Details for: IGLV7 46

Gene ID: 28775

Gene Type:  Other  - A known gene or region type that lacks a specific category. Includes immunoglobulin (Ig), T-cell receptor (TCR) gene segments, and repetitive elements.

Symbol: IGLV7 46

Ensembl ID: ENSG00000211649

Description: immunoglobulin lambda variable 7-46

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • IgA plasma cell CL0000987
    CSI 9.67
    rCSI 9.9%
    PRS 99.44
  • plasmablast CL0000980
    CSI 5.75
    rCSI 4.52%
    PRS 99.8

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

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  • Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [IGLV7 46](/details-gene/28775) is a V (variable) segment gene of the immunoglobulin lambda light chain locus located on chromosome 22. As a fundamental component of the adaptive immune system, it contributes to the vast diversity of antigen-binding sites on B-cell receptors and secreted antibodies. Its expression is highly specific to the B-cell lineage, with data indicating its most significant role is in terminally differentiated, antibody-secreting cells such as [IgA plasma cells](/details-cell/CL0000987) and [plasmablasts](/details-cell/CL0000980). ## Cellular Roles and Expression Landscape The expression profile of [IGLV7 46](/details-gene/28775) firmly establishes its role within the humoral immune system. **Overall**, its significance is highest in cell types dedicated to high-volume antibody production. The top marker status in [IgA plasma cells](/details-cell/CL0000987) (CSI: 9.67) and [plasmablasts](/details-cell/CL0000980) (CSI: 5.75) is consistent with its function as a V-gene segment. These cells are factories for immunoglobulin synthesis and secretion. The high significance in [IgA plasma cells](/details-cell/CL0000987) specifically suggests a potential preferential role in generating antibodies crucial for mucosal immunity. The function of [IGLV7 46](/details-gene/28775) is therefore highly specialized, confined to the later stages of B-cell differentiation where rearranged V(D)J segments are transcribed to form the final antibody product. Its role is not as a general lineage marker for all B-cells, but rather as a critical functional component in activated and differentiated effector cells. ## Pathways and Molecular Function The function of [IGLV7 46](/details-gene/28775) is intrinsically linked to the core processes of humoral immunity. Gene Ontology annotations place it within the [adaptive immune response](/details-cell/GO:0002250) and the broader [immune response](/details-cell/GO:0006955). Following V(D)J recombination and transcription, the protein product of [IGLV7 46](/details-gene/28775) becomes part of the [immunoglobulin complex](/details-cell/GO:0019814), which is the fundamental unit of B-cell receptors and secreted antibodies. This complex is either anchored to the [plasma membrane](/details-cell/GO:0005886) of a B-cell to act as an antigen receptor or secreted by a [plasma cell](/details-cell/CL0000987) to neutralize pathogens. Its involvement in these pathways is a direct reflection of its high expression in [plasmablasts](/details-cell/CL0000980) and [plasma cells](/details-cell/CL0000987), the cell types responsible for executing these functions. ## Research Directions The specific role of [IGLV7 46](/details-gene/28775) beyond its general function as a V-gene segment provides several avenues for future research, particularly concerning its usage in health and disease. **Proposed Hypotheses:** 1. The [IGLV7 46](/details-gene/28775) gene segment is preferentially utilized in the humoral immune response to specific mucosal pathogens, leading to an enrichment of IGLV7-46-containing IgA antibodies in tissues like the gut or respiratory tract during infection. 2. In certain B-cell malignancies, such as multiple myeloma or specific lymphomas, the malignant clone may disproportionately utilize the [IGLV7 46](/details-gene/28775) segment, making its sequence a potential tumor-specific biomarker or idiotype. **Experimental Approach:** To test the first hypothesis regarding pathogen specificity, an effective approach would be to perform B-cell receptor repertoire sequencing (BCR-seq) on sorted [IgA plasma cells](/details-cell/CL0000987) from mucosal biopsies of patients with a known enteric viral infection (e.g., rotavirus) and from healthy controls. A significant increase in the frequency of rearranged [IGLV7 46](/details-gene/28775) usage in the patient cohort compared to controls would provide strong evidence for its specialized role in combating specific classes of pathogens. **Therapeutic Potential:** As a germline gene segment, [IGLV7 46](/details-gene/28775) itself is not a direct drug target. However, the unique antibody variable region (idiotype) it helps to create in a malignant B-cell clone could be a highly specific therapeutic target. If a multiple myeloma clone is found to utilize [IGLV7 46](/details-gene/28775), therapies such as CAR-T cells or bispecific antibodies could be designed to recognize this specific idiotype, allowing for targeted destruction of cancer cells while sparing healthy B-cells that use different V-gene segments. Therefore, its primary clinical relevance may lie in diagnostics as a biomarker for clonal B-cell populations and as a component of a targetable tumor-specific antigen.