Details for: TRBV11 1

Gene ID: 28582

Symbol: TRBV11 1

Ensembl ID: ENSG00000211720

Description: T cell receptor beta variable 11-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0899
    Cell Significance Index: 0.4900
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.0378
    Cell Significance Index: 0.2600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0064
    Cell Significance Index: 0.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0027
    Cell Significance Index: -0.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0040
    Cell Significance Index: -0.8000
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0058
    Cell Significance Index: -0.0500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0103
    Cell Significance Index: -0.1500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0111
    Cell Significance Index: -0.0900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0130
    Cell Significance Index: -0.1700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0158
    Cell Significance Index: -0.1600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0169
    Cell Significance Index: -0.4100
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0181
    Cell Significance Index: -0.1500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0195
    Cell Significance Index: -0.2300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0287
    Cell Significance Index: -0.3900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0300
    Cell Significance Index: -0.2300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0342
    Cell Significance Index: -0.3200
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0345
    Cell Significance Index: -0.3100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0364
    Cell Significance Index: -0.3100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0449
    Cell Significance Index: -1.1500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0498
    Cell Significance Index: -0.4300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0517
    Cell Significance Index: -0.4900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0559
    Cell Significance Index: -0.5800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0565
    Cell Significance Index: -0.8200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0583
    Cell Significance Index: -0.7600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0585
    Cell Significance Index: -0.7900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0604
    Cell Significance Index: -1.1800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0608
    Cell Significance Index: -0.8000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0626
    Cell Significance Index: -0.7900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0641
    Cell Significance Index: -0.8100
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0652
    Cell Significance Index: -0.5500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0654
    Cell Significance Index: -0.6900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0660
    Cell Significance Index: -0.6700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0663
    Cell Significance Index: -0.5700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0663
    Cell Significance Index: -0.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0671
    Cell Significance Index: -1.2400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0690
    Cell Significance Index: -0.7900
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0692
    Cell Significance Index: -0.7900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0715
    Cell Significance Index: -0.8500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0725
    Cell Significance Index: -0.7900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0729
    Cell Significance Index: -1.1800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0733
    Cell Significance Index: -0.5700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0737
    Cell Significance Index: -0.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0749
    Cell Significance Index: -0.7200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0750
    Cell Significance Index: -0.8700
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0756
    Cell Significance Index: -0.8400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0774
    Cell Significance Index: -0.7800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0789
    Cell Significance Index: -0.6900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0801
    Cell Significance Index: -1.3700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0803
    Cell Significance Index: -0.6800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0807
    Cell Significance Index: -0.8700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0832
    Cell Significance Index: -1.1100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0843
    Cell Significance Index: -1.2800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0858
    Cell Significance Index: -0.9100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0893
    Cell Significance Index: -1.0600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0897
    Cell Significance Index: -0.9100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0921
    Cell Significance Index: -0.8700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0929
    Cell Significance Index: -1.3200
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0940
    Cell Significance Index: -1.0300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0942
    Cell Significance Index: -0.8500
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0949
    Cell Significance Index: -0.8300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0949
    Cell Significance Index: -0.9000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0950
    Cell Significance Index: -1.2200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0962
    Cell Significance Index: -0.8900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0973
    Cell Significance Index: -1.1200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0999
    Cell Significance Index: -1.1800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1003
    Cell Significance Index: -0.8300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1005
    Cell Significance Index: -1.3800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1011
    Cell Significance Index: -1.3200
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.1023
    Cell Significance Index: -0.9500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1025
    Cell Significance Index: -1.2600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1026
    Cell Significance Index: -1.2300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1033
    Cell Significance Index: -0.9100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1071
    Cell Significance Index: -1.5800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1081
    Cell Significance Index: -1.3500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1092
    Cell Significance Index: -1.2900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1092
    Cell Significance Index: -0.8400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1094
    Cell Significance Index: -1.3200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1099
    Cell Significance Index: -1.3400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1102
    Cell Significance Index: -1.2200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1102
    Cell Significance Index: -1.2200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1104
    Cell Significance Index: -1.2700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1109
    Cell Significance Index: -1.1800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1111
    Cell Significance Index: -1.1800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1121
    Cell Significance Index: -1.1800
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.1125
    Cell Significance Index: -0.7800
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1129
    Cell Significance Index: -0.8400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1162
    Cell Significance Index: -1.1600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1168
    Cell Significance Index: -1.3900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1171
    Cell Significance Index: -1.3200
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1172
    Cell Significance Index: -1.0700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1180
    Cell Significance Index: -1.1500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1182
    Cell Significance Index: -1.3200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1201
    Cell Significance Index: -1.3000
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1225
    Cell Significance Index: -1.2600
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1267
    Cell Significance Index: -1.0800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1273
    Cell Significance Index: -1.3000
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1283
    Cell Significance Index: -1.3300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1284
    Cell Significance Index: -1.3300
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.1311
    Cell Significance Index: -0.3400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1321
    Cell Significance Index: -1.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The TRBV11-1 gene is a member of the TRBV family, which comprises a diverse set of beta variable regions that contribute to the diversity of the TCR repertoire. The TRBV11-1 gene is characterized by its specificity for recognizing antigens presented by major histocompatibility complex (MHC) class I molecules. This specificity is determined by the unique combination of alpha and beta chains that form the TCR complex. The TRBV11-1 gene is also notable for its expression in various T cell subsets, highlighting its versatility in responding to diverse pathogens and antigens. **Pathways and Functions** The TRBV11-1 gene is involved in several key pathways and functions, including: 1. **Adaptive Immune Response**: The TRBV11-1 gene contributes to the adaptive immune response by enabling T cells to recognize and respond to specific antigens. This recognition is mediated by the TCR complex, which interacts with MHC class I molecules on antigen-presenting cells. 2. **Cell Surface Receptor Signaling Pathway**: The TRBV11-1 gene is part of the cell surface receptor signaling pathway, where it interacts with co-receptors and other signaling molecules to trigger T cell activation and proliferation. 3. **Plasma Membrane**: The TRBV11-1 gene is embedded in the plasma membrane of T cells, where it plays a critical role in recognizing and binding to antigens. 4. **T Cell Receptor Complex**: The TRBV11-1 gene is part of the T cell receptor complex, which is composed of alpha, beta, and gamma chains. This complex is responsible for recognizing and binding to specific antigens. **Clinical Significance** The TRBV11-1 gene has significant clinical implications, particularly in the context of immune-related disorders. Abnormalities in the TRBV11-1 gene have been associated with various diseases, including: 1. **Immunodeficiency Disorders**: Mutations in the TRBV11-1 gene can lead to immunodeficiency disorders, characterized by impaired T cell function and increased susceptibility to infections. 2. **Autoimmune Diseases**: Alterations in the TRBV11-1 gene have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where the immune system mistakenly attacks the body's own tissues. 3. **Cancer**: The TRBV11-1 gene has been implicated in cancer, where it may contribute to the development and progression of tumors by promoting T cell activation and proliferation. In conclusion, the TRBV11-1 gene plays a critical role in the adaptive immune response, enabling T cells to recognize and respond to specific antigens. Its significance extends to various diseases, highlighting the importance of understanding the molecular mechanisms underlying immune function and dysfunction.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.