Details for: TRBV5 5

Gene ID: 28610

Symbol: TRBV5 5

Ensembl ID: ENSG00000211725

Description: T cell receptor beta variable 5-5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5557
    Cell Significance Index: 8.1000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2311
    Cell Significance Index: 1.2600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1130
    Cell Significance Index: 1.4600
  • Cell Name: lung resident memory CD4-positive, alpha-beta T cell (CL4033038)
    Fold Change: 0.0172
    Cell Significance Index: 0.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0109
    Cell Significance Index: -2.1800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0170
    Cell Significance Index: -0.2400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0199
    Cell Significance Index: -0.3400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0220
    Cell Significance Index: -0.2600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0245
    Cell Significance Index: -0.2300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0272
    Cell Significance Index: -0.3700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0293
    Cell Significance Index: -0.7100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0317
    Cell Significance Index: -0.2700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0382
    Cell Significance Index: -0.5600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0479
    Cell Significance Index: -0.6300
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.0501
    Cell Significance Index: -0.4900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0535
    Cell Significance Index: -0.5400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0539
    Cell Significance Index: -0.9300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0607
    Cell Significance Index: -0.8900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0631
    Cell Significance Index: -0.5900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0640
    Cell Significance Index: -0.6600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0694
    Cell Significance Index: -0.7200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0706
    Cell Significance Index: -1.8000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0724
    Cell Significance Index: -0.7800
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0800
    Cell Significance Index: -0.7200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0823
    Cell Significance Index: -0.7800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0852
    Cell Significance Index: -0.6900
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0877
    Cell Significance Index: -0.8000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0901
    Cell Significance Index: -0.6200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0904
    Cell Significance Index: -1.1700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0927
    Cell Significance Index: -0.8000
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0942
    Cell Significance Index: -0.8100
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0977
    Cell Significance Index: -0.8100
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0989
    Cell Significance Index: -1.0500
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1006
    Cell Significance Index: -1.0400
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1017
    Cell Significance Index: -1.0700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1040
    Cell Significance Index: -1.3700
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.1046
    Cell Significance Index: -0.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1077
    Cell Significance Index: -1.9900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1092
    Cell Significance Index: -0.6500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1095
    Cell Significance Index: -2.1400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1100
    Cell Significance Index: -1.1600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1116
    Cell Significance Index: -1.5300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1118
    Cell Significance Index: -1.8100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1139
    Cell Significance Index: -1.1000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1147
    Cell Significance Index: -1.4100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1170
    Cell Significance Index: -2.0000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1209
    Cell Significance Index: -1.4700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1216
    Cell Significance Index: -1.4100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1219
    Cell Significance Index: -1.0300
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1237
    Cell Significance Index: -0.8100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1276
    Cell Significance Index: -1.3900
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1280
    Cell Significance Index: -1.0700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1288
    Cell Significance Index: -1.1700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1312
    Cell Significance Index: -1.6900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1340
    Cell Significance Index: -1.3500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1356
    Cell Significance Index: -1.5400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1363
    Cell Significance Index: -1.1500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1369
    Cell Significance Index: -1.7300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1409
    Cell Significance Index: -1.4300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1410
    Cell Significance Index: -1.4300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1415
    Cell Significance Index: -1.5000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1491
    Cell Significance Index: -1.7700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1508
    Cell Significance Index: -1.0000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1510
    Cell Significance Index: -1.9400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1527
    Cell Significance Index: -1.6700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1533
    Cell Significance Index: -1.8700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1535
    Cell Significance Index: -1.4200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1540
    Cell Significance Index: -2.0100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1542
    Cell Significance Index: -1.7800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1558
    Cell Significance Index: -2.1400
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.1571
    Cell Significance Index: -1.3900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1597
    Cell Significance Index: -1.8000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1607
    Cell Significance Index: -1.7400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1630
    Cell Significance Index: -1.5300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1638
    Cell Significance Index: -1.8300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1641
    Cell Significance Index: -2.1800
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1650
    Cell Significance Index: -1.7300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1661
    Cell Significance Index: -1.0800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1662
    Cell Significance Index: -1.6200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1670
    Cell Significance Index: -1.8000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1676
    Cell Significance Index: -1.9800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1697
    Cell Significance Index: -1.3200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1711
    Cell Significance Index: -1.8200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1713
    Cell Significance Index: -1.8200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1723
    Cell Significance Index: -1.7600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1743
    Cell Significance Index: -1.7400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1747
    Cell Significance Index: -1.9400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1751
    Cell Significance Index: -2.1000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1763
    Cell Significance Index: -1.8000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1793
    Cell Significance Index: -1.5800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1794
    Cell Significance Index: -2.3000
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.1829
    Cell Significance Index: -1.6900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1836
    Cell Significance Index: -2.1600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1851
    Cell Significance Index: -2.1300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1878
    Cell Significance Index: -1.4500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1882
    Cell Significance Index: -2.2700
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.1909
    Cell Significance Index: -1.7400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1915
    Cell Significance Index: -2.2600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1953
    Cell Significance Index: -1.6200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1960
    Cell Significance Index: -2.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV5-5 is a member of the TCR beta (TCRB) family, which is responsible for recognizing and binding to antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells. The TRBV5-5 gene encodes a variable region of the TCR beta chain, which undergoes somatic recombination during T cell development to generate a diverse repertoire of TCRs. This diversity is essential for the immune system to recognize and respond to a wide range of pathogens and self-antigens. **Pathways and Functions:** TRBV5-5 is involved in several key pathways, including: 1. **Adaptive Immune Response:** TRBV5-5 plays a crucial role in the adaptive immune response, where it helps to recognize and respond to antigens presented by MHC molecules. 2. **Cell Surface Receptor Signaling Pathway:** The TCR complex, including TRBV5-5, is a key component of the cell surface receptor signaling pathway, which regulates various cellular processes, including proliferation, differentiation, and survival. 3. **Plasma Membrane:** TRBV5-5 is embedded in the plasma membrane, where it interacts with MHC molecules and other TCRs to regulate immune responses. **Functions:** The functions of TRBV5-5 can be broadly categorized into two main areas: 1. **Antigen Recognition:** TRBV5-5 recognizes and binds to antigens presented by MHC molecules, which triggers a signaling cascade that regulates immune responses. 2. **T Cell Development and Selection:** TRBV5-5 plays a critical role in the development and selection of T cells, ensuring that only functional T cells are produced and that self-reactive T cells are eliminated. **Clinical Significance:** The clinical significance of TRBV5-5 is multifaceted: 1. **Autoimmune Disorders:** Abnormalities in TRBV5-5 have been implicated in various autoimmune disorders, including multiple sclerosis and type 1 diabetes. 2. **Cancer:** TRBV5-5 has been identified as a potential biomarker for cancer, as it is expressed on the surface of neoplastic cells and can be used to monitor disease progression. 3. **Immune System Dysregulation:** TRBV5-5 dysregulation has been linked to immune system dysregulation, which can lead to various diseases, including chronic inflammation and tissue damage. In conclusion, TRBV5-5 is a complex gene with a wide range of functions in the immune system. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining immune homeostasis. Further research is needed to fully understand the mechanisms by which TRBV5-5 regulates immune responses and to explore its potential as a therapeutic target for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.