IGKV1D 16 | ENSG00000241244 | NCBI 28901

Details for: IGKV1D 16

Gene ID: 28901

Symbol: IGKV1D 16

Ensembl ID: ENSG00000241244

Description: immunoglobulin kappa variable 1D-16

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.0099
Cell Significance Index: 0.1500
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.0096
Cell Significance Index: -0.1300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0135
Cell Significance Index: -0.7000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0184
Cell Significance Index: -0.5300
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.0230
Cell Significance Index: -0.1900
Cell Name: plasma cell (CL0000786)
Fold Change: -0.0251
Cell Significance Index: -0.2800
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0330
Cell Significance Index: -0.8400
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.0360
Cell Significance Index: -0.2400
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0367
Cell Significance Index: -0.4800
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.0371
Cell Significance Index: -0.5100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0378
Cell Significance Index: -1.7600
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.0380
Cell Significance Index: -0.4900
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.0396
Cell Significance Index: -0.4500
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: -0.0396
Cell Significance Index: -0.4300
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0402
Cell Significance Index: -0.5200
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.0412
Cell Significance Index: -0.5700
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0511
Cell Significance Index: -1.0600
Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.0541
Cell Significance Index: -0.8700
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0557
Cell Significance Index: -1.3500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0557
Cell Significance Index: -1.0300
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0605
Cell Significance Index: -0.8600
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.0606
Cell Significance Index: -0.8500
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.0615
Cell Significance Index: -0.7900
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.0623
Cell Significance Index: -0.6500
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0639
Cell Significance Index: -1.0400
Cell Name: stromal cell (CL0000499)
Fold Change: -0.0646
Cell Significance Index: -0.6600
Cell Name: B cell (CL0000236)
Fold Change: -0.0652
Cell Significance Index: -0.7700
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0665
Cell Significance Index: -1.3000
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.0666
Cell Significance Index: -0.8100
Cell Name: pericyte (CL0000669)
Fold Change: -0.0675
Cell Significance Index: -0.8100
Cell Name: mast cell (CL0000097)
Fold Change: -0.0676
Cell Significance Index: -0.8900
Cell Name: memory B cell (CL0000787)
Fold Change: -0.0677
Cell Significance Index: -0.7200
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.0677
Cell Significance Index: -0.9000
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.0678
Cell Significance Index: -0.6200
Cell Name: blood cell (CL0000081)
Fold Change: -0.0710
Cell Significance Index: -0.6100
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0716
Cell Significance Index: -1.0400
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.0736
Cell Significance Index: -0.7800
Cell Name: chondrocyte (CL0000138)
Fold Change: -0.0737
Cell Significance Index: -0.8500
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: -0.0742
Cell Significance Index: -0.7500
Cell Name: glial cell (CL0000125)
Fold Change: -0.0758
Cell Significance Index: -0.8300
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.0759
Cell Significance Index: -0.6100
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.0769
Cell Significance Index: -0.9500
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.0772
Cell Significance Index: -1.3200
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: -0.0772
Cell Significance Index: -0.8300
Cell Name: enterocyte (CL0000584)
Fold Change: -0.0774
Cell Significance Index: -0.4800
Cell Name: club cell (CL0000158)
Fold Change: -0.0785
Cell Significance Index: -0.8600
Cell Name: fibroblast (CL0000057)
Fold Change: -0.0799
Cell Significance Index: -0.7500
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.0800
Cell Significance Index: -0.8500
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: -0.0811
Cell Significance Index: -0.8400
Cell Name: naive B cell (CL0000788)
Fold Change: -0.0817
Cell Significance Index: -0.8600
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.0826
Cell Significance Index: -0.8100
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0831
Cell Significance Index: -1.1400
Cell Name: neutrophil (CL0000775)
Fold Change: -0.0837
Cell Significance Index: -1.0500
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.0848
Cell Significance Index: -0.9900
Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.0849
Cell Significance Index: -0.9200
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.0858
Cell Significance Index: -1.0200
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.0859
Cell Significance Index: -1.0200
Cell Name: T cell (CL0000084)
Fold Change: -0.0864
Cell Significance Index: -1.0200
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.0867
Cell Significance Index: -0.9600
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.0869
Cell Significance Index: -1.1400
Cell Name: B-2 B cell (CL0000822)
Fold Change: -0.0869
Cell Significance Index: -0.7700
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.0882
Cell Significance Index: -0.8700
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.0886
Cell Significance Index: -1.0200
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.0889
Cell Significance Index: -1.1600
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.0894
Cell Significance Index: -0.9300
Cell Name: B-1 B cell (CL0000819)
Fold Change: -0.0895
Cell Significance Index: -0.7800
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.0911
Cell Significance Index: -1.0000
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.0914
Cell Significance Index: -1.0600
Cell Name: macrophage (CL0000235)
Fold Change: -0.0916
Cell Significance Index: -0.9400
Cell Name: plasmablast (CL0000980)
Fold Change: -0.0916
