Details for: IGLV4 3

Gene ID: 28786

Symbol: IGLV4 3

Ensembl ID: ENSG00000211672

Description: immunoglobulin lambda variable 4-3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3731
    Cell Significance Index: 4.1700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0685
    Cell Significance Index: 1.0000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0555
    Cell Significance Index: 0.5900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0551
    Cell Significance Index: 0.7600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0058
    Cell Significance Index: -0.0700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0062
    Cell Significance Index: -0.0800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0169
    Cell Significance Index: -0.2000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0178
    Cell Significance Index: -0.2100
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0225
    Cell Significance Index: -0.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0252
    Cell Significance Index: -0.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0281
    Cell Significance Index: -1.8200
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.0293
    Cell Significance Index: -0.2900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0303
    Cell Significance Index: -0.3800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0344
    Cell Significance Index: -0.4300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0431
    Cell Significance Index: -0.4400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0479
    Cell Significance Index: -1.2200
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0483
    Cell Significance Index: -0.4900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0498
    Cell Significance Index: -0.6600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0509
    Cell Significance Index: -0.5200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0531
    Cell Significance Index: -0.6300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0553
    Cell Significance Index: -0.6500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0557
    Cell Significance Index: -0.6300
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0578
    Cell Significance Index: -0.6600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0606
    Cell Significance Index: -0.6600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0609
    Cell Significance Index: -1.1900
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0643
    Cell Significance Index: -0.5800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0662
    Cell Significance Index: -0.8800
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0683
    Cell Significance Index: -0.4600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0688
    Cell Significance Index: -0.8900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0700
    Cell Significance Index: -0.8600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0705
    Cell Significance Index: -0.8900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0708
    Cell Significance Index: -1.2100
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0745
    Cell Significance Index: -0.6600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0748
    Cell Significance Index: -0.9100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0752
    Cell Significance Index: -0.8400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0757
    Cell Significance Index: -0.9000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0770
    Cell Significance Index: -1.0100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0782
    Cell Significance Index: -1.9000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0814
    Cell Significance Index: -0.5400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0821
    Cell Significance Index: -1.3300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0828
    Cell Significance Index: -0.8900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0830
    Cell Significance Index: -0.9600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0869
    Cell Significance Index: -0.9200
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0875
    Cell Significance Index: -0.8000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0888
    Cell Significance Index: -0.9000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0923
    Cell Significance Index: -1.2100
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0937
    Cell Significance Index: -0.6500
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0956
    Cell Significance Index: -0.9700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0959
    Cell Significance Index: -1.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0982
    Cell Significance Index: -1.8200
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0983
    Cell Significance Index: -0.7900
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1000
    Cell Significance Index: -1.0400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1033
    Cell Significance Index: -0.9100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1054
    Cell Significance Index: -1.1100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1056
    Cell Significance Index: -1.1700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1078
    Cell Significance Index: -1.2500
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.1086
    Cell Significance Index: -0.5100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1095
    Cell Significance Index: -1.2600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1129
    Cell Significance Index: -1.1900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1145
    Cell Significance Index: -1.2900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1197
    Cell Significance Index: -1.3300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1197
    Cell Significance Index: -1.2900
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1222
    Cell Significance Index: -1.0600
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.1240
    Cell Significance Index: -0.9100
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1250
    Cell Significance Index: -1.2000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1257
    Cell Significance Index: -1.2800
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1262
    Cell Significance Index: -1.1000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1267
    Cell Significance Index: -1.2800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1272
    Cell Significance Index: -1.2700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1279
    Cell Significance Index: -1.0900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1279
    Cell Significance Index: -1.2100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1289
    Cell Significance Index: -1.2100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1313
    Cell Significance Index: -1.2800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1332
    Cell Significance Index: -1.2400
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1341
    Cell Significance Index: -1.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1342
    Cell Significance Index: -1.2900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1352
    Cell Significance Index: -1.2600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1360
    Cell Significance Index: -1.3700
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.1366
    Cell Significance Index: -1.2600
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1377
    Cell Significance Index: -1.2300
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.1385
    Cell Significance Index: -1.2900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1386
    Cell Significance Index: -1.6500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1392
    Cell Significance Index: -1.3200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1422
    Cell Significance Index: -1.6800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1430
    Cell Significance Index: -0.8900
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.1446
    Cell Significance Index: -1.2700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1454
    Cell Significance Index: -2.2100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1469
    Cell Significance Index: -1.2900
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1492
    Cell Significance Index: -1.3800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1550
    Cell Significance Index: -1.3200
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.1558
    Cell Significance Index: -1.2700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1574
    Cell Significance Index: -1.3300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1576
    Cell Significance Index: -1.3600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1635
    Cell Significance Index: -1.9300
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.1641
    Cell Significance Index: -1.2600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1684
    Cell Significance Index: -1.5800
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1687
    Cell Significance Index: -1.5100
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.1695
    Cell Significance Index: -0.8500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1697
    Cell Significance Index: -1.3200
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1716
    Cell Significance Index: -1.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin lambda family**: The IGLV4-3 gene belongs to the immunoglobulin lambda family, which is responsible for producing antibodies against pathogens. 2. **Significant expression in immune cells**: The IGLV4-3 gene is expressed in various immune cells, including macrophages, conventional dendritic cells, granulocyte monocyte progenitor cells, early T lineage precursors, neutrophils, and mast cells. 3. **X-chromosome location**: The IGLV4-3 gene is located on the X chromosome, which is a critical consideration for its function and expression. 4. **Adaptive immune response**: The IGLV4-3 gene is involved in the adaptive immune response, which is a specific and targeted response to pathogens. **Pathways and Functions:** 1. **Immunoglobulin production**: The IGLV4-3 gene is involved in the production of immunoglobulins, which are proteins that recognize and bind to specific antigens. 2. **Antibody diversity**: The IGLV4-3 gene contributes to the generation of antibody diversity, which is essential for the immune system to recognize and respond to a wide range of pathogens. 3. **Immunoglobulin complex formation**: The IGLV4-3 gene is involved in the formation of immunoglobulin complexes, which are essential for the elimination of pathogens from the body. 4. **Cell signaling**: The IGLV4-3 gene may also be involved in cell signaling pathways, which regulate the activation and function of immune cells. **Clinical Significance:** 1. **Immune deficiency disorders**: Mutations in the IGLV4-3 gene have been associated with immune deficiency disorders, such as X-linked agammaglobulinemia (XLA). 2. **Autoimmune diseases**: Dysregulation of the IGLV4-3 gene may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer immunotherapy**: The IGLV4-3 gene may be a target for cancer immunotherapy, as it is involved in the recognition and elimination of cancer cells. 4. **Vaccine development**: The IGLV4-3 gene may be used as a target for vaccine development, as it is involved in the recognition and response to pathogens. In conclusion, the IGLV4-3 gene is a critical component of the immune system, involved in the production of antibodies and the regulation of immune responses. Its dysregulation has been associated with immune deficiency disorders and autoimmune diseases, highlighting its importance in human health and disease. Further research is needed to fully elucidate the functions and clinical significance of the IGLV4-3 gene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.