Details for: IGKV3 7

Gene ID: 28915

Symbol: IGKV3 7

Ensembl ID: ENSG00000243063

Description: immunoglobulin kappa variable 3-7 (non-functional)

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 802
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 390
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.45
    Marker Score: 296
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 212
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.31
    Marker Score: 296
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.28
    Marker Score: 869
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.19
    Marker Score: 252
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.13
    Marker Score: 292
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 91
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.08
    Marker Score: 71
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.08
    Marker Score: 38
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.07
    Marker Score: 112
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 134
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.07
    Marker Score: 56
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.06
    Marker Score: 76
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.06
    Marker Score: 75
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 62
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.05
    Marker Score: 218
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.04
    Marker Score: 98
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.03
    Marker Score: 34
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.02
    Marker Score: 201
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 125
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 83
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0
    Marker Score: 8

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGKV3-7 gene is a non-functional gene, meaning it does not produce a protein that can interact with the immune system. However, it is significantly expressed in various cell types, including: * Granulocyte-monocyte progenitor cells * Early T lineage precursors * Neutrophil progenitor cells * Neutrophils * Common myeloid progenitor cells * Megakaryocyte-erythroid progenitor cells * Precursor B cells * Fraction A pre-pro B cells * Mast cells * Pro-B cells These cell types are all involved in the development and function of the immune system, suggesting that the IGKV3-7 gene plays a role in regulating immune cell development. **Pathways and Functions:** The IGKV3-7 gene is involved in several immune-related pathways, including: * Adaptive immune response: The IGKV3-7 gene is expressed in precursor B cells, which are responsible for producing antibodies in response to antigens. The presence of this gene in these cells suggests that it may contribute to the regulation of the adaptive immune response. * Extracellular space: The IGKV3-7 gene is also expressed in neutrophils, which are involved in the innate immune response. Neutrophils play a crucial role in the clearance of pathogens and other foreign substances from the extracellular space. * Immune response: The IGKV3-7 gene is expressed in mast cells, which are involved in the regulation of the immune response. Mast cells can produce cytokines and other signaling molecules that influence the activity of other immune cells. **Clinical Significance:** The IGKV3-7 gene has potential clinical significance, particularly in the context of immune-related disorders. For example: * Autoimmune diseases: The IGKV3-7 gene may contribute to the development of autoimmune diseases, such as rheumatoid arthritis, lupus, or multiple sclerosis, by influencing the regulation of immune cell development and function. * Cancer: The IGKV3-7 gene may also be involved in the development of cancer, particularly in the context of immune evasion. Cancer cells can manipulate the expression of immune-related genes, including the IGKV3-7 gene, to evade immune surveillance. * Immunodeficiency disorders: The IGKV3-7 gene may also contribute to immunodeficiency disorders, such as X-linked lymphoproliferative disease, by influencing the regulation of immune cell development and function. In conclusion, the IGKV3-7 gene is a non-functional gene that plays a crucial role in the development and function of various immune cells. Its significant expression in multiple cell types suggests that it may contribute to the regulation of immune cell development and function, potentially influencing the adaptive immune response. Further studies are needed to fully understand the role of the IGKV3-7 gene in immune-related disorders and to explore its potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.