Cell Significance Index: -0.8500
Cell Name: monocyte (CL0000576)
Fold Change: -0.0921
Cell Significance Index: -1.0600
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.0922
Cell Significance Index: -1.0300
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.0930
Cell Significance Index: -0.8700
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.0939
Cell Significance Index: -1.0100
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: -0.0942
Cell Significance Index: -1.0200
Cell Name: smooth muscle cell of the pulmonary artery (CL0002591)
Fold Change: -0.0954
Cell Significance Index: -0.8100
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.0960
Cell Significance Index: -0.9100
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: -0.0962
Cell Significance Index: -0.9400
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.0967
Cell Significance Index: -0.9000
Cell Name: obsolete animal cell (CL0000548)
Fold Change: -0.0976
Cell Significance Index: -0.9900
Cell Name: fibroblast of breast (CL4006000)
Fold Change: -0.0986
Cell Significance Index: -0.6200
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.1000
Cell Significance Index: -1.1100
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.1005
Cell Significance Index: -1.0600
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.1012
Cell Significance Index: -1.0500
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -0.1023
Cell Significance Index: -1.0600
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.1033
Cell Significance Index: -1.1000
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.1064
Cell Significance Index: -1.0800
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.1065
Cell Significance Index: -0.9500
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.1065
Cell Significance Index: -1.2000
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: -0.1084
Cell Significance Index: -1.0200
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: -0.1118
Cell Significance Index: -0.9700
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: -0.1139
Cell Significance Index: -0.9300
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.1141
Cell Significance Index: -1.2300
Cell Name: immature B cell (CL0000816)
Fold Change: -0.1141
Cell Significance Index: -1.0800
Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.1141
Cell Significance Index: -1.0100
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: -0.1147
Cell Significance Index: -1.2200
Cell Name: goblet cell (CL0000160)
Fold Change: -0.1150
Cell Significance Index: -1.0400
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.1152
Cell Significance Index: -1.1500
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: -0.1165
Cell Significance Index: -1.0100
Cell Name: intestine goblet cell (CL0019031)
Fold Change: -0.1172
Cell Significance Index: -1.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** IGKV1D16 is a member of the immunoglobulin kappa variable family, which plays a crucial role in the adaptive immune system. The gene is characterized by its ability to participate in various signaling pathways, including the activation of the B-cell receptor (BCR), the regulation of complement cascade, and the modulation of actin dynamics for phagocytic cup formation. IGKV1D16 is also involved in the scavenging of heme from plasma and the regulation of calcium mobilization, which are essential processes in immune cell function. **Pathways and Functions:** IGKV1D16 is intricately involved in multiple immune-related pathways, including: 1. **Adaptive immune system**: IGKV1D16 plays a crucial role in the activation of B cells and the subsequent production of antibodies, which is essential for the adaptive immune response. 2. **Anti-inflammatory response**: IGKV1D16 is involved in the regulation of anti-inflammatory responses, particularly in the context of Leishmania parasite infection. 3. **Antigen activation**: IGKV1D16 is activated by antigens, leading to the generation of second messengers and the activation of various signaling pathways. 4. **Scavenger receptor-mediated processes**: IGKV1D16 is involved in the binding and uptake of ligands by scavenger receptors, which is essential for the clearance of pathogens and the regulation of immune responses. 5. **Complement cascade**: IGKV1D16 is involved in the regulation of the complement cascade, which is a critical component of the innate immune system. **Clinical Significance:** IGKV1D16's involvement in various immune-related pathways makes it a potential target for the development of novel therapeutic strategies for infectious diseases, such as Leishmania parasite infection. The regulation of IGKV1D16 by Cd22, a molecule involved in the regulation of BCR signaling, highlights the importance of this gene in the development of immunotherapies. Furthermore, the involvement of IGKV1D16 in the regulation of actin dynamics for phagocytic cup formation underscores its potential role in the clearance of pathogens and the regulation of immune responses. In conclusion, IGKV1D16 is a multifunctional gene that plays a critical role in regulating immune responses, particularly in the context of infectious diseases. Further research is needed to fully elucidate the mechanisms underlying IGKV1D16's functions and to explore its potential as a therapeutic target. **Implications for Future Research:** 1. **Investigation of IGKV1D16's role in Leishmania parasite infection**: Further studies are needed to elucidate the mechanisms underlying IGKV1D16's involvement in Leishmania parasite infection and to explore its potential as a therapeutic target. 2. **Regulation of IGKV1D16 by Cd22**: The regulation of IGKV1D16 by Cd22 highlights the importance of this gene in the development of immunotherapies. Further studies are needed to elucidate the mechanisms underlying this regulation and to explore its potential as a therapeutic target. 3. **Investigation of IGKV1D16's role in other immune-related diseases**: IGKV1D16's involvement in various immune-related pathways makes it a potential target for the development of novel therapeutic strategies for other immune-related diseases. In summary, IGKV1D16 is a multifunctional gene that plays a critical role in regulating immune responses, particularly in the context of infectious diseases. Further research is needed to fully elucidate the mechanisms underlying IGKV1D16's functions and to explore its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.