IGLV3 27 | ENSG00000211658 | NCBI 28791

Details for: IGLV3 27

Gene ID: 28791

Symbol: IGLV3 27

Ensembl ID: ENSG00000211658

Description: immunoglobulin lambda variable 3-27

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.2534
Cell Significance Index: 3.9200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0157
Cell Significance Index: -0.7300
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.0277
Cell Significance Index: -0.3100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1183
Cell Significance Index: -23.7300
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.1228
Cell Significance Index: -1.3900
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.1278
Cell Significance Index: -1.8600
Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: -0.1446
Cell Significance Index: -1.9800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1495
Cell Significance Index: -4.0000
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1518
Cell Significance Index: -3.7900
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1664
Cell Significance Index: -4.0300
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1720
Cell Significance Index: -2.1800
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1992
Cell Significance Index: -5.0800
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2009
Cell Significance Index: -4.4000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2348
Cell Significance Index: -4.3400
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.2363
Cell Significance Index: -4.0400
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2470
Cell Significance Index: -4.0000
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.2519
Cell Significance Index: -2.8600
Cell Name: stromal cell (CL0000499)
Fold Change: -0.2603
Cell Significance Index: -2.6600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2749
Cell Significance Index: -4.6000
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2762
Cell Significance Index: -5.4000
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.2762
Cell Significance Index: -2.2800
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.2880
Cell Significance Index: -3.9500
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.3129
Cell Significance Index: -3.8700
Cell Name: glial cell (CL0000125)
Fold Change: -0.3140
Cell Significance Index: -3.4400
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.3185
Cell Significance Index: -3.4300
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.3229
Cell Significance Index: -3.4300
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.3427
Cell Significance Index: -4.0500
Cell Name: astrocyte (CL0000127)
Fold Change: -0.3687
Cell Significance Index: -4.2200
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.3724
Cell Significance Index: -5.1700
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.3740
Cell Significance Index: -3.5900
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.3772
Cell Significance Index: -4.2700
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.3783
Cell Significance Index: -3.0400
Cell Name: platelet (CL0000233)
Fold Change: -0.3805
Cell Significance Index: -3.9200
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.3850
Cell Significance Index: -4.5300
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.3900
Cell Significance Index: -5.1000
Cell Name: neutrophil (CL0000775)
Fold Change: -0.3914
Cell Significance Index: -4.8900
Cell Name: blood cell (CL0000081)
Fold Change: -0.3954
Cell Significance Index: -3.3700
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.3980
Cell Significance Index: -4.5800
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.4020
Cell Significance Index: -4.3800
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.4040
Cell Significance Index: -5.1800
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.4108
Cell Significance Index: -4.5300
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.4114
Cell Significance Index: -4.3400
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.4128
Cell Significance Index: -4.5700
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.4137
Cell Significance Index: -4.4600
Cell Name: intermediate monocyte (CL0002393)
Fold Change: -0.4240
Cell Significance Index: -3.9500
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.4270
Cell Significance Index: -5.5300
Cell Name: naive T cell (CL0000898)
Fold Change: -0.4304
Cell Significance Index: -3.9100
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.4333
Cell Significance Index: -5.1200
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.4341
Cell Significance Index: -4.1700
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.4370
Cell Significance Index: -4.3100
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.4397
Cell Significance Index: -4.4300
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.4419
Cell Significance Index: -4.9800
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.4428
Cell Significance Index: -3.9500
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: -0.4432
Cell Significance Index: -3.9700
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.4477
Cell Significance Index: -4.0000
Cell Name: monocyte (CL0000576)
Fold Change: -0.4493
Cell Significance Index: -5.1700
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.4493
Cell Significance Index: -4.3800
Cell Name: club cell (CL0000158)
Fold Change: -0.4516
Cell Significance Index: -4.9200
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.4528
Cell Significance Index: -3.9600
Cell Name: transitional stage B cell (CL0000818)
Fold Change: -0.4553
Cell Significance Index: -4.0000
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.4565
Cell Significance Index: -5.9900
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: -0.4627
Cell Significance Index: -3.9100
Cell Name: promonocyte (CL0000559)
Fold Change: -0.4738
Cell Significance Index: -5.0600
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: -0.4741
Cell Significance Index: -4.3800
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.4799
Cell Significance Index: -4.7900
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.4824
Cell Significance Index: -4.7200
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.4886
Cell Significance Index: -4.3500
Cell Name: goblet cell (CL0000160)
