Details for: TRBV11 3

Gene ID: 28580

Symbol: TRBV11 3

Ensembl ID: ENSG00000276597

Description: T cell receptor beta variable 11-3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3242
    Cell Significance Index: 4.7300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2494
    Cell Significance Index: 1.3600
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.0639
    Cell Significance Index: 0.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0016
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0031
    Cell Significance Index: -0.5300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0047
    Cell Significance Index: -0.0600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0059
    Cell Significance Index: -0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0078
    Cell Significance Index: -1.5600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0103
    Cell Significance Index: -0.1800
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0145
    Cell Significance Index: -0.1000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0184
    Cell Significance Index: -0.2500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0195
    Cell Significance Index: -0.2300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0223
    Cell Significance Index: -0.5400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0374
    Cell Significance Index: -0.3500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0387
    Cell Significance Index: -0.3300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0396
    Cell Significance Index: -0.4000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0522
    Cell Significance Index: -1.3300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0548
    Cell Significance Index: -0.5200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0695
    Cell Significance Index: -0.6000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0729
    Cell Significance Index: -0.7400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0737
    Cell Significance Index: -1.2600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0739
    Cell Significance Index: -1.4500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0741
    Cell Significance Index: -1.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0760
    Cell Significance Index: -2.0300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0780
    Cell Significance Index: -0.8500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0820
    Cell Significance Index: -1.1500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0846
    Cell Significance Index: -1.3700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0859
    Cell Significance Index: -1.0200
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0861
    Cell Significance Index: -0.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0895
    Cell Significance Index: -0.8600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0943
    Cell Significance Index: -0.8300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0947
    Cell Significance Index: -0.9500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0948
    Cell Significance Index: -1.1000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0952
    Cell Significance Index: -1.1700
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0963
    Cell Significance Index: -0.8900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0966
    Cell Significance Index: -1.2500
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0973
    Cell Significance Index: -0.9000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0983
    Cell Significance Index: -0.9900
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0987
    Cell Significance Index: -0.8300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0995
    Cell Significance Index: -0.8400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1014
    Cell Significance Index: -1.5400
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1031
    Cell Significance Index: -0.8400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1049
    Cell Significance Index: -1.3700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1050
    Cell Significance Index: -1.2500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1056
    Cell Significance Index: -1.3600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1078
    Cell Significance Index: -1.2400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1105
    Cell Significance Index: -1.4200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1109
    Cell Significance Index: -1.4600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1113
    Cell Significance Index: -1.4600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1113
    Cell Significance Index: -1.1800
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1117
    Cell Significance Index: -1.0100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1118
    Cell Significance Index: -1.1600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1121
    Cell Significance Index: -1.4900
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.1126
    Cell Significance Index: -1.2300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1129
    Cell Significance Index: -1.2300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1133
    Cell Significance Index: -1.2600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1139
    Cell Significance Index: -1.1100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1150
    Cell Significance Index: -1.2400
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.1151
    Cell Significance Index: -1.2300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1155
    Cell Significance Index: -1.3700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1164
    Cell Significance Index: -1.3700
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1166
    Cell Significance Index: -1.2300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1178
    Cell Significance Index: -1.2200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1182
    Cell Significance Index: -1.3600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1183
    Cell Significance Index: -1.3100
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1189
    Cell Significance Index: -1.0800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1192
    Cell Significance Index: -1.1900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1192
    Cell Significance Index: -1.4500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1193
    Cell Significance Index: -1.2100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1193
    Cell Significance Index: -1.4900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1207
    Cell Significance Index: -1.3600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1210
    Cell Significance Index: -1.4300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1214
    Cell Significance Index: -1.6800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1226
    Cell Significance Index: -1.3700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1226
    Cell Significance Index: -1.4700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1237
    Cell Significance Index: -1.3700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1237
    Cell Significance Index: -1.5100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1257
    Cell Significance Index: -1.4600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1260
    Cell Significance Index: -0.9800
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.1261
    Cell Significance Index: -1.2800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1264
    Cell Significance Index: -1.0100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1275
    Cell Significance Index: -1.4700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1278
    Cell Significance Index: -1.3600
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1291
    Cell Significance Index: -1.1000
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1291
    Cell Significance Index: -1.2400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1292
    Cell Significance Index: -1.3600
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1312
    Cell Significance Index: -1.3600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1322
    Cell Significance Index: -1.4000
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1330
    Cell Significance Index: -1.3000
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1330
    Cell Significance Index: -1.2200
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1371
    Cell Significance Index: -1.0200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1374
    Cell Significance Index: -1.2900
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1409
    Cell Significance Index: -1.4500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1428
    Cell Significance Index: -1.3300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1430
    Cell Significance Index: -1.4600
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.1470
    Cell Significance Index: -1.2000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1487
    Cell Significance Index: -1.5800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1505
    Cell Significance Index: -1.3400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1505
    Cell Significance Index: -1.2500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1509
    Cell Significance Index: -1.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **TRBV11-3 is a member of the TRB family**: This gene belongs to the T cell receptor beta family, which is essential for recognizing and binding to antigens presented by major histocompatibility complex (MHC) molecules. 2. **Significant expression in various cell types**: TRBV11-3 is expressed in goblet cells, neoplastic cells, abnormal cells, absorptive cells, intestinal crypt stem cells, transit amplifying cells, lymphocytes, brush cells, intestinal epithelial cells, and effector CD8-positive, alpha-beta T cells. 3. **Adaptive immune response involvement**: TRBV11-3 is involved in the adaptive immune response, which is a specific and targeted response to antigens. **Pathways and Functions:** 1. **Cell surface receptor signaling pathway**: TRBV11-3 is part of the T cell receptor complex, which is a crucial component of the adaptive immune response. The T cell receptor complex recognizes and binds to antigens presented by MHC molecules, triggering a signaling cascade that leads to the activation of T cells. 2. **Adaptive immune response**: TRBV11-3 is involved in the adaptive immune response, which is a specific and targeted response to antigens. This response is characterized by the activation of T cells, which then recognize and eliminate infected cells or foreign substances. 3. **Cell surface receptor signaling**: TRBV11-3 is involved in cell surface receptor signaling, which is a crucial process for cell-cell interactions and communication. **Clinical Significance:** 1. **Immunotherapies**: Understanding the functions and pathways of TRBV11-3 can lead to the development of novel immunotherapies for cancer and infectious diseases. 2. **Autoimmune diseases**: TRBV11-3 may play a role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where the adaptive immune response is dysregulated. 3. **Cancer research**: TRBV11-3 is expressed in neoplastic cells and may be involved in the development and progression of cancer. 4. **Gastrointestinal diseases**: TRBV11-3 is expressed in intestinal epithelial cells and may be involved in gastrointestinal diseases, such as inflammatory bowel disease. In conclusion, TRBV11-3 is a critical component of the adaptive immune response, influencing cell surface receptor signaling and the recognition of antigens presented by MHC molecules. Its involvement in various diseases, including cancer and autoimmune disorders, highlights the importance of understanding its functions and pathways. Further research is necessary to fully elucidate the role of TRBV11-3 in the immune system and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.