Details for: TRAV21

Gene ID: 28662

Symbol: TRAV21

Ensembl ID: ENSG00000211801

Description: T cell receptor alpha variable 21

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0022
    Cell Significance Index: -0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0116
    Cell Significance Index: -8.7900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0143
    Cell Significance Index: -0.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0305
    Cell Significance Index: -6.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0363
    Cell Significance Index: -0.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0928
    Cell Significance Index: -4.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1194
    Cell Significance Index: -5.6100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1210
    Cell Significance Index: -2.9300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2196
    Cell Significance Index: -3.1200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2249
    Cell Significance Index: -3.7900
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.2280
    Cell Significance Index: -1.8900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2616
    Cell Significance Index: -3.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2937
    Cell Significance Index: -7.8600
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.3388
    Cell Significance Index: -3.7900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3635
    Cell Significance Index: -9.2600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3643
    Cell Significance Index: -5.0500
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.3681
    Cell Significance Index: -5.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3738
    Cell Significance Index: -9.5500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3786
    Cell Significance Index: -4.5400
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.3829
    Cell Significance Index: -3.7500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3876
    Cell Significance Index: -4.9700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.4084
    Cell Significance Index: -6.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4572
    Cell Significance Index: -8.4500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4708
    Cell Significance Index: -7.1500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.4916
    Cell Significance Index: -5.8100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4941
    Cell Significance Index: -9.6600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.4995
    Cell Significance Index: -5.1800
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.5343
    Cell Significance Index: -4.8900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.5347
    Cell Significance Index: -5.0200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.5477
    Cell Significance Index: -8.8700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.5484
    Cell Significance Index: -6.4800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.5710
    Cell Significance Index: -7.8300
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.5848
    Cell Significance Index: -6.0500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.5928
    Cell Significance Index: -7.4900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.6045
    Cell Significance Index: -9.7200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.6157
    Cell Significance Index: -6.2200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.6163
    Cell Significance Index: -8.0600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.6185
    Cell Significance Index: -7.6500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.6346
    Cell Significance Index: -9.2500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.6401
    Cell Significance Index: -8.4000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.6426
    Cell Significance Index: -8.2600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.6535
    Cell Significance Index: -3.7600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.6605
    Cell Significance Index: -9.0700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.6647
    Cell Significance Index: -7.9100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.6717
    Cell Significance Index: -7.9300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6804
    Cell Significance Index: -11.7300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.6811
    Cell Significance Index: -7.9000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.6944
    Cell Significance Index: -11.8700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.6959
    Cell Significance Index: -11.8200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.7007
    Cell Significance Index: -7.1100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.7052
    Cell Significance Index: -5.7100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.7060
    Cell Significance Index: -7.5000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.7076
    Cell Significance Index: -8.4000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.7077
    Cell Significance Index: -6.7100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.7147
    Cell Significance Index: -9.3300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.7238
    Cell Significance Index: -8.3300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.7287
    Cell Significance Index: -7.4400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.7345
    Cell Significance Index: -7.4000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.7348
    Cell Significance Index: -9.6700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.7403
    Cell Significance Index: -6.4800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.7413
    Cell Significance Index: -10.3900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.7434
    Cell Significance Index: -8.2300
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.7519
    Cell Significance Index: -8.2900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.7521
    Cell Significance Index: -6.4900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.7544
    Cell Significance Index: -8.5700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.7558
    Cell Significance Index: -9.7800
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.7572
    Cell Significance Index: -7.7900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.7630
    Cell Significance Index: -7.6500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.7656
    Cell Significance Index: -8.4800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.7674
    Cell Significance Index: -7.4800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.7689
    Cell Significance Index: -8.2900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.7696
    Cell Significance Index: -9.2900
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.7781
    Cell Significance Index: -7.0000
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.7803
    Cell Significance Index: -7.4900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.7804
    Cell Significance Index: -7.5500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.7811
    Cell Significance Index: -8.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.7824
    Cell Significance Index: -7.5200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.7853
    Cell Significance Index: -8.6200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.7872
    Cell Significance Index: -10.4600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.7913
    Cell Significance Index: -4.3200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.7998
    Cell Significance Index: -8.6000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.8018
    Cell Significance Index: -9.5300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.8031
    Cell Significance Index: -9.7700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.8046
    Cell Significance Index: -6.7900
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.8105
    Cell Significance Index: -10.3800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.8132
    Cell Significance Index: -9.6100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.8137
    Cell Significance Index: -6.3300
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.8151
    Cell Significance Index: -6.9500
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.8172
    Cell Significance Index: -6.0500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.8192
    Cell Significance Index: -8.6300
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.8194
    Cell Significance Index: -8.7600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.8199
    Cell Significance Index: -7.6700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.8280
    Cell Significance Index: -7.1200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.8282
    Cell Significance Index: -9.5300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.8285
    Cell Significance Index: -8.5900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.8294
    Cell Significance Index: -7.0100
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.8315
    Cell Significance Index: -8.8000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.8325
    Cell Significance Index: -7.7000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.8396
    Cell Significance Index: -8.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** The TRAV21 gene is located on chromosome 7q34 and is specifically expressed in various cell types, including glutamatergic neurons, oligodendrocyte precursor cells, progenitor cells, microglial cells, blood vessel endothelial cells, granulocyte-monocyte progenitor cells, early T lineage precursors, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and Cajal-Retzius cells. 2. **Structure and Function:** The TRAV21 gene encodes a variable region of the alpha chain of the TCR, which is essential for recognizing and binding to specific antigens. This region is highly diverse, allowing for the generation of a vast repertoire of TCRs that can recognize a wide range of pathogens and self-antigens. 3. **Evolutionary Conservation:** The TRAV21 gene has been conserved across species, suggesting its importance in the evolution of the immune system. **Pathways and Functions:** 1. **Adaptive Immune Response:** The TRAV21 gene plays a critical role in the adaptive immune response, which involves the activation of T cells in response to specific antigens. The TCR, including the TRAV21 gene, recognizes and binds to antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells. 2. **T Cell Receptor Complex:** The TRAV21 gene is part of the TCR complex, which consists of the alpha, beta, gamma, and delta chains. The TCR complex is responsible for recognizing and binding to antigens, leading to the activation of T cells. 3. **Signal Transduction:** Upon binding to antigens, the TCR complex undergoes signal transduction, which triggers the activation of T cells. The TRAV21 gene is involved in this process, allowing for the generation of a diverse repertoire of TCRs that can recognize a wide range of pathogens. **Clinical Significance:** 1. **Immunological Disorders:** Mutations or alterations in the TRAV21 gene have been implicated in various immunological disorders, including autoimmune diseases such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer:** The TRAV21 gene has been associated with an increased risk of certain types of cancer, including leukemia and lymphoma. 3. **Neurological Disorders:** The TRAV21 gene has been implicated in various neurological disorders, including multiple sclerosis, Parkinson's disease, and Alzheimer's disease. 4. **Transplantation:** The TRAV21 gene has been used as a marker for identifying T cells in transplantation, allowing for the monitoring of graft rejection and the optimization of immunosuppressive regimens. In conclusion, the TRAV21 gene plays a critical role in the adaptive immune response and has significant implications for our understanding of immunological and neurological disorders. Further research is needed to fully elucidate the mechanisms by which the TRAV21 gene contributes to disease and to develop novel therapeutic strategies for the treatment of these disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.