Details for: TRBV7 6

Gene ID: 28592

Symbol: TRBV7 6

Ensembl ID: ENSG00000211727

Description: T cell receptor beta variable 7-6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.36
    Marker Score: 1,566
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 2.21
    Marker Score: 1,268
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.96
    Marker Score: 1,651
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.23
    Marker Score: 1,328
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,691
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.01
    Marker Score: 893
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.88
    Marker Score: 443
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1,346
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.7
    Marker Score: 462
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 390
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 497
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.6
    Marker Score: 1,037
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 235
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 479
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.44
    Marker Score: 789
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.43
    Marker Score: 1,340
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 215
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.36
    Marker Score: 393
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.33
    Marker Score: 188
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.33
    Marker Score: 274
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.3
    Marker Score: 235
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.26
    Marker Score: 120
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.25
    Marker Score: 115
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.21
    Marker Score: 235
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.21
    Marker Score: 157
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.19
    Marker Score: 115
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.19
    Marker Score: 100
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.18
    Marker Score: 231
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.17
    Marker Score: 278
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.17
    Marker Score: 117
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.16
    Marker Score: 304
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.15
    Marker Score: 113
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.14
    Marker Score: 112
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.14
    Marker Score: 154
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.13
    Marker Score: 172
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.13
    Marker Score: 312
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.13
    Marker Score: 121
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.13
    Marker Score: 107
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.12
    Marker Score: 517
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.11
    Marker Score: 253
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.11
    Marker Score: 156
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.11
    Marker Score: 47
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.1
    Marker Score: 92
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.1
    Marker Score: 40
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1
    Marker Score: 5,204
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.1
    Marker Score: 946
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.09
    Marker Score: 96
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.09
    Marker Score: 84
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.09
    Marker Score: 47
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.08
    Marker Score: 59
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.08
    Marker Score: 907
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.08
    Marker Score: 42
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.07
    Marker Score: 65
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.07
    Marker Score: 300
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.07
    Marker Score: 47
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.07
    Marker Score: 47
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.07
    Marker Score: 193
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 137
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.07
    Marker Score: 92
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.06
    Marker Score: 90
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.06
    Marker Score: 40
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.06
    Marker Score: 142
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.05
    Marker Score: 41
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.04
    Marker Score: 45
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.04
    Marker Score: 36
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.04
    Marker Score: 66
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.03
    Marker Score: 36
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 29

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV7-6 is a member of the TCR beta variable (TRBV) family, which comprises a diverse array of genes that encode the variable regions of the TCR beta chain. These genes are responsible for generating the immense diversity of the TCR repertoire, allowing for the recognition of a vast array of antigens. TRBV7-6, in particular, is characterized by its unique combination of amino acid sequences, which confer specificity and affinity for particular antigen-MHC (Major Histocompatibility Complex) interactions. **Pathways and Functions:** TRBV7-6 is integral to the adaptive immune response, which involves the coordinated action of various cell types, including T cells, B cells, and antigen-presenting cells. The TCR, including TRBV7-6, plays a central role in this process by recognizing and binding to peptide-MHC complexes on antigen-presenting cells. This binding event triggers a cascade of signaling events that ultimately lead to T cell activation, proliferation, and differentiation into effector cells. The TCR complex, including TRBV7-6, also interacts with co-receptors, such as CD4 and CD8, which modulate the strength and specificity of antigen recognition. Additionally, TRBV7-6 is involved in the regulation of T cell activation and tolerance, with implications for the prevention of autoimmune diseases and cancer. **Clinical Significance:** Dysregulation or aberrant expression of TRBV7-6 has been implicated in various immunological disorders, including autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. These conditions are characterized by an inappropriate activation of autoreactive T cells, which recognize self-antigens and trigger an immune response against the host. Furthermore, TRBV7-6 has been associated with an increased risk of certain cancers, including leukemia and lymphoma, where T cell dysfunction and aberrant antigen recognition contribute to tumorigenesis. Additionally, TRBV7-6 has been identified as a potential target for immunotherapy, with its unique amino acid sequences potentially conferring specificity and affinity for tumor-specific antigens. In conclusion, TRBV7-6 is a critical component of the adaptive immune system, with significant implications for our understanding of immunological disorders and cancer. Further research into the mechanisms of TRBV7-6 function and dysregulation is essential for the development of novel therapeutic strategies and the prevention of immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.