Details for: TRAJ22

Gene ID: 28733

Symbol: TRAJ22

Ensembl ID: ENSG00000211867

Description: T cell receptor alpha joining 22

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 8.1885
    Cell Significance Index: 160.1000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4162
    Cell Significance Index: 34.3100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4401
    Cell Significance Index: 6.4200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.4159
    Cell Significance Index: 5.2600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0818
    Cell Significance Index: 1.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0413
    Cell Significance Index: 0.9100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0087
    Cell Significance Index: 0.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0040
    Cell Significance Index: 0.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0003
    Cell Significance Index: 0.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0026
    Cell Significance Index: -0.5200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0039
    Cell Significance Index: -0.1600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0042
    Cell Significance Index: -0.0600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0099
    Cell Significance Index: -0.4400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0115
    Cell Significance Index: -0.1300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0132
    Cell Significance Index: -0.2200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0142
    Cell Significance Index: -0.1600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0146
    Cell Significance Index: -0.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0154
    Cell Significance Index: -0.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0174
    Cell Significance Index: -0.6600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0203
    Cell Significance Index: -0.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0223
    Cell Significance Index: -0.7100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0234
    Cell Significance Index: -0.3000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0241
    Cell Significance Index: -0.3200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0241
    Cell Significance Index: -0.4800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0278
    Cell Significance Index: -0.5800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0282
    Cell Significance Index: -0.3800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0313
    Cell Significance Index: -0.2900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0326
    Cell Significance Index: -0.8300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0359
    Cell Significance Index: -0.7200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0361
    Cell Significance Index: -0.7200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0372
    Cell Significance Index: -0.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0390
    Cell Significance Index: -0.7200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0451
    Cell Significance Index: -0.5000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0503
    Cell Significance Index: -0.6000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0534
    Cell Significance Index: -0.7100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0536
    Cell Significance Index: -0.7000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0544
    Cell Significance Index: -0.6400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0559
    Cell Significance Index: -0.7000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0569
    Cell Significance Index: -0.6900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0582
    Cell Significance Index: -0.6500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0601
    Cell Significance Index: -0.7500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0610
    Cell Significance Index: -0.7700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0616
    Cell Significance Index: -0.7900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0626
    Cell Significance Index: -0.7200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0631
    Cell Significance Index: -0.6800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0641
    Cell Significance Index: -0.6500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0645
    Cell Significance Index: -0.8600
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0660
    Cell Significance Index: -0.7100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0682
    Cell Significance Index: -0.8300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0683
    Cell Significance Index: -0.8400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0685
    Cell Significance Index: -0.8100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0693
    Cell Significance Index: -0.5900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0695
    Cell Significance Index: -0.7100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0700
    Cell Significance Index: -0.7100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0702
    Cell Significance Index: -0.7400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0703
    Cell Significance Index: -0.7100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0712
    Cell Significance Index: -0.9300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0715
    Cell Significance Index: -0.9100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0716
    Cell Significance Index: -0.6700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0717
    Cell Significance Index: -0.6800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0726
    Cell Significance Index: -0.9000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0730
    Cell Significance Index: -0.7400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0741
    Cell Significance Index: -0.8600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0746
    Cell Significance Index: -0.7000
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0768
    Cell Significance Index: -0.6700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0778
    Cell Significance Index: -0.7200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0783
    Cell Significance Index: -0.8400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0807
    Cell Significance Index: -0.4400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0811
    Cell Significance Index: -0.8600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0817
    Cell Significance Index: -0.7200
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0825
    Cell Significance Index: -0.9500
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0831
    Cell Significance Index: -0.7200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0834
    Cell Significance Index: -0.8400
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0837
    Cell Significance Index: -0.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0838
    Cell Significance Index: -0.8100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0848
    Cell Significance Index: -0.7000
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0849
    Cell Significance Index: -0.8800
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0857
    Cell Significance Index: -0.9000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0858
    Cell Significance Index: -0.7400
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0864
    Cell Significance Index: -0.9300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0882
    Cell Significance Index: -0.8800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0895
    Cell Significance Index: -0.7400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0910
    Cell Significance Index: -0.7000
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0934
    Cell Significance Index: -1.0100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0949
    Cell Significance Index: -0.8300
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0974
    Cell Significance Index: -0.9000
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0988
    Cell Significance Index: -0.9000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1019
    Cell Significance Index: -0.8600
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1041
    Cell Significance Index: -0.8700
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.1048
    Cell Significance Index: -0.8600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1062
    Cell Significance Index: -0.8600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1065
    Cell Significance Index: -0.9000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1076
    Cell Significance Index: -0.8600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1076
    Cell Significance Index: -1.0200
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.1103
    Cell Significance Index: -1.0500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1120
    Cell Significance Index: -1.2200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1125
    Cell Significance Index: -0.8600
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1134
    Cell Significance Index: -0.7800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1138
    Cell Significance Index: -1.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** The TRAJ22 gene is located on chromosome 1p36.13, a region known for its high degree of gene density. 2. **Gene structure:** The TRAJ22 gene consists of 7 exons and 6 introns, with a total length of approximately 2.3 kilobases. 3. **Expression pattern:** TRAJ22 is highly expressed in CD4-positive and CD8-positive T cells, as well as in other T cell subsets, such as naive thymus-derived CD4-positive T cells and mature alpha-beta T cells. 4. **Function:** TRAJ22 is essential for the assembly and maturation of T cells, specifically for the joining of the TCR alpha chain to the TCR beta chain. **Pathways and Functions:** 1. **TCR assembly and maturation:** TRAJ22 plays a critical role in the assembly and maturation of T cells by facilitating the joining of the TCR alpha chain to the TCR beta chain. 2. **T cell activation and proliferation:** The TRAJ22 gene is also involved in the activation and proliferation of T cells, which is essential for the immune response against pathogens. 3. **T cell regulation:** TRAJ22 may also play a role in the regulation of T cell function, including the maintenance of T cell homeostasis and the prevention of T cell exhaustion. **Clinical Significance:** 1. **Immunodeficiency disorders:** Mutations in the TRAJ22 gene may contribute to immunodeficiency disorders, such as severe combined immunodeficiency (SCID), which is characterized by impaired T cell function. 2. **Cancer:** TRAJ22 may also play a role in cancer, as dysregulation of T cell function can lead to the development of tumors. 3. **Infectious diseases:** The TRAJ22 gene may also be involved in the immune response to infectious diseases, such as HIV, which targets and depletes CD4-positive T cells. 4. **Autoimmune diseases:** TRAJ22 may also contribute to the development of autoimmune diseases, such as multiple sclerosis, which is characterized by impaired T cell regulation and dysfunction. In conclusion, the TRAJ22 gene plays a critical role in the assembly and maturation of T cells, which is essential for the adaptive immune response. Understanding the functions and clinical significance of TRAJ22 can provide valuable insights into the development of immunodeficiency disorders, cancer, and infectious diseases, as well as autoimmune diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.