Details for: TRBV7 6

Gene ID: 28592

Symbol: TRBV7 6

Ensembl ID: ENSG00000211727

Description: T cell receptor beta variable 7-6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.2348
    Cell Significance Index: 13.8000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.7607
    Cell Significance Index: 8.9900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.7006
    Cell Significance Index: 3.8200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4106
    Cell Significance Index: 4.4200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2618
    Cell Significance Index: 3.5900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1350
    Cell Significance Index: 1.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0346
    Cell Significance Index: 0.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0149
    Cell Significance Index: -2.9800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0177
    Cell Significance Index: -0.1600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0188
    Cell Significance Index: -0.3200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0191
    Cell Significance Index: -0.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0215
    Cell Significance Index: -3.8700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0219
    Cell Significance Index: -0.3200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0280
    Cell Significance Index: -0.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0314
    Cell Significance Index: -3.8600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0493
    Cell Significance Index: -0.4200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0520
    Cell Significance Index: -1.2600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0584
    Cell Significance Index: -0.5900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0593
    Cell Significance Index: -0.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0719
    Cell Significance Index: -2.2900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0803
    Cell Significance Index: -0.9500
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0857
    Cell Significance Index: -0.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0907
    Cell Significance Index: -4.1100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1039
    Cell Significance Index: -0.9900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1196
    Cell Significance Index: -2.3700
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1300
    Cell Significance Index: -1.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1336
    Cell Significance Index: -2.8400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1347
    Cell Significance Index: -1.2600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1375
    Cell Significance Index: -1.8100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1395
    Cell Significance Index: -1.2000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1456
    Cell Significance Index: -2.5100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1478
    Cell Significance Index: -1.5000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1484
    Cell Significance Index: -3.7800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1484
    Cell Significance Index: -1.9200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1626
    Cell Significance Index: -1.9300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1648
    Cell Significance Index: -1.6600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1697
    Cell Significance Index: -2.9000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1721
    Cell Significance Index: -2.1500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1781
    Cell Significance Index: -2.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1845
    Cell Significance Index: -3.4100
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1856
    Cell Significance Index: -1.6700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1944
    Cell Significance Index: -3.8000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1967
    Cell Significance Index: -3.1900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2005
    Cell Significance Index: -1.5600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2012
    Cell Significance Index: -2.5400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.2016
    Cell Significance Index: -1.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2033
    Cell Significance Index: -3.4200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2054
    Cell Significance Index: -1.9000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2063
    Cell Significance Index: -1.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2096
    Cell Significance Index: -2.0200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2113
    Cell Significance Index: -3.1200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2130
    Cell Significance Index: -2.3300
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2170
    Cell Significance Index: -3.4900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2189
    Cell Significance Index: -3.1900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2278
    Cell Significance Index: -3.4600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2281
    Cell Significance Index: -2.9300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2343
    Cell Significance Index: -2.8800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2404
    Cell Significance Index: -2.4100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2422
    Cell Significance Index: -2.8100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2478
    Cell Significance Index: -2.7000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2485
    Cell Significance Index: -3.2000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2536
    Cell Significance Index: -2.7500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2538
    Cell Significance Index: -2.9200
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.2552
    Cell Significance Index: -2.8600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2576
    Cell Significance Index: -3.3800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2594
    Cell Significance Index: -2.6900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2625
    Cell Significance Index: -3.6800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2630
    Cell Significance Index: -3.2000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2632
    Cell Significance Index: -3.7400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2640
    Cell Significance Index: -3.1200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2650
    Cell Significance Index: -2.8100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.2664
    Cell Significance Index: -2.8300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2669
    Cell Significance Index: -3.2000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2671
    Cell Significance Index: -3.0100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.2675
    Cell Significance Index: -1.8400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2689
    Cell Significance Index: -3.5100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.2711
    Cell Significance Index: -2.5400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2755
    Cell Significance Index: -3.1700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.2765
    Cell Significance Index: -2.2100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2775
    Cell Significance Index: -2.8300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2785
    Cell Significance Index: -2.3500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2821
    Cell Significance Index: -2.8800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.2841
    Cell Significance Index: -2.3500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2842
    Cell Significance Index: -2.7700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2860
    Cell Significance Index: -3.4000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2863
    Cell Significance Index: -3.0200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2877
    Cell Significance Index: -3.4000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2880
    Cell Significance Index: -3.1900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2882
    Cell Significance Index: -3.2200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2887
    Cell Significance Index: -0.8800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2897
    Cell Significance Index: -2.9600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2898
    Cell Significance Index: -3.9800
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.2920
    Cell Significance Index: -2.4400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2933
    Cell Significance Index: -3.4900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2950
    Cell Significance Index: -3.1800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.2972
    Cell Significance Index: -2.7000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2992
    Cell Significance Index: -2.4700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2993
    Cell Significance Index: -3.4000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3040
    Cell Significance Index: -4.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV7-6 is a member of the TCR beta variable (TRBV) family, which comprises a diverse array of genes that encode the variable regions of the TCR beta chain. These genes are responsible for generating the immense diversity of the TCR repertoire, allowing for the recognition of a vast array of antigens. TRBV7-6, in particular, is characterized by its unique combination of amino acid sequences, which confer specificity and affinity for particular antigen-MHC (Major Histocompatibility Complex) interactions. **Pathways and Functions:** TRBV7-6 is integral to the adaptive immune response, which involves the coordinated action of various cell types, including T cells, B cells, and antigen-presenting cells. The TCR, including TRBV7-6, plays a central role in this process by recognizing and binding to peptide-MHC complexes on antigen-presenting cells. This binding event triggers a cascade of signaling events that ultimately lead to T cell activation, proliferation, and differentiation into effector cells. The TCR complex, including TRBV7-6, also interacts with co-receptors, such as CD4 and CD8, which modulate the strength and specificity of antigen recognition. Additionally, TRBV7-6 is involved in the regulation of T cell activation and tolerance, with implications for the prevention of autoimmune diseases and cancer. **Clinical Significance:** Dysregulation or aberrant expression of TRBV7-6 has been implicated in various immunological disorders, including autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. These conditions are characterized by an inappropriate activation of autoreactive T cells, which recognize self-antigens and trigger an immune response against the host. Furthermore, TRBV7-6 has been associated with an increased risk of certain cancers, including leukemia and lymphoma, where T cell dysfunction and aberrant antigen recognition contribute to tumorigenesis. Additionally, TRBV7-6 has been identified as a potential target for immunotherapy, with its unique amino acid sequences potentially conferring specificity and affinity for tumor-specific antigens. In conclusion, TRBV7-6 is a critical component of the adaptive immune system, with significant implications for our understanding of immunological disorders and cancer. Further research into the mechanisms of TRBV7-6 function and dysregulation is essential for the development of novel therapeutic strategies and the prevention of immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.