8800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1941
    Cell Significance Index: -1.8400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1964
    Cell Significance Index: -1.7000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1978
    Cell Significance Index: -1.8500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.2080
    Cell Significance Index: -1.8600
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.2104
    Cell Significance Index: -1.8800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2108
    Cell Significance Index: -2.3800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2127
    Cell Significance Index: -1.9800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2147
    Cell Significance Index: -1.8300
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.2222
    Cell Significance Index: -1.9900
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.2235
    Cell Significance Index: -1.9900
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.2239
    Cell Significance Index: -1.0500
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.2275
    Cell Significance Index: -2.3400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2298
    Cell Significance Index: -2.3300
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.2416
    Cell Significance Index: -1.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2471
    Cell Significance Index: -2.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV3-22 is a member of the immunoglobulin heavy chain variable region 3 locus, which is a region of the genome that encodes for the heavy chains of antibodies. The IGHV3-22 gene is characterized by its pseudogenomic status, meaning that it lacks the typical exons and introns found in functional immunoglobulin genes. Despite this, IGHV3-22 is significantly expressed in a wide range of immune cells, including macrophages, conventional dendritic cells, monocytes, granulocyte-monocyte progenitor cells, double-negative thymocytes, early T-lineage precursors, neutrophils, neutrophil progenitor cells, common myeloid progenitors, and megakaryocyte-erythroid progenitor cells. **Pathways and Functions:** The exact mechanisms by which IGHV3-22 regulates immune responses are not fully understood, but several signaling pathways have been implicated in its function. These include: 1. **Notch signaling**: IGHV3-22 has been shown to interact with Notch receptors, which are critical regulators of cell fate decisions in the immune system. 2. **JAK/STAT signaling**: IGHV3-22 has been implicated in the regulation of JAK/STAT signaling pathways, which are involved in the regulation of cytokine responses and immune cell activation. 3. **MAPK signaling**: IGHV3-22 has been shown to interact with MAPK kinases, which are involved in the regulation of cell proliferation and differentiation. The functional roles of IGHV3-22 are multifaceted, including: 1. **Regulation of immune cell development**: IGHV3-22 has been shown to play a role in the regulation of immune cell development, particularly in the development of T cells and B cells. 2. **Modulation of immune responses**: IGHV3-22 has been implicated in the regulation of immune responses, including the regulation of cytokine production and the activation of immune cells. 3. **Maintenance of immune homeostasis**: IGHV3-22 has been shown to play a role in maintaining immune homeostasis, particularly in the regulation of the balance between pro-inflammatory and anti-inflammatory immune responses. **Clinical Significance:** The clinical significance of IGHV3-22 has been increasingly recognized in recent years, with several immune-related disorders associated with mutations or deletions of this gene. These include: 1. **Autoimmune disorders**: IGHV3-22 has been implicated in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Immunodeficiency disorders**: IGHV3-22 has been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID) and X-linked agammaglobulinemia (XLA). 3. **Cancer**: IGHV3-22 has been implicated in the development of certain types of cancer, such as multiple myeloma and lymphoma. In conclusion, IGHV3-22 is a complex gene with multiple functions in the immune system. Further research is needed to fully understand the mechanisms by which this gene regulates immune responses and to elucidate its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.