Details for: TRBV30

Gene ID: 28557

Symbol: TRBV30

Ensembl ID: ENSG00000237254

Description: T cell receptor beta variable 30

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.6565
    Cell Significance Index: 3.5800
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.5912
    Cell Significance Index: 4.9000
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.5911
    Cell Significance Index: 5.5600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.5185
    Cell Significance Index: 5.8000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1792
    Cell Significance Index: 1.6500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.1515
    Cell Significance Index: 0.9400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0963
    Cell Significance Index: 1.3200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0953
    Cell Significance Index: 2.3800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.0812
    Cell Significance Index: 0.2500
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0786
    Cell Significance Index: 0.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0208
    Cell Significance Index: 1.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0063
    Cell Significance Index: 0.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0014
    Cell Significance Index: 0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0021
    Cell Significance Index: -1.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0025
    Cell Significance Index: -0.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0030
    Cell Significance Index: -1.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0054
    Cell Significance Index: -0.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0077
    Cell Significance Index: -1.5400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0091
    Cell Significance Index: -0.1300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0097
    Cell Significance Index: -0.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0125
    Cell Significance Index: -1.7200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0139
    Cell Significance Index: -0.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0182
    Cell Significance Index: -2.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0209
    Cell Significance Index: -0.5600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0255
    Cell Significance Index: -0.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0268
    Cell Significance Index: -2.0000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0309
    Cell Significance Index: -0.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0310
    Cell Significance Index: -1.7400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0314
    Cell Significance Index: -0.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0331
    Cell Significance Index: -0.9000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0336
    Cell Significance Index: -0.4200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0430
    Cell Significance Index: -0.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0437
    Cell Significance Index: -1.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0440
    Cell Significance Index: -1.4000
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0440
    Cell Significance Index: -0.5100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0448
    Cell Significance Index: -0.6100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0449
    Cell Significance Index: -0.5300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0464
    Cell Significance Index: -0.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0464
    Cell Significance Index: -1.5200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0465
    Cell Significance Index: -0.7900
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0480
    Cell Significance Index: -0.3300
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0485
    Cell Significance Index: -0.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0487
    Cell Significance Index: -2.2700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0516
    Cell Significance Index: -0.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0517
    Cell Significance Index: -1.3600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0522
    Cell Significance Index: -0.7700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0544
    Cell Significance Index: -0.8000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0545
    Cell Significance Index: -0.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0605
    Cell Significance Index: -1.3100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0609
    Cell Significance Index: -1.5200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0612
    Cell Significance Index: -1.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0622
    Cell Significance Index: -1.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0625
    Cell Significance Index: -1.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0634
    Cell Significance Index: -1.8700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0645
    Cell Significance Index: -0.7000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0648
    Cell Significance Index: -0.8900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0685
    Cell Significance Index: -1.4800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0707
    Cell Significance Index: -0.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0739
    Cell Significance Index: -0.7100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0747
    Cell Significance Index: -1.2100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0768
    Cell Significance Index: -1.1200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0772
    Cell Significance Index: -1.5500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0787
    Cell Significance Index: -1.6700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0790
    Cell Significance Index: -0.6400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0798
    Cell Significance Index: -0.6800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0802
    Cell Significance Index: -0.7600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0803
    Cell Significance Index: -1.5800
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0817
    Cell Significance Index: -0.8900
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.0831
    Cell Significance Index: -0.8800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0842
    Cell Significance Index: -1.6700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0842
    Cell Significance Index: -1.0600
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0846
    Cell Significance Index: -0.9400
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0861
    Cell Significance Index: -1.0900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0880
    Cell Significance Index: -1.2200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0901
    Cell Significance Index: -1.5400
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0909
    Cell Significance Index: -0.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0926
    Cell Significance Index: -1.5500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0927
    Cell Significance Index: -1.2000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0928
    Cell Significance Index: -0.7300
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0933
    Cell Significance Index: -0.8500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0935
    Cell Significance Index: -0.9700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0936
    Cell Significance Index: -1.8300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0953
    Cell Significance Index: -1.1900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0971
    Cell Significance Index: -1.0300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1015
    Cell Significance Index: -1.2000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1028
    Cell Significance Index: -1.2200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1043
    Cell Significance Index: -1.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1044
    Cell Significance Index: -1.9300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1101
    Cell Significance Index: -0.9500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1105
    Cell Significance Index: -1.4200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1114
    Cell Significance Index: -1.1300
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1128
    Cell Significance Index: -0.9700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1139
    Cell Significance Index: -1.7300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1151
    Cell Significance Index: -1.5200
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1183
    Cell Significance Index: -0.8800
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1185
    Cell Significance Index: -0.9900
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.1202
    Cell Significance Index: -1.2200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1231
    Cell Significance Index: -1.2000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1231
    Cell Significance Index: -1.6200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1232
    Cell Significance Index: -1.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV30 is a member of the T cell receptor beta (TRBV) family, which encodes the variable region of the TCR beta chain. This gene is characterized by its unique sequence and structure, which enables it to interact with the TCR alpha chain and other components of the TCR complex. The expression of TRBV30 is restricted to specific cell types, including alpha-beta T cells, effector CD8-positive T cells, and certain progenitor cells. Its expression in goblet cells, intestinal crypt stem cells, and other non-immune cells suggests a broader role in tissue homeostasis and immune regulation. **Pathways and Functions:** TRBV30 is involved in the adaptive immune response, specifically in the recognition and activation of T cells. The TCR complex, of which TRBV30 is a part, recognizes and binds to specific antigens, triggering a series of signaling events that lead to T cell activation, proliferation, and differentiation. The TRBV30 gene contributes to the diversity of the TCR repertoire, enabling the immune system to recognize a wide range of antigens. Additionally, TRBV30 may play a role in the regulation of immune responses, including the modulation of T cell activation and the maintenance of immune homeostasis. **Clinical Significance:** The TRBV30 gene has significant implications for our understanding of immune-related disorders and cancer. Its expression in neoplastic and abnormal cells suggests that TRBV30 may contribute to tumorigenesis or tumor progression. Furthermore, the gene's role in the adaptive immune response highlights its potential as a target for immunotherapeutic interventions. Research into TRBV30 may also provide insights into the development of personalized cancer therapies and the modulation of immune responses in autoimmune diseases. In conclusion, the TRBV30 gene is a crucial component of the adaptive immune system, contributing to the diversity and specificity of T cell responses. Its expression in various cell types highlights its broader role in tissue homeostasis and immune regulation. Further research into TRBV30 may shed light on its clinical significance and potential applications in immunotherapy and cancer treatment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.