IGKV1 17 | ENSG00000240382 | NCBI 28937

Details for: IGKV1 17

Gene ID: 28937

Symbol: IGKV1 17

Ensembl ID: ENSG00000240382

Description: immunoglobulin kappa variable 1-17

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.2483
Cell Significance Index: 2.7800
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.0086
Cell Significance Index: 0.1300
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0052
Cell Significance Index: -0.0800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0069
Cell Significance Index: -5.2100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0535
Cell Significance Index: -5.4600
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0588
Cell Significance Index: -1.4300
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0635
Cell Significance Index: -8.2000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0806
Cell Significance Index: -4.9400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1131
Cell Significance Index: -8.4300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1136
Cell Significance Index: -5.1500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1357
Cell Significance Index: -4.9800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1428
Cell Significance Index: -3.8200
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1656
Cell Significance Index: -4.2200
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1916
Cell Significance Index: -4.7800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1974
Cell Significance Index: -15.1500
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2167
Cell Significance Index: -4.3500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2254
Cell Significance Index: -10.5100
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2260
Cell Significance Index: -3.6600
Cell Name: stromal cell (CL0000499)
Fold Change: -0.2408
Cell Significance Index: -2.4600
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.2465
Cell Significance Index: -2.6500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2519
Cell Significance Index: -5.2300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2538
Cell Significance Index: -4.6900
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.2589
Cell Significance Index: -3.0600
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2644
Cell Significance Index: -5.1700
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2743
Cell Significance Index: -4.6200
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.2829
Cell Significance Index: -4.8400
Cell Name: plasma cell (CL0000786)
Fold Change: -0.2846
Cell Significance Index: -3.1800
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.2873
Cell Significance Index: -4.2400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2924
Cell Significance Index: -15.1900
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.2944
Cell Significance Index: -2.4300
Cell Name: leukocyte (CL0000738)
Fold Change: -0.3044
Cell Significance Index: -5.1700
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.3100
Cell Significance Index: -4.3000
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.3117
Cell Significance Index: -4.2400
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.3289
Cell Significance Index: -4.5100
Cell Name: monocyte (CL0000576)
Fold Change: -0.3329
Cell Significance Index: -3.8300
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.3454
Cell Significance Index: -2.3000
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.3706
Cell Significance Index: -4.2100
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.3706
Cell Significance Index: -4.3600
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.3723
Cell Significance Index: -3.8400
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.3746
Cell Significance Index: -5.4600
Cell Name: neutrophil (CL0000775)
Fold Change: -0.3754
Cell Significance Index: -4.6900
Cell Name: blood cell (CL0000081)
Fold Change: -0.3772
Cell Significance Index: -3.2200
Cell Name: memory B cell (CL0000787)
Fold Change: -0.3868
Cell Significance Index: -4.1200
Cell Name: naive B cell (CL0000788)
Fold Change: -0.3894
Cell Significance Index: -4.1000
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.3903
Cell Significance Index: -5.0500
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.4090
Cell Significance Index: -4.5100
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.4104
Cell Significance Index: -4.3600
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.4134
Cell Significance Index: -3.7800
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.4179
Cell Significance Index: -4.2400
Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.4218
Cell Significance Index: -3.8600
Cell Name: plasmablast (CL0000980)
Fold Change: -0.4235
Cell Significance Index: -3.9300
Cell Name: granulocyte (CL0000094)
Fold Change: -0.4269
Cell Significance Index: -5.1500
Cell Name: glial cell (CL0000125)
Fold Change: -0.4281
Cell Significance Index: -4.6900
Cell Name: acinar cell (CL0000622)
Fold Change: -0.4307
Cell Significance Index: -5.4100
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.4330
Cell Significance Index: -4.9100
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.4363
Cell Significance Index: -4.8300
Cell Name: B cell (CL0000236)
Fold Change: -0.4409
Cell Significance Index: -5.2100
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.4416
Cell Significance Index: -5.8000
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.4454
Cell Significance Index: -5.5100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.4466
Cell Significance Index: -5.0700
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.4467
Cell Significance Index: -5.4300
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.4491
Cell Significance Index: -5.7700
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.4511
Cell Significance Index: -4.3300
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.4532
Cell Significance Index: -5.1300
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.4553
Cell Significance Index: -5.3800
Cell Name: platelet (CL0000233)
