Details for: IGKV3 7

Gene ID: 28915

Symbol: IGKV3 7

Ensembl ID: ENSG00000243063

Description: immunoglobulin kappa variable 3-7 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1215
    Cell Significance Index: 1.5400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0461
    Cell Significance Index: 0.5200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.0025
    Cell Significance Index: 0.0200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0010
    Cell Significance Index: 0.0200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0029
    Cell Significance Index: -0.0300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0077
    Cell Significance Index: -0.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0087
    Cell Significance Index: -0.2500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0130
    Cell Significance Index: -0.2200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0140
    Cell Significance Index: -0.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0273
    Cell Significance Index: -0.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0313
    Cell Significance Index: -1.4600
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0339
    Cell Significance Index: -0.2800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0355
    Cell Significance Index: -0.4600
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0405
    Cell Significance Index: -0.2700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0433
    Cell Significance Index: -0.7400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0474
    Cell Significance Index: -0.5600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0502
    Cell Significance Index: -1.2800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0506
    Cell Significance Index: -0.5700
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0514
    Cell Significance Index: -0.4700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0544
    Cell Significance Index: -0.6800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0556
    Cell Significance Index: -0.6400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0562
    Cell Significance Index: -0.7000
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0607
    Cell Significance Index: -0.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0611
    Cell Significance Index: -1.4800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0621
    Cell Significance Index: -1.2200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0632
    Cell Significance Index: -0.8300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0639
    Cell Significance Index: -0.6800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0647
    Cell Significance Index: -0.8600
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0647
    Cell Significance Index: -0.6700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0652
    Cell Significance Index: -0.7700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0654
    Cell Significance Index: -0.6900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0675
    Cell Significance Index: -0.8300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0676
    Cell Significance Index: -0.6100
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0679
    Cell Significance Index: -0.6300
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0693
    Cell Significance Index: -0.7700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0695
    Cell Significance Index: -0.7100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0704
    Cell Significance Index: -0.9700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0710
    Cell Significance Index: -0.7700
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0710
    Cell Significance Index: -0.8300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0711
    Cell Significance Index: -0.8400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0719
    Cell Significance Index: -1.1700
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0723
    Cell Significance Index: -0.6300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0730
    Cell Significance Index: -0.7400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0733
    Cell Significance Index: -0.7600
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0734
    Cell Significance Index: -0.5900
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.0735
    Cell Significance Index: -0.7800
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0745
    Cell Significance Index: -0.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0747
    Cell Significance Index: -1.3800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0771
    Cell Significance Index: -0.9100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0775
    Cell Significance Index: -1.0200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0786
    Cell Significance Index: -0.9100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0789
    Cell Significance Index: -0.9200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0798
    Cell Significance Index: -0.8100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0810
    Cell Significance Index: -0.8600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0830
    Cell Significance Index: -1.2100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0835
    Cell Significance Index: -1.1700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0836
    Cell Significance Index: -0.8800
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0838
    Cell Significance Index: -0.7700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0840
    Cell Significance Index: -0.8800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0852
    Cell Significance Index: -1.2100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0869
    Cell Significance Index: -1.3200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0876
    Cell Significance Index: -0.7400
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0876
    Cell Significance Index: -0.7600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0881
    Cell Significance Index: -0.8900
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0881
    Cell Significance Index: -0.7700
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0883
    Cell Significance Index: -0.9200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0884
    Cell Significance Index: -0.8300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0889
    Cell Significance Index: -1.0500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0896
    Cell Significance Index: -1.2300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0902
    Cell Significance Index: -2.2500
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0933
    Cell Significance Index: -0.7600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0936
    Cell Significance Index: -0.6100
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0940
    Cell Significance Index: -0.8500
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0941
    Cell Significance Index: -0.8900
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0946
    Cell Significance Index: -0.7600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0963
    Cell Significance Index: -0.8200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0976
    Cell Significance Index: -1.1700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1003
    Cell Significance Index: -1.2200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1004
    Cell Significance Index: -1.2900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1010
    Cell Significance Index: -0.8900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1011
    Cell Significance Index: -1.1200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1042
    Cell Significance Index: -1.2400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1103
    Cell Significance Index: -1.4400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1119
    Cell Significance Index: -1.8000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1122
    Cell Significance Index: -1.1900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1123
    Cell Significance Index: -1.0700
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.1137
    Cell Significance Index: -0.9800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1161
    Cell Significance Index: -1.2900
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1173
    Cell Significance Index: -1.0000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1197
    Cell Significance Index: -0.9900
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1200
    Cell Significance Index: -1.0700
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1208
    Cell Significance Index: -1.1600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1215
    Cell Significance Index: -1.3100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1235
    Cell Significance Index: -1.1600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1270
    Cell Significance Index: -1.1700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1278
    Cell Significance Index: -1.1900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1282
    Cell Significance Index: -1.4500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1295
    Cell Significance Index: -1.3100
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.1307
    Cell Significance Index: -0.9200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1334
    Cell Significance Index: -1.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGKV3-7 gene is a non-functional gene, meaning it does not produce a protein that can interact with the immune system. However, it is significantly expressed in various cell types, including: * Granulocyte-monocyte progenitor cells * Early T lineage precursors * Neutrophil progenitor cells * Neutrophils * Common myeloid progenitor cells * Megakaryocyte-erythroid progenitor cells * Precursor B cells * Fraction A pre-pro B cells * Mast cells * Pro-B cells These cell types are all involved in the development and function of the immune system, suggesting that the IGKV3-7 gene plays a role in regulating immune cell development. **Pathways and Functions:** The IGKV3-7 gene is involved in several immune-related pathways, including: * Adaptive immune response: The IGKV3-7 gene is expressed in precursor B cells, which are responsible for producing antibodies in response to antigens. The presence of this gene in these cells suggests that it may contribute to the regulation of the adaptive immune response. * Extracellular space: The IGKV3-7 gene is also expressed in neutrophils, which are involved in the innate immune response. Neutrophils play a crucial role in the clearance of pathogens and other foreign substances from the extracellular space. * Immune response: The IGKV3-7 gene is expressed in mast cells, which are involved in the regulation of the immune response. Mast cells can produce cytokines and other signaling molecules that influence the activity of other immune cells. **Clinical Significance:** The IGKV3-7 gene has potential clinical significance, particularly in the context of immune-related disorders. For example: * Autoimmune diseases: The IGKV3-7 gene may contribute to the development of autoimmune diseases, such as rheumatoid arthritis, lupus, or multiple sclerosis, by influencing the regulation of immune cell development and function. * Cancer: The IGKV3-7 gene may also be involved in the development of cancer, particularly in the context of immune evasion. Cancer cells can manipulate the expression of immune-related genes, including the IGKV3-7 gene, to evade immune surveillance. * Immunodeficiency disorders: The IGKV3-7 gene may also contribute to immunodeficiency disorders, such as X-linked lymphoproliferative disease, by influencing the regulation of immune cell development and function. In conclusion, the IGKV3-7 gene is a non-functional gene that plays a crucial role in the development and function of various immune cells. Its significant expression in multiple cell types suggests that it may contribute to the regulation of immune cell development and function, potentially influencing the adaptive immune response. Further studies are needed to fully understand the role of the IGKV3-7 gene in immune-related disorders and to explore its potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.