Fold Change: -0.4931
Cell Significance Index: -4.4600
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: -0.4948
Cell Significance Index: -4.0600
Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
Fold Change: -0.4957
Cell Significance Index: -5.3600
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -0.4973
Cell Significance Index: -3.9000
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.4997
Cell Significance Index: -6.6400
Cell Name: plasmablast (CL0000980)
Fold Change: -0.5005
Cell Significance Index: -4.6500
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: -0.5088
Cell Significance Index: -4.8500
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.5104
Cell Significance Index: -5.9300
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.5115
Cell Significance Index: -6.0800
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: -0.5116
Cell Significance Index: -3.9800
Cell Name: intestine goblet cell (CL0019031)
Fold Change: -0.5119
Cell Significance Index: -4.4100
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -0.5192
Cell Significance Index: -5.3800
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: -0.5234
Cell Significance Index: -4.7700
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.5263
Cell Significance Index: -5.3400
Cell Name: T cell (CL0000084)
Fold Change: -0.5302
Cell Significance Index: -6.2600
Cell Name: M cell of gut (CL0000682)
Fold Change: -0.5377
Cell Significance Index: -4.4800
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.5448
Cell Significance Index: -6.3200
Cell Name: promyelocyte (CL0000836)
Fold Change: -0.5463
Cell Significance Index: -5.4000
Cell Name: IgM plasma cell (CL0000986)
Fold Change: -0.5509
Cell Significance Index: -4.2300
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.5510
Cell Significance Index: -5.1300
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: -0.5520
Cell Significance Index: -5.3900
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.5550
Cell Significance Index: -5.8900
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.5593
Cell Significance Index: -6.1400
Cell Name: immature B cell (CL0000816)
Fold Change: -0.5644
Cell Significance Index: -5.3400
Cell Name: preosteoblast (CL0007010)
Fold Change: -0.5658
Cell Significance Index: -5.1400
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: -0.5700
Cell Significance Index: -3.9500
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: -0.5718
Cell Significance Index: -4.0300
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: -0.5725
Cell Significance Index: -4.9400
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: -0.5726
Cell Significance Index: -4.2600
Cell Name: naive B cell (CL0000788)
Fold Change: -0.5727
Cell Significance Index: -6.0300
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.5751
Cell Significance Index: -6.3700
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: -0.5798
Cell Significance Index: -5.3800
Cell Name: alveolar adventitial fibroblast (CL4028006)
Fold Change: -0.5807
Cell Significance Index: -6.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGLV3-27 is characterized by its involvement in various immune-related pathways, including adaptive immune response, anti-inflammatory response, and complement cascade activation. This gene is specifically associated with the recognition and binding of antigens by B cells, leading to the generation of second messengers and the activation of signaling pathways. IGLV3-27 is also implicated in the regulation of actin dynamics, phagocytic cup formation, and calcium mobilization, highlighting its importance in the cellular processes involved in immune responses. **Pathways and Functions** IGLV3-27 is involved in several key immune-related pathways, including: 1. **Adaptive Immune Response**: IGLV3-27 plays a crucial role in the adaptive immune response, particularly in the context of Leishmania infection. This involves the recognition and binding of antigens by B cells, leading to the activation of signaling pathways and the generation of second messengers. 2. **Anti-inflammatory Response**: IGLV3-27 is also involved in the anti-inflammatory response, which is crucial for the control of Leishmania infection. This involves the regulation of complement cascade activation and the production of anti-inflammatory cytokines. 3. **Complement Cascade Activation**: IGLV3-27 is implicated in the regulation of complement cascade activation, which is essential for the elimination of pathogens, including Leishmania parasites. 4. **Phagocytic Activity**: IGLV3-27 is involved in the regulation of phagocytic activity, particularly in the context of Leishmania phagocytosis. This involves the regulation of actin dynamics, phagocytic cup formation, and calcium mobilization. **Clinical Significance** IGLV3-27 has significant clinical implications, particularly in the context of Leishmania infection. This gene is involved in the recognition and binding of antigens by B cells, leading to the activation of signaling pathways and the generation of second messengers. IGLV3-27 is also implicated in the regulation of actin dynamics, phagocytic cup formation, and calcium mobilization, highlighting its importance in the cellular processes involved in immune responses. In the context of Leishmania infection, IGLV3-27 may play a crucial role in the control of the disease. This involves the regulation of complement cascade activation, the production of anti-inflammatory cytokines, and the elimination of Leishmania parasites through phagocytosis. Dysregulation of IGLV3-27 may contribute to the pathogenesis of Leishmania infection, highlighting the importance of this gene in the development of therapeutic strategies for this disease. In conclusion, IGLV3-27 is a gene that plays a crucial role in the adaptive immune response, particularly in the context of Leishmania infection. Its involvement in various immune-related pathways, including adaptive immune response, anti-inflammatory response, and complement cascade activation, highlights its importance in the control of this disease. Further research is needed to fully understand the role of IGLV3-27 in Leishmania infection and to develop therapeutic strategies for the treatment of this disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.