Fold Change: -0.4564
Cell Significance Index: -4.7000
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: -0.4577
Cell Significance Index: -4.8700
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.4621
Cell Significance Index: -4.8700
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: -0.4636
Cell Significance Index: -3.6600
Cell Name: myofibroblast cell (CL0000186)
Fold Change: -0.4641
Cell Significance Index: -4.8700
Cell Name: mast cell (CL0000097)
Fold Change: -0.4645
Cell Significance Index: -6.1100
Cell Name: immature B cell (CL0000816)
Fold Change: -0.4661
Cell Significance Index: -4.4100
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.4685
Cell Significance Index: -5.2800
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.4706
Cell Significance Index: -5.0000
Cell Name: promonocyte (CL0000559)
Fold Change: -0.4710
Cell Significance Index: -5.0300
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.4725
Cell Significance Index: -8.3500
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.4760
Cell Significance Index: -5.7900
Cell Name: mature B cell (CL0000785)
Fold Change: -0.4770
Cell Significance Index: -3.1100
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.4787
Cell Significance Index: -4.2700
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.4800
Cell Significance Index: -5.8400
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.4846
Cell Significance Index: -4.9200
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.4853
Cell Significance Index: -3.9000
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: -0.4872
Cell Significance Index: -5.2800
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: -0.4881
Cell Significance Index: -5.2500
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.4885
Cell Significance Index: -5.4100
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.4903
Cell Significance Index: -6.4000
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.4904
Cell Significance Index: -4.7800
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.4944
Cell Significance Index: -5.3300
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.4966
Cell Significance Index: -5.7700
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: -0.4968
Cell Significance Index: -5.1200
Cell Name: club cell (CL0000158)
Fold Change: -0.4975
Cell Significance Index: -5.4200
Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
Fold Change: -0.4980
Cell Significance Index: -5.3900
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.4988
Cell Significance Index: -5.7400
Cell Name: T cell (CL0000084)
Fold Change: -0.4989
Cell Significance Index: -5.8900
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -0.5028
Cell Significance Index: -5.2100
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.5065
Cell Significance Index: -5.3700
Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.5073
Cell Significance Index: -5.5000
Cell Name: intermediate monocyte (CL0002393)
Fold Change: -0.5077
Cell Significance Index: -4.7300
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.5108
Cell Significance Index: -5.2100
Cell Name: goblet cell (CL0000160)
Fold Change: -0.5130
Cell Significance Index: -4.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** IGKV1-17 is a gene that encodes a kappa light chain variable region, which is a critical component of the IgK antibody. This gene is part of the immunoglobulin kappa (IgK) family, which is responsible for the production of IgK antibodies. IGKV1-17 is significantly expressed in various cell types, including granulocytes, natural killer cells, and epithelial cells. The expression of IGKV1-17 is tightly regulated, and its dysregulation has been implicated in various immune-related disorders. **Pathways and Functions:** IGKV1-17 is involved in multiple immune pathways, including: 1. **Adaptive Immune Response:** IGKV1-17 is part of the adaptive immune system, which is responsible for the specific recognition and elimination of pathogens. The IgK antibody produced by IGKV1-17 recognizes and binds to specific antigens, triggering the activation of immune cells and the production of cytokines. 2. **Leishmania Infection:** IGKV1-17 plays a critical role in the activation of the complement cascade and the phagocytosis of Leishmania parasites. The complement cascade is a group of proteins that work together to eliminate pathogens from the body. IGKV1-17 contributes to the activation of the complement cascade, which leads to the phagocytosis of the parasite. 3. **Antigen Binding:** IGKV1-17 is involved in the binding of antigens to the IgK antibody. This binding event triggers the activation of immune cells and the production of cytokines. 4. **Cell Surface Interactions:** IGKV1-17 is involved in cell surface interactions, including the binding of ligands to scavenger receptors. This interaction is critical for the recognition and elimination of pathogens. **Clinical Significance:** IGKV1-17 has significant clinical implications, particularly in the context of Leishmania infection. Dysregulation of IGKV1-17 has been implicated in various immune-related disorders, including: 1. **Leishmaniasis:** IGKV1-17 plays a critical role in the activation of the complement cascade and the phagocytosis of Leishmania parasites. Dysregulation of IGKV1-17 may contribute to the development of Leishmaniasis. 2. **Autoimmune Disorders:** IGKV1-17 is involved in the production of IgK antibodies, which can contribute to autoimmune disorders, such as rheumatoid arthritis and lupus. 3. **Cancer:** IGKV1-17 is expressed in various cancer cell types, including granulocytes and epithelial cells. Dysregulation of IGKV1-17 may contribute to the development of cancer. In conclusion, IGKV1-17 is a critical component of the adaptive immune system and plays a significant role in the context of Leishmania infection. Further research is needed to fully understand the mechanisms by which IGKV1-17 contributes to immune responses and the development of immune-related disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.