Details for: TRBV6 5

Gene ID: 28602

Symbol: TRBV6 5

Ensembl ID: ENSG00000211721

Description: T cell receptor beta variable 6-5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.8494
    Cell Significance Index: 7.0400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.7684
    Cell Significance Index: 4.1900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.7494
    Cell Significance Index: 8.3800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.2093
    Cell Significance Index: 2.2500
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.1578
    Cell Significance Index: 1.4200
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0042
    Cell Significance Index: -3.1900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0091
    Cell Significance Index: -0.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0297
    Cell Significance Index: -5.9600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0382
    Cell Significance Index: -0.5200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0406
    Cell Significance Index: -0.3800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0412
    Cell Significance Index: -0.4500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0432
    Cell Significance Index: -0.5100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0447
    Cell Significance Index: -0.7600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0458
    Cell Significance Index: -0.6700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0562
    Cell Significance Index: -0.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0626
    Cell Significance Index: -1.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0628
    Cell Significance Index: -1.5200
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0673
    Cell Significance Index: -0.5500
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0837
    Cell Significance Index: -0.7200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1089
    Cell Significance Index: -1.1000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1092
    Cell Significance Index: -1.2900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1098
    Cell Significance Index: -1.8500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1160
    Cell Significance Index: -1.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1240
    Cell Significance Index: -2.0800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1244
    Cell Significance Index: -1.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1257
    Cell Significance Index: -3.2100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1338
    Cell Significance Index: -0.9200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1476
    Cell Significance Index: -3.7600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1636
    Cell Significance Index: -2.8200
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1759
    Cell Significance Index: -1.4700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1793
    Cell Significance Index: -1.7000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1866
    Cell Significance Index: -2.4400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1918
    Cell Significance Index: -2.0900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1921
    Cell Significance Index: -2.8000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1946
    Cell Significance Index: -1.8200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1955
    Cell Significance Index: -2.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1966
    Cell Significance Index: -1.8900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2025
    Cell Significance Index: -2.9400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2050
    Cell Significance Index: -3.3200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2057
    Cell Significance Index: -2.4200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2060
    Cell Significance Index: -2.0900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2126
    Cell Significance Index: -3.6400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2204
    Cell Significance Index: -1.8600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2217
    Cell Significance Index: -4.3400
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.2267
    Cell Significance Index: -2.3900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2305
    Cell Significance Index: -2.3800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2318
    Cell Significance Index: -2.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2418
    Cell Significance Index: -4.4700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2427
    Cell Significance Index: -3.3700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2473
    Cell Significance Index: -2.4800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2481
    Cell Significance Index: -2.5000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2500
    Cell Significance Index: -1.9500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.2571
    Cell Significance Index: -2.0300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2574
    Cell Significance Index: -3.5300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2586
    Cell Significance Index: -3.0000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2588
    Cell Significance Index: -3.2700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2637
    Cell Significance Index: -2.5700
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2658
    Cell Significance Index: -0.8100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.2703
    Cell Significance Index: -2.1600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2724
    Cell Significance Index: -2.9800
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2744
    Cell Significance Index: -3.3100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2756
    Cell Significance Index: -3.1200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2857
    Cell Significance Index: -3.7600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2863
    Cell Significance Index: -3.0400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2866
    Cell Significance Index: -3.4200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2885
    Cell Significance Index: -3.3200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2886
    Cell Significance Index: -3.2100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2891
    Cell Significance Index: -3.0700
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.2904
    Cell Significance Index: -3.1000
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.2940
    Cell Significance Index: -3.1400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2946
    Cell Significance Index: -3.3900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2946
    Cell Significance Index: -3.2100
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.2956
    Cell Significance Index: -2.8300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2961
    Cell Significance Index: -3.0700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2979
    Cell Significance Index: -4.7900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2980
    Cell Significance Index: -3.8900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3010
    Cell Significance Index: -3.9500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3021
    Cell Significance Index: -3.8900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3025
    Cell Significance Index: -3.6800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.3025
    Cell Significance Index: -3.0900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.3028
    Cell Significance Index: -3.0700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.3037
    Cell Significance Index: -3.1500
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.3083
    Cell Significance Index: -3.1300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.3146
    Cell Significance Index: -3.1400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3154
    Cell Significance Index: -4.7900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3176
    Cell Significance Index: -3.7700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3210
    Cell Significance Index: -3.8200
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.3214
    Cell Significance Index: -3.1700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3248
    Cell Significance Index: -3.6600
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3257
    Cell Significance Index: -3.7000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3308
    Cell Significance Index: -4.7000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3310
    Cell Significance Index: -4.6400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3316
    Cell Significance Index: -3.5800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3367
    Cell Significance Index: -2.8700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3367
    Cell Significance Index: -4.3300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3436
    Cell Significance Index: -3.6500
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.3467
    Cell Significance Index: -3.5200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3473
    Cell Significance Index: -3.8800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3512
    Cell Significance Index: -3.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV6-5 is a variable region gene that belongs to the TCR beta family, responsible for encoding the Vβ domain of the TCR. This domain is essential for recognizing and binding to specific antigens, initiating an immune response. The TRBV6-5 gene is significantly expressed in various immune cells, including CD8-positive T cells, which are critical for eliminating infected cells and tumor cells. The expression of TRBV6-5 is also observed in other cell types, such as neutrophils, granulocyte-monocyte progenitor cells, and pro-B cells, highlighting its broader role in the immune system. **Pathways and Functions:** TRBV6-5 is involved in the adaptive immune response, specifically in the T cell receptor complex pathway. This pathway involves the recognition of antigens by the TCR, leading to the activation of immune cells and the initiation of an immune response. The TRBV6-5 gene is also part of the cell surface receptor signaling pathway, which involves the transmission of signals from the TCR to downstream signaling molecules, leading to the activation of various cellular processes. The functions of TRBV6-5 can be broadly categorized into two main areas: antigen recognition and immune cell activation. The Vβ domain of the TRBV6-5 gene recognizes specific antigens, leading to the activation of immune cells and the initiation of an immune response. The expression of TRBV6-5 is also involved in regulating the function of immune cells, including the activation and proliferation of T cells. **Clinical Significance:** The TRBV6-5 gene has significant clinical implications in the context of immune response and disease. Variations in the TRBV6-5 gene have been associated with autoimmune diseases, such as multiple sclerosis and type 1 diabetes, as well as with infectious diseases, such as tuberculosis and HIV. The expression of TRBV6-5 is also involved in the response to cancer, with some studies suggesting that TRBV6-5-positive T cells may play a role in tumor immunity. Furthermore, the TRBV6-5 gene has been used as a biomarker for immune response and disease diagnosis. For example, the expression of TRBV6-5 has been used to monitor the response to immunotherapy in cancer patients. Additionally, the TRBV6-5 gene has been used to develop novel immunotherapies, such as T cell-based therapies, which aim to harness the power of the immune system to combat disease. In conclusion, the TRBV6-5 gene is a critical component of the adaptive immune system, playing a pivotal role in recognizing and responding to pathogens. Its expression is significant in various immune cells and is involved in the regulation of immune responses. The clinical significance of TRBV6-5 is evident, with implications for autoimmune diseases, infectious diseases, and cancer. Further research is needed to fully understand the function and significance of TRBV6-5, but its potential as a biomarker and therapeutic target makes it an exciting area of study.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.