IGKV1D 12 | ENSG00000278857 | NCBI 28903

Details for: IGKV1D 12

Gene ID: 28903

Symbol: IGKV1D 12

Ensembl ID: ENSG00000278857

Description: immunoglobulin kappa variable 1D-12

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: stromal cell (CL0000499)
Fold Change: 0.6146
Cell Significance Index: 6.2800
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.0118
Cell Significance Index: -0.1600
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.0249
Cell Significance Index: -0.4300
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0465
Cell Significance Index: -1.1900
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0525
Cell Significance Index: -0.8500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0563
Cell Significance Index: -2.6300
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.0601
Cell Significance Index: -0.4000
Cell Name: plasma cell (CL0000786)
Fold Change: -0.0604
Cell Significance Index: -0.6800
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.0666
Cell Significance Index: -0.7900
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0670
Cell Significance Index: -1.3100
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0808
Cell Significance Index: -1.0500
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0816
Cell Significance Index: -1.1900
Cell Name: memory B cell (CL0000787)
Fold Change: -0.0855
Cell Significance Index: -0.9100
Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
Fold Change: -0.0860
Cell Significance Index: -0.7600
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0868
Cell Significance Index: -1.1900
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.0892
Cell Significance Index: -0.9100
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.0897
Cell Significance Index: -0.9100
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.0974
Cell Significance Index: -1.1900
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: -0.1019
Cell Significance Index: -1.0600
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.1039
Cell Significance Index: -0.9500
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: -0.1059
Cell Significance Index: -1.0700
Cell Name: naive B cell (CL0000788)
Fold Change: -0.1064
Cell Significance Index: -1.1200
Cell Name: B cell (CL0000236)
Fold Change: -0.1075
Cell Significance Index: -1.2700
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.1087
Cell Significance Index: -1.0900
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.1104
Cell Significance Index: -1.3100
Cell Name: B-2 B cell (CL0000822)
Fold Change: -0.1111
Cell Significance Index: -0.9900
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.1121
Cell Significance Index: -1.2900
Cell Name: neutrophil (CL0000775)
Fold Change: -0.1137
Cell Significance Index: -1.4200
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.1141
Cell Significance Index: -1.2300
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.1152
Cell Significance Index: -1.2700
Cell Name: plasmablast (CL0000980)
Fold Change: -0.1153
Cell Significance Index: -1.0700
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.1154
Cell Significance Index: -1.3000
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.1157
Cell Significance Index: -1.5100
Cell Name: mast cell (CL0000097)
Fold Change: -0.1170
Cell Significance Index: -1.5400
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.1174
Cell Significance Index: -1.3000
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.1174
Cell Significance Index: -1.5400
Cell Name: club cell (CL0000158)
Fold Change: -0.1193
Cell Significance Index: -1.3000
Cell Name: B-1 B cell (CL0000819)
Fold Change: -0.1193
Cell Significance Index: -1.0400
Cell Name: glial cell (CL0000125)
Fold Change: -0.1196
Cell Significance Index: -1.3100
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.1213
Cell Significance Index: -1.2800
Cell Name: monocyte (CL0000576)
Fold Change: -0.1217
Cell Significance Index: -1.4000
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.1222
Cell Significance Index: -1.5700
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.1228
Cell Significance Index: -1.1800
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.1244
Cell Significance Index: -1.2900
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.1244
Cell Significance Index: -1.4700
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.1253
Cell Significance Index: -1.5400
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: -0.1254
Cell Significance Index: -1.2300
Cell Name: immature B cell (CL0000816)
Fold Change: -0.1263
Cell Significance Index: -1.2000
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.1290
Cell Significance Index: -1.3700
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: -0.1324
Cell Significance Index: -1.2300
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: -0.1340
Cell Significance Index: -1.1200
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.1359
Cell Significance Index: -1.5100
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.1379
Cell Significance Index: -1.6000
Cell Name: pericyte (CL0000669)
Fold Change: -0.1384
Cell Significance Index: -1.6600
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.1395
Cell Significance Index: -1.5000
Cell Name: blood cell (CL0000081)
Fold Change: -0.1396
Cell Significance Index: -1.1900
Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.1420
Cell Significance Index: -1.5400
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.1422
Cell Significance Index: -1.2700
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.1449
Cell Significance Index: -1.2900
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: -0.1451
Cell Significance Index: -1.3000
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.1452
Cell Significance Index: -1.5400
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.1463
Cell Significance Index: -1.2800
Cell Name: platelet (CL0000233)
Fold Change: -0.1468
Cell Significance Index: -1.5100
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: -0.1474
Cell Significance Index: -1.1300
Cell Name: obsolete animal cell (CL0000548)
Fold Change: -0.1484
