Details for: IGKV6D 21

Gene ID: 28870

Symbol: IGKV6D 21

Ensembl ID: ENSG00000225523

Description: immunoglobulin kappa variable 6D-21 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0597
    Cell Significance Index: 1.0200
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.0144
    Cell Significance Index: 0.1300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.0058
    Cell Significance Index: 0.0600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0056
    Cell Significance Index: 0.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0013
    Cell Significance Index: 0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0009
    Cell Significance Index: -0.6600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0045
    Cell Significance Index: -0.1200
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0054
    Cell Significance Index: -0.0600
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0075
    Cell Significance Index: -0.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0081
    Cell Significance Index: -0.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0092
    Cell Significance Index: -0.6200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0107
    Cell Significance Index: -0.1500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0159
    Cell Significance Index: -0.1700
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0177
    Cell Significance Index: -0.1900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0215
    Cell Significance Index: -0.2400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0224
    Cell Significance Index: -0.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0251
    Cell Significance Index: -0.5000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0256
    Cell Significance Index: -0.2500
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0260
    Cell Significance Index: -0.2300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0270
    Cell Significance Index: -0.4100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0271
    Cell Significance Index: -0.4000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0279
    Cell Significance Index: -0.4700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0295
    Cell Significance Index: -0.7200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0296
    Cell Significance Index: -0.4800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0304
    Cell Significance Index: -0.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0308
    Cell Significance Index: -0.5700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0311
    Cell Significance Index: -0.5000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0313
    Cell Significance Index: -0.3200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0322
    Cell Significance Index: -0.6300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0329
    Cell Significance Index: -0.3500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0346
    Cell Significance Index: -0.4600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0353
    Cell Significance Index: -0.4200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0358
    Cell Significance Index: -0.5200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0359
    Cell Significance Index: -0.4300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0381
    Cell Significance Index: -0.4500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0381
    Cell Significance Index: -0.4900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0382
    Cell Significance Index: -0.4700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0386
    Cell Significance Index: -0.4100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0395
    Cell Significance Index: -0.5200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0402
    Cell Significance Index: -0.3400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0406
    Cell Significance Index: -0.4400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0417
    Cell Significance Index: -0.4700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0418
    Cell Significance Index: -0.4400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0423
    Cell Significance Index: -0.4500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0438
    Cell Significance Index: -0.4100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0441
    Cell Significance Index: -0.4500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0446
    Cell Significance Index: -0.4600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0456
    Cell Significance Index: -0.4900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0458
    Cell Significance Index: -0.5200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0461
    Cell Significance Index: -0.6100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0467
    Cell Significance Index: -0.6400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0469
    Cell Significance Index: -0.4400
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0479
    Cell Significance Index: -0.5300
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0482
    Cell Significance Index: -0.4200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0483
    Cell Significance Index: -0.5100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0490
    Cell Significance Index: -0.5000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0498
    Cell Significance Index: -0.5100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0504
    Cell Significance Index: -0.5800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0506
    Cell Significance Index: -0.6600
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0506
    Cell Significance Index: -0.4700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0508
    Cell Significance Index: -0.6000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0512
    Cell Significance Index: -0.5200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0522
    Cell Significance Index: -0.5000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0522
    Cell Significance Index: -0.4600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0526
    Cell Significance Index: -0.4900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0526
    Cell Significance Index: -0.6100
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.0534
    Cell Significance Index: -0.4600
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0540
    Cell Significance Index: -0.4600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0542
    Cell Significance Index: -0.6000
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0552
    Cell Significance Index: -0.5600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0554
    Cell Significance Index: -0.4700
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0560
    Cell Significance Index: -0.5300
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0574
    Cell Significance Index: -0.4800
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0579
    Cell Significance Index: -0.6100
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0580
    Cell Significance Index: -0.5300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0580
    Cell Significance Index: -0.5500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0600
    Cell Significance Index: -0.6900
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0608
    Cell Significance Index: -0.6300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0608
    Cell Significance Index: -0.6500
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0610
    Cell Significance Index: -0.4900
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0625
    Cell Significance Index: -0.6000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0633
    Cell Significance Index: -0.4600
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0638
    Cell Significance Index: -0.5200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0640
    Cell Significance Index: -0.6900
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.0640
    Cell Significance Index: -0.4700
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.0641
    Cell Significance Index: -0.4800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0649
    Cell Significance Index: -0.5600
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0651
    Cell Significance Index: -0.6700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0653
    Cell Significance Index: -0.6600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0663
    Cell Significance Index: -0.5800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0671
    Cell Significance Index: -0.6700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0673
    Cell Significance Index: -0.6000
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.0678
    Cell Significance Index: -0.3600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0685
    Cell Significance Index: -0.6900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0693
    Cell Significance Index: -0.4300
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.0698
    Cell Significance Index: -0.3500
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.0716
    Cell Significance Index: -0.5500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0730
    Cell Significance Index: -0.6500
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0731
    Cell Significance Index: -0.4600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0735
    Cell Significance Index: -0.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV6D 21 is a member of the immunoglobulin kappa (IgK) gene family, which encodes for the variable region of the kappa light chain of immunoglobulins. However, unlike other functional IgK genes, IGKV6D 21 is non-functional and lacks the typical immunoglobulin gene structure. This suggests that IGKV6D 21 may have evolved to occupy a unique niche in the intestinal epithelium, potentially serving as a decoy or a regulatory mechanism to modulate the immune response. **Pathways and Functions:** IGKV6D 21 is involved in various cellular processes, including: 1. **Adaptive Immune Response:** IGKV6D 21 is significantly expressed in lymphocytes, suggesting its potential involvement in the adaptive immune response. However, its non-functional nature raises questions about its role in this process. 2. **Immunoglobulin Production:** IGKV6D 21 is also expressed in intestinal epithelial cells, which are responsible for producing immunoglobulins. This suggests that IGKV6D 21 may be involved in regulating immunoglobulin production or modulating the immune response in the intestinal epithelium. 3. **Extracellular Space:** IGKV6D 21 is secreted into the extracellular space, where it may interact with other molecules or cells to modulate the immune response. **Clinical Significance:** IGKV6D 21 has significant implications for our understanding of the intestinal immune system and its relationship to various diseases. Some potential clinical implications of IGKV6D 21 include: 1. **Intestinal Inflammation:** The widespread expression of IGKV6D 21 in the intestinal epithelium may contribute to intestinal inflammation and immune dysregulation in diseases such as inflammatory bowel disease (IBD). 2. **Cancer:** IGKV6D 21 is also expressed in neoplastic cells, suggesting its potential role in cancer development and progression. 3. **Immunological Tolerance:** IGKV6D 21 may play a role in maintaining immunological tolerance in the intestinal epithelium, which is essential for preventing autoimmune diseases. In conclusion, IGKV6D 21 is a non-functional gene with widespread expression in the intestinal epithelium. Its potential functions and mechanisms in the adaptive immune response, immunoglobulin production, and extracellular space are still unclear. Further research is needed to unravel the mystery of IGKV6D 21 and its implications for our understanding of the intestinal immune system and its relationship to various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.