Details for: IGLV7 46

Gene ID: 28775

Symbol: IGLV7 46

Ensembl ID: ENSG00000211649

Description: immunoglobulin lambda variable 7-46

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,085
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8,278
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,844
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3,175
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2,000
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.85
    Marker Score: 3,184
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1,175
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 491
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,692
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,821
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 506
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,816
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,059
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,334
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.68
    Marker Score: 393
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 495
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.54
    Marker Score: 417
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.43
    Marker Score: 359
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.37
    Marker Score: 592
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.31
    Marker Score: 339
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.3
    Marker Score: 271
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.29
    Marker Score: 91
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.26
    Marker Score: 341
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.24
    Marker Score: 266
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.22
    Marker Score: 147
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.18
    Marker Score: 150
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.17
    Marker Score: 116
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.17
    Marker Score: 406
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.15
    Marker Score: 148
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.14
    Marker Score: 55
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.13
    Marker Score: 35
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.13
    Marker Score: 74
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.12
    Marker Score: 99
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.12
    Marker Score: 140
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.11
    Marker Score: 133
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 107
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.11
    Marker Score: 275
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.11
    Marker Score: 59
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1
    Marker Score: 42
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.1
    Marker Score: 44
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.1
    Marker Score: 260
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.09
    Marker Score: 57
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.09
    Marker Score: 88
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.09
    Marker Score: 52
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.09
    Marker Score: 1,005
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.08
    Marker Score: 56
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.08
    Marker Score: 103
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.06
    Marker Score: 79
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.06
    Marker Score: 122
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.06
    Marker Score: 41
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.06
    Marker Score: 51
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.06
    Marker Score: 50
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.05
    Marker Score: 111
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.05
    Marker Score: 40
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.05
    Marker Score: 43
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.05
    Marker Score: 66
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.05
    Marker Score: 45
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.05
    Marker Score: 55

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin Lambda Variable Gene:** IGLV7-46 is a member of the immunoglobulin lambda variable gene family, which codes for the lambda light chains of antibodies. 2. **Significant Expression:** This gene is widely expressed in various cell types, including immune cells (e.g., T cells, microglial cells), neurons (e.g., glutamatergic neurons), and epithelial cells (e.g., colon goblet cells, enterocytes). 3. **Adaptive Immune Response:** IGLV7-46 is involved in the adaptive immune response, which is a specific and targeted response to pathogens, as opposed to the innate immune response, which provides immediate defense against infection. 4. **Plasma Membrane Localization:** The IGLV7-46 gene is localized to the plasma membrane, where it can interact with other immune molecules and influence immune cell function. **Pathways and Functions:** 1. **Immunoglobulin Production:** IGLV7-46 is essential for the production of lambda light chains, which are critical components of immunoglobulins (antibodies). 2. **Antigen Recognition:** The lambda light chains produced by IGLV7-46 recognize and bind to specific antigens, triggering an immune response against pathogens. 3. **Immune Cell Activation:** IGLV7-46 is involved in the activation of immune cells, such as T cells and microglial cells, which are essential for the adaptive immune response. 4. **Cell Signaling:** The IGLV7-46 gene is involved in cell signaling pathways, including those that regulate immune cell function and survival. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of IGLV7-46 has been implicated in various autoimmune diseases, such as rheumatoid arthritis and lupus, where the immune system mistakenly attacks healthy tissues. 2. **Cancer:** Aberrant expression of IGLV7-46 has been observed in certain types of cancer, including multiple myeloma and lymphoma, where it can contribute to tumorigenesis and immune evasion. 3. **Infectious Diseases:** IGLV7-46 plays a critical role in the immune response against infectious diseases, such as bacterial and viral infections, where it can recognize and bind to specific pathogens, triggering an immune response. 4. **Immunodeficiency Disorders:** Mutations or deletions in the IGLV7-46 gene can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia, where individuals are unable to produce antibodies, making them more susceptible to infections. In conclusion, the IGLV7-46 gene is a critical component of the adaptive immune response, playing a pivotal role in the production of lambda light chains and the recognition and binding to specific antigens. Its dysregulation has been implicated in various autoimmune diseases, cancer, and infectious diseases, highlighting the importance of this gene in maintaining immune homeostasis and overall health.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.