IGKV1D 16 | ENSG00000241244 | NCBI 28901

Details for: IGKV1D 16

Gene ID: 28901

Symbol: IGKV1D 16

Ensembl ID: ENSG00000241244

Description: immunoglobulin kappa variable 1D-16

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7,692
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.07
Marker Score: 714
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.96
Marker Score: 2,434
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,353
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,743
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.88
Marker Score: 1,433
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,295
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 713
Cell Name: Unknown (CL0000003)
Fold Change: 0.66
Marker Score: 2,055
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.65
Marker Score: 522
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.29
Marker Score: 374
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.23
Marker Score: 375
Cell Name: plasmablast (CL0000980)
Fold Change: 0.2
Marker Score: 262
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.19
Marker Score: 429
Cell Name: plasma cell (CL0000786)
Fold Change: 0.19
Marker Score: 208
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.18
Marker Score: 104
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.17
Marker Score: 135
Cell Name: naive B cell (CL0000788)
Fold Change: 0.17
Marker Score: 155
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.13
Marker Score: 159
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.12
Marker Score: 508
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.12
Marker Score: 51
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.09
Marker Score: 52
Cell Name: platelet (CL0000233)
Fold Change: 0.09
Marker Score: 41
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.08
Marker Score: 21
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.07
Marker Score: 48
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.07
Marker Score: 45
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.06
Marker Score: 154
Cell Name: memory B cell (CL0000787)
Fold Change: 0.06
Marker Score: 47
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.06
Marker Score: 17
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.06
Marker Score: 52
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.05
Marker Score: 12
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.05
Marker Score: 25
Cell Name: blood cell (CL0000081)
Fold Change: 0.05
Marker Score: 541
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.04
Marker Score: 46
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.04
Marker Score: 29
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.04
Marker Score: 14
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.04
Marker Score: 32
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.04
Marker Score: 66
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.04
Marker Score: 89
Cell Name: B cell (CL0000236)
Fold Change: 0.03
Marker Score: 31
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.03
Marker Score: 15
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.03
Marker Score: 13
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.03
Marker Score: 15
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.03
Marker Score: 33
Cell Name: stromal cell (CL0000499)
Fold Change: 0.03
Marker Score: 32
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.03
Marker Score: 9
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.02
Marker Score: 23
Cell Name: mast cell (CL0000097)
Fold Change: 0.02
Marker Score: 14
Cell Name: pericyte (CL0000669)
Fold Change: 0.02
Marker Score: 14
Cell Name: naive T cell (CL0000898)
Fold Change: 0.02
Marker Score: 15
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.02
Marker Score: 13
Cell Name: Unknown (CL0000548)
Fold Change: 0.02
Marker Score: 15
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.02
Marker Score: 12
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.02
Marker Score: 15
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.02
Marker Score: 14
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.02
Marker Score: 34
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.02
Marker Score: 27
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.02
Marker Score: 15
Cell Name: mature B cell (CL0000785)
Fold Change: 0.02
Marker Score: 14
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.02
Marker Score: 10
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.02
Marker Score: 18
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.02
Marker Score: 14
Cell Name: immature B cell (CL0000816)
Fold Change: 0.02
Marker Score: 12
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.02
Marker Score: 14
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.02
Marker Score: 14
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.01
Marker Score: 29
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.01
Marker Score: 12
Cell Name: monocyte (CL0000576)
Fold Change: 0.01
Marker Score: 19
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.01
Marker Score: 14
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.01
Marker Score: 16
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.01
Marker Score: 12
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.01
Marker Score: 9
Cell Name: fibroblast (CL0000057)
Fold Change: 0.01
Marker Score: 13
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.01
Marker Score: 12
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.01
Marker Score: 11
Cell Name: neutrophil (CL0000775)
Fold Change: 0.01
Marker Score: 8
Cell Name: glial cell (CL0000125)
Fold Change: 0.01
Marker Score: 14
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.01
Marker Score: 15
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.01
Marker Score: 11
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.01
Marker Score: 11
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.01
Marker Score: 20
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.01
Marker Score: 530
Cell Name: macrophage (CL0000235)
Fold Change: 0.01
Marker Score: 10
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.01
Marker Score: 14
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.01
Marker Score: 9
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.01
Marker Score: 9
Cell Name: T cell (CL0000084)
Fold Change: 0.01
Marker Score: 14
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.01
Marker Score: 22
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.01
Marker Score: 11
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.01
Marker Score: 8
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.01
Marker Score: 9
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0
Marker Score: 11
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0
Marker Score: 11
Cell Name: enterocyte (CL0000584)
Fold Change: 0
Marker Score: 19
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0
Marker Score: 201
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0
Marker Score: 9
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0
Marker Score: 14
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0
Marker Score: 15
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0
Marker Score: 7

