Details for: SPANXA1

Gene ID: 30014

Symbol: SPANXA1

Ensembl ID: ENSG00000198021

Description: sperm protein associated with the nucleus, X-linked, family member A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 6.2116
    Cell Significance Index: 100.6100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 5.1366
    Cell Significance Index: 130.8700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.8252
    Cell Significance Index: 31.2000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.7115
    Cell Significance Index: 23.4700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.8510
    Cell Significance Index: 9.0400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.7191
    Cell Significance Index: 9.3100
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.0317
    Cell Significance Index: 0.3700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0217
    Cell Significance Index: 0.2800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0102
    Cell Significance Index: 0.1500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0020
    Cell Significance Index: 0.0200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0091
    Cell Significance Index: -1.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0096
    Cell Significance Index: -1.3200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0212
    Cell Significance Index: -0.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0333
    Cell Significance Index: -2.0500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0487
    Cell Significance Index: -0.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0488
    Cell Significance Index: -2.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0611
    Cell Significance Index: -1.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0619
    Cell Significance Index: -2.0300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0669
    Cell Significance Index: -0.7700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0672
    Cell Significance Index: -0.6500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0794
    Cell Significance Index: -1.9800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0823
    Cell Significance Index: -1.0800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0843
    Cell Significance Index: -1.1100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0866
    Cell Significance Index: -1.8700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0869
    Cell Significance Index: -2.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0908
    Cell Significance Index: -1.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0909
    Cell Significance Index: -1.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0961
    Cell Significance Index: -1.9300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1043
    Cell Significance Index: -2.0800
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.1111
    Cell Significance Index: -1.2400
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1270
    Cell Significance Index: -1.3100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1276
    Cell Significance Index: -1.6700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1296
    Cell Significance Index: -1.3900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1341
    Cell Significance Index: -3.3500
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.1346
    Cell Significance Index: -1.4700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1380
    Cell Significance Index: -1.7700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1420
    Cell Significance Index: -1.9200
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1475
    Cell Significance Index: -1.3500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1520
    Cell Significance Index: -2.0200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1555
    Cell Significance Index: -1.8600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1611
    Cell Significance Index: -4.0200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1646
    Cell Significance Index: -2.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1726
    Cell Significance Index: -4.8200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1828
    Cell Significance Index: -2.1700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1868
    Cell Significance Index: -2.4900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1922
    Cell Significance Index: -2.6200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1959
    Cell Significance Index: -2.0800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1991
    Cell Significance Index: -1.9700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1993
    Cell Significance Index: -2.3900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2014
    Cell Significance Index: -1.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2017
    Cell Significance Index: -5.1900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2030
    Cell Significance Index: -2.5000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2100
    Cell Significance Index: -2.4400
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.2108
    Cell Significance Index: -1.3200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2113
    Cell Significance Index: -2.4000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2171
    Cell Significance Index: -2.7400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2194
    Cell Significance Index: -2.0800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2202
    Cell Significance Index: -2.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2209
    Cell Significance Index: -2.7400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2232
    Cell Significance Index: -2.4200
  • Cell Name: diffuse bipolar 3a cell (CL4033029)
    Fold Change: -0.2277
    Cell Significance Index: -2.7400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2288
    Cell Significance Index: -2.6900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2290
    Cell Significance Index: -2.7300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.2310
    Cell Significance Index: -1.8200
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.2325
    Cell Significance Index: -2.4500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2483
    Cell Significance Index: -3.7700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.2496
    Cell Significance Index: -2.7400
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.2518
    Cell Significance Index: -1.4500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2579
    Cell Significance Index: -2.7200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2620
    Cell Significance Index: -2.4600
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.2640
    Cell Significance Index: -1.6600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2651
    Cell Significance Index: -2.4800
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.2858
    Cell Significance Index: -1.3200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2895
    Cell Significance Index: -4.0600
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.3201
    Cell Significance Index: -2.3700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.3264
    Cell Significance Index: -2.7000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.3266
    Cell Significance Index: -1.2300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3307
    Cell Significance Index: -2.7300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3561
    Cell Significance Index: -2.7400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3609
    Cell Significance Index: -4.3000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.3756
    Cell Significance Index: -2.7300
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.4020
    Cell Significance Index: -1.7500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.4478
    Cell Significance Index: -6.1500
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.4657
    Cell Significance Index: -1.6200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.4914
    Cell Significance Index: -6.4400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.4976
    Cell Significance Index: -5.0800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.5020
    Cell Significance Index: -3.1400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.5080
    Cell Significance Index: -6.1800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.5107
    Cell Significance Index: -4.5000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.5335
    Cell Significance Index: -6.9600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5698
    Cell Significance Index: -8.1900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.6479
    Cell Significance Index: -7.6500
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.6536
    Cell Significance Index: -5.2000
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.6754
    Cell Significance Index: -7.5600
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.7046
    Cell Significance Index: -6.3700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.7899
    Cell Significance Index: -8.9000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.9010
    Cell Significance Index: -9.3200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.9114
    Cell Significance Index: -6.1800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.9637
    Cell Significance Index: -2.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SPANXA1 is a X-linked gene, indicating its involvement in sex-linked traits and diseases. Its expression is restricted to hematopoietic cells, including erythrocytes, megakaryocytes, and precursor B cells, which are essential for the production of blood cells. The gene is also significantly expressed in megakaryocyte-erythroid progenitor cells, mast cells, and epithelial cells of the alveolus of the lung, suggesting its broader role in immune regulation. Furthermore, SPANXA1 is a member of the SPAN family, which consists of proteins that are highly conserved across species and are involved in various cellular processes. **Pathways and Functions:** SPANXA1 is involved in multiple cellular pathways, including protein binding, cytoplasmic, and nuclear pathways. Its primary function is to regulate the development and function of hematopoietic cells, including the production of erythrocytes, megakaryocytes, and precursor B cells. SPANXA1 also modulates the expression of genes involved in the immune response, including those involved in inflammation and immune cell activation. Additionally, its role in protein binding suggests its involvement in protein-protein interactions, which are essential for regulating cellular processes. **Clinical Significance:** The clinical significance of SPANXA1 lies in its potential role in the development and progression of immune-related disorders. Mutations in the SPANXA1 gene have been associated with various hematological malignancies, including acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL). Furthermore, SPANXA1 has been identified as a cancer/testis antigen (CTA), which is a type of protein that is overexpressed in cancer cells and is targeted by the immune system. The identification of SPANXA1 as a CTA has significant implications for the development of immunotherapeutic strategies for cancer treatment. In conclusion, SPANXA1 is a critical regulator of immune responses in hematopoietic cells, and its dysregulation has been implicated in various immune-related disorders. Further research is necessary to fully understand the role of SPANXA1 in human health and disease, but its identification as a cancer/testis antigen holds promise for the development of novel immunotherapeutic strategies. **Recommendations for Future Research:** 1. Investigate the role of SPANXA1 in the development and progression of hematological malignancies. 2. Explore the potential of SPANXA1 as a cancer/testis antigen for immunotherapeutic strategies. 3. Determine the specific mechanisms by which SPANXA1 regulates immune responses in hematopoietic cells. 4. Investigate the expression and function of SPANXA1 in other cell types, including epithelial cells and mast cells. By addressing these research questions, scientists can further elucidate the role of SPANXA1 in human health and disease, ultimately leading to the development of novel therapeutic strategies for immune-related disorders.

