Details for: TRBV15

Gene ID: 28572

Symbol: TRBV15

Ensembl ID: ENSG00000276819

Description: T cell receptor beta variable 15

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5970
    Cell Significance Index: 7.7300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1192
    Cell Significance Index: 0.6500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.0840
    Cell Significance Index: 0.4500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0214
    Cell Significance Index: 0.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0090
    Cell Significance Index: -1.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0159
    Cell Significance Index: -1.8200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0248
    Cell Significance Index: -0.2100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0293
    Cell Significance Index: -0.7100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0298
    Cell Significance Index: -0.5100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0350
    Cell Significance Index: -0.5900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0356
    Cell Significance Index: -0.4500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0373
    Cell Significance Index: -0.3400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0404
    Cell Significance Index: -0.5500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0423
    Cell Significance Index: -0.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0430
    Cell Significance Index: -2.0200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0433
    Cell Significance Index: -0.6300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0435
    Cell Significance Index: -0.7500
  • Cell Name: lung interstitial macrophage (CL4033043)
    Fold Change: -0.0439
    Cell Significance Index: -0.4200
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0455
    Cell Significance Index: -0.4000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0604
    Cell Significance Index: -0.6100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0616
    Cell Significance Index: -1.5700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0620
    Cell Significance Index: -0.5800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0669
    Cell Significance Index: -0.5700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0707
    Cell Significance Index: -0.6700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0737
    Cell Significance Index: -0.9700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0798
    Cell Significance Index: -0.8100
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0800
    Cell Significance Index: -0.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0812
    Cell Significance Index: -0.7800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0819
    Cell Significance Index: -1.6200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0846
    Cell Significance Index: -1.1600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0877
    Cell Significance Index: -1.4200
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0892
    Cell Significance Index: -0.7600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0895
    Cell Significance Index: -1.1700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0918
    Cell Significance Index: -1.8000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0926
    Cell Significance Index: -0.7500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0943
    Cell Significance Index: -1.1200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0988
    Cell Significance Index: -1.0500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0991
    Cell Significance Index: -1.1500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0992
    Cell Significance Index: -1.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0996
    Cell Significance Index: -1.8400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0997
    Cell Significance Index: -0.8600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1001
    Cell Significance Index: -1.2300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1002
    Cell Significance Index: -1.2700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1012
    Cell Significance Index: -0.8700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1019
    Cell Significance Index: -0.8600
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1047
    Cell Significance Index: -0.7200
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1050
    Cell Significance Index: -0.8700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1086
    Cell Significance Index: -1.6500
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.1131
    Cell Significance Index: -1.0500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1132
    Cell Significance Index: -1.6500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1133
    Cell Significance Index: -1.6100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1138
    Cell Significance Index: -1.8300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1141
    Cell Significance Index: -1.1500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1144
    Cell Significance Index: -1.3000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1147
    Cell Significance Index: -1.3500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1159
    Cell Significance Index: -1.3900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1164
    Cell Significance Index: -1.3400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1167
    Cell Significance Index: -1.2100
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1173
    Cell Significance Index: -1.2200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1176
    Cell Significance Index: -1.3300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1178
    Cell Significance Index: -1.2700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1181
    Cell Significance Index: -1.2700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1184
    Cell Significance Index: -1.6600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1223
    Cell Significance Index: -1.2900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1234
    Cell Significance Index: -1.6200
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1244
    Cell Significance Index: -1.1300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1247
    Cell Significance Index: -1.3500
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1250
    Cell Significance Index: -1.0500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1296
    Cell Significance Index: -1.7800
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1297
    Cell Significance Index: -1.3600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1307
    Cell Significance Index: -1.4300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1316
    Cell Significance Index: -1.6000
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.1328
    Cell Significance Index: -1.4500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1331
    Cell Significance Index: -1.4500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1339
    Cell Significance Index: -1.7200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1361
    Cell Significance Index: -1.1900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1363
    Cell Significance Index: -1.2800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1364
    Cell Significance Index: -1.7800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1371
    Cell Significance Index: -1.6300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1371
    Cell Significance Index: -1.3000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1373
    Cell Significance Index: -1.2700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1373
    Cell Significance Index: -1.6700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1383
    Cell Significance Index: -1.3800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1402
    Cell Significance Index: -1.4300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1413
    Cell Significance Index: -1.6700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1435
    Cell Significance Index: -1.4600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1445
    Cell Significance Index: -1.6000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1459
    Cell Significance Index: -1.5500
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1470
    Cell Significance Index: -1.4500
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1474
    Cell Significance Index: -1.4400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1477
    Cell Significance Index: -1.7500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1498
    Cell Significance Index: -1.1700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1503
    Cell Significance Index: -1.7300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1522
    Cell Significance Index: -1.7000
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1527
    Cell Significance Index: -1.7100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1544
    Cell Significance Index: -1.7800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1558
    Cell Significance Index: -2.0700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1560
    Cell Significance Index: -1.6600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1570
    Cell Significance Index: -1.2000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1577
    Cell Significance Index: -1.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene location and structure:** TRBV15 is located on chromosome 7q35.3 and is part of the TCR beta variable family, which consists of approximately 40 beta chain variable regions. 2. **Expression patterns:** TRBV15 is expressed in various immune cells, including effector CD8-positive T cells, central memory CD4-positive T cells, hematopoietic stem cells, mast cells, and precursor B cells. 3. **Molecular weight:** The TRBV15 protein has a molecular weight of approximately 34 kDa. 4. **Sequence conservation:** TRBV15 exhibits high sequence conservation across different species, indicating its evolutionary conservation. **Pathways and Functions:** TRBV15 plays a critical role in the development and function of T cells, which are essential for the adaptive immune response. The TCR complex, including TRBV15, recognizes and binds to specific antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). This interaction triggers a signaling cascade that activates T cell proliferation, differentiation, and effector functions. The TCR complex, including TRBV15, is composed of two chains: alpha (α) and beta (β). The α chain is responsible for antigen recognition, while the β chain mediates signal transduction and T cell activation. TRBV15, as a beta chain variable region, contributes to the diversity and specificity of the TCR complex. **Clinical Significance:** Dysregulation of TRBV15 expression has been implicated in various immune-mediated diseases, including: 1. **Autoimmune disorders:** Altered TRBV15 expression has been linked to autoimmune diseases such as multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. 2. **Cancer:** TRBV15 has been identified as a potential biomarker for cancer diagnosis and prognostication, particularly in T cell-related malignancies. 3. **Infectious diseases:** TRBV15 may play a role in the recognition and elimination of pathogens, as evidenced by its expression in effector CD8-positive T cells and central memory CD4-positive T cells. In conclusion, TRBV15 is a critical component of the TCR complex, which plays a pivotal role in the adaptive immune response. Its diverse expression patterns and functional significance highlight its importance in immune-mediated diseases. Further research is necessary to elucidate the mechanisms underlying TRBV15-mediated immune responses and to explore its potential as a therapeutic target for autoimmune and cancer therapies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.