Cell Significance Index: -1.5100
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -0.1486
Cell Significance Index: -1.5400
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.1514
Cell Significance Index: -1.2900
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.1518
Cell Significance Index: -1.4200
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.1519
Cell Significance Index: -1.5300
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.1531
Cell Significance Index: -1.5100
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.1557
Cell Significance Index: -1.4500
Cell Name: IgM plasma cell (CL0000986)
Fold Change: -0.1615
Cell Significance Index: -1.2400
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: -0.1618
Cell Significance Index: -1.3000
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.1624
Cell Significance Index: -1.5400
Cell Name: macrophage (CL0000235)
Fold Change: -0.1626
Cell Significance Index: -1.6600
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: -0.1648
Cell Significance Index: -1.4300
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: -0.1655
Cell Significance Index: -1.5200
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.1682
Cell Significance Index: -1.5000
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: -0.1684
Cell Significance Index: -1.3100
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: -0.1714
Cell Significance Index: -1.3700
Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.1748
Cell Significance Index: -1.5400
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.1761
Cell Significance Index: -2.0000
Cell Name: elicited macrophage (CL0000861)
Fold Change: -0.1762
Cell Significance Index: -1.5400
Cell Name: basal cell (CL0000646)
Fold Change: -0.1773
Cell Significance Index: -2.1100
Cell Name: T cell (CL0000084)
Fold Change: -0.1796
Cell Significance Index: -2.1200
Cell Name: dendritic cell, human (CL0001056)
Fold Change: -0.1800
Cell Significance Index: -1.6600
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.1803
Cell Significance Index: -2.6600
Cell Name: germinal center B cell (CL0000844)
Fold Change: -0.1804
Cell Significance Index: -1.2800
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: -0.1813
Cell Significance Index: -1.5300
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: -0.1843
Cell Significance Index: -1.5900
Cell Name: mature B cell (CL0000785)
Fold Change: -0.1905
Cell Significance Index: -1.2400
Cell Name: goblet cell (CL0000160)
Fold Change: -0.1924
Cell Significance Index: -1.7400
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: -0.1933
Cell Significance Index: -1.9900
Cell Name: late pro-B cell (CL0002048)
Fold Change: -0.2098
Cell Significance Index: -1.5400
Cell Name: follicular B cell (CL0000843)
Fold Change: -0.2099
Cell Significance Index: -1.0500
Cell Name: enterocyte (CL0000584)
Fold Change: -0.2208
Cell Significance Index: -1.3700
Cell Name: peptic cell (CL0000155)
Fold Change: -0.2368
Cell Significance Index: -2.1000
Cell Name: stem cell (CL0000034)
Fold Change: -0.2408
Cell Significance Index: -1.7500
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: -0.2418
Cell Significance Index: -2.0000
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.2443
Cell Significance Index: -3.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGKV1D12 exhibits several key characteristics that distinguish it from other immunoglobulins: 1. **Variable region**: The IGKV1D12 gene encodes a variable region of a kappa light chain, which is essential for the specificity and diversity of the immune response. 2. **Widespread expression**: IGKV1D12 is expressed in a variety of cell types, including lymphocytes, intestinal epithelial cells, and mast cells, suggesting its involvement in multiple aspects of the immune response. 3. **Leishmania parasite infection**: The gene's involvement in anti-inflammatory responses favoring Leishmania parasite infection highlights its role in modulating the immune response to this particular pathogen. **Pathways and Functions** IGKV1D12 is involved in various pathways and functions, including: 1. **Adaptive immune response**: IGKV1D12 plays a role in the adaptive immune response, specifically in the generation of antibodies against pathogens. 2. **Anti-inflammatory response**: The gene's involvement in anti-inflammatory responses favoring Leishmania parasite infection suggests its role in modulating the immune response to reduce inflammation. 3. **Antigen binding**: IGKV1D12 is involved in antigen binding, which is essential for the activation of B cells and the generation of antibodies. 4. **Complement cascade**: The gene is involved in the complement cascade, which is a critical component of the innate immune response. 5. **Signaling by the B cell receptor (BCR)**: IGKV1D12 is involved in signaling by the BCR, which is essential for the activation of B cells and the generation of antibodies. **Clinical Significance** The clinical significance of IGKV1D12 is multifaceted: 1. **Leishmania parasite infection**: The gene's involvement in anti-inflammatory responses favoring Leishmania parasite infection highlights its potential as a therapeutic target for the treatment of this disease. 2. **Infectious disease**: IGKV1D12's role in the adaptive immune response and complement cascade makes it a potential target for the treatment of various infectious diseases. 3. **Autoimmune diseases**: The gene's involvement in antigen binding and signaling by the BCR suggests its potential role in autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Cancer**: IGKV1D12's expression in various cell types, including neoplastic cells, highlights its potential role in cancer development and progression. In conclusion, IGKV1D12 plays a critical role in the adaptive immune response, anti-inflammatory responses, and complement cascade. Its clinical significance is multifaceted, making it a potential target for the treatment of various diseases, including Leishmania parasite infection, infectious diseases, autoimmune diseases, and cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.