Details for: IGKV1 8

Gene ID: 28942

Symbol: IGKV1 8

Ensembl ID: ENSG00000240671

Description: immunoglobulin kappa variable 1-8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.7994
    Cell Significance Index: 20.1100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1125
    Cell Significance Index: 1.7400
  • Cell Name: lymphocyte of B lineage (CL0000945)
    Fold Change: -0.0365
    Cell Significance Index: -0.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0418
    Cell Significance Index: -4.2700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0655
    Cell Significance Index: -0.8300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0751
    Cell Significance Index: -1.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1020
    Cell Significance Index: -6.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1282
    Cell Significance Index: -3.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1352
    Cell Significance Index: -6.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1545
    Cell Significance Index: -5.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1979
    Cell Significance Index: -5.0600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2143
    Cell Significance Index: -2.1900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2190
    Cell Significance Index: -3.1800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2265
    Cell Significance Index: -5.7700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2328
    Cell Significance Index: -2.8800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2386
    Cell Significance Index: -2.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2657
    Cell Significance Index: -7.2300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2828
    Cell Significance Index: -4.5800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3033
    Cell Significance Index: -5.9300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3362
    Cell Significance Index: -4.6100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3463
    Cell Significance Index: -5.9200
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.3544
    Cell Significance Index: -2.3600
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.3574
    Cell Significance Index: -2.9500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3717
    Cell Significance Index: -6.8700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.3914
    Cell Significance Index: -4.6100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3926
    Cell Significance Index: -9.8100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.4091
    Cell Significance Index: -5.3500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4112
    Cell Significance Index: -7.0900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4137
    Cell Significance Index: -4.7600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.4481
    Cell Significance Index: -4.7600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.4521
    Cell Significance Index: -4.7600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.4820
    Cell Significance Index: -5.3900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.4841
    Cell Significance Index: -5.8400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4938
    Cell Significance Index: -6.3900
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.4972
    Cell Significance Index: -4.7400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.5015
    Cell Significance Index: -5.4300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.5106
    Cell Significance Index: -5.7800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.5227
    Cell Significance Index: -5.8900
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.5230
    Cell Significance Index: -5.7300
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.5260
    Cell Significance Index: -5.8000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.5260
    Cell Significance Index: -6.9900
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.5262
    Cell Significance Index: -5.6200
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.5301
    Cell Significance Index: -5.7900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.5311
    Cell Significance Index: -5.0300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.5363
    Cell Significance Index: -6.7000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.5428
    Cell Significance Index: -6.0100
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.5550
    Cell Significance Index: -5.4300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.5629
    Cell Significance Index: -8.2100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.5638
    Cell Significance Index: -5.8400
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.5644
    Cell Significance Index: -5.7300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.5653
    Cell Significance Index: -5.5100
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.5696
    Cell Significance Index: -5.8600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.5758
    Cell Significance Index: -9.7800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.5840
    Cell Significance Index: -7.0500
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.5923
    Cell Significance Index: -5.2500
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.5937
    Cell Significance Index: -5.0600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.5971
    Cell Significance Index: -7.0500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.5987
    Cell Significance Index: -6.8900
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.5989
    Cell Significance Index: -5.5800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.5999
    Cell Significance Index: -6.4500
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.6032
    Cell Significance Index: -5.7900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.6063
    Cell Significance Index: -6.4500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.6085
    Cell Significance Index: -6.6300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.6178
    Cell Significance Index: -7.3000
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.6239
    Cell Significance Index: -5.7900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.6240
    Cell Significance Index: -4.7700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.6242
    Cell Significance Index: -9.1300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.6251
    Cell Significance Index: -5.8200
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.6311
    Cell Significance Index: -5.5000
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.6314
    Cell Significance Index: -5.4300
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.6332
    Cell Significance Index: -5.8500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.6355
    Cell Significance Index: -7.5100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.6358
    Cell Significance Index: -5.8400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.6419
    Cell Significance Index: -5.8700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.6420
    Cell Significance Index: -7.1100
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.6425
    Cell Significance Index: -5.7100
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.6458
    Cell Significance Index: -5.7600
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.6492
    Cell Significance Index: -5.8000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6522
    Cell Significance Index: -6.8800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.6585
    Cell Significance Index: -7.1000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.6595
    Cell Significance Index: -8.6600
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.6658
    Cell Significance Index: -6.1400
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.6669
    Cell Significance Index: -6.9900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.6673
    Cell Significance Index: -6.2700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.6678
    Cell Significance Index: -8.6000
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.6683
    Cell Significance Index: -5.9500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.6725
    Cell Significance Index: -8.8500
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.6744
    Cell Significance Index: -7.3000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.6751
    Cell Significance Index: -5.9100
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.6765
    Cell Significance Index: -7.0100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.6766
    Cell Significance Index: -7.1900
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.6781
    Cell Significance Index: -5.4500
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.6833
    Cell Significance Index: -6.1800
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.6856
    Cell Significance Index: -5.7300
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.6905
    Cell Significance Index: -7.0100
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.6919
    Cell Significance Index: -5.5600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.6938
    Cell Significance Index: -6.9900
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.6954
    Cell Significance Index: -6.1100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.6954
    Cell Significance Index: -6.8600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.6985
    Cell Significance Index: -6.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV1-8 is a member of the immunoglobulin superfamily, which comprises genes that encode for the variable regions of immunoglobulins. The IgK locus, including IGKV1-8, is characterized by its unique structure and organization, which allows for the generation of a diverse repertoire of kappa light chains. IGKV1-8 is specifically involved in the production of kappa light chains, which are essential for the assembly and function of immunoglobulins. The gene's expression is tightly regulated, and its dysregulation has been implicated in various autoimmune and immunodeficiency disorders. **Pathways and Functions:** IGKV1-8 is involved in several key pathways, including: 1. **Adaptive Immune Response:** IGKV1-8 plays a crucial role in the adaptive immune response by contributing to the production of kappa light chains, which are essential for the assembly and function of immunoglobulins. 2. **Immunoglobulin Complex Formation:** IGKV1-8 is involved in the formation of immunoglobulin complexes, which are composed of heavy and light chains. These complexes are recognized by the immune system and trigger an immune response. 3. **Immunoglobulin Production:** IGKV1-8 is essential for the production of kappa light chains, which are necessary for the assembly and function of immunoglobulins. 4. **Plasma Membrane Function:** IGKV1-8 is also involved in the regulation of plasma membrane function, particularly in the context of immune cell activation and signaling. **Clinical Significance:** IGKV1-8 dysregulation has been implicated in various clinical conditions, including: 1. **Autoimmune Disorders:** Dysregulation of IGKV1-8 has been linked to autoimmune disorders, such as autoimmune hemolytic anemia and autoimmune thrombocytopenia. 2. **Immunodeficiency Disorders:** IGKV1-8 dysregulation has also been implicated in immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). 3. **Cancer:** IGKV1-8 has been found to be overexpressed in certain types of cancer, including lymphoma and leukemia. 4. **Infectious Diseases:** IGKV1-8 has been shown to play a role in the regulation of the immune response to infections, particularly in the context of bacterial and viral infections. In conclusion, IGKV1-8 is a critical component of the adaptive immune response, and its dysregulation has significant clinical implications. Further research is needed to fully elucidate the mechanisms by which IGKV1-8 regulates the immune response and to identify potential therapeutic targets for the treatment of related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.