IGLV3 27 | ENSG00000211658 | NCBI 28791

Details for: IGLV3 27

Gene ID: 28791

Symbol: IGLV3 27

Ensembl ID: ENSG00000211658

Description: immunoglobulin lambda variable 3-27

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin production
(GO:0002377)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: goblet cell (CL0000160)
Fold Change: 1.62
Marker Score: 10,796
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.38
Marker Score: 876
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.25
Marker Score: 7,576
Cell Name: abnormal cell (CL0001061)
Fold Change: 1.22
Marker Score: 3,654
Cell Name: absorptive cell (CL0000212)
Fold Change: 1.06
Marker Score: 32,728
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.05
Marker Score: 802
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,817
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2,401
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5,241
Cell Name: mast cell (CL0000097)
Fold Change: 0.81
Marker Score: 470
Cell Name: brush cell (CL0002204)
Fold Change: 0.81
Marker Score: 737
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,260
Cell Name: T cell (CL0000084)
Fold Change: 0.73
Marker Score: 1,265
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.73
Marker Score: 566
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.71
Marker Score: 182
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.57
Marker Score: 151
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 439
Cell Name: monocyte (CL0000576)
Fold Change: 0.55
Marker Score: 709
Cell Name: fibroblast (CL0000057)
Fold Change: 0.5
Marker Score: 487
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.48
Marker Score: 762
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.46
Marker Score: 444
Cell Name: B cell (CL0000236)
Fold Change: 0.45
Marker Score: 433
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.43
Marker Score: 386
Cell Name: Unknown (CL0000003)
Fold Change: 0.43
Marker Score: 1,327
Cell Name: plasmablast (CL0000980)
Fold Change: 0.43
Marker Score: 566
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 377
Cell Name: plasma cell (CL0000786)
Fold Change: 0.34
Marker Score: 380
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.34
Marker Score: 551
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.28
Marker Score: 368
Cell Name: neutrophil (CL0000775)
Fold Change: 0.26
Marker Score: 159
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.25
Marker Score: 111
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.25
Marker Score: 141
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.23
Marker Score: 153
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.22
Marker Score: 149
Cell Name: platelet (CL0000233)
Fold Change: 0.21
Marker Score: 97
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.21
Marker Score: 505
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.19
Marker Score: 464
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.16
Marker Score: 107
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.15
Marker Score: 347
Cell Name: naive B cell (CL0000788)
Fold Change: 0.15
Marker Score: 132
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.13
Marker Score: 59
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.13
Marker Score: 53
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.12
Marker Score: 106
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.12
Marker Score: 101
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.11
Marker Score: 468
Cell Name: blood cell (CL0000081)
Fold Change: 0.1
Marker Score: 1,159
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.09
Marker Score: 51
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.07
Marker Score: 17
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.07
Marker Score: 65
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.07
Marker Score: 17
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.07
Marker Score: 76
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.07
Marker Score: 42
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.07
Marker Score: 137
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.07
Marker Score: 63
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.06
Marker Score: 43
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.06
Marker Score: 111
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.05
Marker Score: 62
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.05
Marker Score: 17
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.04
Marker Score: 12
Cell Name: immature B cell (CL0000816)
Fold Change: 0.04
Marker Score: 27
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.04
Marker Score: 15
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.04
Marker Score: 13
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.04
Marker Score: 9
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.03
Marker Score: 13
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.03
Marker Score: 9
Cell Name: pericyte (CL0000669)
Fold Change: 0.03
Marker Score: 20
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.03
Marker Score: 20
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.03
Marker Score: 32
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.03
Marker Score: 27
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.03
Marker Score: 17
Cell Name: enucleated reticulocyte (CL0002422)
Fold Change: 0.03
Marker Score: 12
Cell Name: stromal cell (CL0000499)
Fold Change: 0.03
Marker Score: 38
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.03
Marker Score: 13
Cell Name: memory B cell (CL0000787)
Fold Change: 0.03
Marker Score: 22
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.03
Marker Score: 17
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.03
Marker Score: 15
Cell Name: macrophage (CL0000235)
Fold Change: 0.03
Marker Score: 30
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.03
Marker Score: 47
Cell Name: leukocyte (CL0000738)
Fold Change: 0.03
Marker Score: 15
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.02
Marker Score: 30
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.02
Marker Score: 17
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.02
Marker Score: 14
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.02
Marker Score: 17
Cell Name: Unknown (CL0000548)
Fold Change: 0.02
Marker Score: 17
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.02
Marker Score: 12
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.02
Marker Score: 13
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.02
Marker Score: 15
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.02
Marker Score: 13
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.02
Marker Score: 21
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.02
Marker Score: 39
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.02
Marker Score: 15
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.02
Marker Score: 14
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.02
Marker Score: 17
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.02
Marker Score: 15
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.02
Marker Score: 31
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.02
Marker Score: 15
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.02
Marker Score: 29
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.02
Marker Score: 12
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.02
Marker Score: 32
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.02
Marker Score: 51

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics** IGLV3-27 is characterized by its involvement in various immune-related pathways, including adaptive immune response, anti-inflammatory response, and complement cascade activation. This gene is specifically associated with the recognition and binding of antigens by B cells, leading to the generation of second messengers and the activation of signaling pathways. IGLV3-27 is also implicated in the regulation of actin dynamics, phagocytic cup formation, and calcium mobilization, highlighting its importance in the cellular processes involved in immune responses. **Pathways and Functions** IGLV3-27 is involved in several key immune-related pathways, including: 1. **Adaptive Immune Response**: IGLV3-27 plays a crucial role in the adaptive immune response, particularly in the context of Leishmania infection. This involves the recognition and binding of antigens by B cells, leading to the activation of signaling pathways and the generation of second messengers. 2. **Anti-inflammatory Response**: IGLV3-27 is also involved in the anti-inflammatory response, which is crucial for the control of Leishmania infection. This involves the regulation of complement cascade activation and the production of anti-inflammatory cytokines. 3. **Complement Cascade Activation**: IGLV3-27 is implicated in the regulation of complement cascade activation, which is essential for the elimination of pathogens, including Leishmania parasites. 4. **Phagocytic Activity**: IGLV3-27 is involved in the regulation of phagocytic activity, particularly in the context of Leishmania phagocytosis. This involves the regulation of actin dynamics, phagocytic cup formation, and calcium mobilization. **Clinical Significance** IGLV3-27 has significant clinical implications, particularly in the context of Leishmania infection. This gene is involved in the recognition and binding of antigens by B cells, leading to the activation of signaling pathways and the generation of second messengers. IGLV3-27 is also implicated in the regulation of actin dynamics, phagocytic cup formation, and calcium mobilization, highlighting its importance in the cellular processes involved in immune responses. In the context of Leishmania infection, IGLV3-27 may play a crucial role in the control of the disease. This involves the regulation of complement cascade activation, the production of anti-inflammatory cytokines, and the elimination of Leishmania parasites through phagocytosis. Dysregulation of IGLV3-27 may contribute to the pathogenesis of Leishmania infection, highlighting the importance of this gene in the development of therapeutic strategies for this disease. In conclusion, IGLV3-27 is a gene that plays a crucial role in the adaptive immune response, particularly in the context of Leishmania infection. Its involvement in various immune-related pathways, including adaptive immune response, anti-inflammatory response, and complement cascade activation, highlights its importance in the control of this disease. Further research is needed to fully understand the role of IGLV3-27 in Leishmania infection and to develop therapeutic strategies for the treatment of this disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.