IGKV2 30 | ENSG00000243238 | NCBI 28919

Details for: IGKV2 30

Gene ID: 28919

Symbol: IGKV2 30

Ensembl ID: ENSG00000243238

Description: immunoglobulin kappa variable 2-30

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 4.6545
Cell Significance Index: 52.0200
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.2107
Cell Significance Index: 3.2600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0677
Cell Significance Index: 1.8100
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.0178
Cell Significance Index: 0.2600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0052
Cell Significance Index: -3.9000
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0236
Cell Significance Index: -3.0300
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0551
Cell Significance Index: -0.8000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0650
Cell Significance Index: -3.0300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0828
Cell Significance Index: -14.1400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1078
Cell Significance Index: -13.9300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1218
Cell Significance Index: -5.5200
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1485
Cell Significance Index: -3.7100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1669
Cell Significance Index: -4.5400
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.1851
Cell Significance Index: -2.2900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1866
Cell Significance Index: -13.9100
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.1870
Cell Significance Index: -2.2000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1991
Cell Significance Index: -15.2800
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2066
Cell Significance Index: -5.0100
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2106
Cell Significance Index: -7.7300
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2139
Cell Significance Index: -5.4500
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.2204
Cell Significance Index: -2.6100
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.2494
Cell Significance Index: -3.1600
Cell Name: leukocyte (CL0000738)
Fold Change: -0.2567
Cell Significance Index: -4.3600
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.2618
Cell Significance Index: -3.5900
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.2627
Cell Significance Index: -4.4900
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2672
Cell Significance Index: -5.2300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2721
Cell Significance Index: -5.0300
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2741
Cell Significance Index: -4.4400
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: -0.2807
Cell Significance Index: -2.8500
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.2845
Cell Significance Index: -3.7200
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.2878
Cell Significance Index: -3.9800
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.2913
Cell Significance Index: -1.9400
Cell Name: microglial cell (CL0000129)
Fold Change: -0.3035
Cell Significance Index: -3.5700
Cell Name: plasma cell (CL0000786)
Fold Change: -0.3052
Cell Significance Index: -3.4100
Cell Name: monocyte (CL0000576)
Fold Change: -0.3198
Cell Significance Index: -3.6800
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: -0.3342
Cell Significance Index: -4.0100
Cell Name: collagen secreting cell (CL0000667)
Fold Change: -0.3353
Cell Significance Index: -1.8700
Cell Name: stromal cell (CL0000499)
Fold Change: -0.3386
Cell Significance Index: -3.4600
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.3536
Cell Significance Index: -4.0100
Cell Name: blood cell (CL0000081)
Fold Change: -0.3543
Cell Significance Index: -3.0200
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.3563
Cell Significance Index: -4.6100
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.3655
Cell Significance Index: -4.1400
Cell Name: neutrophil (CL0000775)
Fold Change: -0.3698
Cell Significance Index: -4.6200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3703
Cell Significance Index: -4.2100
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.3857
Cell Significance Index: -4.2900
Cell Name: naive B cell (CL0000788)
Fold Change: -0.3903
Cell Significance Index: -4.1100
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: -0.3912
Cell Significance Index: -4.1100
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.4014
Cell Significance Index: -3.5800
Cell Name: osteoclast (CL0000092)
Fold Change: -0.4036
Cell Significance Index: -4.1200
Cell Name: promonocyte (CL0000559)
Fold Change: -0.4045
Cell Significance Index: -4.3200
Cell Name: chondrocyte (CL0000138)
Fold Change: -0.4165
Cell Significance Index: -4.8000
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.4235
Cell Significance Index: -4.3000
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.4267
Cell Significance Index: -5.6000
Cell Name: glial cell (CL0000125)
Fold Change: -0.4272
Cell Significance Index: -4.6800
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.4311
Cell Significance Index: -4.5800
Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
Fold Change: -0.4319
Cell Significance Index: -4.6700
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.4372
Cell Significance Index: -6.4000
Cell Name: granulocyte (CL0000094)
Fold Change: -0.4377
Cell Significance Index: -5.2800
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.4394
Cell Significance Index: -3.9600
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.4502
Cell Significance Index: -5.3200
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.4578
Cell Significance Index: -5.0700
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.4606
Cell Significance Index: -5.1000
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.4608
Cell Significance Index: -5.9200
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: -0.4614
Cell Significance Index: -3.8900
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.4622
