Details for: TRAV8 1

Gene ID: 28685

Symbol: TRAV8 1

Ensembl ID: ENSG00000211782

Description: T cell receptor alpha variable 8-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5173
    Cell Significance Index: 7.5400
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.4735
    Cell Significance Index: 4.2600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2879
    Cell Significance Index: 1.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0089
    Cell Significance Index: -1.7800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0090
    Cell Significance Index: -0.2300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0157
    Cell Significance Index: -0.2200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0198
    Cell Significance Index: -0.2700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0206
    Cell Significance Index: -0.3500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0227
    Cell Significance Index: -0.2100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0268
    Cell Significance Index: -0.3900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0271
    Cell Significance Index: -0.3200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0301
    Cell Significance Index: -0.7300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0333
    Cell Significance Index: -0.2400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0362
    Cell Significance Index: -0.3700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0610
    Cell Significance Index: -0.5200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0613
    Cell Significance Index: -0.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0632
    Cell Significance Index: -1.6900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0634
    Cell Significance Index: -0.6400
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0721
    Cell Significance Index: -0.6200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0725
    Cell Significance Index: -1.2500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0727
    Cell Significance Index: -0.6800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0803
    Cell Significance Index: -1.3500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0858
    Cell Significance Index: -1.3900
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0872
    Cell Significance Index: -0.6000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0877
    Cell Significance Index: -2.2400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0986
    Cell Significance Index: -1.0500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0995
    Cell Significance Index: -1.2600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0999
    Cell Significance Index: -0.9600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1047
    Cell Significance Index: -1.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1087
    Cell Significance Index: -1.8200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1094
    Cell Significance Index: -1.1100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1097
    Cell Significance Index: -1.4200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1107
    Cell Significance Index: -1.0500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1112
    Cell Significance Index: -1.5300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1120
    Cell Significance Index: -1.3300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1124
    Cell Significance Index: -1.1600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1132
    Cell Significance Index: -1.4300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1142
    Cell Significance Index: -1.3500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1161
    Cell Significance Index: -2.2700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1163
    Cell Significance Index: -1.2500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1182
    Cell Significance Index: -2.0200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1208
    Cell Significance Index: -1.6800
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1231
    Cell Significance Index: -1.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1244
    Cell Significance Index: -2.3000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1271
    Cell Significance Index: -1.3900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1289
    Cell Significance Index: -1.4100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1323
    Cell Significance Index: -1.5600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1338
    Cell Significance Index: -1.7500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1350
    Cell Significance Index: -1.6700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1383
    Cell Significance Index: -1.1200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1398
    Cell Significance Index: -1.9600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1408
    Cell Significance Index: -1.4600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1414
    Cell Significance Index: -1.6400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1436
    Cell Significance Index: -1.8900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1442
    Cell Significance Index: -1.9800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1447
    Cell Significance Index: -1.7600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1462
    Cell Significance Index: -1.7200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1468
    Cell Significance Index: -2.2300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1471
    Cell Significance Index: -1.8900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1473
    Cell Significance Index: -1.8400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1478
    Cell Significance Index: -1.9400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1524
    Cell Significance Index: -1.9900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1536
    Cell Significance Index: -1.3300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1544
    Cell Significance Index: -1.7400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1555
    Cell Significance Index: -1.8700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1564
    Cell Significance Index: -1.8000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1582
    Cell Significance Index: -1.3400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1586
    Cell Significance Index: -1.7100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1590
    Cell Significance Index: -1.8900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1599
    Cell Significance Index: -1.8400
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1603
    Cell Significance Index: -1.3400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1619
    Cell Significance Index: -1.9900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1624
    Cell Significance Index: -0.5000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1633
    Cell Significance Index: -1.5100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1639
    Cell Significance Index: -1.9500
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1643
    Cell Significance Index: -1.8400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1658
    Cell Significance Index: -1.6700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1665
    Cell Significance Index: -1.3000
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1678
    Cell Significance Index: -1.6400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1679
    Cell Significance Index: -2.3300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1681
    Cell Significance Index: -1.8500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1688
    Cell Significance Index: -1.8100
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1689
    Cell Significance Index: -1.8400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1692
    Cell Significance Index: -1.8000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1703
    Cell Significance Index: -1.6600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1705
    Cell Significance Index: -1.4100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1711
    Cell Significance Index: -1.3500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1726
    Cell Significance Index: -2.0400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1736
    Cell Significance Index: -1.8000
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1742
    Cell Significance Index: -1.5900
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1748
    Cell Significance Index: -1.4900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1761
    Cell Significance Index: -1.9500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1773
    Cell Significance Index: -1.8700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1794
    Cell Significance Index: -2.1200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1804
    Cell Significance Index: -1.8400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1849
    Cell Significance Index: -1.8800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1853
    Cell Significance Index: -1.7400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1861
    Cell Significance Index: -1.9000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1862
    Cell Significance Index: -2.0800
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1883
    Cell Significance Index: -1.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV8.1 is a member of the TRAV gene family, which codes for alpha variable regions of the TCR alpha chain. The variable region of the TCR alpha chain is responsible for recognizing and binding to peptide-MHC complexes, thereby initiating an immune response. TRAV8.1 is distinct from other TRAV genes due to its unique sequence and expression pattern. Its expression is not limited to T cells, but also found in precursor B cells, neutrophils, and megakaryocyte-erythroid progenitor cells, suggesting a broader role in the immune system. **Pathways and Functions:** TRAV8.1 is intricately involved in the adaptive immune response, particularly in T cell-mediated immunity. The gene's expression is regulated by a complex interplay of transcriptional and post-transcriptional mechanisms, which ensure proper TCR assembly and function. Upon TCR engagement with antigen-presenting cells, TRAV8.1 contributes to the activation, proliferation, and differentiation of T cells. The TCR complex, including TRAV8.1, undergoes somatic recombination during T cell development, resulting in diverse TCR repertoires. This process is crucial for the immune system's ability to recognize and respond to a wide range of pathogens. TRAV8.1's unique sequence and expression pattern facilitate the generation of functional TCRs that can recognize specific antigens, thereby contributing to the immune system's ability to combat infections. **Clinical Significance:** The study of TRAV8.1 has significant implications for our understanding of immune-related disorders. Variations in the TRAV8.1 gene have been associated with autoimmune diseases, such as multiple sclerosis and type 1 diabetes. Furthermore, alterations in TRAV8.1 expression have been linked to cancer, suggesting a potential role in tumor immune evasion. In addition, TRAV8.1's involvement in T cell-mediated immunity makes it a valuable target for immunotherapy. Researchers are exploring the use of TRAV8.1-based TCR therapies to enhance anti-tumor responses and treat autoimmune diseases. In conclusion, TRAV8.1 is a critical component of the adaptive immune response, playing a pivotal role in T cell-mediated immunity. Its unique sequence and expression pattern make it an attractive target for immunotherapy and research into immune-related disorders. Further investigation into TRAV8.1's pathways and functions will provide valuable insights into the complex mechanisms governing the immune system and its role in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.