IGKV2 30 | ENSG00000243238 | NCBI 28919

Details for: IGKV2 30

Gene ID: 28919

Symbol: IGKV2 30

Ensembl ID: ENSG00000243238

Description: immunoglobulin kappa variable 2-30

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin production
(GO:0002377)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.38
Marker Score: 873
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7,691
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,811
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,323
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,742
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.91
Marker Score: 694
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,294
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.86
Marker Score: 669
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.85
Marker Score: 1,388
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 180
Cell Name: T cell (CL0000084)
Fold Change: 0.7
Marker Score: 1,199
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.62
Marker Score: 492
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.61
Marker Score: 722
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 149
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.51
Marker Score: 824
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.5
Marker Score: 422
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.41
Marker Score: 370
Cell Name: mast cell (CL0000097)
Fold Change: 0.39
Marker Score: 227
Cell Name: platelet (CL0000233)
Fold Change: 0.36
Marker Score: 163
Cell Name: plasmablast (CL0000980)
Fold Change: 0.32
Marker Score: 428
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.32
Marker Score: 792
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.29
Marker Score: 165
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.29
Marker Score: 134
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.29
Marker Score: 346
Cell Name: plasma cell (CL0000786)
Fold Change: 0.28
Marker Score: 311
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.26
Marker Score: 342
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.25
Marker Score: 269
Cell Name: blood cell (CL0000081)
Fold Change: 0.23
Marker Score: 2,703
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.21
Marker Score: 144
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.21
Marker Score: 124
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.2
Marker Score: 180
Cell Name: immature B cell (CL0000816)
Fold Change: 0.19
Marker Score: 127
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.19
Marker Score: 182
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.18
Marker Score: 63
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.18
Marker Score: 182
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.18
Marker Score: 172
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.16
Marker Score: 149
Cell Name: B cell (CL0000236)
Fold Change: 0.16
Marker Score: 150
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.16
Marker Score: 133
Cell Name: fibroblast (CL0000057)
Fold Change: 0.15
Marker Score: 147
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.15
Marker Score: 65
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.15
Marker Score: 34
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.15
Marker Score: 287
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.14
Marker Score: 247
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.14
Marker Score: 169
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.14
Marker Score: 113
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.13
Marker Score: 90
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.13
Marker Score: 66
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.13
Marker Score: 32
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.12
Marker Score: 261
Cell Name: naive B cell (CL0000788)
Fold Change: 0.12
Marker Score: 106
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.12
Marker Score: 49
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.11
Marker Score: 61
Cell Name: neutrophil (CL0000775)
Fold Change: 0.11
Marker Score: 65
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.1
Marker Score: 278
Cell Name: mature B cell (CL0000785)
Fold Change: 0.1
Marker Score: 74
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.1
Marker Score: 65
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.09
Marker Score: 26
Cell Name: memory B cell (CL0000787)
Fold Change: 0.09
Marker Score: 71
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.09
Marker Score: 63
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.08
Marker Score: 22
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.07
Marker Score: 40
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.07
Marker Score: 45
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.07
Marker Score: 166
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.07
Marker Score: 17
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.06
Marker Score: 17
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.06
Marker Score: 20
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.06
Marker Score: 22
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.06
Marker Score: 66
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.06
Marker Score: 123
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.06
Marker Score: 50
Cell Name: stromal cell (CL0000499)
Fold Change: 0.06
Marker Score: 68
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.06
Marker Score: 28
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.06
Marker Score: 19
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.05
Marker Score: 13
Cell Name: macrophage (CL0000235)
Fold Change: 0.05
Marker Score: 59
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.05
Marker Score: 31
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.05
Marker Score: 21
Cell Name: monocyte (CL0000576)
Fold Change: 0.05
Marker Score: 62
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.05
Marker Score: 37
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.04
Marker Score: 33
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.04
Marker Score: 98
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.04
Marker Score: 21
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.04
Marker Score: 19
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.04
Marker Score: 30
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.04
Marker Score: 21
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.04
Marker Score: 21
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.04
Marker Score: 14
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.04
Marker Score: 15
Cell Name: peptic cell (CL0000155)
Fold Change: 0.04
Marker Score: 15
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.04
Marker Score: 25
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.03
Marker Score: 14
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.03
Marker Score: 53
Cell Name: promonocyte (CL0000559)
Fold Change: 0.03
Marker Score: 21
Cell Name: pericyte (CL0000669)
Fold Change: 0.03
Marker Score: 19
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.03
Marker Score: 20
Cell Name: memory T cell (CL0000813)
Fold Change: 0.03
Marker Score: 14

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics:** The IGKV2 30 gene is a member of the immunoglobulin kappa chain family, which is involved in the generation of antibodies. It is composed of three exons that encode the variable region of the kappa light chain. The gene is highly variable, with multiple isoforms generated through alternative splicing. IGKV2 30 is expressed in various immune cells, including granulocytes, monocytes, and natural killer cells, which are essential for the defense against pathogens. **Pathways and Functions:** IGKV2 30 is involved in several key immune pathways, including: 1. **Complement Cascade:** The IGKV2 30 gene is part of the classical pathway of the complement cascade, which is activated by the binding of antibodies to antigens on the surface of pathogens. The complement cascade leads to the formation of membrane attack complexes that can lyse pathogens. 2. **Phagocytosis:** IGKV2 30 is involved in the regulation of phagocytosis, which is the process by which immune cells engulf and digest pathogens. The gene is associated with the activation of scavenger receptors, which bind to pathogens and facilitate their uptake by immune cells. 3. **Cytokine Production:** IGKV2 30 is involved in the production of cytokines, which are signaling molecules that coordinate the immune response. The gene is associated with the activation of the NF-κB transcription factor, which regulates the expression of cytokine genes. 4. **Antigen Binding:** The IGKV2 30 gene is involved in the binding of antigens to the B cell receptor (BCR), which is a key step in the activation of B cells. **Clinical Significance:** The IGKV2 30 gene has significant clinical implications, particularly in the context of infectious diseases. For example: 1. **Leishmaniasis:** The IGKV2 30 gene is associated with the regulation of the immune response to Leishmania parasites, which cause this disease. 2. **SARS-CoV:** The gene is involved in the regulation of the immune response to SARS-CoV, which causes severe respiratory illness. 3. **Cancer:** The IGKV2 30 gene is expressed in various types of cancer, including leukemia and lymphoma, where it may contribute to tumorigenesis. 4. **Autoimmune Diseases:** The gene is involved in the regulation of the immune response to self-antigens, which may contribute to autoimmune diseases such as rheumatoid arthritis and lupus. In conclusion, the IGKV2 30 gene is a critical component of the adaptive immune response, involved in the regulation of various immune pathways, including the complement cascade, phagocytosis, and cytokine production. Its clinical significance is evident in the context of infectious diseases, cancer, and autoimmune diseases. Further research is necessary to fully understand the role of the IGKV2 30 gene in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.