IGHV2 70 | ENSG00000274576 | NCBI 28454

Details for: IGHV2 70

Gene ID: 28454

Symbol: IGHV2 70

Ensembl ID: ENSG00000274576

Description: immunoglobulin heavy variable 2-70

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.1427
Cell Significance Index: 1.6000
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0126
Cell Significance Index: 0.2000
Cell Name: smooth muscle cell of the pulmonary artery (CL0002591)
Fold Change: -0.0024
Cell Significance Index: -0.0200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0747
Cell Significance Index: -7.6300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0777
Cell Significance Index: -0.8800
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.0813
Cell Significance Index: -0.8900
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0945
Cell Significance Index: -2.2900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1044
Cell Significance Index: -17.8300
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: -0.2101
Cell Significance Index: -1.8900
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2307
Cell Significance Index: -6.1700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2570
Cell Significance Index: -16.2000
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2663
Cell Significance Index: -6.7900
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2721
Cell Significance Index: -6.9500
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2877
Cell Significance Index: -5.6300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3655
Cell Significance Index: -6.7600
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.3656
Cell Significance Index: -6.2500
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.3661
Cell Significance Index: -5.3200
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.3670
Cell Significance Index: -4.6500
Cell Name: stromal cell (CL0000499)
Fold Change: -0.4013
Cell Significance Index: -4.1000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.4041
Cell Significance Index: -18.8400
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.4137
Cell Significance Index: -6.7000
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.4663
Cell Significance Index: -6.4000
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.4771
Cell Significance Index: -6.2400
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.4927
Cell Significance Index: -6.1000
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.5290
Cell Significance Index: -5.6200
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.5311
Cell Significance Index: -7.0600
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.5401
Cell Significance Index: -5.6200
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.5414
Cell Significance Index: -6.3700
Cell Name: blood cell (CL0000081)
Fold Change: -0.5497
Cell Significance Index: -4.6900
Cell Name: thymocyte (CL0000893)
Fold Change: -0.5560
Cell Significance Index: -7.0300
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.5582
Cell Significance Index: -6.1800
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.5649
Cell Significance Index: -7.3100
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.5686
Cell Significance Index: -6.1300
Cell Name: T cell (CL0000084)
Fold Change: -0.5719
Cell Significance Index: -6.7500
Cell Name: monocyte (CL0000576)
Fold Change: -0.5736
Cell Significance Index: -6.6000
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.5795
Cell Significance Index: -6.8800
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.5889
Cell Significance Index: -6.6900
Cell Name: platelet (CL0000233)
Fold Change: -0.5949
Cell Significance Index: -6.1200
Cell Name: naive B cell (CL0000788)
Fold Change: -0.6012
Cell Significance Index: -6.3300
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.6096
Cell Significance Index: -7.2100
Cell Name: intermediate monocyte (CL0002393)
Fold Change: -0.6118
Cell Significance Index: -5.7000
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.6140
Cell Significance Index: -5.9900
Cell Name: fibroblast (CL0000057)
Fold Change: -0.6146
Cell Significance Index: -5.7700
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.6354
Cell Significance Index: -6.9500
Cell Name: glial cell (CL0000125)
Fold Change: -0.6371
Cell Significance Index: -6.9800
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: -0.6442
Cell Significance Index: -5.8200
Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
Fold Change: -0.6539
Cell Significance Index: -7.0700
Cell Name: dendritic cell, human (CL0001056)
Fold Change: -0.6820
Cell Significance Index: -6.2900
Cell Name: neutrophil (CL0000775)
Fold Change: -0.6868
Cell Significance Index: -8.5800
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.6994
Cell Significance Index: -6.1200
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.7110
Cell Significance Index: -8.6500
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.7209
Cell Significance Index: -6.4300
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.7222
Cell Significance Index: -7.6700
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: -0.7254
Cell Significance Index: -6.7000
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.7277
Cell Significance Index: -8.6500
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.7365
Cell Significance Index: -7.0700
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: -0.7454
Cell Significance Index: -6.2900
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.7464
Cell Significance Index: -6.9500
Cell Name: plasmablast (CL0000980)
Fold Change: -0.7467
Cell Significance Index: -6.9300
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.7482
Cell Significance Index: -8.6100
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.7483
Cell Significance Index: -6.6900
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.7514
Cell Significance Index: -7.5000
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.7552
Cell Significance Index: -8.1200
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.7623
Cell Significance Index: -8.5900
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: -0.7640
Cell Significance Index: -7.4600
