Details for: IGLV4 3

Gene ID: 28786

Symbol: IGLV4 3

Ensembl ID: ENSG00000211672

Description: immunoglobulin lambda variable 4-3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: macrophage (CL0000235)
    Fold Change: 8.56
    Marker Score: 9,525
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1,518
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 388
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 211
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 116
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.12
    Marker Score: 380
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.12
    Marker Score: 266
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1
    Marker Score: 55
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 133
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.06
    Marker Score: 58
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 53
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.06
    Marker Score: 90
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.05
    Marker Score: 63
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.05
    Marker Score: 60
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.05
    Marker Score: 189
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.04
    Marker Score: 57
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.04
    Marker Score: 54
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.04
    Marker Score: 53
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.04
    Marker Score: 43
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.03
    Marker Score: 76
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.02
    Marker Score: 48
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.01
    Marker Score: 41
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.01
    Marker Score: 112
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 108
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 19

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin lambda family**: The IGLV4-3 gene belongs to the immunoglobulin lambda family, which is responsible for producing antibodies against pathogens. 2. **Significant expression in immune cells**: The IGLV4-3 gene is expressed in various immune cells, including macrophages, conventional dendritic cells, granulocyte monocyte progenitor cells, early T lineage precursors, neutrophils, and mast cells. 3. **X-chromosome location**: The IGLV4-3 gene is located on the X chromosome, which is a critical consideration for its function and expression. 4. **Adaptive immune response**: The IGLV4-3 gene is involved in the adaptive immune response, which is a specific and targeted response to pathogens. **Pathways and Functions:** 1. **Immunoglobulin production**: The IGLV4-3 gene is involved in the production of immunoglobulins, which are proteins that recognize and bind to specific antigens. 2. **Antibody diversity**: The IGLV4-3 gene contributes to the generation of antibody diversity, which is essential for the immune system to recognize and respond to a wide range of pathogens. 3. **Immunoglobulin complex formation**: The IGLV4-3 gene is involved in the formation of immunoglobulin complexes, which are essential for the elimination of pathogens from the body. 4. **Cell signaling**: The IGLV4-3 gene may also be involved in cell signaling pathways, which regulate the activation and function of immune cells. **Clinical Significance:** 1. **Immune deficiency disorders**: Mutations in the IGLV4-3 gene have been associated with immune deficiency disorders, such as X-linked agammaglobulinemia (XLA). 2. **Autoimmune diseases**: Dysregulation of the IGLV4-3 gene may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer immunotherapy**: The IGLV4-3 gene may be a target for cancer immunotherapy, as it is involved in the recognition and elimination of cancer cells. 4. **Vaccine development**: The IGLV4-3 gene may be used as a target for vaccine development, as it is involved in the recognition and response to pathogens. In conclusion, the IGLV4-3 gene is a critical component of the immune system, involved in the production of antibodies and the regulation of immune responses. Its dysregulation has been associated with immune deficiency disorders and autoimmune diseases, highlighting its importance in human health and disease. Further research is needed to fully elucidate the functions and clinical significance of the IGLV4-3 gene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.