Details for: TRAV21

Gene ID: 28662

Symbol: TRAV21

Ensembl ID: ENSG00000211801

Description: T cell receptor alpha variable 21

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,086
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8,278
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 6.51
    Marker Score: 41,922
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,844
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,177
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 872
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,059
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 503
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 389
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.49
    Marker Score: 433
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.45
    Marker Score: 1,393
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.43
    Marker Score: 193
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.41
    Marker Score: 704
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.39
    Marker Score: 324
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 213
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.35
    Marker Score: 512
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.29
    Marker Score: 526
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.29
    Marker Score: 226
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.26
    Marker Score: 622
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.23
    Marker Score: 452
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.23
    Marker Score: 967
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.19
    Marker Score: 117
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.19
    Marker Score: 206
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.18
    Marker Score: 1,820
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.17
    Marker Score: 245
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.17
    Marker Score: 9,080
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.15
    Marker Score: 111
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.15
    Marker Score: 144
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.15
    Marker Score: 61
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.15
    Marker Score: 106
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.13
    Marker Score: 76
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.13
    Marker Score: 57
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.13
    Marker Score: 73
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.12
    Marker Score: 1,425
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.12
    Marker Score: 87
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.11
    Marker Score: 120
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.1
    Marker Score: 111
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.1
    Marker Score: 285
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.1
    Marker Score: 75
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.09
    Marker Score: 76
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.09
    Marker Score: 74
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.09
    Marker Score: 46
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.08
    Marker Score: 76
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.08
    Marker Score: 60
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.08
    Marker Score: 312
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.07
    Marker Score: 161
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.07
    Marker Score: 48
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 135
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 61
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.06
    Marker Score: 80
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.06
    Marker Score: 94
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.04
    Marker Score: 110
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: T-helper 2 cell (CL0000546)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.04
    Marker Score: 51
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.03
    Marker Score: 55
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.03
    Marker Score: 40
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.03
    Marker Score: 71
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.02
    Marker Score: 15

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** The TRAV21 gene is located on chromosome 7q34 and is specifically expressed in various cell types, including glutamatergic neurons, oligodendrocyte precursor cells, progenitor cells, microglial cells, blood vessel endothelial cells, granulocyte-monocyte progenitor cells, early T lineage precursors, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and Cajal-Retzius cells. 2. **Structure and Function:** The TRAV21 gene encodes a variable region of the alpha chain of the TCR, which is essential for recognizing and binding to specific antigens. This region is highly diverse, allowing for the generation of a vast repertoire of TCRs that can recognize a wide range of pathogens and self-antigens. 3. **Evolutionary Conservation:** The TRAV21 gene has been conserved across species, suggesting its importance in the evolution of the immune system. **Pathways and Functions:** 1. **Adaptive Immune Response:** The TRAV21 gene plays a critical role in the adaptive immune response, which involves the activation of T cells in response to specific antigens. The TCR, including the TRAV21 gene, recognizes and binds to antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells. 2. **T Cell Receptor Complex:** The TRAV21 gene is part of the TCR complex, which consists of the alpha, beta, gamma, and delta chains. The TCR complex is responsible for recognizing and binding to antigens, leading to the activation of T cells. 3. **Signal Transduction:** Upon binding to antigens, the TCR complex undergoes signal transduction, which triggers the activation of T cells. The TRAV21 gene is involved in this process, allowing for the generation of a diverse repertoire of TCRs that can recognize a wide range of pathogens. **Clinical Significance:** 1. **Immunological Disorders:** Mutations or alterations in the TRAV21 gene have been implicated in various immunological disorders, including autoimmune diseases such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer:** The TRAV21 gene has been associated with an increased risk of certain types of cancer, including leukemia and lymphoma. 3. **Neurological Disorders:** The TRAV21 gene has been implicated in various neurological disorders, including multiple sclerosis, Parkinson's disease, and Alzheimer's disease. 4. **Transplantation:** The TRAV21 gene has been used as a marker for identifying T cells in transplantation, allowing for the monitoring of graft rejection and the optimization of immunosuppressive regimens. In conclusion, the TRAV21 gene plays a critical role in the adaptive immune response and has significant implications for our understanding of immunological and neurological disorders. Further research is needed to fully elucidate the mechanisms by which the TRAV21 gene contributes to disease and to develop novel therapeutic strategies for the treatment of these disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.