Genular Protein ID: 3463266910

Symbol: SPNXA_HUMAN

Name: Cancer/testis antigen 11.1

UniProtKB Accession Codes:

Q9NS26 Q5JWI0

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 2 Bgee 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 2 CTD 2 DMDM 1 DNASU 1 DisGeNET 2 EMBL 28 Ensembl 2 GO 3 GeneCards 2 GeneTree 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 IntAct 1 InterPro 1 KEGG 2 MANE-Select 2 MIM 2 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 2 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10906052

Title: Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa.

PubMed ID: 10906052

DOI: 10.1093/biolreprod/63.2.469

PubMed ID: 12758128

Title: The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines.

PubMed ID: 12758128

DOI: 10.1016/s0378-1119(03)00497-9

PubMed ID: 16251457

Title: Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27.

PubMed ID: 16251457

DOI: 10.1101/gr.4212705

PubMed ID: 17373721

Title: Mutational analysis of SPANX genes in families with X-linked prostate cancer.

PubMed ID: 17373721

DOI: 10.1002/pros.20561

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 97
  • Mass: 11038
  • Checksum: 35DD0CEDF8A71376
  • Sequence:
    • MDKQSSAGGV KRSVPCDSNE ANEMMPETPT GDSDPQPAPK KMKTSESSTI LVVRYRRNFK 
RTSPEELLND HARENRINPL QMEEEEFMEI MVEIPAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.