Cell Significance Index: -4.9700
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: -0.4624
Cell Significance Index: -4.9200
Cell Name: enterocyte (CL0000584)
Fold Change: -0.4682
Cell Significance Index: -2.9100
Cell Name: eosinophil (CL0000771)
Fold Change: -0.4685
Cell Significance Index: -4.1500
Cell Name: mast cell (CL0000097)
Fold Change: -0.4696
Cell Significance Index: -6.1800
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.4703
Cell Significance Index: -6.1400
Cell Name: memory B cell (CL0000787)
Fold Change: -0.4719
Cell Significance Index: -5.0200
Cell Name: immature B cell (CL0000816)
Fold Change: -0.4735
Cell Significance Index: -4.4800
Cell Name: B cell (CL0000236)
Fold Change: -0.4739
Cell Significance Index: -5.6000
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.4739
Cell Significance Index: -5.3400
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.4771
Cell Significance Index: -4.5800
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.4823
Cell Significance Index: -5.5500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4832
Cell Significance Index: -13.8500
Cell Name: myofibroblast cell (CL0000186)
Fold Change: -0.4842
Cell Significance Index: -5.0800
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.4880
Cell Significance Index: -5.6700
Cell Name: platelet (CL0000233)
Fold Change: -0.4918
Cell Significance Index: -5.0600
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.4937
Cell Significance Index: -4.8700
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.4938
Cell Significance Index: -5.6100
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.4944
Cell Significance Index: -5.3300
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.4961
Cell Significance Index: -4.1000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4970
Cell Significance Index: -10.3100
Cell Name: T cell (CL0000084)
Fold Change: -0.4993
Cell Significance Index: -5.9000
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.4998
Cell Significance Index: -6.0800
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: -0.5033
Cell Significance Index: -4.6700
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.5035
Cell Significance Index: -6.1300
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: -0.5102
Cell Significance Index: -4.8500
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.5166
Cell Significance Index: -4.8100
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: -0.5202
Cell Significance Index: -4.6600
Cell Name: plasmablast (CL0000980)
Fold Change: -0.5226
Cell Significance Index: -4.8500
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.5233
Cell Significance Index: -5.5200
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.5242
Cell Significance Index: -6.0800
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.5269
Cell Significance Index: -5.8100
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: -0.5277
Cell Significance Index: -5.6900
Cell Name: fibroblast (CL0000057)
Fold Change: -0.5304
Cell Significance Index: -4.9800
Cell Name: obsolete animal cell (CL0000548)
Fold Change: -0.5316
Cell Significance Index: -5.3900
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: -0.5392
Cell Significance Index: -3.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** The IGKV2 30 gene is a member of the immunoglobulin kappa chain family, which is involved in the generation of antibodies. It is composed of three exons that encode the variable region of the kappa light chain. The gene is highly variable, with multiple isoforms generated through alternative splicing. IGKV2 30 is expressed in various immune cells, including granulocytes, monocytes, and natural killer cells, which are essential for the defense against pathogens. **Pathways and Functions:** IGKV2 30 is involved in several key immune pathways, including: 1. **Complement Cascade:** The IGKV2 30 gene is part of the classical pathway of the complement cascade, which is activated by the binding of antibodies to antigens on the surface of pathogens. The complement cascade leads to the formation of membrane attack complexes that can lyse pathogens. 2. **Phagocytosis:** IGKV2 30 is involved in the regulation of phagocytosis, which is the process by which immune cells engulf and digest pathogens. The gene is associated with the activation of scavenger receptors, which bind to pathogens and facilitate their uptake by immune cells. 3. **Cytokine Production:** IGKV2 30 is involved in the production of cytokines, which are signaling molecules that coordinate the immune response. The gene is associated with the activation of the NF-κB transcription factor, which regulates the expression of cytokine genes. 4. **Antigen Binding:** The IGKV2 30 gene is involved in the binding of antigens to the B cell receptor (BCR), which is a key step in the activation of B cells. **Clinical Significance:** The IGKV2 30 gene has significant clinical implications, particularly in the context of infectious diseases. For example: 1. **Leishmaniasis:** The IGKV2 30 gene is associated with the regulation of the immune response to Leishmania parasites, which cause this disease. 2. **SARS-CoV:** The gene is involved in the regulation of the immune response to SARS-CoV, which causes severe respiratory illness. 3. **Cancer:** The IGKV2 30 gene is expressed in various types of cancer, including leukemia and lymphoma, where it may contribute to tumorigenesis. 4. **Autoimmune Diseases:** The gene is involved in the regulation of the immune response to self-antigens, which may contribute to autoimmune diseases such as rheumatoid arthritis and lupus. In conclusion, the IGKV2 30 gene is a critical component of the adaptive immune response, involved in the regulation of various immune pathways, including the complement cascade, phagocytosis, and cytokine production. Its clinical significance is evident in the context of infectious diseases, cancer, and autoimmune diseases. Further research is necessary to fully understand the role of the IGKV2 30 gene in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.