Details for: IGHV1 58

Gene ID: 28464

Symbol: IGHV1 58

Ensembl ID: ENSG00000211968

Description: immunoglobulin heavy variable 1-58

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1239
    Cell Significance Index: 1.3900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0821
    Cell Significance Index: 1.0400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0542
    Cell Significance Index: 0.7600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0253
    Cell Significance Index: 0.3200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.0059
    Cell Significance Index: 0.0700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0017
    Cell Significance Index: -0.0300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0073
    Cell Significance Index: -0.0700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0098
    Cell Significance Index: -0.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0116
    Cell Significance Index: -1.5000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0127
    Cell Significance Index: -0.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0184
    Cell Significance Index: -1.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0199
    Cell Significance Index: -1.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0206
    Cell Significance Index: -0.9600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0222
    Cell Significance Index: -0.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0323
    Cell Significance Index: -0.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0376
    Cell Significance Index: -0.9600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0389
    Cell Significance Index: -0.4700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0396
    Cell Significance Index: -1.0100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0401
    Cell Significance Index: -0.5500
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0424
    Cell Significance Index: -0.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0454
    Cell Significance Index: -1.1000
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0463
    Cell Significance Index: -0.4700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0522
    Cell Significance Index: -0.7100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0563
    Cell Significance Index: -1.1000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0580
    Cell Significance Index: -0.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0584
    Cell Significance Index: -1.0800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0588
    Cell Significance Index: -0.6200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0597
    Cell Significance Index: -1.0200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0614
    Cell Significance Index: -0.7600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0673
    Cell Significance Index: -1.0900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0680
    Cell Significance Index: -0.7600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0688
    Cell Significance Index: -0.8600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0694
    Cell Significance Index: -0.8200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0731
    Cell Significance Index: -0.7700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0741
    Cell Significance Index: -1.2600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0775
    Cell Significance Index: -1.0300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0800
    Cell Significance Index: -1.0500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0812
    Cell Significance Index: -1.0600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0818
    Cell Significance Index: -0.8800
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0826
    Cell Significance Index: -0.5500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0833
    Cell Significance Index: -0.9800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0843
    Cell Significance Index: -0.9700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0859
    Cell Significance Index: -1.1300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0863
    Cell Significance Index: -1.0200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0866
    Cell Significance Index: -1.5300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0871
    Cell Significance Index: -0.9700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0887
    Cell Significance Index: -1.0900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0908
    Cell Significance Index: -1.3300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0912
    Cell Significance Index: -0.9700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0927
    Cell Significance Index: -0.7900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0930
    Cell Significance Index: -1.0700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0942
    Cell Significance Index: -1.0300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0945
    Cell Significance Index: -1.0700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0951
    Cell Significance Index: -1.0100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0952
    Cell Significance Index: -1.1300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0966
    Cell Significance Index: -1.0700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0974
    Cell Significance Index: -1.0500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0974
    Cell Significance Index: -1.4800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0977
    Cell Significance Index: -1.0600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0992
    Cell Significance Index: -1.6000
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0996
    Cell Significance Index: -1.0300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0997
    Cell Significance Index: -1.2000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1005
    Cell Significance Index: -0.9400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1009
    Cell Significance Index: -1.0300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1016
    Cell Significance Index: -0.9900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1020
    Cell Significance Index: -2.5500
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.1029
    Cell Significance Index: -1.0300
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.1034
    Cell Significance Index: -1.0100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1035
    Cell Significance Index: -1.4700
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.1044
    Cell Significance Index: -1.0300
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1045
    Cell Significance Index: -1.0800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1051
    Cell Significance Index: -1.3500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1052
    Cell Significance Index: -1.2800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1062
    Cell Significance Index: -1.0700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1064
    Cell Significance Index: -1.0800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1070
    Cell Significance Index: -1.5000
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.1072
    Cell Significance Index: -0.9500
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.1084
    Cell Significance Index: -1.0100
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1089
    Cell Significance Index: -1.0300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1092
    Cell Significance Index: -1.0900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1094
    Cell Significance Index: -1.1100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1106
    Cell Significance Index: -1.0300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1107
    Cell Significance Index: -1.0300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1110
    Cell Significance Index: -1.5300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1121
    Cell Significance Index: -1.0300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1129
    Cell Significance Index: -1.3100
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1131
    Cell Significance Index: -1.0100
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.1139
    Cell Significance Index: -1.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1144
    Cell Significance Index: -1.1000
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1149
    Cell Significance Index: -1.0300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1150
    Cell Significance Index: -1.0900
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1162
    Cell Significance Index: -1.0300
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.1170
    Cell Significance Index: -0.9400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1179
    Cell Significance Index: -1.0500
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1187
    Cell Significance Index: -1.0300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1193
    Cell Significance Index: -1.1200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1193
    Cell Significance Index: -1.3000
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1212
    Cell Significance Index: -1.2800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1219
    Cell Significance Index: -1.4500
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1232
    Cell Significance Index: -0.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Location and Function:** The IGHV1 58 gene is located on chromosome 14q32.33 and encodes for the heavy chain of immunoglobulins. The gene is responsible for producing the variable region of the heavy chain, which is critical for antigen recognition and binding. 2. **Expression Pattern:** The IGHV1 58 gene is expressed in a wide range of immune cells, including macrophages, granulocytes, and T lymphocytes. This expression pattern suggests that the gene plays a key role in the immune response against various pathogens. 3. **Gene Structure:** The IGHV1 58 gene consists of three exons and is rearranged during B cell development to produce a diverse repertoire of immunoglobulins. 4. **Evolutionary Conservation:** The IGHV1 58 gene is conserved across different species, including humans, mice, and birds, indicating its importance in the evolution of the immune system. **Pathways and Functions:** 1. **Antigen Binding:** The IGHV1 58 gene plays a critical role in antigen binding, which is the first step in the immune response. The heavy chain of immunoglobulins recognizes and binds to specific antigens, triggering a cascade of downstream signaling events. 2. **Immunoglobulin Complex Pathway:** The IGHV1 58 gene is part of the Immunoglobulin complex pathway, which is essential for the recognition and elimination of pathogens. This pathway involves the interaction between immunoglobulins and their receptors, leading to the activation of immune cells. 3. **Cytokine Production:** The IGHV1 58 gene is also involved in the production of cytokines, which are signaling molecules that coordinate the immune response. Cytokines produced by immune cells recognize specific antigens and trigger an inflammatory response. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations in the IGHV1 58 gene can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). This condition is characterized by a lack of immunoglobulins and impaired immune function. 2. **Autoimmune Diseases:** Dysregulation of the IGHV1 58 gene can contribute to autoimmune diseases, such as rheumatoid arthritis and lupus. In these conditions, the immune system produces antibodies that target self-antigens, leading to tissue damage and inflammation. 3. **Cancer Immunotherapy:** The IGHV1 58 gene is also being explored as a target for cancer immunotherapy. By engineering T cells to recognize and bind to specific cancer antigens, researchers aim to enhance the immune response against cancer cells. In conclusion, the IGHV1 58 gene plays a critical role in the immune system, encoding for the heavy chain of immunoglobulins that recognize and bind to specific antigens. Its expression pattern and evolutionary conservation highlight its importance in the immune response. Further research into the IGHV1 58 gene has the potential to reveal new insights into immunodeficiency disorders, autoimmune diseases, and cancer immunotherapy.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.