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics:** IGKV1D16 is a member of the immunoglobulin kappa variable family, which plays a crucial role in the adaptive immune system. The gene is characterized by its ability to participate in various signaling pathways, including the activation of the B-cell receptor (BCR), the regulation of complement cascade, and the modulation of actin dynamics for phagocytic cup formation. IGKV1D16 is also involved in the scavenging of heme from plasma and the regulation of calcium mobilization, which are essential processes in immune cell function. **Pathways and Functions:** IGKV1D16 is intricately involved in multiple immune-related pathways, including: 1. **Adaptive immune system**: IGKV1D16 plays a crucial role in the activation of B cells and the subsequent production of antibodies, which is essential for the adaptive immune response. 2. **Anti-inflammatory response**: IGKV1D16 is involved in the regulation of anti-inflammatory responses, particularly in the context of Leishmania parasite infection. 3. **Antigen activation**: IGKV1D16 is activated by antigens, leading to the generation of second messengers and the activation of various signaling pathways. 4. **Scavenger receptor-mediated processes**: IGKV1D16 is involved in the binding and uptake of ligands by scavenger receptors, which is essential for the clearance of pathogens and the regulation of immune responses. 5. **Complement cascade**: IGKV1D16 is involved in the regulation of the complement cascade, which is a critical component of the innate immune system. **Clinical Significance:** IGKV1D16's involvement in various immune-related pathways makes it a potential target for the development of novel therapeutic strategies for infectious diseases, such as Leishmania parasite infection. The regulation of IGKV1D16 by Cd22, a molecule involved in the regulation of BCR signaling, highlights the importance of this gene in the development of immunotherapies. Furthermore, the involvement of IGKV1D16 in the regulation of actin dynamics for phagocytic cup formation underscores its potential role in the clearance of pathogens and the regulation of immune responses. In conclusion, IGKV1D16 is a multifunctional gene that plays a critical role in regulating immune responses, particularly in the context of infectious diseases. Further research is needed to fully elucidate the mechanisms underlying IGKV1D16's functions and to explore its potential as a therapeutic target. **Implications for Future Research:** 1. **Investigation of IGKV1D16's role in Leishmania parasite infection**: Further studies are needed to elucidate the mechanisms underlying IGKV1D16's involvement in Leishmania parasite infection and to explore its potential as a therapeutic target. 2. **Regulation of IGKV1D16 by Cd22**: The regulation of IGKV1D16 by Cd22 highlights the importance of this gene in the development of immunotherapies. Further studies are needed to elucidate the mechanisms underlying this regulation and to explore its potential as a therapeutic target. 3. **Investigation of IGKV1D16's role in other immune-related diseases**: IGKV1D16's involvement in various immune-related pathways makes it a potential target for the development of novel therapeutic strategies for other immune-related diseases. In summary, IGKV1D16 is a multifunctional gene that plays a critical role in regulating immune responses, particularly in the context of infectious diseases. Further research is needed to fully elucidate the mechanisms underlying IGKV1D16's functions and to explore its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.