Details for: TRBV15

Gene ID: 28572

Symbol: TRBV15

Ensembl ID: ENSG00000276819

Description: T cell receptor beta variable 15

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.89
    Marker Score: 752
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.59
    Marker Score: 634
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.39
    Marker Score: 207
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.38
    Marker Score: 218
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.27
    Marker Score: 465
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.27
    Marker Score: 112
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.26
    Marker Score: 225
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.25
    Marker Score: 223
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.22
    Marker Score: 143
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.19
    Marker Score: 346
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.15
    Marker Score: 128
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.15
    Marker Score: 473
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.11
    Marker Score: 48
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.08
    Marker Score: 75
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.08
    Marker Score: 62
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.07
    Marker Score: 135
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.06
    Marker Score: 85
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.06
    Marker Score: 66
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.05
    Marker Score: 232
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.05
    Marker Score: 2,809
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.05
    Marker Score: 56
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.05
    Marker Score: 565
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.05
    Marker Score: 38
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.05
    Marker Score: 118
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.05
    Marker Score: 40
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.04
    Marker Score: 132
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.04
    Marker Score: 114
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.04
    Marker Score: 66
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.04
    Marker Score: 89
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.03
    Marker Score: 338
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.03
    Marker Score: 131
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 36
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0
    Marker Score: 19
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 88
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 15

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene location and structure:** TRBV15 is located on chromosome 7q35.3 and is part of the TCR beta variable family, which consists of approximately 40 beta chain variable regions. 2. **Expression patterns:** TRBV15 is expressed in various immune cells, including effector CD8-positive T cells, central memory CD4-positive T cells, hematopoietic stem cells, mast cells, and precursor B cells. 3. **Molecular weight:** The TRBV15 protein has a molecular weight of approximately 34 kDa. 4. **Sequence conservation:** TRBV15 exhibits high sequence conservation across different species, indicating its evolutionary conservation. **Pathways and Functions:** TRBV15 plays a critical role in the development and function of T cells, which are essential for the adaptive immune response. The TCR complex, including TRBV15, recognizes and binds to specific antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). This interaction triggers a signaling cascade that activates T cell proliferation, differentiation, and effector functions. The TCR complex, including TRBV15, is composed of two chains: alpha (α) and beta (β). The α chain is responsible for antigen recognition, while the β chain mediates signal transduction and T cell activation. TRBV15, as a beta chain variable region, contributes to the diversity and specificity of the TCR complex. **Clinical Significance:** Dysregulation of TRBV15 expression has been implicated in various immune-mediated diseases, including: 1. **Autoimmune disorders:** Altered TRBV15 expression has been linked to autoimmune diseases such as multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. 2. **Cancer:** TRBV15 has been identified as a potential biomarker for cancer diagnosis and prognostication, particularly in T cell-related malignancies. 3. **Infectious diseases:** TRBV15 may play a role in the recognition and elimination of pathogens, as evidenced by its expression in effector CD8-positive T cells and central memory CD4-positive T cells. In conclusion, TRBV15 is a critical component of the TCR complex, which plays a pivotal role in the adaptive immune response. Its diverse expression patterns and functional significance highlight its importance in immune-mediated diseases. Further research is necessary to elucidate the mechanisms underlying TRBV15-mediated immune responses and to explore its potential as a therapeutic target for autoimmune and cancer therapies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.