Cell Name: immature B cell (CL0000816)
Fold Change: -0.7641
Cell Significance Index: -7.2300
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.7714
Cell Significance Index: -7.6100
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: -0.7796
Cell Significance Index: -5.8000
Cell Name: club cell (CL0000158)
Fold Change: -0.7838
Cell Significance Index: -8.5400
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.7885
Cell Significance Index: -7.0200
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.7928
Cell Significance Index: -7.6200
Cell Name: transitional stage B cell (CL0000818)
Fold Change: -0.8053
Cell Significance Index: -7.0800
Cell Name: memory B cell (CL0000787)
Fold Change: -0.8079
Cell Significance Index: -8.6000
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: -0.8163
Cell Significance Index: -6.6100
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.8214
Cell Significance Index: -5.4700
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: -0.8258
Cell Significance Index: -5.6800
Cell Name: obsolete animal cell (CL0000548)
Fold Change: -0.8353
Cell Significance Index: -8.4700
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: -0.8444
Cell Significance Index: -8.5300
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.8480
Cell Significance Index: -8.0400
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.8496
Cell Significance Index: -8.5600
Cell Name: exhausted T cell (CL0011025)
Fold Change: -0.8608
Cell Significance Index: -7.0200
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -0.8658
Cell Significance Index: -6.7900
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: -0.8708
Cell Significance Index: -9.0200
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.8712
Cell Significance Index: -8.1500
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: -0.8800
Cell Significance Index: -9.5300
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: -0.8817
Cell Significance Index: -6.1100
Cell Name: IgM plasma cell (CL0000986)
Fold Change: -0.8830
Cell Significance Index: -6.7800
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.8832
Cell Significance Index: -11.5900
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: -0.8908
Cell Significance Index: -6.9300
Cell Name: plasma cell (CL0000786)
Fold Change: -0.9005
Cell Significance Index: -10.0600
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: -0.9079
Cell Significance Index: -7.4500
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.9082
Cell Significance Index: -9.6300
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.9155
Cell Significance Index: -10.1400
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.9225
Cell Significance Index: -9.3600
Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.9279
Cell Significance Index: -10.0600
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -0.9308
Cell Significance Index: -9.6500
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.9491
Cell Significance Index: -12.3900
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.9535
Cell Significance Index: -11.0600
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.9599
Cell Significance Index: -13.9900
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: -0.9648
Cell Significance Index: -8.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** IGHV2-70 is a member of the immunoglobulin heavy chain family, which is essential for the production of antibodies. The gene is characterized by its unique structure, which allows it to interact with various ligands and signaling molecules. IGHV2-70 is expressed in a wide range of cell types, including those involved in innate immunity, such as neutrophils and macrophages. The gene's expression is tightly regulated, with its expression levels influenced by various factors, including cytokines and growth factors. **Pathways and Functions:** IGHV2-70 is involved in multiple signaling pathways, including: 1. **Antigen Binding and Uptake:** IGHV2-70 interacts with antigens, leading to the activation of B cell receptors and the subsequent generation of second messengers. 2. **Complement Cascade:** The gene plays a critical role in the regulation of the complement cascade, influencing the activation of complement proteins and the subsequent elimination of pathogens. 3. **Immune Response Regulation:** IGHV2-70 modulates immune responses by influencing the activation of B cell receptors, the regulation of complement cascades, and the modulation of cytokine production. 4. **Scavenger Receptor Signaling:** The gene interacts with scavenger receptors, influencing the binding and uptake of ligands by these receptors. 5. **FcεRI Signaling:** IGHV2-70 is involved in the signaling pathways of FcεRI, a receptor that plays a crucial role in the regulation of allergic responses. **Clinical Significance:** IGHV2-70 has significant implications for the treatment and management of various diseases, including: 1. **Leishmania Infections:** The gene's role in the regulation of immune responses and the elimination of Leishmania parasites makes it an attractive target for the development of novel therapeutic strategies. 2. **Allergic Diseases:** IGHV2-70's involvement in FcεRI signaling pathways makes it a potential target for the development of treatments for allergic diseases, such as asthma and atopic dermatitis. 3. **Cancer:** The gene's role in the regulation of immune responses and the modulation of cytokine production makes it a potential target for the development of immunotherapies for cancer. 4. **Infectious Diseases:** IGHV2-70's involvement in the regulation of complement cascades and the elimination of pathogens makes it a potential target for the development of novel therapeutic strategies for infectious diseases. In conclusion, IGHV2-70 is a critical component of the adaptive immune system, playing a pivotal role in the regulation of immune responses and the defense against pathogens. Further research is needed to fully understand the functions and significance of this gene, with potential implications for the treatment and management of various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.